Differential Proteomic Analysis Predicts Appropriate Applications for the Secretome of Adipose-Derived Mesenchymal Stem/Stromal Cells and Dermal Fibroblasts by Stefania Niada, Chiara Giannasi, Alice Gualerzi, Giuseppe Banfi, Anna Teresa Brini

“…The adult stem cell secretome is currently under investigation as an alternative to cell-based therapy in regenerative medicine, thanks to the remarkable translational opportunity and the advantages in terms of handling and safety. …”
Get full text

Organoid models: applications and research advances in colorectal cancer by Yijie Wu, Yijie Wu, Yu Sha, Xingpo Guo, Ling Gao, Jian Huang, Song-Bai Liu, Song-Bai Liu

“…This article further analyzes the applications of adult stem cell-derived and pluripotent stem cell-derived organoids in colorectal cancer research and discusses advancements in organoids for basic research, drug research and development, personalized treatment evaluation and prediction, and regenerative medicine. …”
Get full text

The potential of stem cell therapy in Multiple Sclerosis treatment: a review by Sorina Amarculesei, Ava O'Meara Cushen, Cathy Brougham

“…Current knowledge shows that there is potential for adipose derived stem cells to replace other adult stem cell-based therapies, as they are much more readily available and involve less invasive isolation procedures. …”
Get full text

Dysbiosis and extraintestinal cancers by Ruishan He, Pingqian Qi, Linzhen Shu, Yidan Ding, Peng Zeng, Guosheng Wen, Ying Xiong, Huan Deng

“…The oncogenic cascade always engages in the disruption of hormonal regulation and inflammatory responses, the induction of genomic instability and mutations, and the dysregulation of adult stem cell proliferation. This review aims to comprehensively summarize the existing evidence that points to the potential role of dysbiosis in the malignant transformation of extraintestinal organs such as the liver, breast, lung, and pancreas. …”
Get full text

Restoration of a Critical Mandibular Bone Defect Using Human Alveolar Bone-Derived Stem Cells and Porous Nano-HA/Collagen/PLA Scaffold by Xing Wang, Helin Xing, Guilan Zhang, Xia Wu, Xuan Zou, Lin Feng, Dongsheng Wang, Meng Li, Jing Zhao, Jianwei Du, Yan Lv, Lingling E, Hongchen Liu

“…Periodontal bone defects occur in a wide variety of clinical situations. Adult stem cell- and biomaterial-based bone tissue regeneration are a promising alternative to natural bone grafts. …”
Get full text

A tunable human intestinal organoid system achieves controlled balance between self-renewal and differentiation by Li Yang, Xulei Wang, Xingyu Zhou, Hongyu Chen, Sentao Song, Liling Deng, Yao Yao, Xiaolei Yin

“…Abstract A balance between stem cell self-renewal and differentiation is required to maintain concurrent proliferation and cellular diversification in organoids; however, this has proven difficult in homogeneous cultures devoid of in vivo spatial niche gradients for adult stem cell-derived organoids. In this study, we leverage a combination of small molecule pathway modulators to enhance the stemness of organoid stem cells, thereby amplifying their differentiation potential and subsequently increasing cellular diversity within human intestinal organoids without the need for artificial spatial or temporal signaling gradients. …”
Get full text

Comparing Circadian Dynamics in Primary Derived Stem Cells from Different Sources of Human Adult Tissue by Eve H. Rogers, Sandra A. Fawcett, Vanja Pekovic-Vaughan, John A. Hunt

“…Optimising cell/tissue constructs so that they can be successfully accepted and integrated within a host body is essential in modern tissue engineering. To do this, adult stem cells are frequently utilised, but there are many aspects of their environment in vivo that are not completely understood. …”
Get full text

Epigenetic Regulation of Mesenchymal Stem Cells: A Focus on Osteogenic and Adipogenic Differentiation by Chad M. Teven, Xing Liu, Ning Hu, Ni Tang, Stephanie H. Kim, Enyi Huang, Ke Yang, Mi Li, Jian-Li Gao, Hong Liu, Ryan B. Natale, Gaurav Luther, Qing Luo, Linyuan Wang, Richard Rames, Yang Bi, Jinyong Luo, Hue H. Luu, Rex C. Haydon, Russell R. Reid, Tong-Chuan He

“…Stem cells are characterized by their capability to self-renew and terminally differentiate into multiple cell types. Somatic or adult stem cells have a finite self-renewal capacity and are lineage-restricted. …”
Get full text

Mesenchymal Stem Cells as a Potent Cell Source for Bone Regeneration by Elham Zomorodian, Mohamadreza Baghaban Eslaminejad

“…A few cell types, including embryonic stem cells (ESCs), adult osteoblast, and adult stem cells, can be used for this purpose. Mesenchymal stem cells (MSCs), as adult stem cells, possess characteristics that make them good candidate for bone repair. …”
Get full text

Emerging Stem Cell Therapies: Treatment, Safety, and Biology by Joel Sng, Thomas Lufkin

“…The discovery of adult stem cells has led to an ongoing revolution of therapeutic and regenerative medicine and the proposal of novel therapies for previously terminal conditions. …”
Get full text

SHP2-Mediated Signal Networks in Stem Cell Homeostasis and Dysfunction by Chen Kan, Fan Yang, Siying Wang

“…Stem cells, including embryonic stem cells (ESCs) and adult stem cells, play a central role in mammal organism development and homeostasis. …”
Get full text

Mesenchymal Stem Cells: An Excellent Candidate for the Treatment of Diabetes Mellitus by Qiulan Huang, Yanting Huang, Jianping Liu

“…Mesenchymal stem cells (MSCs) are adult stem cells (ASCs) known for repairing damaged cells, exerting anti-inflammatory responses and producing immunoregulatory effects that can be significantly induced into insulin-producing cells (IPCs), providing an inexhaustible supply of functional β cells for cell replacement therapy and disease modeling for diabetes. …”
Get full text

Exploring the Most Promising Stem Cell Therapy in Liver Failure: A Systematic Review by Jeanne AdiwinataPawitan

“…Among the various adult stem cells that were used in human studies, MSCs from the bone marrow or umbilical cord performed better compared to other types of adult stem cells, though no study showed a complete and sustainable performance in the outcome measures. …”
Get full text

Establishment of a Mesenchymal Stem Cell Bank by Khushnuma Cooper, Chandra Viswanathan

“…Adult stem cells have generated great amount of interest amongst the scientific community for their potential therapeutic applications for unmet medical needs. …”
Get full text

Epigenetic Reprogramming of Muscle Progenitors: Inspiration for Clinical Therapies by Silvia Consalvi, Martina Sandoná, Valentina Saccone

“…Therapeutic interventions that promote tissue and organ regeneration have as primary objective the selective control of gene expression in adult stem cells. This requires a deep understanding of the epigenetic mechanisms controlling transcriptional programs in tissue progenitors. …”
Get full text

Stem cells (neoblasts) and positional information jointly dominate regeneration in planarians by Xuhui Chen

“…The unparalleled regenerative capacity and incredible tissue plasticity of planarians, both resulting from the presence of abundant adult stem cells referred to as neoblasts, offer a unique opportunity to investigate the cellular and molecular principles underlying regeneration. …”
Get full text

Generation of Induced Pluripotent Stem (iPS) Cells by Nuclear Reprogramming by Dilip Dey, Gregory R. D. Evans

“…The pluripotent cells can be derived from various differentiated adult cells as well as from adult stem cells by nuclear reprogramming, somatic cell nuclear transfer etc. …”
Get full text

Mesenchymal Stem Cells Isolated from Adipose and Other Tissues: Basic Biological Properties and Clinical Applications by Hakan Orbay, Morikuni Tobita, Hiroshi Mizuno

“…Mesenchymal stem cells (MSCs) are adult stem cells that were initially isolated from bone marrow. …”
Get full text

The Clinical Trials of Mesenchymal Stromal Cells Therapy by Mohammad Reza Kouchakian, Neda Baghban, Seyedeh Farzaneh Moniri, Mandana Baghban, Shabnam Bakhshalizadeh, Vahid Najafzadeh, Zahra Safaei, Safoura Izanlou, Arezoo Khoradmehr, Iraj Nabipour, Reza Shirazi, Amin Tamadon

“…Mesenchymal stromal cells (MSCs) are a heterogeneous population of adult stem cells, which are multipotent and possess the ability to differentiate/transdifferentiate into mesodermal and nonmesodermal cell lineages. …”
Get full text

The Cannabinoid Receptor Type 1 Is Essential for Mesenchymal Stem Cell Survival and Differentiation: Implications for Bone Health by Aoife Gowran, Katey McKayed, Veronica A. Campbell

“…Mesenchymal stem cells (MSCs) are adult stem cells which may represent an ideal cell type for use in cell-based tissue engineered bone regeneration strategies. …”
Get full text