Safety and Efficacy of Nusinersen Focusing on Renal and Hematological Parameters in Spinal Muscular Atrophy by Hüseyin Bahadır Şenol, Gizem Yıldız, Ayşe İpek Polat, Adem Aydın, Ayşe Semra Hız, Alper Soylu, Uluç Yiş

“…Results No significant adverse effects on platelet counts or renal functions were observed. …”
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The cellular response of lipopolysaccharide-induced inflammation in keratoconus human corneal fibroblasts to RB-PDT: Insights into cytokines, chemokines and related signaling pathw... by Ning Chai, Tanja Stachon, Sabrina Häcker, Tim Berger, Zhen Li, Maryam Amini, Shweta Suiwal, Berthold Seitz, Achim Langenbucher, Nóra Szentmáry

“…RB-PDT may have no adverse effects on corneal scar formation of keratoconus corneas in the short term.…”
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Phytomedicine nanoformulations for Parkinson's disease by Chinthu V. Saji, K P Mohanakumar, Rajesh A Shenoi

“…Background: Current medications for Parkinson's disease (PD) primarily offer symptomatic relief, and often lead to adverse effects on long-term use. This highlights the need for disease-modifying therapies. …”
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Efficacy of continuous intravenous infusion of lidocaine on postoperative sore throat after laryngeal mask insertion: a randomized controlled trial by Jianxin Jiang, Jimin Wu, Shuqi Shi, Xiaoli Dong, Jiaxiang Yin, Yini Wu

“…Conclusion Continuous infusion of lidocaine is effective in reducing the incidence and severity of POST after laryngeal mask ventilation, as well as reducing the incidence of adverse effects such as hoarseness and cough. Trial Registration Chinese Clinical Trial Registry (ChiCTR2300070339,04/10/2023).…”
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The efficacy and safety of indobufen in patients with ischemic cardiovascular or cerebrovascular diseases: systematic review and meta-analysis by Xiaolu Luo, Chenglu Lai, Tielong Chen

“…For stroke events, particularly in patients with cerebrovascular diseases, the use of indobufen was associated with some risk.ConclusionIndobufen is associated with a lower risk of adverse reactions and bleeding, making it a viable option for patients at risk of bleeding or adverse effects, particularly in those with cardiovascular diseases. …”
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Vaginal bleeding in pregnancy and adverse clinical outcomes: a systematic review and meta-analysis by Arezoo Karimi, Kourosh Sayehmiri, Mojtaba Vaismoradi, Mostafa Dianatinasab, Salman Daliri

“…This study aimed to investigate the association between vaginal bleeding during the first trimester of pregnancy and clinical adverse effects using a systematic review and meta-analysis.Methods Databases of Scopus, Web of Science, PubMed (including Medline), Cochrane Library and Science Direct were searched until June of 2023. …”
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PFAS contamination and mitigation: A comprehensive analysis of research trends and global contributions by Motasem Y.D. Alazaiza, Tharaa M. Alzghoul, Madhusudhan Bangalore Ramu, Salem S. Abu Amr, Mohammed F.M. Abushammala

“…Per- and polyfluoroalkyl substances (PFAS) are a group of synthetic chemicals known for their persistence in the environment and potential adverse effects on human health. This study conducted a bibliometric analysis of 581 publications from the Scopus database, covering the period from 2015 to November 2024, to assess research trends and developments related to PFAS. …”
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Chronic inflammatory bowel diseases: the course and treatment methods in Russian Federation (Results of multicenter population-based one-stage observational study) by L. . Khalif, M. V. Shapina, A. O. Golovenko, Ye. A. Belousova, Ye. Yu. Chashkova, A. V. Lakhin, O. V. Knyazev, A. Yu. Baranovsky, N. N. Nikolayeva, A. V. Tkachev

“…The clinical data, treatment methods, laboratory tests results and the rate of adverse effects for patients with inflammatory bowel diseases (IBD) from 8 gastroenterological centers were obtained. …”
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EFFECT OF DIFFERENT WEED MANAGEMENT PRACTICES ON GROWTH AND YIELD OF INDIAN MUSTARD (BRASSICA JUNCEA) by Puspa Raj Bista, Krishna Bohara, Dhirendra Man Thapa, Keshav Bahadur Karki, Keshar Bahadur Shahi

“…The results showed that hand weeding and Pendimethalin @ 1.25 kg/ha were effective in promoting plant growth and yield attributes, while Clodinoflop @ 0.75 kg/ha had adverse effects on growth and yield. In terms of yield, hand weeding resulted in the highest seed yield, Stover yield, and biological yield, while the weed check treatment exhibited the lowest values. …”
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Pimavanserin Treatment for Parkinson’s Disease Psychosis in Clinical Practice by Khashayar Dashtipour, Fiona Gupta, Robert A. Hauser, Cherian A. Karunapuzha, John C. Morgan

“…., tremor, bradykinesia, and dyskinesia), although they may also have adverse effects that contribute to symptoms of PDP.…”
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Understanding Cognition, Oxytocin, and Pain in Elders (UCOPE): protocol for a double-blinded cross-over trial in chronic knee osteoarthritis pain by Yenisel Cruz-Almeida, Soamy Montesino-Goicolea, Pedro Valdes-Hernandez, Zhiguang Huo, Roland Staud, Natalie C. Ebner

“…Specifically, there is an urgent need to develop better analgesics for individuals with OA-related pain, since currently used analgesics frequently fail to provide adequate relief or must be discontinued owing to adverse effects. A promising treatment is the neuropeptide oxytocin (OT), which has been shown to play a role in endogenous analgesia with human and animal studies demonstrating anti-nociceptive effects. …”
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3-MA attenuates collagen-induced arthritis in vivo via anti-inflammatory effect and autophagy inhibition by Chong Feng, Zi-rou Wang, Chen-yu Li, Xiang-yu Zhang, Xin-xing Wang

“…However, present clinical drugs have various disadvantages such as poor bioavailability and short biological half-life and drug resistance, or adverse effects. A recent study showed autophagy modulation may be a novel strategy in the treatment of RA. 3-Methylademine (3-MA), is the most widely used autophagy inhibitor, which blocks autophagy at the initiation and maturation stages. …”
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An Intelligent Crow Search Optimization and Bi-GRU for Forest Fire Detection System Using Internet of Things by Syed Abdul Moeed, Bellam Surendra Babu, M. Sreevani, B. V. Devendra Rao, R. Raja Kumar and Gouse Baig Mohammed

“…These environmental challenges have led to significant biodiversity loss, disruption of natural habitats, and adverse effects on climate change. The integration of Artificial Intelligence (AI) and Optimization techniques has made a revolutionary impact in disaster management, offering new avenues for early detection and prevention strategies. …”
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A case report of exacerbation of extrapyramidal symptoms following the switch from risperidone to paliperidone during valproate therapy by Emi Hata, Masatoshi Miyauchi, Nobuhiko Noguchi, Takeshi Asami

“…Despite clinical observations suggesting these interactions, case reports documenting such adverse effects are scarce. Case presentation. We report a case of a 48-year-old Japanese male with epilepsy-associated psychosis and mild intellectual disability who experienced severe EPS during a gradual cross-titration from risperidone to paliperidone while on valproate therapy. …”
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Flavouring group evaluation 418 (FGE. 418): 3‐[3‐(2‐isopropyl‐5‐methyl‐cyclohexyl)‐ureido]‐butyric acid ethyl ester by EFSA Panel on Food Additives and Flavourings (FAF), Laurence Castle, Monica Andreassen, Gabriele Aquilina, Maria Bastos, Polly Boon, Biagio Fallico, Reginald FitzGerald, Maria Jose Frutos Fernandez, Bettina Grasl‐Kraupp, Ursula Gundert‐Remy, Rainer Gürtler, Eric Houdeau, Marcin Kurek, Henriqueta Louro, Patricia Morales, Sabina Passamonti, Romualdo Benigni, Kevin Chipman, Eugenia Cordelli, Gisela Degen, Karl‐Heinz Engel, Paul Fowler, Maria Carfí, Gabriele Gagliardi, Agnieszka Mech, Salvatore Multari, Carla Martino

“…In a 90‐day toxicity study in rats, no adverse effects were observed. In this study, the Panel considered that the NOAEL is 777 and 923 mg/kg bw per day (the highest dose tested) for male and female rats, respectively. …”
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Prevalence and correlates of burn-out among Nigerian medical doctors during the COVID-19 pandemic: a cross-sectional study by Ruth Eshikotse Pius, Janet Ngozi Ajuluchukwu, Alero Ann Roberts

“…Additionally, physicians who had a person with COVID-19 in their immediate environment had an independent correlation with higher work-related burn-out scores (p=0.043).Conclusion The prevalence of burn-out is high among Nigerian doctors and is linked to some sociodemographic, work-related and COVID-19-related factors. Due to the adverse effects of burn-out on physician well-being and patient care, strategies need to be put in place to identify and mitigate burn-out among Nigerian physicians.…”
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Pathogenesis of Disorders of the Motor Function of the Large Intestine in Functional Constipation by M. M. Galagudza, Yu. P. Uspensky, Yu. A. Fominykh, D. Yu. Butko

“…Functional constipation is a classic multifactorial disease, in the etiology of which the adverse effects of the genotype are combined with multiple acquired risk factors. …”
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Total glucosides of paeony for rheumatoid arthritis: a protocol for a systematic review by Jing Luo, Guo-Yan Yang, Di-Er Jin, Ying-Ze Zhang, Jian-Ming Wang, Wei-Ping Kong, Qing-Wen Tao

“…The secondary outcomes will be surrogate outcomes, symptoms, adverse effects, and quality of life. Two reviewers will independently extract data on participants, interventions, comparisons, outcomes, etc. …”
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The efficacy of mindfulness-based interventions for patients with COPD: a systematic review and meta-analysis protocol by Li Li, Ying Wu, Ying Zhang, Lingyun Tian, Yinglan Li

“…Introduction Chronic obstructive pulmonary disease (COPD) is a common chronic respiratory disease. It has adverse effects on patients’ physical health, mental well-being and quality of life. …”
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Hymecromone Efficacy in the Treatment of Biliary Pancreatitis by A. V. Okhlobystin, M. A. Tatarkina, O. Z. Okhlobystina, S. A. Budzinskiy, P. V. Pavlov, L. A. Labut

“…An analysis of the efficacy and safety of the studied drug was performed on the 21st day of treatment based on the results of laboratory tests, abdominal ultrasound, cholecystography and endosonography of the pancreatobiliary zone, quality-of-life assessment according to the SF-36 questionnaire, the frequency and severity of adverse effects (AE).Results. CP signs were found in 6.3 % of patients with gallbladder BS. …”
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