Modeling Climate‐Driven Vegetation Changes Under Contrasting Temperate and Arid Conditions in the Mediterranean Basin by Marco Bianchini, Mohamed Tarhouni, Matteo Francioni, Marco Fiorentini, Chiara Rivosecchi, Jamila Msadek, Abderrazak Tlili, Farah Chouikhi, Marina Allegrezza, Giulio Tesei, Paola Antonia Deligios, Roberto Orsini, Luigi Ledda, Maria Karatassiou, Athanasios Ragkos, Paride D'Ottavio

“…The models indicated significant shifts in areal distribution and environmental conditions, affecting habitat suitability and ecosystem dynamics. …”
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Cx43 Inhibition Attenuates Sepsis-Induced Intestinal Injury via Downregulating ROS Transfer and the Activation of the JNK1/Sirt1/FoxO3a Signaling Pathway by Zhaowei Zou, Bin Liu, Lisi Zeng, Xianzi Yang, Renli Huang, Cheng Wu, Huijuan Zhu, Yi Gao, Dongdong Yuan, Jinlong Yu

“…The changes of Cx43 channel function regulated ROS transfer between the neighboring cells, which mediated the activation of the JNK1/Sirt1/FoxO3a signaling pathway. FoxO3a directly affected its downstream target genes, Bim and Puma, which are responsible for cell or tissue apoptosis. …”
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Macro-environment oscillation notably up risk of water quality degradation: A case study in Shanxi Reservoir, China by Wangwei Cai, Jihong Xia, Zewen Liu, Jiayi Zu, Shuyi Ji, Yue Wang, Qihua Wang

“…However, the mechanism of macro-environment affect water quality risk still is unclear. Water quality is a complex system which should be able to adapt to small fluctuation of macro-environment, but turn into deterioration under significant macro-environment oscillation. …”
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Age- and sex-specific differences in myocardial sympathetic tone and left ventricular remodeling following myocardial injury by Achi Haider, Susan Bengs, Angela Portmann, Sandro Fröhlich, Dominik Etter, Monika Maredziak, Geoffrey I. Warnock, Alexander Akhmedov, Sebastian Kozerke, Claudia Keller, Fabrizio Montecucco, Bruno Weber, Linjing Mu, Ronny R. Buechel, Vera Regitz-Zagrosek, Philipp A. Kaufmann, Giovanni G. Camici, Simon M. Ametamey, Catherine Gebhard

“…In female animals, estrogen depletion did not affect MSA (ovariectomy effect, p = 0.892). Female animals showed an age-dependent increase in MSA (p = 0.011), which was absent in males. …”
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Bisphenol A attenuates testosterone synthesis via increasing apolipoprotein A1-mediated reverse cholesterol transport in mice by Tong Zhao, Tong Zhao, Wenzhe Yang, Wenzhe Yang, Feilong Pan, Feilong Pan, Jinhao Wang, Jinhao Wang, Wenqi Shao, Wenqi Shao, Fangfang Chen, Fangfang Chen, Kexiang Liu, Kexiang Liu, Shuchen Zhao, Shuchen Zhao, Lijia Zhao, Lijia Zhao

“…However, research on the mechanisms by which BPA affects testosterone synthesis from the perspective of reverse cholesterol transport (RCT) remains limited. …”
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Key Decision‐Making in Post‐Failed Internal Fixation of Intertrochanteric Fractures Hip Arthroplasty: A Multicenter Retrospective Study on Fracture Healing's Impact on Femoral Comp... by Jiexin Huang, Jiagu Huang, Haiqi Ding, Jianhua Lyu, Changyu Huang, Yang Chen, Qijin Wang, Hongyan Li, Baijian Wu, Ying Huang, Minghui Yang, Xinyu Fang, Wenming Zhang

“…This study aimed to explore how the healing status of fractures after FIF‐ITF failure affects the choice of femoral stem and clinical outcomes. …”
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Regulation of glycolipid and amino acid metabolism in juvenile triploid crucian carp (Carassius auratus) by oral administration of aspartic acid by Yu Wang, Bo Dong, Liyun Wu, Dong Han, Xiaoming Zhu, Haokun Liu, Yunxia Yang, Shouqi Xie, Zhen Liu, Junyan Jin

“…However, aspartic acid did not affect the gene expression of key enzymes involved in hepatic fatty acid β-oxidation. …”
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PDL1 inhibitors may be associated with a lower risk of allograft rejection than PD1 and CTLA4 inhibitors: analysis of the WHO pharmacovigilance database by Alexandre O. Gérard, Alexandre O. Gérard, Alexandre O. Gérard, Diane Merino, Diane Merino, Jonathan Benzaquen, Alexandre Destere, Delphine Borchiellini, Clément Gosset, Clément Gosset, Fanny Rocher, Marine Andreani, Charles-Hugo Marquette, Henri Montaudié, Henri Montaudié, Milou-Daniel Drici, Antoine Sicard, Antoine Sicard

“…The comparative Reporting Odds Ratios (ROR) for AR, between PD1 and PDL1 inhibitors, was calculated.ResultsWe gathered 159 AR involving an ICI, especially nivolumab (73, 45.9%), mostly affecting kidneys (87, 54.7%). Median time to onset: 28 days. …”
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Lipids and C-reactive protein predict anhedonia and reward circuit functional connectivity responses to anti-cytokine and dopaminergic therapies in patients with depression by Aditya Singh, Mandakh Bekhbat, David R. Goldsmith, Ngoc-Anh Le, Evanthia C. Wommack, Zhihao Li, Ebrahim Haroon, Jennifer C. Felger

“…Increased inflammation and associated metabolic disturbances have been shown to affect neurotransmitters and brain circuits, contributing to an immunometabolic phenotype of anhedonic depression. …”
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Spatiotemporal characteristics of macroinvertebrate functional feeding groups and biological assessment of water quality in the Hulan River Basin by Peilun Li, Shuhan Xiong, Jiacheng Liu, Xiangsheng Meng, Anqi Wang, Chunfeng Wang, Yanshen Zhang, Jilong Wang

“…In order to evaluate the health of river ecosystems, it is essential to look at how macroinvertebrates are affected by changes in their habitat and how they react to environmental influences. …”
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Conservation Tillage Mitigates Soil Organic Carbon Losses While Maintaining Maize Yield Stability Under Future Climate Change Scenarios in Northeast China: A Simulation of the Agri... by Hongrun Liu, Baocai Su, Rui Liu, Jiajie Wang, Ting Wang, Yijia Lian, Zhenzong Lu, Xue Yuan, Zhenwei Song, Runzhi Li

“…To address this concern in Northeast China, one of the world’s major maize production areas, the maize Agricultural Production Systems Simulator Model (APSIM) was used to evaluate how different tillage methods and straw return practices affect maize yields and SOC under future climate scenarios. …”
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The Association of Cell-Free LncH19 and miR-29b Expression with the PI3K/AKT/HIF-1/VEGF Pathway in Patients with Diabetic Nephropathy: In Silico Prediction and Clinical Validation by Noha M. Abd El-Fadeal, Basma Osman Sultan, Asmaa K. K. AbdelMaogood, Essam Al Ageeli, Fatma Tohamy Mekhamer, Sherihan Rohayem, Ahmed Shahidy, Nora Hosny, Manal S. Fawzy, Mohammed M. Ismail, Hidi A. A. Abdellatif

“…Diabetic nephropathy (DN) affects about one-third of patients with diabetes and can lead to end-stage renal disease despite numerous trials aimed at improving diabetic management. …”
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Coagulation Profile of Convalescent Plasma Donors and Recipients by Hanna H Pitkänen MD, PhD, Tuukka Helin MD, PhD, Tamim Khawaja MD, Jukka-Pekka Pietilä MD, Mikael Kajova MD, Hanna Välimaa MD, PhD, DDS, Tero Vahlberg MSc, Jarkko Ihalainen MD, Antti Vierikko MD, Olli Vapalahti MD, PhD, Anu Kantele MD, PhD, Riitta Lassila MD, PhD

“…We investigated whether administration of CP to hospitalized patients affects their coagulation profile. Fifty-four patients randomized in a double-blinded fashion received either placebo, low-titer CP (LCP) or high-titer CP (HCP). …”
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Demographic and Clinical Characteristics of Patients with Corneal Ectasia at Multiple Medical Centers in Saudi Arabia: A Hospital-based Study by Waleed Alghamdi, Sulaiman Aldakhil, Saif Hassan Alrasheed, Kareem Allinjawi, Mustafa Abdu, Raghda F. Mutwaly, Khaled Al Rashah, Hani M. Ghazal, Ghassan H. Radwan, Naveen Kumar Challa

“…Males and age groups between 14 and 45 years were more affected. The mean age of onset was 7.1 years, ranging from 2–32 years, which was higher among patients from the western region. …”
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Evaluation of oral cholera vaccine (Euvichol-Plus) effectiveness against Vibrio cholerae in Bangladesh: an interim analysis by Amanda Tiffany, Ashraful Islam Khan, Firdausi Qadri, John D Clemens, Faisal Ahmmed, Farhana Khanam, Tahmina Shirin, Fahima Chowdhury, Md. Taufiqul Islam, Md Nazmul Islam, Md Nazmul Hasan Rajib, Md Ismail Hossen, Md. Taufiqur Rahman Bhuiyan, Shahinur Haque, Prasanta Kumar Biswas, Amirul Islam Bhuiyan, Zahid Hasan Khan, Mohammad Ashraful Amin, Aninda Rahman, S M Shahriar Rizvi, Lucy Breakwell

“…Introduction Millions of Euvichol-Plus doses have been deployed from the global oral cholera vaccine stockpile in over 20 cholera-affected countries. However, information on Euvichol-Plus’s effectiveness is limited. …”
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Flavonoids and anthocyanins in seagrasses: implications for climate change adaptation and resilience by Jana Botes, Jana Botes, Xiao Ma, Xiao Ma, Jiyang Chang, Jiyang Chang, Yves Van de Peer, Yves Van de Peer, Yves Van de Peer, Yves Van de Peer, Dave Kenneth Berger, Dave Kenneth Berger

“…Flavonoids will likely prove to be effective and versatile agents in combating the new host of stress conditions introduced to marine environments by anthropogenic climate change, which affects marine environments differently from terrestrial ones. …”
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Assessment of Different Conventional and Biofortified Wheat Genotypes Based on Biology and Damage Pattern of <i>Rhyzopertha dominica</i> and <i>Trogoderma granarium</i> by Hafiz Muhammad Bilal Yousuf, Muhammad Yasin, Muhammad Asif Khan, Asim Abbasi, Muhammad Arshad, Muhammad Anjum Aqueel, Inzamam Ul Haq, Waleed A. A. Alsakkaf, Marwa I. Mackled, Nazih Y. Rebouh, Hayssam M. Ali

“…These findings indicate that the nutritional qualities of Zn-biofortified wheat genotypes negatively affected the development of both insect species; thus, it can be an efficacious approach not only for ensuring food security but also for protecting grains against storage pests.…”
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The Correlation of Serum Adropin with Cardiovascular Risk Factors in the Experimental Rat Model of Chronic Kidney Disease and Its Implication in the Ameliorative Effect of Angioten... by Samaa Salah Abd-El-Fatah, Maha A. Fathy, Mohamed Ali Alabiad, Raja Aljafil, Mai Ahmed Gobran, Enssaf A. Ahmad, Ashwag S. Alsharidah, Mohammed Alorini, Sulaiman Mohammed Alnasser, Sara A. Awadh, Enas N. Morgan

“…It also refers to its implication in the ameliorative effect of ACEI treatment, possibly by affecting VEGFR-2 and nitric oxide release.…”
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Factors and barriers to sulfadoxine-pyrimethamine uptake for intermittent preventive treatment during pregnancy in Ghana by Akua Kumi Yeboah, Patrick Ohemeng Gyaase, Richmond Bediako Nsiah, Regina Amoa-Tutu, Saida Abdul-Rahman Zakaria, Lynna Naa Adede Obeng, Frank Prempeh, Phenihas Kwadwo Opoku, Amos Andoono, Gilbert Elara Dagoe, Kwame Kusi Agyemang, Jonathan Mawutor Gmanyami, Dominic Nyarko, Paul Kofi Awuah, Gifty Sefaah Owusu, Solomon Anum-Doku

“…Perceived susceptibility to malaria did not significantly affect uptake. Sociodemographic factors such as age, education, and parity showed no significant associations. …”
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Multidrug-Resistant Tuberculosis and Its Association with Adrenal Insufficiency: Assessment with the Low-Dose ACTH Stimulation Test by René Rodríguez-Gutiérrez, Adrian Rendon, Maximiliano Barrera-Sánchez, Kevin Erick Gabriel Carlos-Reyna, Neri Alejandro Álvarez-Villalobos, Gloria González-Saldivar, José Gerardo González-González

“…Multidrug-resistant tuberculosis (MDR-TB) is a major public health care concern that affects the life of millions of people around the world. …”
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