Successful treatment of etanercept- and adalimumab-resistant pyoderma gangrenosum with spesolimab, moderate-dose corticosteroids, and minocycline by Hanlin Zhang, Chao Wu, Hongzhong Jin

“…Complete ulcer healing was achieved within six weeks of starting spesolimab, with no adverse effects reported.Conclusions This case demonstrates the potential efficacy of spesolimab for treating refractory PG, particularly in patients unresponsive to TNF-α inhibitors. …”
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Bioretention Design Simulation for Efficient Urban Stormwater Reduction by Ega Fajar Wicaksono, Entin Hidayah, Cantika Almas Fildzah

“…Low Impact Development (LID) techniques, such as bioretention, have emerged as promising solutions to mitigate the adverse effects of increased impervious surfaces on stormwater management. …”
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Prescription Patterns of Analgesics for Oral Conditions in India - Analysis of Large Medical Audit Data of Outpatients in India’s Private Healthcare Sector by Saif Sayeed, Manu Raj Mathur, Vijay Kumar Mishra, Deepti Nagrath, Richard G. Watt

“…Background: Analgesic use needs to be regulated due to its adverse effects. This study aimed to analyse the change in prescription rates and patterns of the analgesics prescribed for various oral conditions and to analyse their trends across different age groups and gender to promote rational prescription of drugs and eventually influence regulatory policies. …”
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Endogeneity, Heterogeneity and Determinants of Inefficiencies in Crop-Producing Farmers: Evidences from Central Highlands of Ethiopia by Oumer Beriso

“…The low level of efficiency can be addressed by facilitating farmers’ access to more arable-land and modern farming tools and machinery, creating targeted support programs for female farmers, improving technologies that promote soil-fertility and reduce weather adverse effects in central highlands of Ethiopia. …”
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Triterpene esters from Uncaria rhynchophylla hooks as potent HIV-1 protease inhibitors and their molecular docking study by JiSuk Lee

“…Abstract Despite significant advancements with combination anti-retroviral agents, eradicating human immunodeficiency virus (HIV) remains a challenge due to adverse effects, adherence issues, and emerging viral resistance to existing therapies. …”
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Unlocking the potential of microbotox compared with fractional carbon dioxide laser in the treatment of postacne scars: a comparative split-face study by Walid Medhat, Noha Moftah, Ahmed F. Rezk

“…The study did not encounter any major adverse effects, apart from mild discomfort, temporary redness, and a few cases of postinflammatory hyperpigmentation. …”
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Adverse Reactions due to the Usage Ofadverse Effects due to the Usage of T biomodulina and corticotropin in Patients Suffering from Multiple Sclerosis by Rosa F. Lara Rodríguez, Roman Rodríguez, Alicia Vargas Batista, Miriam Bolet Arostavista, Rebeca A. Fernández Carriera, Idalmis Suárez Luis, Alina González-Quevedo Monteagudo, Lorenzo Gómez Morales

“…<strong>Objetives:</strong> To compare the adverse effects of the biomodulina and corticotroprin in the treatment of multiple sclerosis. …”
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Exclusive Cutaneous and Subcutaneous Sarcoidal Granulomatous Inflammation due to Immune Checkpoint Inhibitors: Report of Two Cases with Unusual Manifestations and Review of the Lit... by Narciss Mobini, Rummit Dhillon, Jason Dickey, Jordan Spoon, Kaviyon Sadrolashrafi

“…This enhanced immune response can induce autoimmune adverse effects in many organs. Although skin toxicities are the most common, sarcoidal inflammation with exclusive cutaneous involvement is a rare occurrence with only 6 cases reported to date. …”
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Comparison between paracervical block and intrauterine lidocaine for pain management in surgical termination of first-trimester miscarriage: a randomized clinical trial by Doaa M. Effat, Mona A. Elkafrawy, Amira A.E. Shaban

“…There was an insignificant difference in the frequency of adverse effects of drug like nausea, vomiting, drowsiness, and dizziness among the study groups. …”
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Youth Suicides in the Second Wave of the Pandemic in Turkiye by Leman Akcan Yıldız, Ayla Akca Çağlar, Halise Akça, Funda Kurt, Elif Benderlioğlu, Esra Çöp

“…Conclusions: The findings of our study highlight the evident long-term adverse effects on mental health during the second wave of the pandemic. …”
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Bladeless dust collection system to prevent scattering in cosmetics manufacturing process by Nana TSURUTA, Michihiro HAKODA, Ken’ichi YANO, Yohei NAGAMITSU, Yoshiyuki HIRAYAMA

“…If inhaled by workers, the dust can have adverse effects on health, such as dust lung and asthma, and can also lead to contamination of the work environment and of the product. …”
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Effectiveness of Distant/Remote Blessing Treatment on Cognitive-motor Function: A Randomized Double-blind Placebo-controlled Trial by Alice Branton, Mahendra Kumar Trivedi, Dahryn Trivedi, Sambhu Mondal, Snehasis Jana

“…Moreover, in the blessing intervention group, a substantial improvement was observed in locomotion (*p* \<0.0001), standing balance (*p* \<0.01), dexterity (*p* \<0.01), grip strength (*p* \<0.05), and muscle endurance (*p* \<0.05) compared to the naïve control and sham control groups. Importantly, no adverse effects were reported during the study period.…”
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Misbehavior or misalignment? Examining the drift towards bureaucratic box-ticking in Competency-Based Medical Education. by Alicia C Strand, Andrea Gingerich, Vijay John Daniels

“…Recent implementation studies describe successes but also adverse effects, including residents and preceptors drifting towards bureaucratic / purely administrative behaviors and attitudes, although the drivers behind this tendency are not adequately understood. …”
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Dynamics Analysis of Spatial Parallel Mechanism with Irregular Spherical Joint Clearance by Xiulong Chen, Yuewen Li

“…Therefore, it can be inferred that the irregular clearance has more adverse effects on the mechanism and aggravates the wear between the elements of the kinematic joint; in addition, the stability and the reliability of the mechanism can be reduced.…”
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Frequency and Causes of Methotrexate Intolerance and Discontinuation in Rheumatoid Arthritis Patients in Qena Governorate by Sondos Mohammed Sayed, Mohamed Ismail Abdelkareem, Eman Ragab Abdelradi, Wael Abd El-Mohsen Abady

“…Results: A total number of 90 (45%) patients stopped using MTX within 3months to 26 years duration for various reasons; the most frequent reasons for stopping were gastrointestinal and hepatic adverse effects, representing together 55.5% of causes of discontinuation. …”
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Incentive Mechanism Design for Distributed Autonomous Organizations Based on the Mutual Insurance Scenario by Yiguang Pan, Xiaomei Deng

“…Driven by cooperation efficiency and split supervision based on homogeneous clustering, the comprehensive application of the market elimination mechanism can effectively combat moral hazards, restrain the adverse effects of member flow, expand the living space of small- and medium-sized insurance organizations, curb the emergence of a large-scale monopoly risk pool, and improve market vitality. …”
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Ancient Stone Inscription Image Denoising and Inpainting Methods Based on Deep Neural Networks by Haoming Zhang, Yue Qi, Xiaoting Xue, Yahui Nan

“…However, due to the long history of the ancient stone inscriptions, natural erosion, and poor early protection measures, there are a lot of noise in the existing ancient stone inscriptions, which has adverse effects on reading these stone inscriptions and their aesthetic appreciation. …”
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Urban growth dynamics and its influence on land surface temperature in Bhubaneswar metropolitan city: a 1990–2021 analysis by Monashree Panigrahi, Arabinda Sharma

“…These findings underscore the critical role of sustainable urban planning in mitigating the adverse effects of urban heat islands and guiding future development policies in Bhubaneswar. …”
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Evaluation of Some Properties of Acrylic Resin Denture Base Reinforced with Calcium Carbonate Nano-Particles by Jawad Mikael, Salem Al-Samaraie, Fahd Ikram

“…Conclusion: Addition of 4% CaCO3 nanoparticles to the heat cure acrylic resin increases the radiopacity of the denture base significantly, without adverse effects on the color. …”
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Healthy or skinny? The negotiation between fear appeal and danmu in anorexia awareness videos by Mengsu Shi, Shuang Chen, Kexin Wang

“…Conclusions These results imply that anorexia awareness videos should strive to evoke appropriate levels of fear while also addressing the potential adverse effects of pro-anorexia danmu, which may glorify anorexic bodies and undermine the intended protective outcomes.…”
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