A multi-modal multi-branch framework for retinal vessel segmentation using ultra-widefield fundus photographs by Qihang Xie, Qihang Xie, Xuefei Li, Yuanyuan Li, Yuanyuan Li, Jiayi Lu, Jiayi Lu, Shaodong Ma, Yitian Zhao, Yitian Zhao, Jiong Zhang, Jiong Zhang

“…Within this field, Ultra-WideField (UWF) fundus images offer distinct advantages, including an expansive imaging range, detailed lesion data, and minimal adverse effects. However, the high resolution and low contrast inherent to UWF fundus images present significant challenges for accurate segmentation using deep learning methods, thereby complicating disease analysis in this context.MethodsTo address these issues, this study introduces M3B-Net, a novel multi-modal, multi-branch framework that leverages fundus fluorescence angiography (FFA) images to improve retinal vessel segmentation in UWF fundus images. …”
Get full text

Unlocking the therapeutic mechanism of Caesalpinia sappan: a comprehensive review of its antioxidant and anti-cancer properties, ethnopharmacology, and phytochemistry by Estéfani Alves Asevedo, Estéfani Alves Asevedo, Livia Ramos Santiago, Livia Ramos Santiago, Hyo Jeong Kim, Rony Abdi Syahputra, Moon Nyeo Park, Rosy Iara Maciel Azambuja Ribeiro, Bonglee Kim

“…Particularly noteworthy is C. sappan’s potential in combination therapies, where it may synergistically target multiple cancer pathways, enhance therapeutic outcomes, and mitigate adverse effects. This review synthesizes the findings from the past decade, providing a comprehensive evaluation of C. sappan’s pharmacological promise while identifying critical areas for future research. …”
Get full text

Safety and efficacy of laryngeal mask airway placement in term of oropharyngeal leak pressure: A comparison between conventional insertion and laryngoscope guided insertion by Ayan Ghorui, Baisakhi Laha, Sandip Roy Basunia, Debasish Saha

“…OLP, first attempt success rate, time taken for insertion, hemodynamic variation, and adverse effects were recorded and compared between the groups. …”
Get full text

Decrease in HBsAg After TAF Switching from Entecavir During Long-Term Treatment of Chronic Hepatitis B Virus Infection by Kazuto Tajiri, Yuka Hayashi, Aiko Murayama, Nozomu Muraishi, Masami Minemura, Ichiro Yasuda

“…HBsAg loss occurred in three patients who switched to TAF. No adverse effects were observed, and TAF was well tolerated. …”
Get full text

Repeated Autologous Bone Marrow Transfusion through Portal Vein for Treating Decompensated Liver Cirrhosis after Splenectomy by Weiwei Zhang, Mujian Teng, Baochi Liu, Qiling Liu, Xin Liu, Yanhui Si, Lei Li

“…No significant changes were observed in AFP in the control group, but it decreased in the ABMT group. No major adverse effects were noted during the follow-up period in the patients of either group. …”
Get full text

Low-level auricular vagus nerve stimulation lowers blood pressure and heart rate in paroxysmal atrial fibrillation patients: a self-controlled study by Yu Jiang, Yu Jiang, Di Su, Jingwen Xiao, Jingwen Xiao, Wenbo Cheng, Yuemei Hou, Yan Zhang, Yan Zhang

“…The systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate maximum (HRmax), heart rate minimum (HRmin), left ventricular ejection fraction (LVEF), left atrial diameter (LAD), Atrial Fibrillation Severity Scale (AFSS) symptom subscale, and Memorial Symptom Assessment Scale-Heart Failure (MSAS-HF) before and after the treatment were observed and compared. In addition, adverse effects of the LL-aVNS procedure and 6-month follow-up were recorded.ResultsSBP, DBP, and HRmin were lower after the treatment than before the treatment (p < 0.05); AFSS symptom subscale scores and MSAS-HF scores after the treatment were lower before the treatment (p < 0.05); itching of the skin was observed in one case during the course of LL-aVNS; and two patients were hospitalized for acute exacerbation of chronic heart failure between 4 months and 6 months after the treatment.ConclusionLL-aVNS in patients with paroxysmal atrial fibrillation can assist in controlling blood pressure and heart rate, effectively relieving symptoms, and the treatment process is safe and feasible.…”
Get full text

Titanium dioxide -mediated regulation of enzymatic and non-enzymatic antioxidants, pigments, and diosgenin content promotes cold stress tolerance in Trigonella foenum-graecum L. by Mohamad Javad Babaei, Amin Ebrahimi, Parviz Heidari, Elham Azadvari, Shahrokh Gharanjik, Zeinab Chaghakaboodi

“…It also effectively reduced electrolyte leakage and malondialdehyde content, mitigating the adverse effects of cold stress. The study also highlighted TiO2 NPs’ affirmative impact on defense signaling pathways, including abscisic acid, nitric oxide, and auxin, in fenugreek. …”
Get full text

Gonadal health benefits of black cumin (Nigella sativa) seed oil on chronic lead-exposed male Wistar rats by Afrina Mustari, Mahabub Alam, Samia Rashid, A.G.M.Sofi Uddin Mahamud, Mohammad Alam Miah, Emdadul Hauqe Chowdhury

“…However, the administration of NSO effectively counteracted the adverse effects induced by chronic Pb exposure in rats. …”
Get full text

Medicinal plants as alternatives for the management of hypertension and diabetes in Nigeria: Analysis of the structured interview of Nigerian patients by Rosemary A. Sylver-Francis, Olavi Pelkonen

“…Potentially, the use may predispose patients to severe hypotension or hypoglycaemia and other adverse effects e.g. drug interactions and direct toxicities. …”
Get full text

Kinetic-pharmacodynamic model to predict post-rituximab B-cell repletion as a predictor of relapse in pediatric idiopathic nephrotic syndrome by Ziwei Li, Qian Shen, Hong Xu, Zhiping Li

“…However, vast majority of children inevitably experience relapse with B-cell repletion, necessitating repeat course of rituximab, which may increase the risk of adverse effects. The timing of additional dosing and optional dosing regimen of rituximab in pediatric patients with INS have yet to be determined. …”
Get full text

Rare Cell Population Analysis in Early-Stage Breast Cancer Patients by Stefan Schreier, Prapaphan Budchart, Suparerk Borwornpinyo, Lakkana Adireklarpwong, Prakasit Chirappapha, Wannapong Triampo, Panuwat Lertsithichai

“…Furthermore, certain cell profile patterns may be associated with treatment-related adverse effects. The sensitivity in detecting tumor-presence and cancer-associated abnormality before surgery was 43% and 85.7%, respectively, and the specificity was 100% and 96.6%, respectively. …”
Get full text

Risk factors of functional dyspepsia, gastrointestinal reflux disease and non-erosive reflux disease by Malik Ayesha, Din Rafi Ud, Asif Mahrosh, Naeem Iqra, Habib Aamir, Khan Asma Arshad

“…Background/Aim: Functional dyspepsia, erosive and non-erosive gastroesophageal reflux disease (GERD) present a major health burden, adversely effecting quality of life. A range of factors are hypothesised to have a positive and negative influence on these diseases. …”
Get full text

The effect of R&D capitalization on revenue-expense matching: Focusing on the bio-pharmaceutical industries in South Korea by Dongjoon Choi, Inkyung Yoon, Hansol Lee

“…The results indicate that R&D capitalization generally weakens revenue-expense matching in these industries. However, the adverse effects are mitigated by the effective implementation of corporate governance mechanisms. …”
Get full text

Acupuncture for Chronic Prostatitis or Chronic Pelvic Pain Syndrome: An Updated Systematic Review and Meta-Analysis by Juanhong Pan, Song Jin, Quan Xie, Ying Wang, Zhipeng Wu, Jianfeng Sun, Tai Pin Guo, Di Zhang

“…Meta-analysis showed that compared to sham acupuncture (SAT) and western medicine (WM), acupuncture (AT) played superior roles for CP/CPPS patients in pain score, NIH-CPSI score, quality of life score, urinary symptom, and efficacy rate. As for the adverse effects, 4 RCTs described mild hematoma and pain in AT and SAT groups, while specific symptoms including nausea, abdominal pain, dizziness, and low blood pressure were reported in WM groups. …”
Get full text

Factors associated with early-onset androgenetic alopecia: A scoping review. by Li-Ping Liu, Mary Adumo Wariboko, Xiao Hu, Zi-Han Wang, Qian Wu, Yu-Mei Li

“…This scoping review aims to explore the risk factors and etiology, associated conditions, and adverse effects on wellbeing in early-onset AGA.<h4>Methods</h4>Electronic literature searches were conducted in MEDLINE, EMBASE and CENTRIAL. …”
Get full text

Individual physical activity preferences of adolescents in the Czech Republic and Poland: a 14-year comparative study reflecting the gender trends and prospective responses to glob... by Michal Kudlacek, Karel Fromel, Dorota Groffik, Josef Mitas

“…Addressing these adverse effects post-pandemic by supporting preferred physical activities among young individuals is crucial. …”
Get full text

The impact of Sudafed on spleen of albino mice by L. Alsaadi Yasmin, K. Abdul Ameer Bassam, Jasim Mohamad Ban, Kathum Omra Faiza

“…This investigation demonstrated some pathological effects of this drug on spleen of albino mice at higher doses as compared to lower doses and control which recommends the use of minimal doses of PSE to avoid its adverse effects.…”
Get full text

Ecological and human health implications of mercury contamination in the coastal water by A. Mallongi, A.U. Rauf, R.D.P. Astuti, S. Palutturi, H. Ishak

“…Additionally, the Monte Carlo simulation model revealed that the non-carcinogenic risk caused by mercury exposure in adults and children was greater than 1 (Total Hazard Index>1), indicating the health adverse effects for both receptors. From the simulation results, the concentration of mercury at 23.3% and exposure time of 21.3 percent were the most influential and dominant factors in non-cancer risk for adults and children, respectively. …”
Get full text

Associations between phenol and paraben exposure and the risk of developing breast cancer in adult women: a cross-sectional study by Yao Xiong, Zhiyu Li, Xiong Xiong, Zixuan Luo, Kaixin Zhong, Jiawei Hu, Shengrong Sun, Chuang Chen

“…Abstract Increasing evidence suggests that endocrine-disrupting chemicals (EDCs) have adverse effects on breast cancer (BC). The aim of this study was to assess the association between exposure to prevalent EDCs—phenols and parabens—and the risk of developing BC. …”
Get full text

Harnessing artificial intelligence in sepsis care: advances in early detection, personalized treatment, and real-time monitoring by Fang Li, Shengguo Wang, Zhi Gao, Maofeng Qing, Shan Pan, Yingying Liu, Chengchen Hu

“…Personalized treatment plans developed through AI algorithms predict patient-specific responses to therapies, optimizing therapeutic efficacy and minimizing adverse effects. AI-driven continuous monitoring systems, including wearable devices, provide real-time predictions of sepsis-related complications, enabling timely interventions. …”
Get full text