Synthesis and Anti-Cancer Activity In Vitro of Synephrine Derivatives by Ekaterina M. Zhidkova, Evgeniya S. Oleynik, Ekaterina A. Mikhina, Daria V. Stepanycheva, Diana D. Grigoreva, Lyubov E. Grebenkina, Kirill V. Gordeev, Ekaterina D. Savina, Andrey V. Matveev, Marianna G. Yakubovskaya, Ekaterina A. Lesovaya

“…Glucocorticoids (GCs) are routinely used to treat hematological malignancies; however, long-term treatment with GCs can lead to atrophic and metabolic adverse effects. Selective glucocorticoid receptor agonists (SEGRAs) with reduced side effects may act as a superior alternative to GCs. …”
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Latitudinal patterns of tree β-diversity and relevant ecological processes vary across spatial extents in forests of southeastern China by Maochou Liu, Wenxiang Wu, Ke Wang, Xinshuai Ren, Xueqin Zhang, Lei Wang, Jing Geng, Bo Yang

“…We recommend that conservation efforts maintain diverse forests and heterogeneous environments at multiple spatial extents to mitigate the adverse effects of climate change.…”
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Identification and Quality Evaluation of Raw and Processed Asarum Species Using Microscopy, DNA Barcoding, and Gas Chromatography-Mass Spectrometry by Guangzhe Yao, Wenjuan Ma, Xuhua Huang, Qi Jia, Jiayuan Shen, Yanxu Chang, Huizi Ouyang, Jun He

“…Therefore, Asarum is normally processed to reduce such toxicity and adverse effects. The bioactive ingredients contained in different Asarum herbs vary significantly; this variation may be attributed to their differences in species, origins, or processing methods. …”
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Efficacy of Adjunctive Antiseptic Lavage Solution in Managing Acute Hip/Knee Prosthetic Joint Infection: A Comparative Study in a Tertiary Revision Center by Jonathan Quinn, FRACS, Bernard H. van Duren, DPhil, FRCS, Reshid Berber, PhD, FRCS, Mark Higgins, FRCS, Hosam E. Matar, FRCS, Andrew R. Manktelow, FRCS, Benjamin V. Bloch, FRCS

“…Subgroup analysis demonstrated no difference in knee DAIRs (P = .761) but a trend toward significance in hip DAIRs (P = .262). No adverse effects of Bactisure use were noted intraoperatively or postoperatively. …”
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Acupuncture treatment of restless legs syndrome: a randomized clinical controlled study protocol based on PET-CT and fMRI by Lin Tang, Na Zhao, Xiaolin Gao, Jinjin Li, Xintong Yu, Ruilong Liang, Chen Xie, Lutong Li, Qianqian Wang, Wenjia Yang

“…The objective evaluation tools will be polysomnography, positron emission tomography–computed tomography (PET-CT), and functional magnetic resonance imaging (fMRI) of the brain. All adverse effects will be assessed by the Treatment Emergent Symptom Scale. …”
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Predictors, patterns, and correlates of moderate-severe psychological distress among New York City College Students during Waves 2–4 of COVID-19 by Craig J. Heck, Deborah A. Theodore, April Autry, Brit Sovic, Cynthia Yang, Sarah Ann Anderson-Burnett, Caroline Ray, Eloise Austin, Joshua Rotbert, Jason Zucker, Marina Catallozzi, Magdalena E. Sobieszczyk, Delivette Castor

“…Given its complexity, improving and preserving college students’ mental health necessitates comprehensive, multi-component activities to change adjustable stressors while attenuating the adverse effects of immutable influences.…”
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Haemodynamic changes of interatrial shunting devices for heart failure: a systematic review and meta‐analysis by Tieci Yi, Min Li, Fangfang Fan, Lin Qiu, Zhi Wang, Haoyu Weng, Xiaoke Shang, Changdong Zhang, Wei Ma, Yan Zhang, Yong Huo

“…Conclusions Interatrial shunting device can effectively reduce PCWP, increase CO and 6MWD, and has no obvious adverse effects on the right heart and pulmonary pressure. …”
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Ramadan during pregnancy and the role of dietary intake for neonatal health in Kaduna, Northwestern Nigeria: a cross-sectional study by Musa Abubakar Kana, Bilkisu Usman, Amina Mohammed-Durosinlorun, Jennifer Ahmed, Hassana Habiba Abubakar, Yakub Abdulmalik, Fabienne Pradella

“…Conclusions Dietary intake during non-fasting hours might mitigate potential adverse effects of Ramadan fasting on birth weight. With more than 25% of the global population adhering to Islam, this study highlights the need for additional research on Ramadan during pregnancy across different settings.…”
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Liposomal encapsulation of cholecalciferol mitigates in vivo toxicity and delays tumor growth by Miriam Ezcurra-Hualde, Miriam Ezcurra-Hualde, Sara Zalba, Sara Zalba, Ángela Bella, Ángela Bella, Leire Arrizabalaga, Leire Arrizabalaga, Aline Risson, Aline Risson, Román García-Fuentes, Román García-Fuentes, Celia Gomar, Celia Gomar, Nuria Ardaiz, Nuria Ardaiz, Virginia Belsue, Virginia Belsue, David Ruiz-Guillamon, David Ruiz-Guillamon, Alejandro Serrano-Alcaide, Alejandro Serrano-Alcaide, Ainara Salgado, Ainara Salgado, Fernando Aranda, Fernando Aranda, Maria J. Garrido, Maria J. Garrido, Pedro Berraondo, Pedro Berraondo, Pedro Berraondo

“…VD-LP shows potential for enhanced therapeutic applications with reduced adverse effects, warranting further clinical exploration.…”
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Inebilizumab treatment in a patient with co-occurring AQP4-IgG positive neuromyelitis optica spectrum disorder and myasthenia gravis: a case report and literature review by Xiaoqian Song, Xiaoqian Song, Jingjiao Chen, Chenyang Jin, Yilong Peng, Yuewen Sun, Xueping Zheng

“…Despite previous reports, a consensus on treating NMOSD concurrent with MG is lacking.MethodsWe present the case of a 55-year-old female with both anti-aquaporin-4 (AQP4) antibody-positive NMOSD and anti-acetylcholine receptor (AChR) antibody-positive MG, who achieved stable disease control following treatment with inebilizumab without significant adverse effects. We also conducted a literature review to evaluate the clinical profile of this comorbidity.ResultsOur review identified 85 patients with concurrent NMOSD and MG. …”
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Survival and risk factors for metastatic colorectal cancer patients with a history of prior malignancy by Yiwen Qiu, Nida Cao, Dan Meng, Jian Yuan, Yingjie Zhu

“…Subgroup analyses revealed that a prior diagnosis of a skin tumour (AHR = 1.37; 95% CI [1.11–1.69]) and a history of prior malignancy of more than five years (AHR = 1.39; 95% CI [1.23–1.57]) had adverse effects on the clinical outcomes of patients with mCRC. …”
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Analysis of the potential of dumpsite leachates towards circular economy: a case of Pugu dumpsite in Dar es Salaam, Tanzania by Yasin Yohana Kifwe, Godlisten Namwel Shao, Christina Fabian Pius

“…However, the concentrations of PO4-P and NH4-N exceeded the permissible limit of TBS, which could have adverse effects on the ecosystem. The study proposes a subtle method to recover plant nutrients from leachate, thus contributing to the circular economy.…”
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Supervised and Unsupervised Screen Time and Its Association With Physical, Mental, and Social Health of School-Going Children in Dhaka, Bangladesh: Cross-Sectional Study by Shahria Hafiz Kakon, Tanjir Rashid Soron, Mohammad Sharif Hossain, Rashidul Haque, Fahmida Tofail

“… Abstract BackgroundChildren’s screen time has substantially increased worldwide, including in Bangladesh, especially since the pandemic, which is raising concern about its potential adverse effects on their physical, mental, and social health. …”
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Combined alverine citrate and simeticonein preparation in the treatment of irritable bowel syndrome by Ye. A. Poluektova, S. Yu. Kuchumova, V. T. Ivashkin

“…According to analysis of patients’ diaries, examinations at physician’s visits no adverse effects in the majority of investigated patients has been marked, that confirmed good tolerability of meteospasmyl in all patients.Conclusions. …”
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Cognitive improvement and prefrontal network interactions in individuals with remitted bipolar disorder after transcranial infrared laser stimulation by Douglas W. Barrett, Roger E. Davis, Jennifer E. Siegel-Ramsay, Amy Bichlmeier, Jorge R. C. Almeida, F. Gonzalez-Lima

“…Changes in PFC network interactions were measured with functional near-infrared spectroscopy (fNIRS) because this method can measure TILS effects on oxygen metabolism in the PFC of individuals with BD.ResultsParticipants reported no adverse effects from treatment, confirming the safety of this intervention in individuals with BD. …”
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Investigation of Mechanical and Tribological Characteristics of Medical Grade Ti6al4v Titanium Alloy in Addition with Corrosion Study for Wire EDM Process by S. Prakash, C. S. Abdul Favas, I. Ameeth Basha, R. Venkatesh, M. Prabhahar, V. P. Durairaj, K. Gomathi, Haiter Lenin

“…To prevent these adverse effects of metals, researchers have focused their efforts on developing various coating techniques, facilitating surface coating, or obtaining functional surfaces. …”
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Association between exposure to environmental pollutants and increased oral health risks, a comprehensive review by Li Zhu, Mengchen Tang, Yinyin Cai, Yinyin Cai, Panpan Wang, Panpan Wang

“…The burden of disease and death attributable to environmental pollution is a growing public health challenge worldwide, particularly in developing countries. While the adverse effects of environmental pollution on oral health have garnered increasing attention, a comprehensive and systematic assessment remains lacking. …”
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The effects of training female students in emotion regulation techniques on their social problem-solving skills and social anxiety: a randomized controlled trial by Ashraf Akbari, Camellia Torabizadeh, Narjes Nick, Giti Setoodeh, Parvin Ghaemmaghami

“…Abstract Background Social anxiety is one of the most prevalent anxiety-related disorders among adolescents with many adverse effects on the social and academic lives of this population. …”
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Application Progress of Transcranial Direct Current Stimulation in Rehabilitation of Chronic Low Back Pain by SHI Jian, WAN Ruihan, WANG Yafei, GONG Chen, WANG Yuling

“…Long-term use of analgesics may result in some adverse effects in such patients, including the increased risk of depression and fracture. …”
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Combined Replacement of Fishmeal and Fish Oil by Poultry Byproduct Meal and Mixed Oil: Effects on the Growth Performance, Body Composition, and Muscle Quality of Tiger Puffer by Lili Zhao, Lin Li, Feiran Zhang, Peng Li, Yanlu Li, Jian Liu, Yuliang Wei, Mengqing Liang, Qiang Ma, Houguo Xu

“…In conclusion, combined fishmeal (10% of the diet) and fish oil (5% of the diet) replacement with poultry byproduct and mixed oil (poultry oil + coconut oil) had no adverse effects on the growth performance and body proximate composition of farmed tiger puffer. …”
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