Neuroprotective Efficacy of <i>Astragalus mongholicus</i> in Ischemic Stroke: Antioxidant and Anti-Inflammatory Mechanisms by Yongjae Hong, Geon Ko, Yeong-Jae Jeon, Hyeon-Man Baek, Juni Lee, Donghun Lee, Jieun Park, Jaehong Kim, Keun-A Chang

“…Stroke affects over 12 million people annually, leading to high mortality, long-term disability, and substantial healthcare costs. …”
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Evaluation of the merit of ethanolic extract of Annona reticulata as an anti-cancer agent in human colon cancer cell lines (HCT-116) [version 2; peer review: 2 approved, 1 not appr... by Sri Pragnya Cheruku, Krishnananda Prabhu, Akshatha G Nayak, Vijetha Shenoy Belle, Vanishree Rao, Pooja Prakash Rao, Nitesh Kumar

“…The bioinformatics analysis of these phytochemicals showed a high potential to affect the levels of key proteins driving colon cancer progression, inhibiting the enzymes and proteins overexpressed in cancer. …”
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Pulmonary aspergillosis in US Veterans with COVID-19: a nationwide, retrospective cohort study by Kaitlin Swinnerton, Nathanael R. Fillmore, Ikwo Oboho, Janet Grubber, Mary Brophy, Nhan V Do, Paul A Monach, Westyn Branch-Elliman

“…Data about incidence of aspergillosis and characteristics of affected patients after mid-2021 are limited. Methods: A retrospective, nationwide cohort of US Veterans with SARS-CoV-2 from 1/1/2020 to 2/7/2024 was created. …”
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Embryo Mosaicism Rate in National Referral Hospital of Indonesia Detected Using Next-Generation Sequencing: A Retrospective Study by Achmad Kemal Harzif, Muhammad Ikhsan, Pritta Ameilia Iffanolida, Kresna Mutia, Budi Wiweko, R Muharam, Kanadi Sumapraja, Gita Pratama, Mila Maidarti, Vita Silvana, Amalia Shadrina, Irene Sinta Febriana, Nafi'atul Ummah, Aisyah Retno Puspawardani, Andon Hestiantoro

“…Chromosomes 9,8, and 6 were the most frequently affected. There was a significant difference in the high mosaicism rate for PGT-Arelatedunexplained infertility causes.…”
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Compulsive Buying Disorder among Medicine, Dentistry, and Nursing Undergraduate Students from Chengalpattu District, Tamil Nadu, India: A Cross-sectional Study by A Hari Narayanan, Vedapriya Dande Rajasekar, Raja Danasekaran, BN Surya, P Manoj, S Madhush Kumar, Rehana Syed, R Harishma

“…Introduction: Compulsive Buying Disorder (CBD), also known as buying shopping disorder or Oniomania, is a growing concern that affects mental health, relationships, and financial stability. …”
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Nicotine dependence is associated with an increased risk of developing chronic, non-communicable inflammatory disease: a large-scale retrospective cohort study by Khalaf Kridin, Khalaf Kridin, Khalaf Kridin, Cristian Papara, Katja Bieber, David A. De Luca, Jan Philipp Klein, Marlene A. Ludwig, Philip Curman, Philip Curman, Philip Curman, Philip Curman, Artem Vorobyev, Astrid Dempfle, Ralf J. Ludwig

“…IntroductionChronic, non-communicable inflammatory diseases (CIDs) affect a large portion of the population, imposing a significant morbidity, encompassing a substantial mortality. …”
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Transcriptome and Metabolome Analysis Unveil Anthocyanin Metabolism in Pink and Red Testa of Peanut (Arachis hypogaea L.) by Qiqin Xue, Xiurong Zhang, Hui Yang, Huadong Li, Yuying Lv, Kun Zhang, Yongguang Liu, Fengzhen Liu, Yongshan Wan

“…Peanut (Arachis hypogaea L.) is an important source of oil and food around the world, and the testa color affects its appearance and commercial value. However, few studies focused on the mechanism of pigment formation in peanut testa. …”
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Exploring the Impact of the Multimodal CAPABLE eHealth Intervention on Health-Related Quality of Life in Patients With Melanoma Undergoing Immune-Checkpoint Inhibition: Prospective... by Itske Fraterman, Lucia Sacchi, Henk Mallo, Valentina Tibollo, Savannah Lucia Catherina Glaser, Stephanie Medlock, Ronald Cornet, Matteo Gabetta, Vitali Hisko, Vadzim Khadakou, Ella Barkan, Laura Del Campo, David Glasspool, Alexandra Kogan, Giordano Lanzola, Roy Leizer, Manuel Ottaviano, Mor Peleg, Konrad Śniatała, Aneta Lisowska, Szymon Wilk, Enea Parimbelli, Silvana Quaglini, Mimma Rizzo, Laura Deborah Locati, Annelies Boekhout, Lonneke V van de Poll-Franse, Sofie Wilgenhof

“… Abstract BackgroundPatients with melanoma receiving immunotherapy with immune-checkpoint inhibitors often experience immune-related adverse events, cancer-related fatigue, and emotional distress, affecting health-related quality of life () and clinical outcome to immunotherapy. eHealth tools can aid patients with cancer in addressing issues, such as adverse events and psychosocial well-being, from various perspectives. …”
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Frailty-adjusted therapy in Transplant Non-Eligible patients with newly diagnosed Multiple Myeloma (FiTNEss (UK-MRA Myeloma XIV Trial)): a study protocol for a randomised phase III... by Roger Owen, John Jones, David Meads, David A Cairns, Christopher Parrish, Gordon Cook, Neil Rabin, Matthew Jenner, Martin Kaiser, Kevin Boyd, Graham Jackson, Catherine Olivier, Amy Beth Coulson, Kara-Louise Royle, Charlotte Pawlyn, Anna Hockaday, Jennifer Bird, Stella Bowcock, Ruth de Tute, Hayley Gardner, Bryony Dawkins, Rowena Henderson, Phillip Best, Bhuvan Kishore, Mark Drayson

“…Introduction Multiple myeloma is a bone marrow cancer, which predominantly affects older people. The incidence is increasing in an ageing population.Over the last 10 years, patient outcomes have improved. …”
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Transcription factor RUNX1 regulates coagulation factor XIII-A (F13A1): decreased platelet-megakaryocyte F13A1 expression and clot contraction in RUNX1 haplodeficiency by Fabiola Del Carpio-Cano, Natthapol Songdej, Liying Guan, Guangfen Mao, Lawrence E. Goldfinger, Jeremy G.T. Wurtzel, Kiwon Lee, Michele P. Lambert, Mortimer Poncz, A. Koneti Rao

“…Platelet-driven clot contraction was decreased in the patient and affected daughter. Promoter studies in HEL cells showed that RUNX1 regulates F13A1 transcription; RUNX1 overexpression increased, and small inhibitor RNA RUNX1 KD reduced F13A1 promoter activity and protein. …”
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Metabolic Profiling by UPLC–Orbitrap–MS/MS of Liver from C57BL/6 Mice with DSS-Induced Inflammatory Bowel Disease by Zhongquan Xin, Zhenya Zhai, Hongrong Long, Fan Zhang, Xiaojun Ni, Jinping Deng, Lunzhao Yi, Baichuan Deng

“…Spearman correlation analysis showed that the majority of the biomarkers have a significant correlation with cytokines (TNF-α, IL-1β, IL-6, and IL-10), indicating that those biomarkers may act as potential targets to interact directly or indirectly with cecropin A and antibiotics to affect liver inflammation. Collectively, our results extend the understanding of the molecular alteration of liver disorders occurring in IBD and offer an opportunity for discovering potential therapeutic targets in the IBD process.…”
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Reactive arthritis incidence in a community cohort following a large waterborne campylobacteriosis outbreak in Havelock North, New Zealand by Nicholas Jones, Rebecca Grainger, Michael G Baker, Tim Wood, Tiffany A Walker, Terence Quirke, Rebekah Roos, Jill Sherwood, Graham Mackereth, Tomasz Kiedrzynski, Rachel Eyre, Shevaun Paine, Anita Jagroop

“…Objectives In August 2016, Campylobacter spp contaminated an untreated reticulated water supply resulting in a large-scale gastroenteritis outbreak affecting an estimated 8320 people. We aimed to determine the incidence of probable reactive arthritis (ReA) cases in individuals with culture-confirmed campylobacteriosis (CC), self-reported probable campylobacteriosis (PC) and those reporting no diarrhoea (ND).Design We conducted a retrospective cohort study to identify incidence of probable ReA cases. …”
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CD21low B cells reveal a unique glycosylation pattern with hypersialylation and hyperfucosylation by Peter Tobias Felixberger, Peter Tobias Felixberger, Geoffroy Andrieux, Andrea Maul-Pavicic, Andrea Maul-Pavicic, Sigune Goldacker, Sigune Goldacker, Ina Harder, Ina Harder, Sylvia Gutenberger, Sylvia Gutenberger, Jonathan J. M. Landry, Vladimir Benes, Till Fabian Jakob, Melanie Boerries, Melanie Boerries, Lars Nitschke, Reinhard Edmund Voll, Reinhard Edmund Voll, Klaus Warnatz, Klaus Warnatz, Baerbel Keller, Baerbel Keller

“…This may implicate altered lectin-ligand interactions on the cell surface potentially affecting the CD21low B-cell function. These glycome changes appear to be driven by the prominent type I immune response in complicated CVID patients. …”
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AnaDetect: An extensive dataset for advancing anemia detection, diagnostic methods, and predictive analytics in healthcareMendeley Data by Mayen Uddin Mojumdar, Dhiman Sarker, Md Assaduzzaman, Md. Anisul Haque Sajeeb, Md. Mohaimenur Rahman, Md Shadikul Bari, Shah Md Tanvir Siddiquee, Narayan Ranjan Chakraborty

“…The study examines how various treatment plans can affect blood characteristics, potentially leading to improved treatment strategies. …”
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Ground-based Characterization of (98943) Torifune 2001 CC21, the Target of the Hayabusa2# Space Mission by Marcel M. Popescu, Eri Tatsumi, Javier Licandro, Miguel R. Alarcon, Javier Rodríguez Rodríguez, Miquel Serra-Ricart, Julia de León, Joaquín Fernandez Martin, David Morate, Gabriel N. Simion, Bogdan Alexandru Dumitru, Daniel Nicolae Berteşteanu, George Pantelimon Prodan, Masatoshi Hirabayashi

“…The spectral data indicate a surface affected by moderate space weathering effects.…”
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Metabolic changes before and after weaning in Dezhou donkey foals in relation to gut microbiota by Qiwen Yang, Qiwen Yang, Haibing Liu, Halima Jafari, Bing Liu, Zhaofei Wang, Jiangtian Su, Fuwen Wang, Ge Yang, Minhao Sun, Jie Cheng, Boying Dong, Min Li, Mingjian Gen, Jie Yu

“…Riboflavin was associated with the development of the small intestine and affected the absorption of the small intestine. We also found that the changes in the gut microbiome of the foals were significantly correlated with changes in serum metabolites, including lysophosphatidylcholine (LPC; 12,0) and positively correlated with Lachnoclostridium and Roseburia. …”
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Ice-nucleating particles active below −24&thinsp;°C in a Finnish boreal forest and their relationship to bioaerosols by F. Vogel, F. Vogel, M. P. Adams, L. Lacher, P. B. Foster, G. C. E. Porter, G. C. E. Porter, B. Bertozzi, B. Bertozzi, K. Höhler, J. Schneider, T. Schorr, N. S. Umo, J. Nadolny, Z. Brasseur, P. Heikkilä, E. S. Thomson, N. Büttner, M. I. Daily, R. Fösig, A. D. Harrison, J. Keskinen, U. Proske, U. Proske, U. Proske, J. Duplissy, J. Duplissy, M. Kulmala, T. Petäjä, O. Möhler, B. J. Murray

“…This study should motivate further work to establish whether the commonality in bioaerosol ice-nucleating properties between spring in Finland and summer in Colorado is more generally applicable to different coniferous forest locations and times and also to determine to what extent these bioaerosols are transported to locations where they may affect clouds.</p>…”
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Monitoring Moso bamboo (Phyllostachys pubescens) forests damage caused by Pantana phyllostachysae Chao considering phenological differences between on-year and off-year using UAV h... by Anqi He, Zhanghua Xu, Yifan Li, Bin Li, Xuying Huang, Huafeng Zhang, Xiaoyu Guo, Zenglu Li

“…Pantana phyllostachysae Chao is a leaf-feeding pest that affects Moso bamboo. However, monitoring P. phyllostachysae damage using remote sensing data is challenging because the off-year Moso bamboo has physiological characteristics similar to on-year Moso bamboo infested with P. phyllostachysae. …”
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Use of approved cefazolin based intramammary dry goat treatment and its effects on the milk microbiota by Delower Hossain, Filippo Biscarini, Valentina Monistero, Paola Cremonesi, Bianca Castiglioni, Anoar Jamai Masroure, Alessandro Marinoni, Sara Fusar Poli, Matteo Mezzetti, Maria Filippa Addis, Valerio Bronzo, Erminio Trevisi, Paolo Moroni

“…Despite the reduction in SCC and infection rates, cefazolin-based treatment did not significantly affect the alpha- and beta-diversity between the TG and CG. …”
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Management and Outcome of Parathyroid Carcinoma-Induced Primary Hyperparathyroidism: A Single-Centre Experience by Loredana De Pasquale, Antonio Mario Bulfamante, Giovanni Felisati, Luca Castellani, Giorgio Ghilardi, Alberto Maria Saibene

“…We identified and individually described the patients affected with PC. Then, we split all patients treated for PHPT into four groups based on the cause: PC, adenoma, atypical adenoma, and hyperplasia. …”
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