Comparative Analysis of γ-Cyclodextrin, Perilla Oil, and Their Inclusion Complexes on Liver Injury and Dyslipidemia Associated with Elevated Gastrointestinal 12-Hydroxylated Bile A... by Keisuke Yoshikiyo, Hidehisa Shimizu, Edward G. Nagato, Satoshi Ishizuka, Tatsuyuki Yamamoto

“…Our previous study demonstrated that γ-cyclodextrin (γ-CD)–perilla oil inclusion complexes increase plasma α-linolenic acid and eicosapentaenoic acid levels in healthy rats without adverse effects. The present study examined the effects of perilla oil, γ-CD, and their inclusion complexes on rats fed cholic acid (CA) to mimic the elevated gastrointestinal 12-hydroxylated (12OH) bile acid levels in high-fat diet-fed rats. …”
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Phthalates toxicity in vivo to rats, mice, birds, and fish: A thematic scoping review by Mohammad Shah Alam, Zannatul Maowa, Mohammad Nazmol Hasan

“…These will assist policymakers in adopting strategies to minimize public exposure and adverse effects.…”
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Epilepsy Treatment Outcome and Its Predictors among Ambulatory Patients with Epilepsy at Mizan-Tepi University Teaching Hospital, Southwest Ethiopia by Ameha Zewudie, Yitagesu Mamo, Desalegn Feyissa, Mohammed Yimam, Gosaye Mekonen, Ahmed Abdela

“…The majority (72.7%) of the patients had developed one or more antiepileptic-related adverse effects. Medium medication adherence (adjusted odds ratio (AOR) = 5.4; 95% CI = 1.52–19.23; p=0.009), poor medication adherence (AOR = 8.16; 95% CI = 3.04–21.90; p=0.001), head injury before seizure occurrence (AOR = 4.9; 95% CI = 1.25–19.27; p=0.02), and seizure attacks ≥4 episodes/week before AEDs initiation (AOR = 8.52; % CI = 2.41–13.45; p=0.001) were the predictors of uncontrolled seizure. …”
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Influence of forage-to-concentrate ratio on the effects of a radiata pine bark extract on methane production and fermentation using the rumen simulation technique by N. Vera, S. Suescun-Ospina, C. Gutiérrez-Gómez, P. Williams, C. Fuentealba, R. Allende, J. Ávila-Stagno

“…Additionally, nutrient disappearance was dependent on the F:C ratio of the diet, without adverse effects on ruminal fermentation. Hence, the incorporation of radiata PBE into HF diets could serve as an environmentally friendly additive, potentially offering an alternative use for a forestry industry by-product, while beneficially modulating ruminal fermentation.…”
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HyProCure for Flatfoot Deformity: A Clinical Characteristics Analysis in China by Shaoling Fu, Chenglin Wu, Cheng Wang, Jiazheng Wang, Zhongmin Shi

“…HyProCure can be removed without additional adverse effects.…”
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Comparative study between high and low dose methylene blue infusion in septic cancer patients: a randomized, blinded, controlled study by Ehab Hanafy Shaker, Ahmed Mohamed Soliman, Ahmed Abd Elmohsen Bedewy, Mai Mohamed Elrawas

“…No significant difference between high and low MB bolus doses, and no significant adverse effects were noted. Compared to placebo, the 4 mg/kg bolus dose shows a survival advantage. …”
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Dietary incorporation of biological curcumin nanoparticles improved growth performance, ileal architecture, antioxidative status, serum lipid profile, and humoral immune response o... by Abdel-Moneim Eid Abdel-Moneim, Noura M. Mesalam, Bing Yang, Mohamed Farouk Elsadek

“…Heat stress greatly impairs poultry productivity, underscoring the urgent need for effective strategies to mitigate these adverse effects and improve overall poultry health. This study assessed the impact of dietary curcumin nanoparticles (CurNPs) on blood metabolites, immunity, redox status, ileal histomorphometry, and growth of broilers subjected to heat stress. …”
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Effect of a Sodium and Calcium DL-β-Hydroxybutyrate Salt in Healthy Adults by Tobias Fischer, Ulrike Och, Ira Klawon, Tim Och, Marianne Grüneberg, Manfred Fobker, Ursula Bordewick-Dell, Thorsten Marquardt

“…Excessive regular consumption without medical observation is not free of adverse effects. The tested product can therefore not be recommended unconditionally.…”
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Voriconazole Pharmacokinetics Administered at 4 mg/kg IM and IV in Nursehound Sharks (<i>Scyliorhinus stellaris</i>) Under Human Care by Daniela Cañizares-Cooz, Daniel García-Párraga, Sonia Rubio-Langre, Teresa Encinas, Pablo Morón-Elorza

“…Clearance (Cl) values were 0.12 ± 0.01 mL/min after IV administration and 0.29 ± 0.05 mL/min after IM administration. No adverse effects were detected during the study or four weeks after administration. …”
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Levilactobacillus brevis CD2 as a multifaceted probiotic to preserve oral health: results of a double-blind, randomized, placebo-controlled trial in healthy adults by Serena Altamura, Francesca Lombardi, Francesca Rosaria Augello, Antonella Barone, Mario Giannoni, Benedetta Cinque, Davide Pietropaoli

“…Salivary glucose and D-lactate levels were lower in the probiotic group post-treatment and after washout. sIgA values increased and remained stable after washout in the probiotic group. No adverse effects were reported. Conclusions The treatment with L. brevis CD2 significantly improved clinical and salivary parameters, supporting its efficacy as a probiotic for oral health. …”
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Highly Stable Antitumor Silver-Lipid Nanoparticles Optimized for Targeted Therapy by Darwish A, Sándor N, Szenti I, Marosvölgyi T, Juhász K, Rónavári A, Kachal E, Kutus B, Kónya Z, Balogi Z

“…To enhance bioavailability, minimize adverse effects and enable targeted drug delivery AgNPs may be encapsulated in liposomes. …”
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Mapping Habitat Structures of Endangered Open Grassland Species (<i>E. aurinia</i>) Using a Biotope Classification Based on Very High-Resolution Imagery by Steffen Dietenberger, Marlin M. Mueller, Andreas Henkel, Clémence Dubois, Christian Thiel, Sören Hese

“…Our findings underscore the critical role of human intervention in preserving habitat suitability, particularly in mitigating the adverse effects of natural succession dominated by shrubs and trees. …”
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Effects of epidural esketamine versus sufentanil on labor analgesia and postpartum depression: a retrospective cohort study by Kunyue Li, Ziqi Chai, Chunyun Deng, Guoying Niu, Xiaoyuan Geng, Yu Zhang, Yuxia Wang, Tao Wang

“…Group KR has considerably decreased rates of pruritus compared to Group SR (P < 0.05). The other adverse effects showed no significant difference (all P > 0.05). …”
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Ethnobotanical survey of plants locally used in the control of termite pests among rural communities in northern Uganda by Betty C. Okori, Christine Oryema, Robert Opiro, Acur Amos, Gilbert I. Obici, Karlmax Rutaro, Geoffrey M. Malinga, Eric Sande

“…Current control of termites mostly relies on chemical pesticides. However, the adverse effects of chemical insecticides necessitate the need to search for and popularize the usage of environmentally safer options. …”
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Study on the comparison between Bosentan and Macitentan in the treatment of persistent pulmonary hypertension of the newborns, simultaneously on sildenafil: A randomized double-bli... by Mandana Kashaki, Arash Mohazzab, Mohammad Radgoudarzi, Arash Bordbar, Sama Dabbagh

“…Drug resistance and the adverse effects of current therapeutic agents warrant investigation of other targeted therapies. …”
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Migration of Health Workers and Its Impacts on the Nigerian Health Care Sector: Protocol for a Scoping Review by David Omiyi, Ebenezer Arubuola, Marcus Chilaka, Md Shafiqur Rahman Jabin

“…By synthesizing existing evidence, the scoping review will guide future research and policy efforts to mitigate the adverse effects of migration on health care systems and workforce sustainability. …”
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Non-pharmacological interventions for primary hypertension: a systematic review and network meta-analysis protocol by Tao Xu, Fan-rong Liang, Qifu Li, Taipin Guo, Ziwen Chen, Yun-Jie Shu, Xueli Zhou

“…Many patients require a combination of multiple medications to reach targets, but adverse effects and financial burdens undermine adherence. …”
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Biologics for eosinophilic oesophagitis: a systematic review and meta-analysis by Beibei Zeng, Doudou Jia, Shengen Li, Xuna Liu, Boxu Zhu, Yanqi Zhang, Yan Zhuang, Fei Dai

“…Key outcomes of this meta-analysis include the following: Anti-IL-5 biologics exhibited statistically significant benefits in histological remission (RR 2.03 [CI 1.45–2.85]; p < 0.0001) compared to the placebo, but there was no significant difference in symptom relief (RR 1.06 [CI 0.88 to 1.28]; p = 0.53); anti-IL-4/13 biologics had significant effects on histologic improvement (RR 10.48 [CI 5.54–19.82]; p < 0.00001) and symptom related score reduction (RR 1.44 [CI 1.08–1.93]; p = 0.01), with a better outcome for endoscopic remission than with placebo (SMD–1.06 [CI–1.26–0.86], p < 0.00001); no statistically significant differences in adverse effects were observed between the intervention and control groups.Conclusions Our findings suggest that the biologics currently being investigated are considered safe and effective treatments for EoE, while their efficiency varies. …”
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Risperidone versus placebo for aggression following traumatic brain injury: a feasibility randomised controlled trial by Paul Bassett, Tim Weaver, Shoumitro Deb, Mike Crawford, David Sharp, Lina Aimola, Verity Leeson, Mayur Bodani, Lucia Li

“…Follow-up participants at 12 weeks using a battery of assessment scales to measure changes in aggressive behaviour and irritability (Modified Overt Aggression Scale (MOAS)-primary outcome, Irritability Questionnaire) as well as global functioning (Glasgow Outcome Scale-Extended, Clinical Global impression) and quality of life (EQ-5D-5L, SF-12), mental health (Hospital Anxiety and Depression Scale) and medication adverse effects (Udvalg for Kliniske Undersøgelser).Results Six participants were randomised to the active arm of the trial and eight to the placebo arm over a 10-month period (28% of our target). …”
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Regular human insulins versus rapid-acting insulin analogues in children and adolescents with type 1 diabetes: a protocol for a systematic review with meta-analysis and Trial Seque... by Johanne Juul Petersen, Sophie Juul, Caroline Barkholt Kamp, Pascal Faltermeier, Christina Dam Bjerregaard Sillassen, Tiago Jeronimo Dos Santos, Janus Christian Jakobsen

“…Discussion The beneficial and adverse effects of regular human insulins versus rapid-acting insulin analogues have not been systematically assessed in children and adolescents. …”
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