INBRX-120, a CD8α-targeted detuned IL-2 that selectively expands and activates tumoricidal effector cells for safe and durable in vivo responses by Jason Ho, Chelsie Macedo, Garrett Cyprus, Rajay Pandit, Anya Polovina, Nadja Kern, Abrahim Hussain, Sae Jeong Ahn, William Crago, Emily Rowell, Florian J Sulzmaier, John C Timmer, Brendan P Eckelman

“…Preclinical safety, as well as pharmacodynamic (PD) and PK profiling was carried out in non-human primates.Results INBRX-120 effectively expanded and enhanced the cytotoxic capacity of CD8 T cells and natural killer cells towards tumor cells without affecting regulatory T cells in vitro and in vivo. …”
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Effect of gonadectomy and estradiol on the expression of insulin signaling cascade genes in female and male mice by T. V. Iakovleva, N. E. Kostina, E. N. Makarova, N. M. Bazhan

“…In males, gonadectomy, on the contrary, increased the blood estradiol level, decreased blood insulin level and insulin resistance. Estradiol did not affect the parameters studied in males. The development of insulin resistance in gonadectomized females was associated with a decreased expression of the Irs2 gene in the liver. …”
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ECONOMIC ASPECT OF CRIMINAL LAW COUNTERACTION TO JUSTIFICATION OF ARMED AGGRESSION AGAINST UKRAINE: RISKS FOR THE STATE BUDGET IN THE LIGHT OF THE PRACTICE OF THE EUROPEAN COURT OF... by Andrii Lapkin, Daryna Yevtieieva, Daria Kukovynets

“…Based on the average amount of compensation in cases against Ukraine of 13,190.8 EUR and the number of convictions under Article 4362 of the CCU, as well as taking into account the factors that may affect the number of applications to the ECHR by persons convicted under this Article, an approximate total amount of possible satisfaction was calculated in the range of 264,000 EUR - 923,000 EUR. …”
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Adults with Longstanding Strabismus: Psychosocial and Functional Impacts and Reasons behind Surgery Delay by Rami Al-Omari, Hisham M Jammal, Yousef Khader, Dema Atoum, Wedad Al-dolat, Moawiah Khatatbeh

“…Strabismus has a profound psychosocial and functional impact on affected individuals, especially females and patients with large deviation sizes. …”
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Prediction model study focusing on eHealth in the management of urinary incontinence: the Personalised Advantage Index as a decision-making aid by Huibert Burger, Henk van der Worp, Marco H Blanker, Marjolein Y Berger, Anne Martina Maria Loohuis, Nienke Wessels, Janny Dekker, Alec GGA Malmberg

“…For each participant, we then predicted treatment outcomes and calculated a Personalised Advantage Index (PAI).Results Baseline UI severity (prognostic) and age, educational level and impact on quality of life (modifiers) independently affected treatment effect of eHealth. The mean PAI was 0.99±0.79 points, being of clinical relevance in 21% of individuals. …”
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Ilaser Submucous Destruction in the Treatment of Hemorrhoids by S. A. Frolov, D. V. Vyshegorodtsev, A. M. Kuzminov, Yu. L. Trubacheva, V. Yu. Korolik, I. S. Bogormistrov, I. A. Mukhin, A. N. Ryndin, A. A. Anarbaeva

“…The proposed method applying a fiber laser with a diode pump with a wavelength of 1940 nm makes it possible to affect transdermally the internal hemorrhoidal node without damaging the mucosa of the anal canal. …”
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Perceived stress, trust, safety and severity of SARS-CoV-2 infection among patients discharged from hospital during the COVID-19 pandemic’s first wave: a PREMs survey by Henk Verloo, Eric Bonvin, Nadine Tacchini-Jacquier, Sevrine Monnay

“…Associations were found between SARS-CoV-2 infected participants and the perceived SARS-CoV-2 severity score (Rs=−0.087), between trust scores and feelings of safety (Rs=0.147), and perceived severity of a SARS-CoV-2 infection (Rs=0.123).Discussion The results indicated that inpatients experienced significant feelings of stress regarding perceived symptoms of the illness, yet this did not affect their feelings of safety, trust in healthcare staff or perception of the severity of SARS-CoV-2 infection. …”
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Histopathology of liver, kidney, intestine, spleen, and bile of catfish with Jaundice by Farhan Asrido, Sri Nuryati, Widanarni Widanarni

“… Jaundice is a disease that can affect catfish, resulting in low or unsalable selling prices. …”
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Hubungan Indeks Massa Tubuh dengan Kejadian Preeklampsia di RSUP Dr. M. Djamil Padang by Cintya Andriani, Nur Indrawati Lipoeto, Bobby Indra Utama

“…The exact cause of preeclampsia still unknown, but there are risk factors that affect the preeclampsia’s incident. There was an increase of preeclampsia’s case in RSUP Dr. …”
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Glasswort as a Strategic Crop in Coastal Wetlands: Intercropping Results with Swiss Chard by Anna Rita Bernadette Cammerino, Michela Ingaramo, Vincenzo Rizzi, Maurizio Gioiosa, Massimo Monteleone

“…In terms of salinity, about 18 million ha of land, or 25% of the total irrigated area in the Mediterranean, is salt affected. The use of halophytes as intercropping species to mitigate the effects of salt stress is attractive. …”
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Empresarios, capitales e industrias en la región Caribe colombiana bajo el despegue del modelo agroexportador a comienzos del siglo XX by SEGIO PAOLO SOLANO

“…Therefore what we show is that there was no continuity line with the business of the nineteenth century and the beginning of the next century, which ended up affecting the scope of maintenance and expansion of industries.…”
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Phosphorus transitions driven by cyclone biparjoy linked middle east North Africa (MENA) and Indian Thar Desert dust storm pathways in Asia’s largest grassland by Rupak Dey, Seema B. Sharma, Mahesh G. Thakkar, Ranjit Kumar Sarangi, Abhiroop Chowdhury, Aliya Naz

“…The SW cyclone ‘Biparjoy’, which followed the same track of aerosol loading (MENA), made landfall in this zone (June 16, 2023) and affected the P depositional patterns. The pre-cyclone, post-cyclone and 20 DAC (days after cyclone) had AP values of 15.15, 22.54 and 24.06, respectively. …”
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Does diabetes modify the triglyceride–glucose index associated with cardiovascular events and mortality? A meta-analysis of 50 cohorts involving 7,239,790 participants by Jun Zhang, Qiye Zhan, Zhihao Deng, Ling Lin, Zhaolan Feng, Huabin He, Deju Zhang, Huilei Zhao, Xiang Gu, Xiaoping Yin, Peng Yu, Xiao Liu

“…However, whether diabetes affects TyG-cardiovascular diseases (CVD) is still unclear. …”
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Diagnosis and Numerical Simulation of Low-level Wind Shear over the Hengduan Mountains in Winter by Ren Juzhang, Yang Xue, Tao Yun, Fu Zhijia, Chen Yan, Zhong Yahan, Wang Man, Jin Yan

“…The rapid fluctuations in wind direction and speed near the ground in the dam area on the east side of the airport significantly affects aviation safety. With the weakening of the solar radiation, the prevailing wind and valley wind begins to weaken at night, and the mountain wind circulation shifts towards the dam area on the east side of the airport, resulting in an increase in vertical subsidence movements. …”
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Impact of COVID-19 on rheumatic diseases in india: Determinants of mortality and adverse outcome: A retrospective, cross-sectional cohort study by Avinash Jain, Vineeta Shobha, S Chandrashekara, Padmanabha Shenoy, Sapan C Pandya, Prakash Chotalia, Sharath Kumar, Sourabh Malviya, Yogesh Preet Singh, Abhishek Patil, Vikas Gupta, Puja Srivastava, Vijaya Prasanna Parimi, Chanakya Kodishala, Ramya Janardana, Benzeeta Pinto, Sudhir Bhandari, Govind Rankawat, Praveen Pratap Jadhav, Damodaram Potugari, Vishnu Sharma, Alpana Parmar, Sunitha Kayidhi, Paul T Antony, Ashish Badika, Amit Sharma

“…None of the other factors affected COVID-19 outcome. Conclusion: This is the largest cohort from a single nation looking at the interface between RD and COVID. …”
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Analyzing the Effect of Dividends on Default Probability According to Signaling and Agency Theories by Alireza Najjarpour, Saeed Fathi, Ali Foroush Bastani

“…Dividend as a sign of cash flow or as a sign of ownership of wealth is one of the factors affecting the probability of default. There are two theories of dividend signaling theory and agency theory regarding the effect of dividends on credit risk. …”
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Changes in the menstrual hygiene management facilities and usage among Bangladeshi school girls and its effect on school absenteeism from 2014 to 2018 by Farjana Jahan, Noshin Sayiara Shuchi, Abul Kasham Shoab, Mahbub-Ul Alam, Sk. Md. Kamrul Bashar, Khairul Islam, Hasin Jahan, Mahadi Hasan, Md. Masud Alam, Mahbubur Rahman

“…In the GEE model, we found that living in rural areas (coef: −5.6; CI: −10.06 to −1.14), parental restrictions on going outside (coef: 4.47; CI: 0.75 to 8.2), education levels of girls (coef: −9.48; CI: −14.17 to −4.79), girl’s belief that menstruation affects school performance (coef: 23.32; CI: 19.71 to 26.93), and using old cloths (coef: −4.2; CI: −7.6 to −0.79) were significantly associated with higher absenteeism. …”
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Professional Action Competence in Education for Sustainability Among Pre-service Physical Education Teachers: A Mixed Method Approach by Valérian Cece, Thomas Royet, Olivier Vors, Vanessa Lentillon-Kaestner

“…This approach emphases the bodily dimension, learning through action, and affective and sensory aspects. However, EfS is not currently implemented in PE yet. …”
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The Impact of the Urban Heat Island Effect on Ground-Level Ozone Pollution in the Sichuan Basin, China by Xingtao Song, Haoyuan Shi, Langchang Jin, Sijing Pang, Shenglan Zeng

“…With urbanization, ozone (O₃) pollution and the urban heat island (UHI) effect have become increasingly prominent. UHI can affect O₃ production and its dilution and dispersion, but the underlying mechanisms remain unclear. …”
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Subchronic cyanuric acid treatment impairs spatial flexible behavior in female adolescent rats through depressing GluN2B-dependent neuronal and synaptic function by Wei Sun, Haiyang Yu, Xiaoliang Li, Yiwen Wan, Yazi Mei, Yang Yang, Lei An

“…We found that subchronic CA exposure impairs reversal learning ability with dose-dependent effects but did not affect spatial learning and memory, or learning strategy. …”
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