Association of walking cadence to changes in knee pain and physical function: The multicenter osteoarthritis study by Khara A. James, Tuhina Neogi, David T. Felson, Patrick Corrigan, Cara L. Lewis, Irene S. Davis, Kathryn L. Bacon, James C. Torner, Cora E. Lewis, Michael C. Nevitt, Joshua J. Stefanik

“…Objective: Determine the association of walking cadence to incident and worsening knee pain and physical function over 2 years in adults with or at risk for knee OA. Design: Participants from the Multicenter Osteoarthritis study were included.Cadence was measured using a GAITRite walkway. …”
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Quantitative evaluation of essential amino acids and omega-3 long-chain polyunsaturated fatty acids from global marine bivalve aquaculture by Karsoon Tan, Peng Xu, Leiheng Huang, Cong Luo, KhaiHang Choong, Zexin Li, Yu Guo, Kit-Leong Cheong

“…Current production levels of EPA + DHA and EAAs from bivalve aquaculture are sufficient to meet the dietary needs of 78.68 million and 17.3 million healthy adults, respectively. Among different bivalve species, clams and scallops are the most efficient producers of EPA + DHA and EAAs, while oysters produce the least. …”
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Standardization in the management of gram-negative bloodstream infections after implementation of a clinical care guideline at a large academic, safety-net institution: a quasi-exp... by Michael A. Deaney, Katherine C. Shihadeh, Alexandra Craig, Margaret M. Cooper, Paul D. Paratore, Timothy C. Jenkins

“…Setting: A large academic safety-net institution. Participants: Adults (≥18 years) with GN-BSI, defined by at least one positive blood culture for specific gram-negative organisms. …”
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The association between TyG index and cardiovascular mortality is modified by antidiabetic or lipid-lowering agent: a prospective cohort study by Changchang Fang, Nanqin Peng, Jiang Cheng, Xiyu Zhang, Wenli Gu, Zicheng Zhu, Xiaoping Yin, Zhiwei Yan, Jing Zhang, Peng Yu, Xiao Liu

“…Results A total of 5,046 adults (representing 42,753,806 individuals, weighted mean age 61.08 years [SE: 0.24]; 49.35% female) were analyzed. …”
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Global magnitude and temporal trends of stroke attributable to lead exposure from 1990 to 2021 by Ying Wang, Ran Liu, Wenxia Li, PengNan Bao, JinWei Zhang, Wei Yue

“…The burden was disproportionately higher in older adults, particularly those over 70 years, with IS and ICH contributing significantly. …”
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The intestinal microbial community and function of Riptortus pedestris at different developmental stages and its effects on development by Yanbin Wang, Rong Li, Chunjing Wang, Ting Sun, Hongjuan Zhang, Fang Zhao, Jiehui Liu, Yuqiong Hao, Xiansheng Xie

“…However, the composition and function of the gut microbiota at different developmental stages remain unclear.MethodsHere, metagenomic sequencing was performed to clarify the gut microbial diversity and function in 2nd-, 3rd-, 4th-, and 5th- instar nymphs (2 N–5 N) and female adults (FAs) of R. pedestris and the effects of vital gut bacteria on development was detected. …”
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Relationship between TyG-related index and hearing loss in people over 45 s in China by Chao Wang, Mengdi Shi, Liangzhen Xie, Chenhao Jiang, Yunxin Li, Jingxiao Li, Shulin Li, Yan Li

“…The results suggest that as the population ages, higher BMI and TyG-BMI indices may increase the risk of hearing impairment.ConclusionWhile the TyG index does not show a significant link to hearing loss, higher BMI and TyG-BMI indices are associated with an increased risk of hearing loss, especially in older adults. These findings highlight the importance of considering aging-related factors in public health initiatives aimed at preventing hearing loss. …”
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The clinical frailty scale is associated with an increased risk of postoperative complications and the development of post-traumatic osteoarthritis in elderly patients with trimall... by Qingsong Zhou, Wei Deng, Ming Zhao, Wei Zhou, Duo Chen, Heng Wang, Shengtao Wang, Hongsheng Yang, Yong Yin

“…Abstract Background The Clinical Frailty Scale (CFS) is a tool to assess the overall health of older adults. There are few reports of CFS and prognosis of ankle fracture. …”
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Effect of empowerment-based interventions on self-efficacy and self-care capacity among patients with sickle cell disease: A randomized controlled trial by Zohour Ibrahim Rashwan, Hasan Abdali Khalil, Leena Mohamed Khonji, Gayathripriya Narayanan, Marwan Kamal Altheeb, Roseben Pradeep, Rajeswari Krishnasamy, Magda Mohamed Bayoumi

“…Objective: This study aimed to investigate the effect of empowerment-based interventions on self-efficacy and self-care capacity among adults with sickle cell disease (SCD). Methods: A randomized control trial was conducted [NCT06296654]. …”
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Investigation of calonysterone and 20-hydroxyecdysone effects in high-fat, high-sugar diet-induced obesity rat model by Alaa AM. Osman, Dávid Laczkó, Máté Vágvölgyi, Adrienn Seres-Bokor, Anita Sztojkov-Ivanov, Kata Kira Kemény, Attila Hunyadi, Eszter Ducza

“…Globally, the incidence of obesity among adults has significantly risen since 1990, with a more than twofold rise in prevalence. …”
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Abdominal fat distribution and its relationship to brain changes: the differential effects of age on cerebellar structure and function: a cross-sectional, exploratory study by Yvonne Böttcher, Michael Stumvoll, Kees Straatman, Matthias Raschpichler, Matthias Leopold Schroeter, Katrin Arelin, Haiko Schlögl, Dominik Fritzsch, Meinhard Mende, André Pampel, Arno Villringer, Karsten Mueller

“…Furthermore, these associations seem to be age dependent, with younger adults’ brains being adversely affected.…”
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Elevated plasma trimethyllysine is associated with incident atrial fibrillation by Mads M Svenningsson, Gard FT Svingen, Per M Ueland, Gerhard Sulo, Espen Ø Bjørnestad, Eva R Pedersen, Indu Dhar, Dennis W. Nilsen, Ottar Nygård

“…Conclusion: TML was associated with, and improved risk classification of, new-onset AF in this large cohort of community dwelling adults. Our results motivate further studies on the association between TML and cardiac arrhythmias.…”
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Racial disparities in acute care utilization among individuals with myasthenia gravis by Cynthia Qi, Pushpa Narayanaswami, Ashley E. L. Anderson, Deborah Gelinas, Yuebing Li, Jeffrey T. Guptill, Dakshinamoorthy Amirthaganesan, Charlotte Ward, Rupesh Panchal, Amit Goyal, Glenn Phillips

“…This study aimed to investigate the independent association between race/ethnicity and acute care utilization during the 2 years post-diagnosis among patients with MG.MethodsA retrospective cohort study was conducted among adults (≥18 years) with newly diagnosed MG in the United States using Optum’s de-identified Market Clarity Data from January 1, 2010, to December 31, 2019. …”
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Acute Severe Anaphylaxis in Nepali Patients with Neurotoxic Snakebite Envenoming Treated with the VINS Polyvalent Antivenom by Sanjib Kumar Sharma, Emilie Alirol, Anup Ghimire, Suman Shrestha, Rupesh Jha, Surya B. Parajuli, Deekshya Shrestha, Surya Jyoti Shrestha, Amir Bista, David Warrell, Ulrich Kuch, Francois Chappuis, Walter Robert John Taylor

“…Of 155 envenomed patients who received ≥ 1 antivenom dose, 13 (8.4%), three children (aged 5−11 years) and 10 adults (18−52 years), developed clinical features consistent with severe ARA, including six with overlapping signs of severe envenoming. …”
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The morphological, clinical, and prognostic factors in the management of giant anterior communicating artery aneurysms: A systematic review of cases by Roua Nasir, Midhat e Zahra Naqvi, Salaar Ahmed, Maarij ul Hassan, Rabeet Tariq, Saad Akhter Khan, Pia Koeskemeier, Rajiv K. Khajuria, Mohammad Hamza Bajwa, Sajjad Muhammad

“…Discussion and conclusion: Immediate suspicion is warranted for visual impairment with headaches in adults or seizures in the elderly. Direct clipping is the first-line treatment for ruptured cases closely followed by surgical bypass and trapping for unruptured cases. …”
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Impact of empiric antibiotics on risk of Clostridioides difficile—a causal inference observational analysis by Matthew A. Pappas, Shoshana J. Herzig, Andrew D. Auerbach, Abhishek Deshpande, Eunice Blanchard, Michael B. Rothberg

“…Methods: Using a multicenter retrospective cohort of adults admitted between March 2, 2020 and February 11, 2021 for the treatment of SARS-CoV-2, we used a series of three-level logistic regression models to estimate the probability of receiving each of several antibiotics of interest. …”
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Developing a core outcome set for interventions in people with mild cognitive impairment: study protocol by Angus G K McNair, Nicholas Turner, Alan Richardson, Elizabeth Coulthard, Jemima Dooley, Julie Clayton, Sam Harding, Sarah Rudd, Victoria Grace Gabb, Winsome Barrett-Muir, Natalie Woodward, Sophie Alderman, Joseph Webb

“…This study aims to develop a COS for adults living with MCI intended for use in interventional and clinical settings.Methods and analysis The COS will be developed using a five-stage study design: (1) systematic literature search, (2) qualitative interviews, (3) evidence synthesis from stages 1 and 2, (4) two-round Delphi survey and (5) consensus meeting(s). …”
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Glia control experience-dependent plasticity in an olfactory critical period by Hans C Leier, Alexander J Foden, Darren A Jindal, Abigail J Wilkov, Paola Van der Linden Costello, Pamela J Vanderzalm, Jaeda Coutinho-Budd, Masashi Tabuchi, Heather T Broihier

“…We recently found that glia shape antennal lobe development in young adults, leading us to ask if glia also drive experience-dependent plasticity during this period. …”
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Gene–Environment Interaction: Small Deletions (DELs) and Transcriptomic Profiles in Non-Melanoma Skin Cancer (NMSC) and Potential Implications for Therapy by Farzana Jasmine, Armando Almazan, Yuliia Khamkevych, Maria Argos, Mohammad Shahriar, Tariqul Islam, Christopher R. Shea, Habibul Ahsan, Muhammad G. Kibriya

“…From a six-year follow-up study on 7000 adults exposed to As, we reported the associations of single-nucleotide variation in tumor tissue and gene expression. …”
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The prevalence of online food delivery service usage and its association with anthropometric measurements in Muscat, Oman; a cross-sectional study by Ahmed Yahya Al Kharusi, Safa Khamis Ambusaidi, Marwa Abdullah Al Raisi, Haitham Mohammed Al Mahrouqi, Asma Ali Al Kendi, Muna Mohammed Almatrushi, Mohammed Juma Al Abdali, Sanjay Jaju, Maisa Hamed Al Kiyumi

“…Methods: This is a cross-sectional study that was conducted in six randomly selected primary healthcare centres in the two most populous areas in Muscat region. Adults aged 18 years or older, who were able to read and write, and who attended the local health centre for any reason, were included. …”
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