Does outsourcing enable the survival of good care homes? A longitudinal analysis of all care homes in England, 2011–2023 by Anders Malthe Bach-Mortensen, Michelle Degli Esposti, Benjamin Goodair

“…Lastly, the quality of for-profit homes is heavily influenced by area deprivation, and the best active homes in deprived areas are operated by public and third sector providers.Conclusion Our findings suggest that outsourcing of care services has not promoted the survival of the best care homes and may have adverse effects on the equity and accessibility of care. …”
Get full text

Efficacy of Anti-Cancer Immune Responses Elicited Using Tumor-Targeted IL-2 Cytokine and Its Derivatives in Combined Preclinical Therapies by Sahar Balkhi, Giorgia Bilato, Andrea De Lerma Barbaro, Paola Orecchia, Alessandro Poggi, Lorenzo Mortara

“…These approaches mitigate the limitations of high-dose soluble IL-2 therapy, promoting immune activation and minimizing adverse effects. This review critically explores advances in IL-2-based therapies, focusing on immunotoxins, immunocytokines, and IL-2 derivatives. …”
Get full text

Improving Individualized Salbutamol Treatment: A Population Pharmacokinetic Model for Oral Salbutamol in Virtual Patients by Lara Marques, Nuno Vale

“…Each formulation exhibits distinct pharmacokinetic (PK) and pharmacodynamic (PD) profiles, influencing therapeutic outcomes and adverse effects. Although asthma management predominantly relies on inhaled salbutamol, understanding how these formulations interact with patient-specific characteristics could improve personalized medicine approaches, potentially uncovering the therapeutic benefits of alternative formulations for an individual patient. …”
Get full text

Cardiovascular Safety of Clonidine and Dexmedetomidine in Critically Ill Patients after Cardiac Surgery by Angelina Grest, Judith Kurmann, Markus Müller, Victor Jeger, Bernard Krüger, Donat R. Spahn, Dominique Bettex, Alain Rudiger

“…The aim of this retrospective study was to assess the haemodynamic adverse effects of clonidine and dexmedetomidine in critically ill patients after cardiac surgery. …”
Get full text

Influence of Methylprednisolone Pulse Therapy on Liver Function in Patients with Graves’ Orbitopathy by Piotr Miśkiewicz, Anna Jankowska, Kinga Brodzińska, Justyna Milczarek-Banach, Urszula Ambroziak

“…Intravenous methylprednisolone (IVMP) pulse therapy is the first-line treatment in active moderate-to-severe Graves’ orbitopathy (GO) and dysthyroid optic neuropathy (DON). One of the adverse effects of this therapy is liver dysfunction that can be mild (ALT < 100 U/L), moderate (ALT: 100–300 U/L), and severe defined as acute liver injury (ALI) (ALT > 300 U/L). …”
Get full text

Five-Year Clinical Outcomes of Local versus General Anesthesia Deep Brain Stimulation for Parkinson’s Disease by Sheng-Tzung Tsai, Tsung-Ying Chen, Sheng-Huang Lin, Shin-Yuan Chen

“…Significantly less number of MER tracts in GA was found (p=0.04). Adverse effects were similar in both groups. Conclusions. …”
Get full text

Effect of preoperative immunonutrition on complications after salvage surgery in head and neck cancer by Simon Andreas Mueller, Catherine Mayer, Beat Bojaxhiu, Carla Aeberhard, Philipp Schuetz, Zeno Stanga, Roland Giger

“…Abstract Background Patients undergoing salvage surgery for recurrent head and neck squamous cell carcinoma are at high risk of postoperative complications due to the adverse effects of radiotherapy on wound healing. Malnutrition is an additional risk factor and we tested the hypothesis that preoperative administration of immunonutrition would decrease complications in this high risk population. …”
Get full text

Assessment of Anti-Inflammatory and Antioxidant Activities of a Proprietary Preparation of Quercetin–Rutin Blend (SophorOx™) in Exercised Rats by Devanand Shanmugasundaram, James Martin Roza

“…Rats that received SophorOx™ showed no signs of adverse effects, and no significant changes were observed in body weight, feed consumption, liver enzymes, and blood glucose levels. …”
Get full text

Comparison Of Isoconazole Nitrate Versus Nystatin For The Treatment Of Otomycosis by Amna Kausar, Sadia Chaudhry, Nighat Qammar, Ansa Umara Akram, Ashar Alamgir, Wajid Hussain

“… Objective: To compare the efficacy and local adverse effects of Isoconazole Nitrate versus Nystatin for the treatment of patients having Otomycosis  Sudy Design: Group experimental study. …”
Get full text

PENIAPHOBIA AS A COMPONENT OF THE DESTRUCTIVE DIGITAL MEDIA DISCOURSE IN THE ASIA-PACIFIC REGION by Margarita D. Lagutkina, Zhang Yi, Chang Thi Thu Huong

“…Meanwhile, intense exploitation by the media of alleged financial insolvency, looming economic crises, food shortages and impending hunger, the adverse effects of international labor migration and the deplorable state of the labor markets rapidly generate protest moods in society, changing social perceptions of money, food and food consumption. …”
Get full text

Are free school meals failing families? Exploring the relationship between child food insecurity, child mental health and free school meal status during COVID-19: national cross-se... by Maria Bryant, Tiffany C Yang, Madeleine Power, Bridget Lockyer, Rachael H Moss, Wendy Burton, Bob Doherty

“…Free school meals (FSM) are considered a critical tool for reducing the adverse effects of poverty but apply a highly restrictive eligibility criteria. …”
Get full text

Risks to human and animal health from the presence of bromide in food and feed by EFSA Scientific Committee, Susanne Hougaard Bennekou, Ana Allende, Angela Bearth, Josep Casacuberta, Laurence Castle, Tamara Coja, Amélie Crépet, Thorhallur Halldorsson, Laurentius (Ron) Hoogenboom, Helle Knutsen, Konstantinos Koutsoumanis, Claude Lambré, Søren Nielsen, Dominique Turck, Antonio Vicent Civera, Roberto Villa, Holger Zorn, Vasileios Bampidis, Jacqueline Castenmiller, Marie‐Christine Chagnon, Bruce Cottrill, Keyvin Darney, Jürgen Gropp, Secundino Lopez Puente, Martin Rose, Marco Vinceti, Maria Bastaki, Petra Gergelová, Luna Greco, Matteo Lorenzo Innocenti, Judit Janossy, Anna Lanzoni, Andrea Terron, Diane Benford

“…Changes in thyroid hormone homeostasis could result in neurodevelopmental toxicity, among other adverse effects. Changes in thyroid hormone concentrations and neurophysiological parameters have also been observed in experimental human studies, but the evidence was limited. …”
Get full text

Efficacy and safety of high-intensity focused ultrasound combined with suction curettage for the treatment of caesarean scar pregnancy: a systematic review and single-arm meta-anal... by Yu Jiang, Yang Liu, Nian Liu, Shize Qin, Shuting Zhong, Xiaohua Huang

“…The treatment had a remarkable success rate of 97.60% and a subsequent pregnancy rate of 68.70%.Conclusion While the combination of HIFU and suction-curettage may induce common adverse effects such as lower abdominal or limb pain, these reactions typically do not necessitate therapeutic intervention. …”
Get full text

Effects of Dual Peroxisome Proliferator-Activated Receptors α and γ Activation in Two Rat Models of Neuropathic Pain by Mohammad Alsalem, Mansour Haddad, Sara A. Aldossary, Heba Kalbouneh, Belal Azab, Aala Dweik, Amer Imraish, Khalid El-Salem

“…Currently used analgesics such as opioids are associated with adverse effects; urging the need for safer alternatives. …”
Get full text

Nicotine-free vape liquids containing essential oils of peppermint, lavender, and tangerine: safety and efficacy profiles by Rahmad Aji Prasetya, Djamilah Arifiyana, Zain Budi Syulthoni

“…This safety was also supported by all study subjects who did not report any adverse effects. The efficacy test showed that subjects who used vape liquids with essential oils (F1-F4) experienced a significant decrease in heart rate and systolic blood pressure. …”
Get full text

Tanshinlactone triggers methuosis in breast cancer cells via NRF2 activation by Wanjun Lin, Zifeng Huang, Xuening Zhang, Dayuan Zheng, Yanchao Yang, Meina Shi, Dongfang Yang, Tong Chu, Wenzhe Ma

“…While significant strides have been made in breast cancer management, these interventions are often impeded by substantial adverse effects that undermine patients’ quality of life and confront limitations due to the eventual development of multi-drug resistance. …”
Get full text

Improving the Metal Inert Gas Welding Efficiency and Microstructural Stability in the Butt and Lap Joints of Aluminum Automotive Components Using Sc- and Zr-Enhanced Filler Wires by Hansol Ko, Hye-Jin Kim, Dong-Yoon Kim, Jiyoung Yu

“…The coarsening of the microstructure with the increased heat input was disadvantageous for the tensile-shear strength, and the increased weld size offset the adverse effects of the coarse microstructure. These results indicate that the heat input and the amount of deposited metal must be optimized to ensure stiffness in various joints of automotive components.…”
Get full text

Role of polyethylene glycol to alleviate lead stress in Raphanus sativus by Muhammad Sajid, Shakil Ahmed, Rehana Sardar, Aamir Ali, Nasim Ahmad Yasin

“…These changes collectively played a role in mitigating the adverse effects of Pb on plant physiology. Our data revealed that PEG interceded stress extenuation encompasses numerous regulatory mechanisms including scavenging of ROS through antioxidant and non-antioxidants, improved photosynthetic activity and appropriate nutrition. …”
Get full text

The Safety and Efficacy of Lansoprazole plus Metoclopramide among Neonates with Gastroesophageal Reflux Disease Resistant to Conservative Therapy and Monotherapy: A Clinical Trial by Peymaneh Alizadeh Taheri, Elahe Validad, Kambiz Eftekhari

“…There were no drug adverse effects in either group during intervention (secondary outcome). …”
Get full text

A Lightweight Mitigation Technique Against a Modified Version Number Attack in IoT Networks by Ibrahim S. Alsukayti, Mohammed Alreshoodi, Mehdi Rouissat

“…It succeeded in mitigating the adverse effects of the attacks with considerable reductions of 179% and 142% in energy consumption and network overhead, respectively. …”
Get full text