Fungal and oomycete pathogens and heavy metals: an inglorious couple in the environment by Joanna Gajewska, Jolanta Floryszak-Wieczorek, Ewa Sobieszczuk-Nowicka, Autar Mattoo, Magdalena Arasimowicz-Jelonek

“…Toxicity at cellular level leads to disturbance of redox homeostasis manifested by the formation of nitro-oxidative intermediates and to the induction of antioxidant machinery. Despite such adverse effects, published data is indicative of the fact that fungal and oomycete pathogens have a relatively high tolerance to HMs in comparison to other groups of microbes such as bacteria. …”
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DNA replication stress underpins the vulnerability to oxidative phosphorylation inhibition in colorectal cancer by Xiao Hong Zhao, Man Man Han, Qian Qian Yan, Yi Meng Yue, Kaihong Ye, Yuan Yuan Zhang, Liu Teng, Liang Xu, Xiao-Jing Shi, Ting La, Yu Chen Feng, Ran Xu, Vinod K. Narayana, David P. De Souza, Lake-Ee Quek, Jeff Holst, Tao Liu, Mark A. Baker, Rick F. Thorne, Xu Dong Zhang, Lei Jin

“…These results propose GOT1 targeting as a potential avenue to sensitize cancer cells to OXPHOS inhibitors, thus lowering the necessary doses to efficiently inhibit cancer growth while alleviating their adverse effects.…”
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Eribulin Provides a Remarkable Effect in Trabectedin-Resistant Myxoid Liposarcoma by Hironari Tamiya, Hideaki Sabe, Katsunari Yamashita, Yoshinori Imura, Toru Wakamatsu, Satoshi Takenaka

“…Eribulin was subsequently started and has been considerably effective for more than 2 years without severe adverse effects. In conclusion, we experienced a case showing the remarkable and long-lasting effect of eribulin against trabectedin-resistant myxoid liposarcoma.…”
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Evolution of Alzheimer’s Disease Therapeutics: From Conventional Drugs to Medicinal Plants, Immunotherapy, Microbiotherapy and Nanotherapy by Emma Ortiz-Islas, Pedro Montes, Citlali Ekaterina Rodríguez-Pérez, Elizabeth Ruiz-Sánchez, Talía Sánchez-Barbosa, Diego Pichardo-Rojas, Cecilia Zavala-Tecuapetla, Karla Carvajal-Aguilera, Victoria Campos-Peña

“…Current FDA-approved drugs, such as rivastigmine, donepezil, galantamine, and memantine, offer only modest symptomatic relief and are frequently associated with significant adverse effects. Faced with this challenge and in line with advances in the understanding of the pathophysiology of this neurodegenerative condition, various innovative therapeutic strategies have been explored. …”
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Impact of polyvinyl chloride nano-plastics on the biochemical status of Oreochromis niloticus under a predicted global warming scenario by Ahmed Mohamed Soliman, Ayman S. Mohamed, Amr A. Abdel-Khalek, Shereen R. Badran

“…Despite harmful studies on both subjects, there are few studies on how temperature increases plastics’ adverse effects on aquatic animals, mainly freshwater species. …”
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Nanostructured lipid carriers co-encapsulating Apigenin and Melatonin: An innovative strategy against cancer by Lorena Bonilla-Vidal, Marta Świtalska, Marta Espina, Joanna Wietrzyk, María Luisa García, Eliana B Souto, Anna Gliszczyńska, Elena Sánchez-López

“…However, current treatments are frequently associated with adverse effects and can exhibit limitations in therapeutic efficacy. …”
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Dietary exposure to Arsenic, Cadmium, and lead amongst under-five Syrian refugee and Lebanese children in rural Lebanon by Sara Daher, Fouad Ziade, Moomen Baroudi

“…The adverse effects of toxic elements exposure are more intense among infants and children compared with adults. …”
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Rescue Therapy with a Proton Pump Inhibitor Plus Amoxicillin and Rifabutin for Helicobacter pylori Infection: A Systematic Review and Meta-Analysis by Xiaoqun Liu, Hui Wang, Zhifa Lv, Youhua Wang, Ben Wang, Yong Xie, Xiaojiang Zhou, Nonghua Lv

“…The pooled eradication rate was 66.4% for the test regimen and 67.4% for the control group by ITT. The total adverse effects incidence were 25.1% for the test regimen. …”
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Intratonsillar Immunotherapy: A Convenient and Effective Alternative to Subcutaneous Immunotherapy for Allergic Rhinitis by Tian Gu, Wei Zhang, Lu Tan, Rong Xiang, Peiqiang Liu, Jingyu Huang, Qin Deng, Yuqin Deng, Zezhang Tao, Shiming Chen, Yu Xu

“…Allergen-specific immunotherapy (AIT) is the only treatment that addresses the root cause of immunoglobulin E (IgE)-mediated allergies, but conventional methods face challenges with treatment duration, patient compliance, and adverse effects. In this study, we propose intratonsillar immunotherapy (ITIT) as a new effective and safer route for AIT. …”
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Epigenetic Properties of Compounds Contained in Functional Foods Against Cancer by Giulia Casari, Brenda Romaldi, Andrea Scirè, Cristina Minnelli, Daniela Marzioni, Gianna Ferretti, Tatiana Armeni

“…Due to the reversibility of the modifications that they induce, their minimal adverse effects, and their potent epigenetic regulatory activity, dietary phytochemicals hold significant promise as antitumor agents and warrant further investigation. …”
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The Place of Dipeptidyl Peptidase-4 Inhibitors in Type 2 Diabetes Therapeutics: A “Me Too” or “the Special One” Antidiabetic Class? by Ricardo Godinho, Cristina Mega, Edite Teixeira-de-Lemos, Eugénia Carvalho, Frederico Teixeira, Rosa Fernandes, Flávio Reis

“…Clinical studies have shown good glycaemic control with minimal risk of hypoglycaemia or any other adverse effects, despite the reports of pancreatitis, whose association remains to be proved. …”
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TRPV1 Activation Attenuates High-Salt Diet-Induced Cardiac Hypertrophy and Fibrosis through PPAR-δ Upregulation by Feng Gao, Yi Liang, Xiang Wang, Zongshi Lu, Li Li, Shanjun Zhu, Daoyan Liu, Zhencheng Yan, Zhiming Zhu

“…These alterations were associated with downregulation of PPAR-δ, UCP2 expression, upregulation of iNOS production, and increased oxidative/nitrotyrosine stress. These adverse effects of long-term high-salt diet were attenuated by chronic treatment with capsaicin. …”
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Case report: Selpercatinib in the treatment of RET fusion-positive advanced lung adenocarcinoma: a challenging clinical case by Raffaella Pagliaro, Raffaella Pagliaro, Paola Maria Medusa, Paola Maria Medusa, Fabiana Vitiello, Luigi Aronne, Luigi Aronne, Susan F. M. Campbell, Susan F. M. Campbell, Fabio Perrotta, Fabio Perrotta, Andrea Bianco, Andrea Bianco

“…The patient experienced a significant reduction in tumor burden and reported improved symptom control, with no significant adverse effects during the 21-month follow-up period.ConclusionsThis case highlights the efficacy and tolerability of selpercatinib in treating advanced lung adenocarcinoma with a RET fusion. …”
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Dietary Quercetin Regulates Gut Microbiome Diversity and Abundance in <i>Apis cerana</i> (Hymenoptera Apidae) by Haodong Wu, Conghui Ji, Ruisheng Wang, Lijiao Gao, Wenhua Luo, Jialin Liu

“…On day 9, the gut microbial community had recovered from the adverse effects, and <i>Gilliamella</i> abundance increased in response to 37.8 mg/L quercetin treatment. …”
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Biomarker‐induced gold aggregates enable activatable near‐infrared‐II photoacoustic image‐guided radiosensitization by Qinrui Fu, Chuang Wei, Xiao Yang, Mengzhen Wang, Jibin Song

“…Therefore, there is an urgent need for precise RT techniques that can optimize tumor control while minimizing adverse effects on surrounding healthy tissues. In this study, we developed a nanodrug (AuNR@Peptide) composed of furin‐responsive RVRR peptide‐conjugated AuNRs, which integrates an activatable probe and a radiosensitizer into a single system for accurate tumor localization, enabling image‐guided precision RT. …”
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Degradation dynamics of Trifluralin in Qinghai-Tibet Plateau and screening of its degrading strains by Dong Zhao, Lei Wang, Shuo Shen, Enyu Lu, Junlong Feng, Nima Bai, Hongyu Chen, Wei Li

“…Moreover, the optimal degradation conditions for these strains were determined, and it was verified that they had no adverse effects on the germination and seedling growth of rapeseed, wheat, and barley. …”
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Pantoprazole Decreases Cell Viability and Function of Human Osteoclasts In Vitro by Markus Prause, Claudine Seeliger, Marina Unger, Elizabeth Rosado Balmayor, Martijn van Griensven, Alexander Tobias Haug

“…Proton pump inhibitors (PPIs) are commonly prescribed drugs that decrease stomach acidity and are thus often used to treat gastroesophageal reflux disease and as a preventative agent for the adverse effects of nonsteroidal anti-inflammatory drugs on the stomach mucosa. …”
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Telephone-Based Reeducation of Drug Administration for Helicobacterpylori Eradication: A Multicenter Randomized Controlled Study by Yan Zhao, Mudan Ren, Xin Wang, Guifang Lu, Xinlan Lu, Dan Zhang, Shuixiang He

“…Overall, the results from this study suggest that telephone-based reeducation can be potentially applied to improve the H. pylori eradication rate in clinical practice, without significantly increasing the adverse effects.…”
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A Reduced-Order Controller Considering High-Order Modal Information of High-Rise Buildings for AMD Control System with Time-Delay by Zuo-Hua Li, Chao-Jun Chen, Jun Teng, Wei-Hua Hu, Hou-Bing Xing, Ying Wang

“…Then, a control gain design method based on Guaranteed Cost Control (GCC) algorithm is presented to eliminate the adverse effects of data acquisition and actuator response time-delays in the design process of the reduced-order controller. …”
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Phytochemicals in Breast Cancer Prevention and Treatment: A Comprehensive Review by Adil Farooq Wali, Jayachithra Ramakrishna Pillai, Sirajunisa Talath, Pooja Shivappa, Sathvik Belagodu Sridhar, Mohamed El-Tanani, Imran Rashid Rangraze, Omnia Ibrahim Mohamed, Nowar Nizar Al Ani

“…Besides, the study also covers the potential adverse effects of these phytochemicals. Regarding mechanisms, the widest attention is paid to Complementary and synergistic strategies are discussed which indicate that it would be realistic to alter the dosage and delivery systems of liposomes, nanoparticles, nanoemulsions, and films to enhance efficacy. …”
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