Modes-of-Action Related to Repeated Dose Toxicity: Tissue-Specific Biological Roles of PPARγ Ligand-Dependent Dysregulation in Nonalcoholic Fatty Liver Disease by Merilin Al Sharif, Petko Alov, Vessela Vitcheva, Ilza Pajeva, Ivanka Tsakovska

“…Growing evidence stresses on the PPARγ ligand-dependent dysregulation as a key molecular initiating event (MIE) for this adverse effect. The aim of this work was to analyze and systematize the numerous scientific data about the steatogenic role of PPARγ. …”
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Factors Influencing the Pore Structure and Gas-Bearing Characteristics of Shales: Insights from the Longmaxi Formation, Southern Sichuan Basin and Northern Yunnan-Guizhou Depressio... by Li Dong, Changcheng Han, M. Santosh, Yongkai Qiu, Geng Liu, Jinghui Ma, Hao He, Chenlin Hu

“…The porosity and the SSA are positively correlated with the total organic carbon (TOC), whereas clay minerals have an adverse effect on the SSA of pores in the study area. …”
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Severe Lipoatrophy in a Growth Hormone Deficient Toddler Girl Treated with a Non-Pegylated Long-Acting Growth Hormone by Atilla Büyükgebiz, And Demir

“…Following the onset of this adverse effect, her treatment was adjusted to daily rhGH, with strict instructions to rotate injection sites. …”
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GABARAPL1 is essential for ACR-induced autophagic cell death of mouse Leydig cells by Jiahui Meng, Linlin Xu, Bingchun Ma, Chaoju Hao, Yanning Guo, Jinglei Wang, Jiaxiang Chen

“…Acrylamide (ACR), a chemical extensively utilized in industry and food processing sectors, has been recognized for its potentially irreversible adverse effect on male reproductive system; however, the underlying mechanism remains elusive. …”
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Clozapine-Induced Late Agranulocytosis and Severe Neutropenia Complicated with Streptococcus pneumonia, Venous Thromboembolism, and Allergic Vasculitis in Treatment-Resistant Femal... by Christina Voulgari, Raphael Giannas, Georgios Paterakis, Anna Kanellou, Nikolaos Anagnostopoulos, Stamata Pagoni

“…Finally, clozapine-induced allergic vasculitis is confirmed as a late adverse effect of clozapine therapy.…”
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An Effective Robust Total Least-Squares Solution Based on “Total Residuals” for Seafloor Geodetic Control Point Positioning by Zhipeng Lv, Guorui Xiao

“…A robust alternative needs to be introduced to suppress the adverse effect of outliers. The conventional Robust TLS (RTLS) strategy is to adopt the selection weight iteration method based on each single prediction residual. …”
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Impact of Strontium and Krypton Release from Ghana’s MNSR following a Conjectural Accident Scenario by S. A. Birikorang, R. G. Abrefah, H. K. Obeng, K. Gyamfi

“…The estimated dose values recorded were found to be within the recommended regulatory safety limits of 50 mSv for onsite workers and 1 mSv for the general public. No adverse effect was experienced with respect to human health and the environment.…”
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Safety evaluation of the food enzyme α‐amylase from the non‐genetically modified Aspergillus sp. strain FUA by EFSA Panel on Food Enzymes (FEZ), Holger Zorn, José Manuel Barat Baviera, Claudia Bolognesi, Francesco Catania, Gabriele Gadermaier, Ralf Greiner, Baltasar Mayo, Alicja Mortensen, Yrjö Henrik Roos, Marize L. M. Solano, Monika Sramkova, Henk Van Loveren, Laurence Vernis, Cristina Fernàndez‐Fraguas, Magdalena Andryszkiewicz, Natalia Kovalkovicova, Eleonora Marini, Yi Liu

“…The Panel identified a no observed adverse effect level of 2000 mg TOS/kg bw per day, the highest dose tested, which when compared with the estimated dietary exposure, results in a margin of exposure of at least 2911. …”
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Impact of silver ions and silver nanoparticles on the plant growth and soil microorganisms by D. Tomacheski, M. Pittol, D.N. Simões, V.F. Ribeiro, R.M.C. Santana

“…To some degree, Ag+_bentonite impacted plants development and AgNp_silica causes an adverse effect on microbial abundance. The impact on plants and microorganisms was contradictory and varied according to soil and particles physicochemical characteristics.…”
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Study on the Multi-Hazard Responses of Transmission Tower-Line Systems Under Fire and Wind Loads Using ABAQUS by Xiwei He, Huichao Ma, Shibo Zhang, Wenming Wang, Lijuan Zhang

“…In addition, the uneven horizontal spacing distribution and changes in the elevation of the target tower have an adverse effect on the stability of the transmission tower-line system. …”
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An Assessment of Usual Salt Intake among Older Normotensive Adults in Atonsu, a Suburb of Kumasi in the Ashanti Region of Ghana by Rufai Safianu, Jacob Plange-Rhule

“…Experimental and epidemiological studies as well as studies involving clinical trials show the existence of adverse effect of salt consumption on the blood pressure of adults. …”
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Suprainguinal fascia iliaca compartment block in pediatric-aged patients: An educational focused review by Anuranjan Ghimire, Sidhant Kalsotra, Joseph D. Tobias, Giorgio Veneziano

“…Regional anesthesia has become an integral component of postoperative analgesia and multimodal analgesia during surgery, providing opioid sparing effects and maintaining a beneficial adverse effect profile. Although neuraxial techniques were initially the primary techniques used for intraoperative and postoperative anesthesia and analgesia, many of these techniques have been replaced by selective nerve blockade. …”
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Institutional Incidence of Severe tPA-Induced Angioedema in Ischemic Cerebral Vascular Accidents by Matthew Sczepanski, Paul Bozyk

“…Tissue plasminogen activator (tPA) is commonly used in ischemic cerebral vascular accidents (CVAs). tPA is generally well tolerated; however, orolingual angioedema is a well-documented adverse effect. Angioedema is generally mild, transient, and unilateral but can manifest as severe, life-threatening upper airway obstruction requiring intubation. …”
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Non-Destructive Evaluation of Thermal Treatment Influence on Elastic Engineering Parameters of Poplar by Tuğba Yılmaz Aydın, Murat Aydın

“…The common point of the treatment on moduli was that intense application caused the highest adverse effect, particularly for ET and GRT. Contrary to moduli, apart from νRT and νTR, the lowest values for Poisson’s ratios were not obtained at the intense application. …”
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Prospective Randomized Controlled Study of Hemostatic Efficacy with Kaolin-Impregnated Dressings in Diabetic Foot Ulcers Taking Anticoagulants Undergoing Debridement in an Outpatie... by Yeok Gu Hwang, Jin Woo Lee, Eun Ae Won, Seung Hwan Han

“…With kaolin-impregnated gauze, 100% of patients show complete hemostasis at 10 minutes versus 58.3% in the standard gauze (P<.001). An adverse effect was not noted in all patients. Conclusions. …”
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Clinical features, treatment, and prognosis of secukinumab-induced inflammatory bowel disease by Ronghui Li, Haibo Lei, Chunjiang Wang, Xiang Liu

“…Abstract Background Inflammatory bowel disease (IBD) is a rare adverse effect linked to secukinumab, with limited clinical data available. …”
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Treatment of Multiple Sclerosis with Cladribine Tablets: Literature Review and the Guidance of the Lithuanian Association of Neurologists by R. Kizlaitienė, D. Mickevičienė, L. Malcienė, N. Giedraitienė, R. Balnytė, D. Jatužis

“…Cladribine tablets are denoted by good safety characteristics, with the most prominent adverse effect being lymphopenia, which does not lead to an increased risk of infections other than Herpes zoster. …”
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Effects of dietary supplementation of combined safflower meal and sunflower meal on fattening performance and carcass quality characteristics in quails by Tuba Bulbul, Elmas Ulutas, Vural Ozdemir, Aziz Bulbul, Mustafa Evcimen

“…<p> <b>Conclusions:</b> It may be stated that the supplementation of safflower-sunflower meal (C:S, 1:1) in combination to diets has no any adverse effect on the some performance and carcass quality characteristics, and as well as the supplementation of up to 30% of these might be more effective on feed conversion ratio in quails.…”
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A Randomized Comparative Trial on the Therapeutic Efficacy of Topical Aloe vera and Calendula officinalis on Diaper Dermatitis in Children by Yunes Panahi, Mohamad Reza Sharif, Alireza Sharif, Fatemeh Beiraghdar, Zahra Zahiri, Golnoush Amirchoopani, Eisa Tahmasbpour Marzony, Amirhossein Sahebkar

“…The severity of dermatitis was graded at baseline as well as at the end of trial using a 5-point scale. The adverse effects of study medications were assessed during the trial. …”
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Therapeutic modalities for iatrogenic late paresthesia in oral tissues innervated by mandibular branch of trigeminal nerve: a systematic review by Elham Keykha, Elahe Tahmasebi, Mahdi Hadilou

“…Main text As a common side effect of dental procedures, paresthesia can exert a profound adverse effect on patients’ quality of life. The inferior alveolar nerve (IAN) and lingual nerve (LN) have the highest chance of injury during several dental procedures, including mandibular orthognathic surgeries, implant placement, extraction of the third molar, anesthetic injections, flap elevation, and endodontic treatments. …”
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