Aflatoxin B1 impairs the growth and development of chicken PGCs through oxidative stress and mitochondrial dysfunction by Ying-Jie Niu, Jun Wu, Wenjie Ren, Guangzheng Liu, Gaoyuan Wu, Yixiu Peng, Dan Zheng, Kai Jin, Qisheng Zuo, Guohui Li, Wei Han, Xiang-Shun Cui, Guohong Chen, Bichun Li

“…This study illuminates AFB1's toxic effects on chicken PGCs and provides insights into potential mechanisms, establishing a basis for strategies to prevent and treat AFB1's adverse effects on poultry genetic transmission.…”
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Orphan G protein-coupled receptor GPRC5B controls macrophage function by facilitating prostaglandin E receptor 2 signaling by Jeonghyeon Kwon, Haruya Kawase, Kenny Mattonet, Stefan Guenther, Lisa Hahnefeld, Jamal Shamsara, Jan Heering, Michael Kurz, Sina Kirchhofer, Cornelius Krasel, Michaela Ulrich, Margherita Persechino, Sripriya Murthy, Cesare Orlandi, Christian D. Sadik, Gerd Geisslinger, Moritz Bünemann, Peter Kolb, Stefan Offermanns, Nina Wettschureck

“…In other models such as myocardial infarction, increased myeloid cell recruitment has adverse effects. Mechanistically, we found that GPRC5B physically interacts with GPCRs of the prostanoid receptor family, resulting in enhanced signaling through the prostaglandin E receptor 2 (EP2). …”
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Research progress of acupoint application therapy based on midnight-noon ebb-flow in the treatment of constipation after lumbar surgery (子午流注择时穴位贴敷改善腰椎术后便秘的研究进展)... by WANG Qiujie (王秋洁), WANG Yuanyuan (王媛媛), QING Jingwen (秦婧文), ZHANG Jianmeng (张建萌), GENG Qingwen (耿庆文)

“…However, there are limitations such as drug dependence and adverse effects. The acupoint application therapy based on midnight-noon ebb-flow shows advantages in the treatment of constipation. …”
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p-Norm Broad Learning for Negative Emotion Classification in Social Networks by Guanghao Chen, Sancheng Peng, Rong Zeng, Zhongwang Hu, Lihong Cao, Yongmei Zhou, Zhouhao Ouyang, Xiangyu Nie

“…Moreover, it can suppress the adverse effects of more outliers and noise in data by flexibly changing the value of p. …”
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Synergistic effect of inhibiting CHK2 and DNA replication on cancer cell growth by Flavie Coquel, Sing-Zong Ho, Keng-Chang Tsai, Chun-Yen Yang, Antoine Aze, Julie Devin, Ting-Hsiang Chang, Marie Kong-Hap, Audrey Bioteau, Jerome Moreaux, Domenico Maiorano, Philippe Pourquier, Wen-Chin Yang, Yea-Lih Lin, Philippe Pasero

“…Thus far, treatments that combine these two strategies have shown promise but also have severe adverse effects. To identify novel, better-tolerated anticancer combinations, we screened a collection of plant extracts and found two natural compounds from the plant, Psoralea corylifolia, that synergistically inhibit cancer cell proliferation. …”
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Assessment of Heavy Metals in Water, Sediment, and Fishes of a Large Tropical Hydroelectric Dam in Sarawak, Malaysia by Siong Fong Sim, Teck Yee Ling, Lee Nyanti, Norliza Gerunsin, Yiew Ee Wong, Liang Ping Kho

“…The health risk assessment suggested that Barbonymus schwanenfeldii, Puntioplites waandersii, Cyclocheilichthys apogon, and Hemibagrus planiceps were characterised by hazard index > 1 implying possible adverse effects. The amount of fish recommended for adults and children was in the range of 500–775 g/week and 33–135 g/week, respectively.…”
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Molecular and cellular mechanisms underlying peripheral nerve injury-induced cellular ecological shifts: Implications for neuroregeneration by Limao Wu, Jinglan He, Na Shen, Song Chen

“…Despite the advent of sophisticated microsurgical techniques, the repair of peripheral nerve injuries frequently proves inadequate, resulting in adverse effects on patients' quality of life. Accordingly, the continued pursuit of more efficacious treatments is of paramount importance. …”
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Sacrificing Alginate in Decellularized Extracellular Matrix Scaffolds for Implantable Artificial Livers by Chanh-Trung Nguyen, Van Phu Le, Thi Huong Le, Jeong Sook Kim, Sung Hoon Back, Kyo-in Koo

“…Furthermore, three-week implantation studies in rats showed a stable integration to the host with no adverse effects. This approach offers significant potential for advancing functional liver tissue replacements, combining accelerated diffusion, enhanced albumin secretion, improved urea synthesis, dense vascular network formation, and stable implantation outcomes.…”
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Gamma Knife Radiosurgery Treatment for Metastatic Melanoma of the Trigeminal Nerve and Brainstem: A Case Report and a Review of the Literature by Halloran E. Peterson, Erik W. Larson, Robert K. Fairbanks, Wayne T. Lamoreaux, Alexander R. Mackay, Jason A. Call, John J. Demakas, Barton S. Cooke, Christopher M. Lee

“…GKRS has proven in this case to be effective in limiting the growth of this metastatic melanoma without acute adverse effects.…”
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The corpus callosum in people with congenital adrenal hyperplasia (CAH) by Eileen Luders, Debra Spencer, Caitlin Dale, Ieuan A. Hughes, Ajay Thankamony, Umasuthan Srirangalingam, Helena Gleeson, Helen Simpson, Melissa Hines, Florian Kurth

“…Our findings corroborate previous studies highlighting white matter alterations in CAH and may suggest that callosal integrity is compromised due to potentially adverse effects of glucocorticoids, a standard treatment for both men and women with CAH.…”
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Dipropyl phthalate induces craniofacial chondrogenic defects in zebrafish embryos by Qinyuan Shen, Weitao Hu, Fasheng Liu, Si Dong, Xinya Peng, Yihang Zhong, Chao Chen, Yuhua Zuo, Chenkai Ge, Weirong Li, Wenwen Zha, Zhijun Ye, Zigang Cao, Lan Liao

“…The present study demonstrates that DPRP induces developmental toxicity of zebrafish craniofacial cartilage, which may have adverse effects on other aquatic organisms and humans.…”
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A perspective on intermittent fasting and cardiovascular risk in the era of obesity pharmacotherapy by Aristides G. Eliopoulos, Aristides G. Eliopoulos, Aristides G. Eliopoulos, Kalliopi K. Gkouskou, Kalliopi K. Gkouskou, Konstantinos Tsioufis, Despina Sanoudou, Despina Sanoudou, Despina Sanoudou

“…In this perspective, we discuss evidence that may support potential adverse effects of intermittent fasting on cardiovascular health through the loss of lean mass, circadian misalignment and poor dietary choices associated with reward-based eating. …”
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Research progress on solid slow-release carbon source for enhancing wastewater nitrogen removal by XU Huchun, YANG Hui, YU Ting, ZHANG Junbo, CHEN Zhongtai, WANG Siya, SUN Yuxin, XU Guangjing

“…If this issue is not addressed properly, it can lead to total nitrogen in the effluent exceeding of legal emission limits, which would have adverse effects on the environment. To tackle this challenge, researchers have explored and utilized novel solid slow-release carbon sources as a potential alternative to traditional soluble carbon sources. …”
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Thermally Affected Zone (TAZ) Assessment in Open-Loop Low-Enthalpy Groundwater Heat Pump Systems (GWHPs): Potential of Analytical Solutions by Martina Gizzi, Glenda Taddia, Elena Cerino Abdin, Stefano Lo Russo

“…Thermal perturbation produced in the subsurface by open-loop groundwater heat pump systems (GWHPs) must be predicted and constantly controlled, especially in the shallow aquifers of more densely urbanized areas, in order to guarantee plants’ long-term sustainable use and to avoid adverse effects on adjacent geothermal systems. Transient conditions in the flow dynamic can be successfully modelled by means of numerical modelling tools. …”
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How endocrine disruptors affect fish reproduction on multiple levels: A review by Socha Magdalena, Chyb Jarosław, Suder Aleksandra, Bojarski Bartosz

“…In this review, we provide an overview of the adverse effects of these pollutants on both female and male fish reproduction (i.e., hormonal disruption in the HPG axis, gametogenesis disorders, disturbed embryogenesis, etc.). …”
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Mesenchymal Stem Cells in Renal Fibrosis: The Flame of Cytotherapy by Quan Zhuang, Ruoyu Ma, Yanshuang Yin, Tianhao Lan, Meng Yu, Yingzi Ming

“…Because of their many advantages like ubiquitous sources, convenient procurement and collection, low immunogenicity, and low adverse effects, with their special identification markers, mesenchymal stem MSC-based therapy is getting more and more attention. …”
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Phospholipogenic Pharmaceuticals Are Associated with a Higher Incidence of Histological Findings than Nonphospholipogenic Pharmaceuticals in Preclinical Toxicology Studies by Linda R. Barone, Scott Boyer, James R. Damewood, James Fikes, Paul J. Ciaccio

“…While phospholipidosis is thought to be an adaptive response to chemical challenge, many phospholipogenic compounds are known to display adverse effects in preclinical species and humans. To investigate the link between phospholipogenic administration and incidence of preclinical histological signals, an internal AstraZeneca in vivo toxicology report database was searched to identify phospholipogenic and nonphospholipogenic compounds. …”
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Zolpidem: Efficacy and Side Effects for Insomnia by Amber N. Edinoff, Natalie Wu, Yahya T. Ghaffar, Rosemary Prejean, Rachel Gremillion, Mark Cogburn, Azem A. Chami, Adam M. Kaye, Alan D. Kaye

“…However, zolpidem has a wide variety of adverse effects and has some special considerations noted in the literature…”
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Reproductive effects of the tumor necrosis factor (TNF) deficiency in mice by S. O. Maslennikova, G. V. Kontsevaya, M. A. Zolotykh, M. V. Anisimova, N. A. Feofanova, M. P. Moshkin, S. A. Nedospasov, L. A. Gerlinskaya

“…TNF is a multifunctional cytokine that, at physiological concentrations, maintains the balance between apoptosis and survival of male germ cells and, at higher concentrations, has adverse effects on various stages of the reproductive process. …”
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Intranasally administrated fusion-inhibitory lipopeptides block SARS-CoV-2 infection in mice and enable long-term protective immunity by Said Mougari, Valérie Favède, Camilla Predella, Olivier Reynard, Stephanie Durand, Magalie Mazelier, Edoardo Pizzioli, Didier Decimo, Francesca T. Bovier, Lauren M. Lapsley, Candace Castagna, Nicole A. P. Lieberman, Guillaume Noel, Cyrille Mathieu, Bernard Malissen, Thomas Briese, Alexander L. Greninger, Christopher A. Alabi, N. Valerio Dorrello, Stéphane Marot, Anne-Geneviève Marcelin, Ana Zarubica, Anne Moscona, Matteo Porotto, Branka Horvat

“…Prolonged administration of high-dose lipopeptides has neither adverse effects nor impairs peptide efficacy in subsequent SARS-CoV-2 challenges. …”
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