Evaluation of urban water cycle health status based on DPSIRM framework and AHP-FCE-Cloud model by Jiageng Hu, Fuqiang Wang, Peiheng Liu, Subing Lü, Cheng Lü, Furong Yu

“…Zhengzhou is used as a case study to evaluate the health status of the water cycle across three periods: 2010–2013, 2014–2017, and 2018–2021, comparing results with the traditional AHP-FCE model while exploring the obstacles affecting water cycle health. The results indicate a continuous improvement in Zhengzhou’s water cycle health, rising from an unhealthy level in 2010–2013 to a sub-healthy level in 2014–2021. …”
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Exosome-mediated delivery of miR-9 induces cancer-associated fibroblast-like properties in human breast fibroblasts by Sara Baroni, S Romero-Cordoba, I Plantamura, M Dugo, E D’Ippolito, A Cataldo, G Cosentino, V Angeloni, A Rossini, M G Daidone, M V Iorio

“…Here we show that miR-9, upregulated in various breast cancer cell lines and identified as pro-metastatic miRNA, affects the properties of human breast fibroblasts, enhancing the switch to CAF phenotype, thus contributing to tumor growth. …”
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Impact of antibody architecture and paratope valency on effector functions of bispecific NKp30 x EGFR natural killer cell engagers by Ammelie Svea Boje, Lukas Pekar, Katharina Koep, Britta Lipinski, Brian Rabinovich, Andreas Evers, Carina Lynn Gehlert, Steffen Krohn, Yanping Xiao, Simon Krah, Rinat Zaynagetdinov, Lars Toleikis, Sven Poetzsch, Matthias Peipp, Stefan Zielonka, Katja Klausz

“…While having a pronounced impact on NK cell killing efficacy, the capabilities of triggering antibody-dependent cellular phagocytosis or complement-dependent cytotoxicity were not significantly affected comparing the bivalent IgG-like NKCEs with cetuximab. …”
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A novel de novo GABRA2 gene missense variant causing developmental epileptic encephalopathy in a Chinese patient by Li Yang, Xingyu Wan, Ran Hua, Junhong Jiang, Baotian Wang, Rui Tao, De Wu

“…If analysis revealed that the variant did not affect subcellular localization. Conclusion This study identified a novel likely pathogenic GABRA2 extracellular domain variant in a Chinese family causing the DEE phenotype. …”
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Congenital Zika Syndrome: Insights from Integrated Proteomic and Metabolomic Analysis by Leticia Gomes-de-Pontes, Lucila Akune Barreiros, Lillian Nunes Gomes, Ranieri Coelho Salgado, Sarah Maria da Silva Napoleão, Paulo V. Soeiro-Pereira, Saulo Duarte Passos, Antonio Condino-Neto

“…Our objective was to identify specific molecular signatures in the EVs of patients with CZS, focusing on their potential as biomarkers and on cellular pathways affected by the infection. <b>Methods:</b> We conducted advanced proteomic and metabolomic analyses using mass spectrometry for protein and metabolite identification. …”
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Drought stress tolerance based on selection indices of resistant crops variety by R. Daneshvar rad, H. Heidari Sharifabad, M. Torabi, R. Azizinejad, H.R. Salemi, M. Heidari Soltanabadi

“…BACKGROUND AND OBJECTIVES: The stress caused by dryness can affect plant growth and physiology. Several coping mechanisms (recovery, avoidance, tolerance and drought escape) have been developed to mitigate the impact of drought stress, and  most strategies involve survival during stress condition. …”
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Intraoperative Hyperspectral Imaging Predicts Early Allograft Dysfunction and Overall Survival in Liver Transplantation by Andri Lederer, MD, Antonia Alina Geisler, MD, Robert Sucher, MD, Daniel Seehofer, MD, Hans-Michael Hau, MD, Uwe Scheuermann, PD, Sebastian Rademacher, MD

“…However, a significant proportion of recipients experience EAD, which affects graft and OS. EAD is associated with ischemia-reperfusion injury. …”
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High Stability Single-Port Dual Band Microwave Sensor Based on Interdigital Capacitor Structure With Asymmetry Branch Feedline by Syah Alam, Indra Surjati, Lydia Sari, Raden Deiny Mardian, Teguh Firmansyah, Muhammad Iqbal, Slamet Widodo, Mudrik Alaydrus, Zahriladha Zakaria

“…Therefore, this sensor can be recommended for several applications such as biomedical industry, pharmaceuticals and material quality control especially for outdoor measurements that are potentially affected by electromagnetic interference and disturbance.…”
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Efficacy and safety of pharmacotherapy for cancer cachexia: A systematic review and network meta‐analysis by Hao Chen, Masashi Ishihara, Hiroki Kazahari, Ryusuke Ochiai, Shigeru Tanzawa, Takeshi Honda, Yasuko Ichikawa, Nobuyuki Horita, Hisashi Nagai, Kiyotaka Watanabe, Nobuhiko Seki

“…Abstract Background Cancer cachexia affects more than half of all cancer patients, reducing survival rates. …”
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Nutritive Parameters and Antioxidant Quality of Minimally Processed "Cime di Rapa" ( Brassica rapa subsp. sylvestris ) Vary as Influenced by Genotype and Storage Time by Donato Giannino, Giulio Testone, Chiara Nicolodi, Lucia Giorgetti, Lorenza Bellani, Maria Gonnella, Marco Ciardi, Paolo Cappuccio, Stefano Moscatello, Alberto Battistelli, Vincenzo Longo

“…As for shelf life, storage time was the major factor affecting antioxidant properties, while genotype and interaction effects were minimal.…”
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Assessment of the Utility of Selected Inflammatory Markers in Correlation with Magnetic Resonance Enterography (MRE) Findings in the Diagnosis of Crohn’s Disease by Justyna Lorenc-Góra, Dariusz Waniczek, Zenon P. Czuba, Mariusz Kryj, Zbigniew Lorenc, Małgorzata Muc-Wierzgoń

“…Crohn’s Disease (CD) is a chronic inflammatory bowel disease affecting the gastrointestinal tract. The search continues for new markers for assessing the activity of CD. …”
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Upregulation of Cardiac IL-10 and Downregulation of IFN-γ in Balb/c IL-4−/− in Acute Chagasic Myocarditis due to Colombian Strain of Trypanosoma cruzi by Marcos Vinicius da Silva, Vera Lúcia de Almeida, Wendyson Duarte de Oliveira, Natália Carasek Matos Cascudo, Pollyana Guimarães de Oliveira, Crislaine Aparecida da Silva, Aline Cristina Souza da Silva, Maria Luíza Gonçalves dos Reis Monteiro, Rosana Rosa Miranda Correa, Milton Adriano Pelli Oliveira, Ruy de Sousa Lino-Júnior, Mara Rúbia Nunes Celes, Juliana Reis Machado

“…IL-4 absence culminated in lower cardiac tissue IFN-γ production, although it did not affect TNF-α expression in situ. It also decreased TNF-α systemic production and increased IL-10, both systemically and in situ. …”
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UNet-Att: a self-supervised denoising and recovery model for two-photon microscopic image by Yuer Lu, Yongfa Ying, Chen Lin, Yan Wang, Jun Jin, Xiaoming Jiang, Jianwei Shuai, Xiang Li, Jinjin Zhong

“…While existing denoising methods such as CNNs, Noise2Noise, and DeepCAD serve broad applications in imaging, they still have limitations in preserving texture structures and fine details in two-photon microscopic images affected by complex noise, particularly in sophisticated structures like neuronal synapses. …”
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Effect of daily alcohol consumption and age over 40 years on COVID-19 vaccination antibody titers in the Delta era among hospital workers in northern Okinawa, Japan: A retrospectiv... by Takuji Kishimoto, Daisuke Tasato, Yoshitaka Nagasawa, Akihiro Yamashiro, Hayashi Shokita

“…To enhance vaccine effectiveness, it is not only important to develop more effective vaccines but also to clarify factors, including lifestyle, that affect the immune response. The aim of this study was to investigate the impact of lifestyle factors on COVID-19 vaccination antibody titers. …”
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Growth of the prefrontal cortical glioblastoma altered cognitive and emotional behaviors via mediating miRNAs and GABA-A receptor signaling pathways in rats by Sepide Nateghi, Ameneh Rezayof, Fatemeh Kouhkan, Ladan Delphi, Yavar Bagheri Davisaraei, Fatemeh Rostami, Fatemeh Tirgar, Houri Sepehri

“…Muscimol treatment dose-dependently affected these behaviors in the animals with the mPFC-GBM, bringing their performance with that of the sham group at the dose of 1 µg/rat/2.5 μl. …”
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Longitudinal association of thyroid-stimulating immunoglobulin levels with clinical characteristics in thyroid eye disease by Kyung In Woo, Suk-Woo Yang, Jeong Kyu Lee, Sang In Khwarg, Jin Sook Yoon, Sehyun Baek, Jae Wook Yang, JaeSang Ko, Koung Hoon Kook, Sang Duck Kim, Jun Hyuk Son, Helen Lew, Sung Bok Lee, Jae Woo Jang, Hee Young Choi, Mi Jung Chi

“…Subgroup analysis of patients with a baseline CAS≥4 demonstrated that within-person changes in TSI levels affected the CAS and NOSPECS score.Conclusions Follow-up measurement of serum TSI and TBII levels may help evaluate TED prognosis and enable accurate clinical decision-making.…”
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Prevalence of disability in Iranian older adults in Tehran, Iran: A population-based study by Vahid Rashedi, Mohsen Asadi-Lari, Mahshid Foroughan, Ahmad Delbari, Reza Fadayevatan

“…Conclusion: For older adults, disability directly affects daily functioning by restricting physical and social activities, the ability to maintain self-sufficiency, and ultimately the freedom to live a chosen lifestyle. …”
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Improving diagnostic precision in thyroid nodule segmentation from ultrasound images with a self-attention mechanism-based Swin U-Net model by Changan Yang, Muhammad Awais Ashraf, Mudassar Riaz, Pascal Umwanzavugaye, Kavimbi Chipusu, Kavimbi Chipusu, Hongyuan Huang, Yueqin Xu

“…These challenges directly affect the precision of thyroid disorder diagnoses, which are crucial for metabolic and hormonal regulation.MethodsThis study proposes a novel segmentation approach utilizing a Swin U-Net architecture enhanced with a self-attention mechanism. …”
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Premorbid predictors of death at initial presentation of coronary heart disease in the Women's Health Initiative study by Ming-Li Chen, Jin Li, Kruthika R. Iyer, Catherine Tcheandjieu, Shirin Jimenez, Elias Levy Itshak Salfati, Liana C. Del Gobbo, Marcia L Stefanick, Manisha Desai, Xiaonan Xue, Themistocles L Assimes

“…Conclusions: Modifiable factors affect a post-menopausal woman's risk of dying from her initial presentation of CHD. …”
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Amyloid-β and heart failure in Alzheimer’s disease: the new vistas by Hayder M. Al-Kuraishy, Ghassan M. Sulaiman, Hamdoon A. Mohammed, Sohaib G. Mohammed, Ali I. Al-Gareeb, Ali K. Albuhadily, Retaj A. Dawood, Amer Al Ali, Mohammed H. Abu-Alghayth

“…Interestingly, AD is regarded as a systemic disease that causes systemic inflammation and oxidative stress, which in turn affects peripheral organs, including the heart. Aβ through deranged BBB can be transported into the systemic circulation from the brain and accumulated in the heart, leading to the development of HF. …”
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