An initial benchmark of the quality of the diagnosis and surgical treatment of breast cancer in South Africa by S Nietz, H Cubasch, I Buccimazza, S Čačala, B Phakathi, M Joffe, W C C Chen, S Norris, P Ruff

“…Unit volumes were achieved consistently in Gauteng Province, but only for some years in KwaZulu-Natal Province; surgeon volumes were achieved across all units. HIV status did not affect adherence levels. Most quality indicators were well measurable, but data quality on reoperations and surgeon volumes was poor. …”
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COVID-19 and children with congenital anomalies: a European survey of parents’ experiences of healthcare services by Ingeborg Barisic, Carlos Matias Dias, Amanda Neville, Anna Pierini, Anke Rissmann, Joan K Morris, Judith Rankin, Ester Garne, Anna Latos-Bielenska, Elena Marcus, Anna Jamry-Dziurla, Ljubica Odak, Clara Cavero- Carbonell, Elly Den Hond, Lucas Genard, Ana João Santos, L Renée Lutke, Christina Neergaard Pedersen, Annika Niemann, Lucía Páramo-Rodríguez

“…In Poland, 43% (136/314) of parents reported that changes to their child’s ongoing treatment had moderately to severely affected their child’s health, significantly higher than all other countries (p<0.001). …”
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Evaluation of nitrous oxide reduction in solid carbon source-driven counter-diffusional biofilm denitrification system by Yingrui Liu, Feng Chen, Yanying He, Yufen Wang, Tingting Zhu, Yindong Tong, Yingxin Zhao, Bing-Jie Ni, Yiwen Liu

“…Solid carbon-driven biofilm system can provide sufficient carbon source for denitrification, while its counter-diffusional structure could inevitably induce the delayed carbon-nitrogen contact and electron transport, further affecting carbon footprints mainly contributed by nitrous oxide (N2O) at wastewater treatment plants (WWTPs). …”
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Multisensory Stimulation in Rehabilitation of Dementia: A Systematic Review by Andrea Calderone, Angela Marra, Rosaria De Luca, Desirèe Latella, Francesco Corallo, Angelo Quartarone, Francesco Tomaiuolo, Rocco Salvatore Calabrò

“…<b>Background/Objectives</b>: Dementia leads to cognitive decline, affecting memory, reasoning, and daily activities, often requiring full-time care. …”
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Dietary Choline Deprivation Exacerbates Kidney Injury in Streptozotocin-Induced Diabetes in Adult Rats by Ahmed W. Al-Humadi, Carel W. le Roux, Neil G. Docherty, Werd Al-Najim, Martin Tze Wah Kueh, Andreas C. Lazaris, Charis Liapi

“…<b>Conclusions</b>: Ch deprivation affected kidney function and structure in STZ-induced diabetic rats. …”
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Liver Biomarkers and Lipid Profiles in Mexican and Mexican-American 10- to 14-Year-Old Adolescents at Risk for Type 2 Diabetes by Ana Cecilia Fernández-Gaxiola, Roxana Valdés-Ramos, Kimberly Fulda, Ana Laura Guadarrama López, Beatriz E. Martínez-Carrillo, Susan F. Franks, Shane Fernando

“…Mexican-American adolescents are disproportionately affected by T2DM, while in Mexico its prevalence is emerging. …”
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Potential Research Tool of Stem Cells from Human Exfoliated Deciduous Teeth: Lentiviral Bmi-1 Immortalization with EGFP Marker by Siqi Yao, Lingping Tan, Huan Chen, Xiaojun Huang, Wei Zhao, Yan Wang

“…Our results confirmed that Bmi-1 immortalization did not affect the main features of SHED. SHED-Bmi1-EGFP could be passaged for a long time and stably expressed EGFP. …”
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Temporal trends and future projections of incidence rate and mortality for asthma in China: an analysis of the Global Burden of Disease Study 2021 by Xi Chen, Xi Chen, Dandan Ma, Hangyu Li, Yilin Liu, Guixing Xu, Xinyu Deng, Qi Li, Junqi Li, Hui Pan

“…BackgroundAsthma poses a significant public health burden in China, affecting millions with substantial incidence and mortality. …”
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Cardiac Abnormalities in Acromegaly Patients: A Cardiac Magnetic Resonance Study by Xiaopeng Guo, Jian Cao, Peijun Liu, Yihan Cao, Xiao Li, Lu Gao, Zihao Wang, Ligang Fang, Zhengyu Jin, Yining Wang, Bing Xing

“…In conclusion, structural and functional cardiac abnormalities can be comprehensively evaluated by CMR in acromegaly patients. Gender greatly affects the presence of cardiac abnormalities. Age, BMI, disease duration, and hypertension but not GH or IGF-1 levels are associated clinical factors.…”
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The impact of dietary phosphorus levels on growth, slaughter, and digestive metabolism in growing sheep by Shoupei Zhao, Xiaojun Ni, Jia Zhou, Xiaoqi Zhao, Xiao Wen, Xiaolin Wang, Mingyu Cao, Yanfei Zhao, Chong Shao, Lianghao Lu, Yuanyuan Chen, Bao Zhang, Huaming Yang, Bai Xue, Guobo Quan

“…Carcass traits such as left half carcass rate and net rib rate varied significantly (p &lt; 0.05), showing quadratic trends. P levels also affected P, calcium, protein, and energy metabolism, as well as apparent digestibility of acid detergent fiber (p &lt; 0.05). …”
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JAK/STAT3 signaling promotes pain and depression-like behaviors in rats with bone cancer pain by regulating Th17 cell differentiation by Shuyan Wu, Jundan Jiang, Danfeng Wang, Daoyi Lin, Mingxue Lin, Pinzhong Chen, Jianghu Chen, Honghong Zhang, Ying Wang, Xiaohui Chen, Xiaochun Zheng

“…Background: Pain and depression are common complications in patients with advanced cancer, which significantly affects their quality of life and survival. Dysregulation of the JAK/STAT3 pathway in the central nervous system is associated with pain and brain inflammatory disorders, but its role in bone cancer pain (BCP) remains unclear. …”
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3D echocardiography derived reference values and determinants of left ventricular twist and torsion from the population-based STAAB cohort study by Julia Napp, Götz Gelbrich, Floran Sahiti, Vladimir Cejka, Dora Pelin, Lena Schmidbauer, Mengmeng Chen, Niklas Hitschrich, Marcus Schreckenberg, Stefan Frantz, Peter U. Heuschmann, Stefan Störk, Caroline Morbach

“…LV rotation is determined by a complex interplay of sub-endocardial and sub-epicardial fibers which might be affected differentially by potential risk factors. …”
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Celastrol boosts fluconazole efficacy against vaginal candidiasis: in vitro and in vivo evidence by Fatma Al-zahraa A. Yehia, Hisham A Abbas, Tarek M. Ibrahim, Basem Mansour, Zuhier A. Awan, Mohammed W. Al-Rabia, Wesam H. Abdulaal, Mustafa Adnan Zeyadi, Solomon Z. Okbazghi, Tarek S. Ibrahim, Wael A. H. Hegazy, Salwa E. Gomaa

“…However, overgrowth of C. albicans can result in vulvovaginal candidiasis (VVC), one of the most prevalent fungal infections affecting women. The rapid emergence of azole resistance in C. albicans, in addition to the limited available antifungal agents, complicates the treatment and emphasizes the urgent need for novel therapeutic options. …”
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Social determinants of oral health in an indigenous community of Chile: preliminary data of a mixed qualitative and quantitative study by Cynthia Cantarutti, Gerardo Yévenes, Agueda Muñoz-del-Carpio-Toia, Daniela Adorno-Farias, Ricardo Fernández-Ramires, Alan Roger Santos-Silva, Jean Nunes dos Santos, Ignacio Molina-Ávila, Wilfredo Alejandro González-Arriagada

“…Educational level and rurality were identified as factors potentially affecting the oral health status of this community. …”
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A nomogram for predicting mortality risk in geriatric patients with hip fractures complicated by pneumonia: A multicenter study by Kaiming Zhang, Xiangwei Li, Yujia Xiao, Cheng Zhou, Yu Liu, Fan Zhen, Hao Zhang, Mao Nie

“…Conclusions: Coinfection with pneumonia adversely affected both recovery of hip function and survival in geriatric patients with hip fractures. …”
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Coupled CRC 2D and ALI 3D Cultures Express Receptors of Emerging Viruses and Are More Suitable for the Study of Viral Infections Compared to Conventional Cell Lines by Siyu Xia, Jun Liu, Yan Yang, Ming Wu, Lina Ye, Si Chen, Tao Zhang, Zhihong Zeng, Kang Zhang, Kaihong Cai, Xiang Long, Wenbin Gao, Shisong Fang, Hui Li

“…Infections of emerging and reemerging viruses (SARS-CoVs, influenza H1N1, etc.) largely and globally affect human health. Animal models often fail to reflect a physiological status because of species tropism of virus infection. …”
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Association between geriatric nutritional risk index and overactive bladder in the elderly population: a cross-sectional study by Wei Zheng, Wei Zheng, Chuanzan Zhou, Jia Miao, Yunkai Yang, Xuanhan Hu, Heng Wang, Xinyu Zhang, Qi Zhang, Yifan Wang

“…BackgroundThe prevalence of overactive bladder (OAB) is increasing in the elderly population and there is growing evidence that malnutrition affects the urinary system. Despite this, research on the relationship between nutritional factors and OAB remains limited.MethodsWe included 17,161 elderly individuals from the National Health and Nutrition Examination Survey conducted between 2005 and 2018. …”
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Glutamine deprivation confers immunotherapy resistance by inhibiting IFN-γ signaling in cancer cells by Zhiwei Yuan, Taiyan Yu, Xu Wang, Kelin Meng, Tianlai Wang, Boyu Wang, Yu Xi, Congjian Wang, Chenxi Zeng, Shaojie Hu, Yitao Tian, Hui Xiong, Qi Wang, Wenbin Zou, Xue Wang, Yi Gao, Xiangning Fu, Lequn Li

“…Given that the tumor-intrinsic response to interferon-γ (IFN-γ) is a key determinant of immunotherapy efficacy, we investigated whether and how glutamine deprivation in cancer cells affects their response to IFN-γ. By using human lung cancer cell lines, patient-derived tumor explants, and a syngeneic mouse model of lung cancer, we demonstrated that glutamine deprivation reduced the IFN-γ-driven response in cancer cells by promoting autophagy-dependent IFN-γ receptor (IFNGR1) degradation and rendering tumors resistant to anti-PD-1 or anti-PD-L1 therapy. …”
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Investigating the potential immunomodulatory effects of commercial oral probiotic supplements on equine gastrointestinal tract barrier function by Agnieszka Żak-Bochenek, Paulina Żebrowska-Różańska, Joanna Bajzert, Łukasz Łaczmański, Bogumiła Szponar, Natalia Siwińska, Klaudia Gładysz, Katarzyna Sikorska, Anna Chełmońska-Soyta

“…It is hypothesized that the presence of probiotic strains can both modulate the intestinal microbiota and affect mucosal immunity parameters. Such a study has not yet been conducted in horses.MethodsThis study involved 12 healthy horses, which were randomly divided into a control group and a group that received a commercial oral probiotic formula containing Lactobacillus rhamnosus, Pedioccus acidilactici or Enterococcus faecium for 84 days. …”
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Early onset neonatal bloodstream infections in South African hospitals by Genevieve Theron, Adrie Bekker, Larisse Bolton, Andrew Whitelaw, Arnoldus Engelbrecht, Louisa Erasmus, Aaqilah Fataar, Chandre Geldenhuys, Marlize Kunneke, Dave Le Roux, Natasha O’Connell, Kessendri Reddy, Natasha Rhoda, Lloyd Tooke, Mark Wates, Thandi Wessels, Angela Dramowski

“…Preterm (93/136; 68.3%) and low birth weight (84/136; 61.8%) neonates were most affected. The predominant pathogens were Streptococcus agalactiae (46/136; 34%), Klebsiella pneumoniae (17/136; 13%), Listeria monocytogenes (11/136; 8%), Acinetobacter baumannii (11/136; 8%) and Escherichia coli (11/136; 8%). …”
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