Angiotensin IV Receptors in the Rat Prefrontal Cortex: Neuronal Expression and NMDA Inhibition by Zsolt Tamás Papp, Polett Ribiczey, Erzsébet Kató, Zsuzsanna E. Tóth, Zoltán V. Varga, Zoltán Giricz, Adrienn Hanuska, Mahmoud Al-Khrasani, Ákos Zsembery, Tibor Zelles, Laszlo G. Harsing, László Köles

“…Synaptic isolation of pyramidal neurons did not affect the Ang IV-mediated inhibition of NMDA currents. …”
Get full text

Pharmacist-led DE-eSCALation of opioids post-surgical dischargE (DESCALE) – A multi-centre, non-randomised, feasibility study protocol [version 2; peer review: 1 approved, 2 approv... by Ellie Santer, Julie H Hedayioglu, Vanessa J Short, Sabina Hulbert, Emma L Veale, Melanie Rees-Roberts, Johanna Theron

“…Feasibility outcomes will focus on recruitment, fidelity of CPs to deliver the MUR, and barriers within primary care that affect delivery of the intervention, with a maximum sample size of 100. …”
Get full text

Cooperation Between <i>Rhodococcus qinshengii</i> and <i>Rhodococcus erythropolis</i> for Carbendazim Degradation by Roosivelt Solano-Rodríguez, Fortunata Santoyo-Tepole, Mario Figueroa, Voleta Larios-Serrato, Nora Ruiz-Ordaz, Abigail Pérez-Valdespino, Everardo Curiel-Quesada

“…Excessive use of this xenobiotic causes environmental deterioration and affects human health. Microbial metabolism is one of the most efficient ways of carbendazim elimination. …”
Get full text

Clinical Profile and Outcome in Patients with Coronary Slow Flow Phenomenon by Xiaogang Zhu, Hua Shen, Fei Gao, Sijing Wu, Qian Ma, Shuo Jia, Ziwei Zhao, Shan Tong, Zhihao Zhang, Yujie Zhou

“…Multivariate analysis showed that the risk of MACE approximately doubles with age >50 years (hazard ratio (HR) = 2.2, 95% CI: 1.0 to 4.9, and P=0.042), hypertension (HR = 2.1, 95% CI: 1.1 to 4.2, and P=0.021), and dyslipidemia (HR = 2.0, 95% CI: 1.0 to 3.9, and P=0.042). CSFP affects predominantly patients at middle age and above but can occur in any age group; CSFP should be more concerned, particularly in patients >50 years old with hypertension and dyslipidemia.…”
Get full text

Clinical Significance of Screening Electrocardiograms for the Administration of Propranolol for Problematic Infantile Hemangiomas by James D. Phillips, Tyler Merrill, J. Reed Gardner, R. Thomas Collins, Jenika Sanchez, Adam B. Johnson, Brian K. Eble, Larry D. Hartzell, Jay M. Kincannon, Gresham T. Richter

“…Screening electrocardiograms (ECG) are performed prior to the initiation of propranolol to minimize the risk of exacerbating undiagnosed heart block. How ECG results affect subsequent propranolol usage and patient management remains unclear. …”
Get full text

Analysis of influencing factors of washed microbiota transplantation in treating patients with metabolic syndrome by De-Jiang Lin, Dong-Xia Hu, Qing-Ting Wu, Lin-Gui Huang, Zi-Han Lin, Jia-Ting Xu, Xing-Xiang He, Lei Wu, Lei Wu

“…Therefore, we can improve the efficacy of WMT by reducing independent influencing factors that affect gut microbiota homeostasis.…”
Get full text

Evaluation of variation in special educational needs provision and its impact on health and education using administrative records for England: umbrella protocol for a mixed-method... by Stuart Logan, Ruth Gilbert, Tamsin Ford, Johnny Downs, Jugnoo Rahi, Ania Zylbersztejn, Katie Harron, Kate Boddy, Bianca De Stavola, Vincent Nguyen, Isaac Winterburn, Kate Lewis, Lucy Karwatowska, Lorraine Dearden, Sarah Barnes, Jacob Matthews, Matthew Lilliman, Jennifer Saxton, Antony Stone, Kristine Black-Hawkins

“…Next, we describe health and education outcomes (WP1) and individual, school-level and area-level factors affecting variation in SEN provision across different phenotypes (WP2). …”
Get full text

The efficacy of Artichoke leaf extract conjugated with organic zinc nanoparticles on growth, carcass traits and blood biochemical parameters of broilers by Elwy A. Ashour, Ahmed K. Aldhalmi, Mahmoud Kamal, Salem S. Salem, Samir A. Mahgoub, Abdulmohsen H. Alqhtani, Mahmoud Madkour, Ahmed A. Elolimy, Mohamed E. Abd El-Hack, Ayman A. Swelum

“…ABSTRACT: This study aimed to discover how using nano artichoke leaf extract Stabilized with zinc Nanoparticles (ZnO-Nano-ALPE) as an alternative to antibiotics and an antioxidant in broiler feed affected their growth, meat quality, and blood. In a completely randomized design experiment, 210 1-day-old chicks (Arbor Acres) were assigned to three trial groups. …”
Get full text

MP-LLAVRec: an agricultural product recommendation algorithm based on LLAVA and user modal preference by Peishan Li, Peishan Li, Peishan Li, Lutao Gao, Lutao Gao, Lutao Gao, Lilian Zhang, Lilian Zhang, Lilian Zhang, Lin Peng, Lin Peng, Lin Peng, Chunhui Bai, Chunhui Bai, Chunhui Bai, Linnan Yang, Linnan Yang, Linnan Yang

“…However, the following three problems still exist in the traditional agricultural product recommendation domain: (1) the problem of missing modalities made it difficult for consumers to intuitively and comprehensively understood the product information; (2) most of them relied on shallow information about the basic attributes of agricultural products and ignored the deeper associations among the products; (3) they ignored the deeper connections among individual users and the intrinsic associations between the user embedding and the localized user representation in different modalities, which affected the accuracy of user modeling and hindered the final recommendation effect.MethodsTo address these problems, this paper innovatively proposed an agricultural product recommendation algorithm based on LLAVA and user behavioral characteristics, MP-LLaVRec(Modal Preference - Large Language and Vision Recommendation). …”
Get full text

Land-use and land-cover changes and emerging non-tuberculous and tuberculous infectious diseases in humans and animals: a mixed-methods review of research findings from global and... by Jean-François Guégan, Carlos A Vargas Campos, Christine Chevillon, Ahmadou Sylla, Magdalene Dogbe, Kayla M Fast, Jennifer Pechal, Alex Rakestraw, Matthew E Scott, Michael W Sandel, Heather Jordan, M Eric Benbow

“…Here, using both a bibliometric and scoping review method, we summarize the reliability and availability of published relevant studies on LULC effects on mycobacteria, an important group of infectious bacteria that affect humans and both wild and domestic animals. …”
Get full text

RADAR-AD: assessment of multiple remote monitoring technologies for early detection of Alzheimer’s disease by Manuel Lentzen, Srinivasan Vairavan, Marijn Muurling, Vasilis Alepopoulos, Alankar Atreya, Merce Boada, Casper de Boer, Pauline Conde, Jelena Curcic, Giovanni Frisoni, Samantha Galluzzi, Martha Therese Gjestsen, Mara Gkioka, Margarita Grammatikopoulou, Lucrezia Hausner, Chris Hinds, Ioulietta Lazarou, Alexandre de Mendonça, Spiros Nikolopoulos, Dorota Religa, Gaetano Scebba, Pieter Jelle Visser, Gayle Wittenberg, Vaibhav A. Narayan, Neva Coello, Anna-Katharine Brem, Dag Aarsland, Holger Fröhlich, on behalf of RADAR-AD

“…Abstract Background Alzheimer’s disease (AD) is a progressive neurodegenerative disorder affecting millions worldwide, leading to cognitive and functional decline. …”
Get full text

Integrated multiomics approach and pathological analyses provide new insights into hepatic injury and metabolic alterations in Saanen goats after dietary exposure to aflatoxin B1 by Donghua Su, Jing Peng, Jingjing Hao, Xi Wang, Peiqiang Yu, Shengli Li, Haitao Shi

“…Integrative analysis of transcriptomics and metabolomics revealed that glycerophospholipids metabolism and choline metabolism in cancer were the most affected pathways related to AFB1 exposure. The identified differential metabolites, DEG, and pathways might have played a crucial role in the hepatic injury induced by AFB1 in goats.…”
Get full text

Differential diversity and structure of autotrophs in agricultural soils of Qinghai Province by Lianyu Zhou, Xuelan Ma, Qiaoyu Luo, Feng Qiao, Huichun Xie, Longrui Wang, Wenjuan Sun, Yu Liu, Yun Ma

“…Autotrophic bacteria that utilize inorganic compounds as electron donors for growth fix CO2 photosynthetically or chemo-autotrophically in diverse ecosystems and affect soil organic carbon sequestration. Soil properties, agronomic management measures, and environmental factors can influence the community composition, abundance, and activity of CO2-assimilating bacteria. …”
Get full text

The immunological landscape of CCL26High invasive oral squamous cell carcinoma by Lingyun Liu, Lingyun Liu, Shuo Guan, Shuo Guan, Yizhuo Xue, Yizhuo Xue, Yijia He, Yijia He, Liang Ding, Yong Fu, Sheng Chen, Zhiyong Wang, Yi Wang

“…However, CCL26 did not affect T/B/NK lymphocytes in peripheral blood of OSCC patients.ConclusionCCL26 could regulate Immune balance and promote invasiveness of OSCC, which gave a new insight into a potential immunotherapy strategy.…”
Get full text

Brain penetration of peripheral extracellular vesicles from Alzheimer's patients and induction of microglia activation by Hermine Counil, Rummenigge Oliveira Silva, Jean‐Michel Rabanel, Charlotte Zaouter, Mohamed Haddad, Mohamed Raâfet Ben Khedher, Davide Brambilla, Tamas Fülöp, Shunmoogum A. Patten, Charles Ramassamy

“…These findings contribute to novel insights into the fate of pEVs following their passage through the BBB in vitro and in vivo, and demonstrate for the first time that pEVs from AD patients affect microglia activity. This suggests a potential mechanism through which peripheral tissue cues may contribute to AD pathogenesis.…”
Get full text

Effects of plant functional group removal on caterpillars (Gynaephora alpherakii) performance and plant production in an alpine meadow by Rui Cao, Han Chen, Jingran Cai, Chen Hang, Ziyu Zhang, Yingchun Miao, Peng Xie

“…Our results show that forb removal significantly decreased the aboveground plant biomass (APB) by 41.3%, but did not affect the APB of sedges. The presence of caterpillars significantly decreased total APB by 16.7% and APB of sedges by 34.8%, but these effects disappeared with forbs removed. …”
Get full text

Prohexadione Calcium Improves Rice Yield Under Salt Stress by Regulating Source–Sink Relationships During the Filling Period by Rui Deng, Dianfeng Zheng, Naijie Feng, Aaqil Khan, Jianqin Zhang, Zhiyuan Sun, Jiahuan Li, Jian Xiong, Linchong Ding, Xiaohui Yang, Zihui Huang, Yuecen Liao

“…Salt stress is an important factor affecting the growth and development of rice, and prohexadione calcium (Pro-Ca) plays an important role in alleviating rice salt stress and improving rice yield. …”
Get full text

METTL14-mediated m6A modification of DDIT4 promotes its mRNA stability in aging-related idiopathic pulmonary fibrosis by Dan Li, Li Qian, Yufeng Du, Lifang Liu, Ziyue Sun, Yongkang Han, Xiangrui Guo, Chao Shen, Zheng Zhang, Xuejun Liu

“…The association analysis showed that 749 DEGs were affected by m6A methylation in IPF. Among the m6A regulators, the expression of METTL14 decreased in IPF. …”
Get full text

Life after prostate cancer diagnosis: protocol for a UK-wide patient-reported outcomes study by David H Brewster, Victoria Cairnduff, Eila Watson, Amy Downing, Adam W Glaser, Penny Wright, William Cross, Conan Donnelly, Anna Gavin, Carol Rivas, Richard Wagland, Peter Selby, Luke Hounsome, Therese Kearney, Rebecca Mottram, Majorie Allen, Oonagh McSorley, Hugh Butcher, Paul Kind, James W H Catto, Dyfed Huws, Emma McNair, Lauren Matheson, Johana Nayoan, Mike Horton, Jessica Corner, Julia Verne

“…Background Prostate cancer and its treatment may impact physically, psychologically and socially; affecting the health-related quality of life of men and their partners/spouses. …”
Get full text

Effects of replacing fishmeal with soybean meal on growth performance, liver antioxidant capacity and intestinal health in juvenile Asian red-tailed catfish (Hemibagrus wyckioides) by Weijia Cai, Xinping Li, Minglang Cai, Zhe Tang, Bo Zhu, Mengxi Yang, Yi Hu, Jihong Dai

“…Substitution levels exceeding this range, such as 45 % and 60 %, adversely affect liver and intestinal health.…”
Get full text