Exercise as a mean to reverse the detrimental effect of high-fat diet on bone’s fracture characteristics by Ilias Doulamis, Despina N. Perrea, Panagiotis E. Chatzistergos, Athanasios S. Mitousoudis, Stavros K. Kourkoulis

“…The aim of this study is to investigate whether exercise can reverse some of the adverse effects of high-fat-diet-induced obesity on lipid metabolism and bone biomechanical properties. …”
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Water excess events in the written press (system Ventania, Argentina) by María Ortuño Cano, Jorge Gentili, Belén Moretto, Alicia Campo

“…Water excess events are environmental problems derived from a meteorological- climatic origin that generate adverse effects over population. Its consequences reflect that societies continue to being vulnerable to them. …”
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ImagTIDS: an internet of things intrusion detection framework utilizing GADF imaging encoding and improved Transformer by Peng Wang, Yafei Song, Xiaodan Wang, Xiangke Guo, Qian Xiang

“…ImagTIDS utilizes the self-attention mechanism to dynamically adjust the attention weights and adaptively focus on the important features, effectively suppressing the adverse effects of redundant features. Furthermore, due to the serious class imbalance problem in IoT intrusion detection, we utilize Focal Loss to dynamically scale the model gradient and adaptively reduce the weights of simple samples to focus on hard-to-classify classes. …”
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Prevention of Elevation in Plasma Triacylglycerol with High-Dose Bezafibrate Treatment Abolishes Insulin Resistance and Attenuates Glucose Intolerance Induced by Short-Term Treatme... by Maiara Destro Inácio, Alex Rafacho, Nathália Aparecida de Paula Camaforte, Poliana Teixeira, Priscilla Maria Ponce Vareda, Natália Moretti Violato, José Roberto Bosqueiro

“…Thus, we aimed to describe the potential of bezafibrate in preventing or attenuating the adverse effects of GCs on glucose and lipid homeostasis. …”
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Natural compounds in the management of polycystic ovary syndrome: a comprehensive review of hormonal regulation and therapeutic potential by Jingyi Yuan, Zhenmin Li, Yongjiang Yu, Xiuge Wang, Yunyun Zhao

“…However, these treatments may often lead to adverse effects, and most medications prescribed for PCOS are used off-label and have not secured approval from the U.S. …”
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Mexiletine dosing and tolerability in refractory chronic migraine: Insights from post-lidocaine infusion treatment by Lucia Liao, Hsiangkuo Yuan, Dylan Selbst, Emily Casaletto, Jiangang Liao, Clinton G. Lauritsen

“…This retrospective study describes the dosing, treatment duration, and adverse effects of mexiletine in a group of patients with rCM following lidocaine infusion. …”
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Safety Profile and Effects of Pulsed Methylprednisolone on Vital Signs in Thyroid Eye Disease by Kai-Ling Yong, Chiaw Ling Chng, Hla Myint Htoon, Lee Hooi Lim, Lay Leng Seah

“…To analyze changes in vital signs (heart rate (HR), systolic (SBP), and diastolic blood pressure (DBP)) during and after intravenous methylprednisolone (IVMP) and any other adverse effects. Methods. Retrospective review of charts of patients who received IVMP as treatment regime for thyroid eye disease. …”
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Evaluation of the Safety and Effectiveness of Intense Pulsed Light in the Treatment of Meibomian Gland Dysfunction by Xiaodan Jiang, Huibin Lv, Hang Song, Mingzhou Zhang, Yan Liu, Xiaodan Hu, Xuemin Li, Wei Wang

“…Best spectacle corrected visual acuity, intraocular pressure (IOP), conjunctival injection, upper and lower tear meniscus height (TMH), tear break-up time (TBUT), corneal staining, lid margin and meibomian gland assessments, and meibography were also recorded at every visit, as well as the adverse effects on the eye and ocular surface. Results. …”
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Functionalization of collagen fiber with nano-islands of silver via atomic layer deposition to promote bone healing by Sarah Hashemi Astaneh, Leonardo P. Faverani, Harshdeep Bhatia, Eduardo Dallazen, Monique Gonçalves Costa, Edilson Ervolino, Valentim A.R. Barão, Cortino Sukotjo, Christos G. Takoudis

“…This novel solvent-free method can be used to functionalize sensitive materials used in surgeries as bone grafting agents to enhance osteopromotive properties without any adverse effects to the cellular environment.…”
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IUPHAR review: Drug repurposing in Schizophrenia – An updated review of clinical trials by Jihan K. Zaki, Jakub Tomasik, Sabine Bahn

“…Moving beyond the traditional dopaminergic paradigm of schizophrenia, such findings highlight opportunities to improve treatment-resistant symptoms and alleviate adverse effects. Overall, the evolving drug repurposing landscape illustrates a significant shift in the rationale for schizophrenia drug development, highlighting the potential of in silico strategies, biomarker-based patient stratification, and personalized treatments that align with underlying pathophysiological processes.…”
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Improving the N-glycosylation occupancy of plant-produced IgG1 by engineering the amino acid environment at Asn297 by Kathrin Göritzer, Valentina Ruocco, Ulrike Vavra, Shiva Izadi, Omayra C. Bolaños-Martínez, Thareeya Phetphoung, Nuttapat Pisuttinusart, Waranyoo Phoolcharoen, Richard Strasser

“…However, plant-produced human IgG1 often shows significant underglycosylation with potential adverse effects for immune functions and stability. This study addressed this limitation of the widely used plant-based expression platform Nicotiana benthamiana by employing protein engineering to enhance N-glycosylation occupancy in plant-produced IgG1. …”
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Welfare Implications of Low-Dose Atipamezole Reversal of Tiletamine/Zolazepam/Xylazine Anaesthesia in Pigs by Rachel Layton, David S. Beggs, Andrew Fisher, Peter Mansell, Daniel Layton, Peter A. Durr, Teegan Allen, Grace Taylor, Michael L. Kelly, David T. Williams, Kelly J. Stanger

“…Judicious use of anaesthesia can mitigate experimental, human safety, and animal welfare concerns, but it does not eliminate the potential for adverse effects. The use of reversal agents can shorten recovery time and reduce the physiological impacts of anaesthesia but can also cause additional side effects. …”
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Pharmacological Treatment of Presbyopia Using Pilocarpine 1.25% Eye Drops by Seyed Abolghasem Mousavi, Zhale Rajavi, Hamideh Sabbaghi, Saeid Abdi, Nafeeseh Montazerin, Bahareh Kheiri, Azadeh Haseli- Monfared, Kourosh Sheibani, Hemn Baghban Jaldian

“…Both ophthalmic drugs were safe and none of them were associated with significant adverse effects. …”
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Smoking Exposure and Survival of Patients with Esophagus Cancer: A Systematic Review and Meta-Analysis by Jun-jie Kuang, Zhi-min Jiang, Yan-xian Chen, Wei-peng Ye, Qiong Yang, Hui-zhong Wang, De-rong Xie

“…In the subgroup analysis, adverse effects on current smoker compared with never smoker were also observed in China and the other countries (HR = 1.5, 95% CI 1.18–1.92, and HR = 1.36, 95% CI 1.12–1.65, resp.). …”
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Cancer vaccines: platforms and current progress by Wanting Lei, Kexun Zhou, Ye Lei, Qiu Li, Hong Zhu

“…Overcoming barriers such as effective antigen identification, immunosuppressive microenvironments, and adverse effects is critical for advancing vaccine development. …”
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New LC-MS/MS method for the determination of unconventional organic pollutants: perfluoroalkyl sulfonic acids in wastewater, surface water, and drinking water by Florentina Laura Chiriac, Andreea Valentina Petre, Antonia-Ioana Cimpean, Victor Constantin Cojocaru, Iuliana Paun, Florinela Pirvu, Vasile Ion Iancu

“…The implementation of such methods is crucial for ensuring water quality and protecting ecosystems from the adverse effects of PFSAs, ultimately fostering a safer environment for human health and biodiversity.…”
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Ionospheric Storm Scale Index Based on High Time Resolution UPC‐IonSAT Global Ionospheric Maps (IsUG) by Qi Liu, Manuel Hernández‐Pajares, Haixia Lyu, Michi Nishioka, Heng Yang, Enric Monte‐Moreno, Tamara Gulyaeva, Yannick Béniguel, Volker Wilken, Germán Olivares‐Pulido, Raül Orús‐Pérez

“…Abstract The ionospheric storms have adverse effects on the radio communications, satellite communications and also the Global Navigation Satellite Systems (GNSS) application. …”
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The Role of Concerned Countries in the Effectiveness of Unilateral Sanctions (Relying on the Unilateral Sanctions of the United States of America Against Iran) by Ahdieh Zangi Ahrami, Ahad Bagherzadeh, Hamid Azizi Moradpour

“…Although unilateral sanctions usually evoke the special role of the sanctioner countries as the main cause of human rights adverse effects caused by the imposition of sanctions, but this issue should not lead to ignoring the role and responsibility of the target countries in the extent of the effects and providing the human rights needs of their residents. …”
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Everolimus Implicated in Case of Severe Gastrointestinal Hemorrhage by Paul Gonzales, Seth Klusewitz, Johanna Marowske, John Gancayco, Michael B. Osswald, Robert Setlik

“…However, with the use of these agents come adverse effects, some of which are still being characterized. …”
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Modulatory Effects of Astragalus Polysaccharides on T-Cell Polarization in Mice with Polymicrobial Sepsis by Yu-Chen Hou, Jin-Ming Wu, Ming-Yang Wang, Ming-Hsun Wu, Kuen-Yuan Chen, Sung-Ling Yeh, Ming-Tsan Lin

“…High-dose APS administration led to excessive responses of Th17 cells which may have adverse effects in sepsis-induced organ injury.…”
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