Conceptual basis for the development of guidance for the use of biomarkers of effect in regulatory risk assessment of chemicals by European Food Safety Authority (EFSA), Antonio Hernández‐Jerez, Susanne Hougaard Bennekou, Laurentius (Ron) Hoogenboom, Henry Mcardle, Christina Pieper, Tanja Schwerdtle, Hendrik Van Loveren, Zainab Al Harraq, Cristina Croera, Anna Christodoulidou, Agnès De Sesmaisons, Chantra Eskes, Sara Levorato, Silvia Valtueña Martínez, Georgia Bompola, Lucian Farcal

Subjects: Get full text

Constitutive androstane receptor, liver pathophysiology and chemical contaminants: current evidence and perspectives by Francesca De Battistis, Aleksandra Buha Djordjevic, Luciano Saso, Alberto Mantovani, Alberto Mantovani

Subjects: Get full text

Adverse Outcome Pathways (AOPs) Oriented Approach to Assess In Vitro Hazard of Silica and Lignin Nanomaterials Derived from Biomass Residues by Rossella Daniela Bengalli, Maurizio Gualtieri, Mariana Ornelas, Tzanko Tzanov, Paride Mantecca

Subjects: “…adverse outcome pathways…”
Get full text

Comprehensive computational analysis via Adverse Outcome Pathways and Aggregate Exposure Pathways in exploring synergistic effects from radon and tobacco smoke on lung cancer by Thomas Jaylet, Vinita Chauhan, Laura Mezquita, Nadia Boroumand, Olivier Laurent, Karine Elihn, Lovisa Lundholm, Olivier Armant, Karine Audouze

Subjects: Get full text

Refinement of a workflow for human relevance assessment of adverse outcome pathways and associated new approach methodologies by Annick D. van den Brand, Julia J. Meerman, Christina H. J. Veltman, Mirjam Luijten

Subjects: Get full text

Evaluation of a hypothesized Sertoli cell-based adverse outcome pathway for effects of diisononyl phthalate on the developing testis by J.M. Rogers, A.N. Buerger, M.M. Heintz, C.M. Palermo, L.C. Haws, I.A. Lea

Subjects: Get full text

An overview of immune safety avatar: mimicking the effects of immunomodulatory therapies on the immune system by Vanessa Neuhaus, Laure-Alix Clerbaux, Katherina Sewald

Subjects: “…Adverse outcome pathway…”
Get full text

Adverse outcome pathway for the neurotoxicity of per- and polyfluoroalkyl substances: A systematic review by Shenpan Li, Shuangjian Qin, Huixian Zeng, Weichun Chou, Anna Oudin, Katja M. Kanninen, Pasi Jalava, Guanghui Dong, Xiaowen Zeng

Subjects: Get full text

An Adverse Outcome Pathway for food nanomaterial-induced intestinal barrier disruption by Deborah Stanco, Dorelia Lipsa, Alessia Bogni, Susanne Bremer-Hoffmann, Laure-Alix Clerbaux

Subjects: Get full text

Using irAOP for non-clinical safety evaluation of biotechnology-derived pharmaceuticals and ATMPs: a paradigm shift into a systematic and holistic framework by Armin Braun, Susann Dehmel

Subjects: “…Adverse outcome pathway…”
Get full text

Editorial: Women in nanotoxicology 2023–2024 by Iseult Lynch, Ilika Ghosh

Subjects: Get full text

Molecular regulatory networks of microplastics and cadmium mediated hepatotoxicity from NAFLD to tumorigenesis via integrated approaches by Yuhan Li, Yulun Jian, Jinjin Zhou, Min Zhang, Yanfeng Zhou, Yang Ge, Hui Wang, Wei Mu

Subjects: Get full text

Air Pollution and Stroke: An Emerging Challenge From Cardio‐Cerebrovascular Multimorbidity by Ruiyang Ding, Xiaoke Ren, Qinglin Sun, Mo Yang, Yilong Wang, Zhiwei Sun, Junchao Duan

Subjects: “…adverse outcome pathway…”
Get full text

Associating prenatal phthalate exposure with childhood autistic traits: Investigating potential adverse outcome pathways and the modifying effects of maternal vitamin D by Hui Gao, Cheng Zhang, Beibei Zhu, Menglong Geng, Juan Tong, Zixiang Zhan, Yi Zhang, De Wu, Kun Huang, Fangbiao Tao

Subjects: Get full text

Using interactive platforms to encode, manage and explore immune-related adverse outcome pathways by Alexander Mazein, Muhammad Shoaib, Miriam Alb, Christina Sakellariou, Charline Sommer, Katherina Sewald, Kristin Reiche, Patricia Gogesch, Luise A. Roser, Samira Ortega Iannazzo, Sapna Sheth, Susanne Schiffmann, Zoe Waibler, Vanessa Neuhaus, Susann Dehmel, Venkata Satagopam, Reinhard Schneider, Marek Ostaszewski, Wei Gu

Subjects: Get full text

Temperature-dependent toxicity and mechanisms of florfenicol on the embryonic development of marine medaka (Oryzias melastigma) by Xingying Guo, Xu Gong, Jinhui Wang, Tan-Duc Nguyen, Syed Shabi Ul Hassan Kazmi, Jiezhang Mo, Feng Hua, Wenhua Liu, Zhen Wang

Subjects: Get full text

Adverse outcome pathway (AOP) framework for predicting toxic mechanisms in E-cigarette-induced lung injury by Yan Chen, Hongqian Jiang, Wei Liu, Zhenguang Du, Zhenyuan Wang, Zhicheng Zhou, Fusheng Chi

Subjects: Get full text

Constructing adverse outcome pathway for per- and polyfluoroalkyl substances and retinoblastoma based on PI3K-AKT/MAPK signaling pathway by Yuyan GUI, Tingji WANG, Minghao WANG, Yaqi XU, Yunhui ZHANG

Subjects: Get full text

A developmental neurotoxicity adverse outcome pathway (DNT‐AOP) with voltage gate sodium channel (VGSC) inhibition as a molecular initiating event (MiE) by European Food Safety Authority (EFSA), Kevin M. Crofton, Martin Paparella, Anna Price, Iris Mangas, Laura Martino, Andrea Terron, Antonio Hernández‐Jerez

Subjects: “…adverse outcome pathway…”
Get full text

Analyzing IL-2-induced vascular leakage with an irAOP as tool by Patricia Gogesch, Samira Ortega Iannazzo, Tamara Zimmermann, Remi Villenave, Katherina Sewald, Zoe Waibler

Subjects: “…immune related adverse outcome pathway…”
Get full text