Early determination of potential critical quality attributes of therapeutic antibodies in developability studies through surface plasmon resonance-based relative binding activity a... by Shuai Wang, Yanqiu Wang, Zhenzhen Li, Ye Hong, Zhaohui Wang, Jiteng Fan, Qiong Wang, Yuanjie Ge, Xiaofeng Zhao, Guangcun Cheng, Changyan Chen, Yadan Wu, Yayuan Fu

“…Some potential CQAs affected binding affinity of antibody and resulted in a reduction of binding activity. …”
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Advanced analysis of soil pollution in southwestern Ghana using Variational Autoencoders (VAE) and positive matrix factorization (PMF) by Raymond Webrah Kazapoe, Daniel Kwayisi, Seidu Alidu, Samuel Dzidefo Sagoe, Aliyu Ohiani Umaru, Ebenezer Ebo Yahans Amuah, Millicent Obeng Addai, Obed Fiifi Fynn

“…Integrating chemometric and machine learning techniques provides a dynamic system that can monitor pollution shifts early, to aid remediation efforts in highly affected areas.…”
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Spatial-temporal Variation and Local Source Identification of Air Pollutants in a Semi-urban Settlement in Nigeria Using Low-cost Sensors by Oyediran Kayode Owoade, Pelumi Olaitan Abiodun, Opeyemi R. Omokungbe, Olusegun Gabriel Fawole, Felix Samuel Olise, Olalekan O. M. Popoola, Roderic L. Jones, Philip K. Hopke

“…Mitigation strategies need to be established to avoid further deterioration of ambient air quality that negatively affect public health.…”
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Investigation in blood-brain barrier integrity and susceptibility to immune cell penetration in a mouse model of Dravet syndrome by Cristina Alonso, Alicia García-Culebras, Valentina Satta, Inés Hernández-Fisac, Álvaro Sierra, José A. Guimaré, Ignacio Lizasoain, Javier Fernández-Ruiz, Onintza Sagredo

“…However, the levels of endogenous IgG in this brain structure were significantly elevated in DS mice compared to controls, directly indicating the occurrence of extravasation into the brain parenchyma and indirectly that the BBB in DS mice may be relatively affected, a fact confirmed by the reduction in the levels of BBB-related proteins such as ZO-1 in these mice. …”
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Isolation, Characterization, and Safety Evaluation of Human Skin-Derived Precursors from an Adherent Monolayer Culture System by Ru Dai, Wei Hua, Wei Chen, Lidan Xiong, Li Li, Yiming Li

“…The potential mixture of FBs in spheres did not affect the biosafety of tSKPs, as both of which had normal karyotype and nontumorigenicity. …”
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Characterization of G2/M checkpoint classifier for personalized treatment in uterine corpus endometrial carcinoma by Yiming Liu, Yusi Wang, Shu Tan, Xiaochen Shi, Jinglin Wen, Dejia Chen, Yue Zhao, Wenjing Pan, Zhaoyang Jia, Chunru Lu, Ge Lou

“…The excessive activation of G2/M checkpoint genes is a crucial factor affecting malignancy prognosis and promoting treatment resistance. …”
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Organic iron and iodine in laying hen diet: Performance, egg quality, thyroid hormones, antioxidant status, serum and yolk lipids, and egg iron and iodine contents by Sima Sarlak, Sayed Ali Tabeidian, Majid Toghyani, Amir Davar Foroozandeh Shahraki, Mohammad Goli, Mahmood Habibian

“…Results: Dietary iodine did not affect bird performance. However, egg laying and feed intake decreased, and feed conversion ratio increased in the absence of supplemental iron. …”
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Diagnostic pathways for breast cancer in 10 International Cancer Benchmarking Partnership (ICBP) jurisdictions: an international comparative cohort study based on questionnaire and... by David Weller, Usha Menon, Alina Zalounina Falborg, Henry Jensen, Andriana Barisic, Anne Kari Knudsen, David H Brewster, Victoria Cairnduff, Eva Grunfeld, Elizabeth Harland, Mats Lambe, Rebecca-Jane Law, Yulan Lin, Martin Malmberg, Donna Turner, Richard D Neal, Victoria White, Samantha Harrison, Peter Vedsted, Una MacLeod, Conan Donnelly, Anna Gavin, Jon Emery, Oliver Bucher, Jatinderpal Kalsi, Chantelle Anandan, Evangelia Ourania Fourkala, Therese Kearney, Marie-Louise Essink-Bot, Sigrun Saur Almberg, Breann Hawryluk, Jacqueline Kelly, Jackie Boylan, Jan Willem Coebergh, David Brewster, Stefan Bergström, Victoria Hammersley, Rebecca Bergin, Alina Zalounina Falborg, Andriana Barisi, Kerry Moore, Maria Rejmyr Davis

“…Objectives A growing body of evidence suggests longer time between symptom onset and start of treatment affects breast cancer prognosis. To explore this association, the International Cancer Benchmarking Partnership Module 4 examined differences in breast cancer diagnostic pathways in 10 jurisdictions across Australia, Canada, Denmark, Norway, Sweden and the UK.Setting Primary care in 10 jurisdictions.Participant Data were collated from 3471 women aged >40 diagnosed for the first time with breast cancer and surveyed between 2013 and 2015. …”
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The Role of Coal Mechanical Characteristics on Reservoir Permeability Evolution and Its Effects on CO2 Sequestration and Enhanced Coalbed Methane Recovery by Hao Han, Shun Liang, Yaowu Liang, Xuehai Fu, Junqiang Kang, Liqiang Yu, Chuanjin Tang

“…Elastic modulus is an important parameter affecting the permeability change in the process of coalbed methane (CBM)/enhanced coalbed methane (ECBM) production, which will change with the variable gas content. …”
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Effects of farming specialisation on grassland birds in Mediterranean High Nature Value farmland by Joana Santana, Pedro J. Leitão, Paulo Flores Ribeiro, Pedro Beja, Ângela Lomba, Rui Pedroso, Rui Morgado, Ricardo C. Martins, Inês Catry, Ana Teresa Marques, Luís Reino, Francisco Moreira

“…We investigated how specialisation affects birds in open farmland of southern Portugal, by analysing spatial associations between farming systems, land uses, and birds’ species richness and occurrence. …”
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Efficacy of a new treatment algorithm for capsulitis of the fingers in rock climbers by Volker Rainer Schöffl, Volker Rainer Schöffl, Volker Rainer Schöffl, Volker Rainer Schöffl, Volker Rainer Schöffl, Christoph Lutter, Christoph Lutter, Hans-Christoph Lang, Mario Perl, Othmar Moser, Michael Simon

“…Outcomes were assessed using visual analogue scale (VAS), Buck-Gramcko score and a climbing specific outcome score with secondary patient recall.ResultsThe proximal interphalangeal joint of the middle finger was the most commonly affected joint, and there was no correlation with osteoarthritis. …”
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Community case study: an academia-industry-government partnership that monitors and predicts outbreaks in Tri-County Detroit area since 2017 by Irene Xagoraraki, Liang Zhao, Yabing Li, Brijen Miyani, John Norton, James Broz, Andrew Kaye, Anna Mehrotra, Anil Gosine, Scott Withington, Stacey McFarlane, Russell A. Faust

“…In 2017, to explore innovative methods that may provide early warnings of outbreaks affecting populations in the TCDA, an exploratory partnership that was funded by a U.S. …”
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Agronomic assessment of solar dried recycled olive mill sludge on Maize agrophysiological traits and soil fertility by Bouhia Youness, Lyamlouli Karim, Yedir Oudouch, El Mehdi El Boukhari Mohamed, Mohamed Hafidi

“…Despite improving soil fertility, SDy-OMWS application negatively affected the plant development at early stages. However, such effect was completely alleviated at the end of the experiment.…”
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A novel agricultural drought index based on multi-source remote sensing data and interpretable machine learning by Hao Chen, Ni Yang, Xuanhua Song, Chunhua Lu, Menglan Lu, Tan Chen, Shulin Deng

“…The results show that IMLDI has a higher spatial and temporal consistency with standardized precipitation evapotranspiration index, can better reflect the real-world observed drought-affected cropland areas and gross primary production, and can also well describe the evolutions of 2009/2010 and 2019 drought events in the eastern parts of China, indicating higher drought monitoring performance of IMLDI. …”
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Familial Hypercholesterolemia: Genetics, Symptoms, Diagnosis and Treatment - A Literature Overview by Maciej Rutkiewicz, Sabina Przygodzka, Katarzyna Gadżała, Karolina Garbino, Katarzyna Brudniak, Antoni Szuścik, Magdalena Czyczerska

“…These are: LDL-Receptor (LDLR), Apolipoprotein B (ApoB), and Proprotein convertase subtilisin/kexin 9 (PCSK9). People who are affected by mutation have around thirteen times higher risk of coronary artery disease (CAD) and, in order to that, premature death. …”
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The impact of particle size of nanostructured lipid carriers on follicular drug delivery: A comprehensive analysis of mouse and human hair follicle penetration by Saman Heydari, Mohammad Barzegar-Jalali, Mostafa Heydari, Afsaneh Radmehr, Ana Cláudia Paiva-Santos, Maryam Kouhsoltani, Hamed Hamishehkar

“…Particle size is one of the important factors affecting the penetration and accumulation of particles in the hair follicles, and there is a controversy in different studies for the best particle size for follicular delivery. …”
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Combat the growing prevalence of anaemia through underutilised iron-rich plant-based foods by Naman Kaur, Arthittaya Thuanthong, Simran Kaur, Aparna Agarwal, Manisha Sabharwal, Jatinder K. Sahu, Jayashree Arcot, Abhishek Dutt Tripathi, Pankaj Koirala, Nilesh Nirmal

“…Anaemia is a condition where a lowered level of red blood cells or haemoglobin is detected, which adversely affects an individual working capacity. World Health Organization and Food and Agriculture Organization have recommended four approaches to manage micronutrient deficiency – nutrition education, fortification, supplementation, and dietary diversity. …”
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Transcriptomic, histological and biochemical analyses of Macrobrachium nipponense response to acute heat stress by Xiao Wu, Yaoran Fan, Jianbin Feng, Keyi Ma, Jiale Li

“…Temperature is an essential environmental factor affecting the viability of organisms. Temperature changes could cause damages or even death. …”
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Stapled End-To-Side Ileocolic Anastomosis in Crohn’s Disease: Old Dog, Reliable Tricks? A Retrospective Two-Center Cohort Study by Volkan Doğru, MD, Jean H. Ashburn, MD, Umut Akova, BS, Alton G. Sutter, MD, Eren Esen, MD, Emily M. Gardner, MD, Andre da Luz Moreira, MD, Arman Erkan, MD, John Kirat, MD, Michael J. Grieco, MD, Feza H. Remzi, MD

“…The choice of technical approach to ileocolic anastomosis after ileocecal resection for Crohn’s disease affects surgical outcomes and recurrence. Yet, despite heterogeneous data from different anastomotic configurations, there remains no clear guidance as to the optimal technique. …”
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Effect of Dry, Vacuum, and Modified Atmosphere Ageing on Physicochemical Properties of Roe Deer Meat by Natalia Kasałka-Czarna, Róża Biegańska-Marecik, Jędrzej Proch, Aleksandra Orłowska, Magdalena Montowska

“…The high oxygen atmosphere negatively affected the quality of this game species. It carries the risk of increased oxidation of proteins and lipids which may promote the formation of potentially detrimental compounds.…”
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