Comparison of efficacy and safety between palonosetron and ondansetron to prevent postoperative nausea and vomiting in patients undergoing non-laparoscopic surgery: A systematic re... by Babu Lal, Ragavi Alagarsamy, Jitendra Kumar, Anshul J. Rai, Vineeta Yadav, Rajnish Joshi, Md. Yunus

“…Methods: A PRISMA-guided systematic review and meta-analysis was conducted in PubMed, Google Scholar, Semantic Scholar, and Cochrane Library to identify comparative studies that reported the efficacy (nausea and vomiting) at postoperative time points, namely T1 (0–2 hours), T2 (0–6 hours), T3 (12–24 hours), T4 (24–48 hours), and T5 (24–72 hours), as well as safety (number of incidence of adverse effects). A meta-analysis of the efficacy and safety groups was performed using a random-effects model. …”
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Environmental impact assessment of rapeseed production using the LCA method: Part two: Life cycle impact assessment by Kiš Ferenc, Đurišić-Mladenović Nataša, Marjanović-Jeromela Ana

“…The ReCiPe 2016 method identified and assessed the impact of approximately 750 different emissions with adverse effects on the environment, as well as the impact of around 250 different forms of natural resources consumed or used in the rapeseed production chain. …”
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Paracrine activity of Smurf1-silenced mesenchymal stem cells enhances bone regeneration and reduces bone loss in postmenopausal osteoporosis by Alberto González-González, Itziar Álvarez-Iglesias, Daniel García-Sánchez, Monica Dotta, Ricardo Reyes, Ana Alfonso-Fernández, Alfonso Bolado-Carrancio, Patricia Díaz-Rodríguez, María Isabel Pérez-Núñez, José Carlos Rodríguez-Rey, Jesús Delgado-Calle, Flor M. Pérez-Campo

“…Although current pharmacological treatments are effective, their long-term use is often associated with adverse effects, highlighting the need for safer, more sustainable therapeutic strategies. …”
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Development and validation of the pain management competency scale for nurses and a nationwide survey of Chinese nurses by Yixue Wu, Xiang Pan, Lihui Gu, Yingge Tong, Siyi Chen, Ke Ni, Hangyan Du, Meng Yang, Jianyi Wang, Yi Chen, Yeling Wei, Lingling Luo, Wenqian Cheng

“…Results The PMCSN comprised six primary dimensions—Pain Assessment and Monitoring, Pharmacological Pain Management, Non-Pharmacological Pain Management, Management of Analgesic Adverse Effects, Patient/Family Education, and Professional Development—and includes 52 tertiary items. …”
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Effects of autolytical fish protein hydrolysate on growth performance, survival rate, and hematological indices in farmed juvenile beluga, Huso huso by Ali Hosseinpour Zelaty

“…Conclusion: In conclusion, the present study demonstrated that the replacement of fishmeal with hydrolyzed protein up to level of 8.25% resulted in increased survival and improved growth performance of juvenile beluga compared to the control group, without any adverse effects on blood indices.…”
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Insufficient Evidence to Recommend Shu Mian Capsule in Managing Depression With or Without Comorbid Insomnia: A Systematic Review With Meta-Analysis and Trial Sequential Analysis by Zhao FY, Xu P, Kennedy GA, Jin X, Wang YM, Zhang WJ, Yue LP, Ho YS, Fu QQ, Conduit R

“…In depressed patients with comorbid insomnia, the combination of SMC and psychotropic drugs significantly reduced HAM-D [SMD = − 1.29, 95% CI (− 1.96, − 0.62), p < 0.01] and Pittsburgh Sleep Quality Index scores [SMD = − 1.53, 95% CI (− 1.95, − 1.11), p < 0.01], and exhibited a lower incidence of various drug-related adverse effects compared to psychotropic drugs alone. …”
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Integrated removal of chromium, lead, and cadmium using nano-zero-valent iron-supported biochar: Mechanistic insights and eco-toxicity assessment by Yuzhen Wei, Jialu Yu, Fasih Ullah Haider, Qinhu Zhang, Run Chu, Cai Liqun

“…Nevertheless, an observed shift in toxicity occurred when the composites dosage for Cr6+, Pb2+, and Cd2+ exceeded 2, 4, and 4 g L−1, respectively, thereby instigating adverse effects on the early stages of plant growth. This work elucidates the removal mechanism and intricate reactions between co-existing HMs, highlighting the potential of nZVI-BC as a remediation strategy for HMs contamination.…”
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Metabolite Profiling and Association Analysis of Leaf Tipburn in Heat-Tolerant Bunching Onion Varieties by Tetsuya Nakajima, Reina Yamamoto, Kanako Matsuse, Masato Fuji, Koei Fujii, Sho Hirata, Mostafa Abdelrahman, Muneo Sato, Masami Yokota Hirai, Masayoshi Shigyo

“…However, in recent years, the challenges posed by climate change and global warming have resulted in adverse effects on bunching onions, including stunted growth, discoloration, and the development of leaf tipburn, threatening both crop quality and yield. …”
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An integrated assessment of technological pathways and socioeconomic impacts for sustainable power system transition in Indonesia by Widodo Wahyu Purwanto, Djoni Hartono, Akhmad Herman Yunowo, Heri Hermansyah, Nadhilah Reyseliani, Ahmad Syauqi, Rosa Citra Aprilia

“…However, PA1.5PO can better mitigate adverse effects. The key findings could provide an insight for policymakers better understand transition pathway and its socioeconomic impacts to ensure a fair transition towards a carbon-neutral economy.…”
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Physical health in young males and risk of chronic musculoskeletal, cardiovascular, and respiratory diseases by middle age: A population-based cohort study. by Aleksandra Turkiewicz, Karin Magnusson, Simon Timpka, Ali Kiadaliri, Andrea Dell'Isola, Martin Englund

“…We confirmed the adverse effects of smoking, with risk ratios when comparing 11+ cigarettes per day to non-smoking of 1.14 (95% CI 1.06, 1.22) for musculoskeletal, 1.58 (95% CI 1.44, 1.74) for cardiovascular, and 1.93 (95% CI 1.60, 2.32) for respiratory diseases. …”
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Utilizing rice-husk waste as an effective weed control mulch for Holy Basil (Ocimum sanctum ) production in a tropical environment by Vivian Ogechi Osadebe, Uchenna Noble Ukwu, Nathaniel Dauda, Ifesinachi M Nwamba, Amos Ejike Ede, Anthony I Onah

“…Purpose: The growing adverse effects of agrochemicals on environmental health and safety warrant an examination of ecologically safe alternatives for weed control. …”
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Balneotherapy for the treatment of post-COVID syndrome: a randomized controlled trial by Diana Ovejero, Anna Ribes, Judit Villar-García, Marta Trenchs-Rodriguez, Daniel Lopez, Xavier Nogués, Robert Güerri-Fernandez, Natalia Garcia-Giralt

“…Among these, SF-36’s energy/fatigue and pain subscales exhibited the most prominent changes with a Beta-coefficient [95%CI] of -17.45 [-24.23;-10.66] and − 21.634 [-30.48;-12.78], respectively (p-value < 0.0001). No severe adverse effects were reported during BT although seventeen patients reported mild and transient worsening of preexisting symptoms, particularly fatigue/post-exertional malaise mainly in the first sessions of BT. …”
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Secreted PD-L1 alleviates inflammatory arthritis in mice through local and systemic AAV gene therapy by Wenjun Li, Wenjun Li, Junjiang Sun, Susi Feng, Ariana La Rosa, Panli Zhang, Eveline Y. Wu, Richard Loeser, Chengwen Li, Chengwen Li, Chengwen Li

“…Current treatments for RA are limited in terms of duration, efficacy, and adverse effects. PD-L1 is a checkpoint protein that plays important roles in immune regulation and has been implicated in the initiation and progression of multiple autoimmune diseases.MethodIn a previous study, we demonstrated that intra-articular injection with adeno-associated virus (AAV) vectors encoding wild type PD-L1 improved local inflammation in the joint in the collagen-induced arthritis (CIA) mouse model of RA. …”
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Evaluation of in-vitro and in-silico antidiabetic potential, glucose metabolism, antioxidant, cytotoxicity and phytochemical content of Ipomoea bolusiana Schinz and Ipomoea crassip... by Garland Kgosi More, Nolitha Nkobole, Charmy Twala, Sechaba Machedi, Tebogo Amos Moswetsa, Ramakwala Christinah Chokwe

“…Despite efforts to treat or manage this disease, current therapeutic agents have detrimental side effects, presenting a considerable need to develop new effective drugs with fewer adverse effects. The aim of the study: This study aimed to evaluate the inhibitory capacity of I. bolusiana and I. crassipe plant extracts on α-amylase enzyme and to assess the antioxidant capacity. …”
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Etelcalcetide: What we know eight years since its approval by Pedro Freitas, Luciano Pereira

“…This narrative review aims to summarize the published data about etelcalcetide, focusing on biochemical, cardiovascular (CV) and bone endpoints, as well as adverse effects and all-cause mortality. Materials and methods: A literature review of the use of etelcalcetide in hemodialysis patients with SHPT was conducted. …”
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A humanized anti-MSLN×4-1BB bispecific antibody exhibits potent antitumour activity through 4-1BB signaling activation and fc function without systemic toxicity by Da-yan Zhang, Zhi-hua Zhang, Wen-ting Liu, Wei-ming Zhou, Peng-fei Zhou, Juan-juan Wei, Xue-jing Dai, Xiao-li Zeng, Yu-qiong Zhou, Han-wang Li, Heng Zhang, Ao-lin Shen, Lian-sheng Cheng, Guo-dong Shen, Yi-fu He

“…Furthermore, HK013-G1 did not induce nonspecific production of proinflammatory cytokines and showed good tolerability up to the highest tested dose (30 mg/kg weekly) for 5 weeks, with no HK013-G1-related adverse effects observed in cynomolgus monkeys. In addition, the mean half-life of HK013-G1 was approximately 61 and 97 h at single doses of 3 and 30 mg/kg, respectively. …”
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Recomendaciones para el diagnóstico y tratamiento de las vasculitis asociadas a anticuerpos anticitoplasma de neutrófilo by Enrique Morales, Iñigo Rúa-Figueroa, José Luis Callejas Rubio, Ana Ávila Bernabéu, Ricardo Blanco Alonso, Maria C. Cid Xutgla, Gema Fernández Juárez, Natalia Mena-Vázquez, Juan José Ríos Blanco, Joaquín Manrique Escola, F. Javier Narváez García, Bernardo Sopeña, Luis F. Quintana Porras, Susana Romero-Yuste, Roser Solans Laqué

“…In recent years, a better knowledge of B lymphocyte function and the role of complement inhibition has transformed the course of this disease while minimising treatment-related adverse effects.This multidisciplinary document of recommendations is based on the consensus of three scientific societies (Internal Medicine, Nephrology and Rheumatology) and on the best available evidence on diagnosis, treatment and follow-up of patients with ANCA-associated vasculitis, including some special situations. …”
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Urine kidney injury molecule-1 predicts subclinical kidney disease among persons living with HIV initiating tenofovir disoproxil fumarate-based ART in Zambia by Freeman W. Chabala, Edward D. Siew, Edward D. Siew, Edward D. Siew, C. William Wester, C. William Wester, Alana T. Brennan, Alana T. Brennan, Alana T. Brennan, Masauso M. Phiri, Michael J. Vinikoor, Michael J. Vinikoor, Sepiso K. Masenga, Muktar H. Aliyu, Muktar H. Aliyu, Muktar H. Aliyu

“…IntroductionAntiretroviral therapy (ART) increases the life expectancy of persons living with HIV (PLWH), but not without potentially serious adverse effects. Tenofovir disoproxil fumarate (TDF) can cause nephrotoxicity, manifesting as acute kidney injury (AKI) that may persist after treatment discontinuation. …”
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Recommendations for the diagnosis and treatment of anti-neutrophil cytoplasmic autoantibody associated vasculitis by Enrique Morales, Iñigo Rúa-Figueroa, José Luis Callejas Rubio, Ana Ávila Bernabéu, Ricardo Blanco Alonso, María C. Cid Xutgla, Gema Fernández Juárez, Natalia Mena-Vázquez, Juan José Ríos Blanco, Joaquín Manrique Escola, F. Javier Narváez García, Bernardo Sopeña, Luis F. Quintana Porras, Susana Romero-Yuste, Roser Solans Laqué

“…In recent years, a better knowledge of B lymphocyte function and the role of complement inhibition has transformed the course of this disease while minimising treatment-related adverse effects.This multidisciplinary document of recommendations is based on the consensus of three scientific societies (Internal Medicine, Nephrology and Rheumatology) and on the best available evidence on diagnosis, treatment and follow-up of patients with ANCA-associated vasculitis, including some special situations. …”
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Neoadjuvant immunotherapy for DNA mismatch repair proficient/microsatellite stable non-metastatic rectal cancer: a systematic review and meta-analysis by Huan Zhang, Jing Huang, Huanji Xu, Nanhao Yin, Nanhao Yin, Liyan Zhou, Liyan Zhou, Jianxin Xue, Jianxin Xue, Jianxin Xue, Min Ren

“…Non-metastatic pMMR/MSS RC receiving the short-course radiotherapy (SCRT) in neoadjuvant setting exhibited superior pooled pCR and MPR than long-course radiotherapy (LCRT) without upregulating the incidence of adverse effects. Furthermore, patients with MSS RC underwent neoadjuvant treatment with anti-PD-1 inhibitors demonstrated higher pooled pCR, MPR, cCR compared to those receiving PD-L1 inhibitors. …”
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