Characterization of heart failure patients with reverse left ventricular remodelling post‐angiotensin receptor blockers/neprilysin inhibitors therapy by Leonid Maizels, Yishay Wasserstrum, Boris Fishman, Amitai Segev, David Ben‐Nun, Anan Younis, Dov Freimark, Israel Mazin, Avishay Grupper

“…Subgroup analysis revealed several parameters associated with significant LVEF improvement, including baseline LVEF <30%, non‐ischaemic HF aetiology, lack of cardiac resynchronization therapy (CRT), better initial functional class and ARNI initiation within 3 years from HF diagnosis (P ≤ 0.001 for all). …”
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Cardiovascular outcomes associated with treatment of type 2 diabetes in patients with ischaemic heart failure by Thomas R. Godec, Daniel I. Bromage, Mar Pujades‐Rodriguez, Antonio Cannatà, Arturo Gonzalez‐Izquierdo, Spiros Denaxas, Harry Hemingway, Ajay M. Shah, Derek M. Yellon, Theresa A. McDonagh

“…We compared outcomes of patients with T2DM and HF of ischaemic aetiology according to antidiabetic treatment. Methods and results This study used linked data from primary care, hospital admissions, and death registries for 4.7 million inhabitants in England, as part of the CALIBER resource. …”
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Psychiatric comorbidities in epilepsy: population co-occurrence, genetic correlations and causal effects by Neil M Davies, Dheeraj Rai, Harriet Forbes, Christina Dalman, Torbjörn Tomson, Daniel Berglind, Michael Lundberg, Cecilia Magnusson, Craig Newschaffer, Brian K Lee, Viktor H Ahlqvist, Paul Madley-Dowd, Christina Dardani, Jessica Rast, Caichen Zhong, Renee M Gardner, Kristen Lyall

“…We then used summary data from genome-wide association studies to investigate whether the identified observational associations could be attributed to a shared underlying genetic aetiology using cross-trait linkage disequilibrium score regression. …”
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Thrombus composition and its implication in ischemic stroke assessment and revascularization treatments by Juan Marta-Enguita, Florencio J.D. Machado, Josune Orbe, Roberto Muñoz

“…Development: Thrombotic pathways involved in the different vascular beds share common mechanisms, causing difficulties in the identification of specific patterns associated with stroke aetiology. However, other factors such as clot formation time, associated inflammatory status, or activation of additional immune and coagulation pathways (neutrophil extracellular trap [NET] delivery, platelet aggregation, endothelial activation, and von Willebrand Factor release) have been described as determinants in thrombus characteristics. …”
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Pulmonary artery catheter use in acute myocardial infarction‐cardiogenic shock by Saraschandra Vallabhajosyula, Aditi Shankar, Sri Harsha Patlolla, Abhiram Prasad, Malcolm R. Bell, Jacob C. Jentzer, Shilpkumar Arora, Saarwaani Vallabhajosyula, Bernard J. Gersh, Allan S. Jaffe, David R. Holmes Jr, Shannon M. Dunlay, Gregory W. Barsness

“…Admissions with concomitant cardiac surgery or non‐AMI aetiology for cardiogenic shock were excluded. The outcomes of interest were in‐hospital mortality, resource utilization, and temporal trends in cohorts with and without PAC use. …”
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Wits Transplant Unit Annual Report 2022: Adult and paediatric liver transplantation by E U Wessels, K Kinandu, M Beretta, S Berkenfeld, B Bobat, L Brannigan, R Britz, D Demopoulos, L Doedens, P Gaylard, H Maher, A Mahomed, V Mudau, D Parbhoo, S Rambarran, M Reynders, F van der Schyff, B Ströbele, J Fabian, J Loveland

“…In the paediatric population, the most common aetiologies for both pretransplant candidates and transplant recipients remained cholestatic disease and acute liver failure. …”
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Associations of FTO and MC4R Variants with Obesity Traits in Indians and the Role of Rural/Urban Environment as a Possible Effect Modifier by A. E. Taylor, M. N. Sandeep, C. S. Janipalli, C. Giambartolomei, D. M. Evans, M. V. Kranthi Kumar, D. G. Vinay, P. Smitha, V. Gupta, M. Aruna, S. Kinra, R. M. Sullivan, L. Bowen, N. J. Timpson, G. Davey Smith, F. Dudbridge, D. Prabhakaran, Y. Ben-Shlomo, K. S. Reddy, S. Ebrahim, G. R. Chandak

“…In the context of rapid urbanisation, resulting in significant lifestyle changes, understanding the aetiology of obesity is important. We investigated associations of FTO and MC4R variants with obesity traits in 3390 sibling pairs from four Indian cities, most of whom were discordant for current dwelling (rural or urban). …”
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Clinical Recommendations of Russian Gastroenterological Association and RENDO Endoscopic Society on Diagnosis and Treatment of Gastritis and Duodenitis by V. T. Ivashkin, I. V. Maev, T. L. Lapina, E. D. Fedorov, A. A. Sheptulin, A. S. Trukhmanov, A. V. Kononov, R. A. Abdulkhakov, O. P. Alexeeva, S. A. Alekseenko, D. N. Andreev, E. K. Baranskaya, N. N. Dekhnich, I. L. Klyaritskaya, R. S. Kozlov, E. A. Kogan, M. P. Korolev, N. V. Korochanskaya, S. A. Kurilovich, M. A. Livsan, M. F. Osipenko, P. V. Pavlov, S. S. Pirogov, A. S. Sarsenbaeva, V. I. Simanenkov, A. S. Tertychny, A. V. Tkachev, Yu. P. Uspensky, I. B. Khlynov, V. V. Tsukanov

“…The recommendations condense current knowledge on the aetiology and pathogenesis of gastritis and duodenitis, as well as laboratory and instrumental diagnostic techniques, main approaches to aetiological H. pylori eradication and treatment of dyspeptic states.…”
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The Protective Role of HLA-DRB113 in Autoimmune Diseases by Andreia Bettencourt, Cláudia Carvalho, Bárbara Leal, Sandra Brás, Dina Lopes, Ana Martins da Silva, Ernestina Santos, Tiago Torres, Isabel Almeida, Fátima Farinha, Paulo Barbosa, António Marinho, Manuela Selores, João Correia, Carlos Vasconcelos, Paulo P. Costa, Berta Martins da Silva

“…Autoimmune diseases (AIDs) are characterized by a multifactorial aetiology and a complex genetic background, with the MHC region playing a major role. …”
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Association of chronic heart failure with mortality in old intensive care patients suffering from Covid‐19 by Raphael Romano Bruno, Bernhard Wernly, Georg Wolff, Jesper Fjølner, Antonio Artigas, Bernardo Bollen Pinto, Joerg C. Schefold, Detlef Kindgen‐Milles, Philipp Heinrich Baldia, Malte Kelm, Michael Beil, Sigal Sviri, Peter Vernon vanHeerden, Wojciech Szczeklik, Arzu Topeli, Muhammed Elhadi, Michael Joannidis, Sandra Oeyen, Eumorfia Kondili, Brian Marsh, Finn H. Andersen, Rui Moreno, Susannah Leaver, Ariane Boumendil, Dylan W. De Lange, Bertrand Guidet, Hans Flaatten, Christian Jung, COVIP study group

“…More patients suffered from pre‐existing ischaemic than from non‐ischaemic disease [233 vs. 328 patients (n = 5 unknown aetiology)]. There were no differences in baseline characteristics between ischaemic and non‐ischaemic disease or between HFrEF, HFmrEF, and HFpEF. …”
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Genetic insights into psychotic major depressive disorder: bridging the mood-psychotic disorder spectrumResearch in context by Thuy-Dung Nguyen, Joeri J. Meijsen, Robert Sigström, Ralf Kuja-Halkola, Ying Xiong, Arvid Harder, Kaarina Kowalec, Joëlle A. Pasman, Carolina Scarpa, Elin Hörbeck, Lina Jonsson, Sara Hägg, Niamh Mullins, Kevin S. O’Connell, Christina Dalman, Dorte Helenius, Richard Zetterberg, Henrik Larsson, Paul Lichtenstein, Ole A. Andreassen, Thomas Werge, Alfonso Buil, Mikael Landén, Patrick F. Sullivan, Yi Lu

“…These findings advance our understanding of the aetiology of psychotic MDD and contribute to the limited body of evidence on this phenotype by utilising large-scale population-based data. …”
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Interplay between oxidative stress, neuroinflammatory cytokines and melatonin in Alzheimer's disease: Insights from cerebrospinal fluid analysis by Francisco Artime-Naveda, David Hevia, Rebeca Alonso-Arias, Carmen Martínez, Isabel Quirós-González, Rafael Cernuda-Cernuda, Alejando Alvarez-Artime, Iván Menéndez-Valle, Rosa M. Sainz, Juan C. Mayo

“…Other factors previously associated with the aetiology of AD, including redox indicators or proinflammatory biomarkers, were also included. …”
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LRH‐1/NR5A2 targets mitochondrial dynamics to reprogram type 1 diabetes macrophages and dendritic cells into an immune tolerance phenotype by Nadia Cobo‐Vuilleumier, Silvia Rodríguez‐Fernandez, Livia López‐Noriega, Petra I. Lorenzo, Jaime M. Franco, Christian C. Lachaud, Eugenia Martin Vazquez, Raquel Araujo Legido, Akaitz Dorronsoro, Raul López‐Férnandez‐Sobrino, Beatriz Fernández‐Santos, Carmen Espejo Serrano, Daniel Salas‐Lloret, Nila vanOverbeek, Mireia Ramos‐Rodriguez, Carmen Mateo‐Rodríguez, Lucia Hidalgo, Sandra Marin‐Canas, Rita Nano, Ana I. Arroba, Antonio Campos Caro, Alfred CO Vertegaal, Alejandro Martín‐Montalvo, Franz Martín, Manuel Aguilar‐Diosdado, Lorenzo Piemonti, Lorenzo Pasquali, Roman González Prieto, Maria Isabel García Sánchez, Decio L. Eizirik, Maria Asuncion Martínez‐Brocca, Marta Vives‐Pi, Benoit R. Gauthier

“…Abstract Background The complex aetiology of type 1 diabetes (T1D), characterised by a detrimental cross‐talk between the immune system and insulin‐producing beta cells, has hindered the development of effective disease‐modifying therapies. …”
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Screening for Q Fever during Other Bacterial Endocarditis in Endemic Areas: Our Experience with Three Patients by Said Younis, Michal Stein, Sharon Reisfeld

“…We suggest screening patients with endocarditis from other aetiologies to Q fever.…”
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Pseudoporphyria Associated with Nonhemodialyzed Renal Insufficiency, Successfully Treated with Oral N-Acetylcysteine by A. C. Katoulis, D. Ferra, E. Toumbis, E. Papadavid, A. Kanelleas, I. Panayiotides, D. Rigopoulos

“…Such cases support the view that renal impairment itself may play a more important aetiological role in developing PP than it was originally considered.…”
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Clinical Practice Guidelines for Acute Pericarditis Treatment by Félix Rolando Jorrín Román, Lázaro De la Cruz Aviles, Roberto Vega Hernández, Francisco Riverón Mena

“…It has been defined as a syndrome caused by the inflammation of the pericardium for diverse aetiologies. The etiological agents, clinical presentation, diagnostic methods and steps that must be taken are described in this document. …”
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Clinical Practice Guidelines for Hypovolemic Shock. by Alba Enseñat Álvarez, Omar Bárbaro Rojas Santana, Alexis Díaz Mesa, Ariamna Fleites Gómez

“…This document includes a description of the concept and different stages of the disease, aetiological classification and comments about the main elements related with diagnosis and treatment, stressing volemic restoration. …”
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Clinical Practice Guidelines for Acute Renal Failure. by Argelio Alberto Santana Cano, Marta Patricia Casanova González, Belkys Rodríguez Llerena, Eddy Pereira Valdés

“…It a syndrome characterized by the abrupt deterioration of basal renal functions (abrupt reduction of glomerular filtration) and the consequent increase of nitrogenous products in the blood as well as the homeostasis of the body. It aetiological agents, clinical presentation, therapeutic and diagnostic methods are described. …”
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Quality of Life in Painful Peripheral Neuropathies: A Systematic Review by Ayesha Girach, Thomas Henry Julian, Giustino Varrassi, Antonella Paladini, Athina Vadalouka, Panagiotis Zis

“…The aim of this review was to overview the current literature that focuses on QoL in painful PN of various aetiologies. We sought to clarify the direct effect of pain and its treatment on patients’ QoL. …”
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Acute Gastric Dilatation Resulting in Gastric Emphysema Following Postpartum Hemorrhage by Suhail Aslam Khan, Edmond Boko, Haseeb Anwar Khookhar, Sheila Woods, A. H. Nasr

“…Acute gastric dilatation is a rare entity, with varying aetiologies the majority of which are benign. Delay in diagnosis and treatment could result in sequelae such as gastric emphysema (pneumatosis), emphysematous gastritis, gangrene, and perforation. …”
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