Investigating the Role of Osteopontin (OPN) in the Progression of Breast, Prostate, Renal and Skin Cancers by Gautam Kundu, Selvakumar Elangovan

“…<b>Background/Objectives</b>: Cancer is caused by disruptions in the homeostatic state of normal cells, which results in dysregulation of the cell cycle, and uncontrolled growth and proliferation in affected cells to form tumors. Successful development of tumorous cells proceeds through the activation of pathways promoting cell development and functionality, as well as the suppression of immune signaling pathways; thereby providing these cells with proliferative advantages, which subsequently metastasize into surrounding tissues. …”
Get full text

Shenmai injection revives cardiac function in rats with hypertensive heart failure: involvement of microbial-host co-metabolism by Lin Li, Senjie Zhong, Jiahao Ye, Siyuan Hu, Xiajun Xiong, Guangyu Chen, Zhixi Hu

“…According to metabolomics and 16S rRNA sequencing, by reestablishing homeostasis in the gut microbiota, SMI affects vital metabolic pathways, such as energy metabolism, amino acid metabolism, and bile acid metabolism. …”
Get full text

Prevalence and factors associated with depression and anxiety among patients recovered from COVID-19: a cross-sectional study in a tertiary care hospital in Nepal by Biraj Man Karmacharya, Kamal Gautam, Kalpana Chaudhary, Prasanna Rai, Shalik Ram Dhital, Shrinkhala Shrestha, Bandana Paneru, Akina Shrestha

“…Introduction COVID-19 has immensely affected the mental health of all people with prominent effects among the COVID-19 survivors who underwent hospitalisation. …”
Get full text

Mortality trends and disparities for coexisting chronic obstructive pulmonary disease and cardiovascular disease: A retrospective analysis of deaths in the United States from 1999-... by Aman Goyal, Humza Saeed, Wania Sultan, Ajeet Singh, Abdullah, Muhammad Khubaib Arshad, Zubair Amin, Mah I Kan Changez, Gauranga Mahalwar, Rozi Khan, Wael AlJaroudi

“…This study analyzes mortality trends and disparities among individuals in the United States (US) affected by both CVD and COPD.<h4>Methods</h4>This study analyzed death certificates from the CDC WONDER database for individuals aged 25 and older who died between 1999 and 2020 with both CVD (ICD I00-I99) and COPD (ICD J41-J44). …”
Get full text

Using RNA-Seq to Explore the Repair Mechanism of the Three Methods and Three-Acupoint Technique on DRGs in Sciatic Nerve Injured Rats by Tao-tao Lv, Yan-jun Mo, Tian-yuan Yu, Shuai Shao, Meng-qian Lu, Yu-ting Luo, Yi Shen, Yu-mo Zhang, Wong Steven

“…Point-pressing, plucking, and kneading methods were administered quantitatively at Yinmen (BL37), Chengshan (BL57), and Yanglingquan (GB34) points on the affected side once a day, beginning 7 days after modeling. …”
Get full text

Regulation of NK cell development, maturation, and antitumor responses by the nuclear receptor NR2F6 by Johannes Woelk, Florian Hornsteiner, Stephanie Aschauer-Wallner, Patrizia Stoitzner, Gottfried Baier, Natascha Hermann-Kleiter

“…Of importance, Nr2f6-deficient mice are protected against MHC-I negative B16-F10 melanoma lung metastasis formation, especially with IL-15 complex treatment, indicating the potential of NR2F6 to affect NKp46-dependent NK cell-mediated tumor surveillance. …”
Get full text

Achilles Tendon Repair by Decellularized and Engineered Xenografts in a Rabbit Model by Marta Bottagisio, Daniele D’Arrigo, Giuseppe Talò, Matilde Bongio, Marco Ferroni, Federica Boschetti, Matteo Moretti, Arianna B. Lovati

“…Whereas, DG demonstrated a massive inflammatory and giant cell response associated with graft destruction and necrosis, absence of type I and III collagen, and a higher amount of proteoglycans and MMP-2, thus unfavourably affecting the biomechanical response. In conclusion, this in vivo study suggests a potential use of the proposed tissue-engineered constructs for tendon reconstruction.…”
Get full text

Effects of Enterocytozoon hepatopenaei infection on intestinal immune defense and physiological processes of Penaeus vannamei by Zheng Cao, Chuanyu He, Zhipeng Yin, Caiyi Chen, Fan Li, Dongchun Yan, Ting Li, Linrui Chang, Lingjun Si

“…Unfortunately, it remains in a state of nutrient deficiency that ultimately affects growth.…”
Get full text

Investigation of malaria vectors Anopheles in non-endemic areas of Thailand: in proximity to workplaces housing foreign migrant workers by Nurhadi Eko Firmansyah, Thaksaporn Thongseesuksai, Thidarut Boonmars, Porntip Laummaunwai

“…This situation raises concerns regarding the potential transmission of malaria infections to regions not traditionally affected by the disease. Epidemiological studies on malaria vectors should not solely concentrate on endemic regions but also extend to non-endemic areas because of the mobility of migrant workers throughout the country. …”
Get full text

Study on the Dynamic Response of the Carbody–Anti-Bending Bars System by Ioana-Izabela Apostol, Traian Mazilu, Mădălina Dumitriu

“…The resonance frequency of the first bending mode (FBM) of such vehicle is within the most sensitive frequency range that affects ride comfort. Anti-bending bars consist of two bars that are mounted under the longitudinal beams of the carbody chassis using vertical supports. …”
Get full text

Accounting for racial bias and social determinants of health in a model of hypertension control by Yang Hu, Nicholas Cordella, Rebecca G. Mishuris, Ioannis Ch. Paschalidis

“…Race-specific models revealed different sets of social variables predicting high SBP, with Black patients being affected by structural barriers (e.g., food and transportation) and White patients by personal and demographic factors (e.g., marital status). …”
Get full text

F-box protein Fbx23 acts as a transcriptional coactivator to recognize and activate transcription factor Ace1. by Zhongjiao Liu, Kexuan Ma, Panpan Zhang, Siqi Zhang, Xin Song, Yuqi Qin

“…Deleting the Pofbx23 gene does not affect Poace1 gene transcription but results in the remarkable accumulation of all versions of the PoAce1 protein. …”
Get full text

Clinical Role of Epigenetics and Network Analysis in Eye Diseases: A Translational Science Review by Michele Lanza, Giuditta Benincasa, Dario Costa, Claudio Napoli

“…PF-04523655, a 19-nucleotide methylated double-stranded siRNA targeting the RTP80 gene, showed a dose-related improvement in best-corrected visual acuity (BCVA) in patients affected by diabetic macular edema. The observed results support a clinical network-based research program aimed to clarify the role of epigenetic regulators in the development of ocular diseases and personalized therapy.…”
Get full text

Edible Film Whey-Gelatin: Lama Gelasi, Solubilitas dan Mikrostruktur dengan Penggabungan Bubuk Teh Hijau by Fahrullah Fahrullah, Basriani Basriani, Cis Anita, Farah Febryanti, Fitriyani Fitriyani

“…Results indicate that green tea powder significantly affects gelation time and solubility (P<0.01). …”
Get full text

Herpes Simplex Virus Type 2 (HSV-2) and Cytomegalovirus (CMV) among Women with Macerated Stillbirth: A Cross-Sectional Hospital-Based Study from Mwanza, Tanzania by Helmut A. Nyawale, Elieza Chibwe, Fridolin Mujuni, Lidya Maiga, Albert Silvin, Alda Ester Chongo, Bertrand Msemwa, Vitus Silago, Mtebe Majigo, Doreen Kamori, Stephen E. Mshana, Mariam M. Mirambo

“…Stillbirth adversely affects pregnancy outcomes in low- and middle-income countries (LMICs). …”
Get full text

High Incidence of Refeeding Syndrome during the Transition from F75 to Ready-to-Use Therapeutic Feeds among Children 6 to 59 Months with Severe Acute Malnutrition at the Pediatric... by Wani Muzeyi, Teddy Ochieng Andra, Lorraine Oriokot, Victor Musiime

“…Phosphorus, potassium, and magnesium are the main electrolytes affected when it occurs. However, hypophosphatemia is the hallmark of the diagnosis of refeeding syndrome. …”
Get full text

A Review of Potentially Toxic Elements in Sediment, Water, and Aquatic Species from the River Ecosystems by Md Muzammel Hossain, Iffat Jahan, Mudasir A. Dar, Maruti J. Dhanavade, Al Fattah Bin Mamtaz, Stephen J. Maxwell, Song Han, Daochen Zhu

“…The river’s water, sediment, and aquatic life are all severely affected by the release of chemical and urban waste. …”
Get full text

Dual-Mechanism Gastroretentive Tablets with Encapsulated Gentian Root Extract by Jelena Mudrić, Ljiljana Đekić, Nemanja Krgović, Đorđe Medarević, Katarina Šavikin, Milica Radan, Nada Ćujić Nikolić, Tijana Ilić, Bojana Vidović, Jelena Đuriš

“…HSH time positively affected powder stability and negatively gentiopicroside release. …”
Get full text

Assessment of Cellular Responses after Short- and Long-Term Exposure to Silver Nanoparticles in Human Neuroblastoma (SH-SY5Y) and Astrocytoma (D384) Cells by Teresa Coccini, Luigi Manzo, Vittorio Bellotti, Uliana De Simone

“…Colony number decrease in SH-SY5Y and D384 was 50% and 25%, respectively, at 1 μg/ml, and lower dose (0.5 μg/ml) was significantly effective towards SH-SY5Y and pulmonary cells; (ii) cell proliferation activity was more affected by AgNO3 than AgNPs. In summary, AgNP-induced cytotoxic effects after short-term and prolonged exposure (even at low doses) were evidenced regardless of cell model types.…”
Get full text

Antimicrobial Activity of the Synthesized of Copper Chalcogenide Nanoparticles by N. G. Mbewana-Ntshanka, M. J. Moloto, P. K. Mubiayi

“…The sensitivity of copper oxide nanoparticles is attributed to the smaller size of oxygen atom which strongly affects its reactivity and stability and hence very stable and highly reactive compared to sulfur and selenium.…”
Get full text