Systematic preclinical evaluation of CD33-directed chimeric antigen receptor T cell immunotherapy for acute myeloid leukemia defines optimized construct design by Haiying Qin, Nirali N Shah, Terry J Fry, Lila Yang, John A Chukinas, Samiksha Tarun, Marie Pouzolles, Christopher D Chien, Lisa M Niswander, Anthony R Welch, Sarah K Tasian, Naomi A Taylor

“…Background Successful development of chimeric antigen receptor (CAR) T cell immunotherapy for children and adults with relapsed/refractory acute myeloid leukemia (AML) is highly desired given their poor clinical prognosis and frequent inability to achieve cure with conventional chemotherapy. …”
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The Topographic Relationships and Geographic Distribution of Prevascular Vitreous Fissures and Cisterns Assessed by Ultrawidefield En Face Vitreous Images by Fei Deng, MD, Mengying Tao, MD, Yanjie Zhu, MD, Xiaoyu Xu, MD, Yue Wu, MD, Lisha Li, Ying Lin, MD, PhD, Yan Luo, MD, PhD

“…In 96 eyes of healthy young and middle-aged adults, PVFs were identified in all participants, presenting a continuous course. …”
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Variations in Sources, Composition, and Exposure Risks of PM2.5 in both Pre-Heating and Heating Seasons by Dingyuan Yang, Zhiyong Li, Ziyuan Yue, Jixiang Liu, Zhen Zhai, Zelin Li, Minglei Gao, Ailian Hu, Wenjia Zhu, Ning Ding, Zhenxin Li, Songtao Guo, Xiangxue Wang, Lei Wang, Jihong Wei

“…In contrast, the non-CRs for children and adults decreased in the HS due to a reduction in Ba of 85.5% in the HS. …”
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Ultrasound and histopathological assessment of benign, borderline, and malignant thyroid tumors in pediatric patients: an illustrative review and literature overview by Dominika Januś, Dominika Januś, Monika Kujdowicz, Monika Kujdowicz, Aleksandra Kiszka-Wiłkojć, Aleksandra Kiszka-Wiłkojć, Konrad Kaleta, Anna Taczanowska-Niemczuk, Anna Taczanowska-Niemczuk, Jan Radliński, Kamil Możdżeń, Zuzanna Nowak, Wojciech Górecki, Wojciech Górecki, Jerzy B. Starzyk, Jerzy B. Starzyk

“…BackgroundThe risk of malignancy in thyroid nodules is higher in children than in adults, often necessitating a more aggressive endocrine and surgical approach. …”
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Teneur nutritionnelle des aliments « préférés » et « non-préférés » du Mangabey de Sanje (Cercocebus sanjei). Test du modèle «fallback foods » et choix saisonnier de nourriture... by Guillaume Pagès

“…Après 30 minutes, un nouvel adulte était choisi, en suivant une liste nominative aléatoire préalablement créée. …”
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Etude du suivi du regard chez le babouin (Papio anubis) : Mesure des effets d’un changement d’orientation de la tête d’un expérimentateur sur le comportement des babouins by Carole Parron, Thérèse Bonnefon, Adrien Meguerditchian

“…Des analyses supplémentaires montrent que cet effet concerne très majoritairement les singes juvéniles, les adultes ne se déplaçant que très rarement en réaction au changement d’orientation de la tête de l’expérimentateur. …”
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Primary Synovial Sarcoma of Kidney: A Rare Differential Diagnosis of Renomegaly by Gaurang Modi, Irappa Madabhavi, Harsha Panchal, Asha Anand, Apurva Patel, Sonia Parikh, Swaroop Revannasiddaiah

“…Synovial sarcomas (SS) are classified as subgroup of soft tissue sarcomas affecting mainly extremities of young adults. Primary SS of kidney are very rare tumours with poor prognosis. …”
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Progress in the application of motor imagery therapy in upper limb motor function rehabilitation of stroke patients with hemiplegia by Shuying Shen, Tianchen Chu, Jing Wang, Hangyu Zhao, Jinli Tang, Linya Xu, Wei Ni, Liping Tan, Yu Chen

“…Stroke is the leading cause of disability in Chinese adults. Upper limb motor dysfunction is a common manifestation of neurological dysfunction after stroke and can exert significant effects on a patient’s daily living ability and quality-of-life. …”
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The Roles of FOXO1 in Periodontal Homeostasis and Disease by Liang Ren, Jing Yang, Jun Wang, Xuedong Zhou, Chengcheng Liu

“…The prevalence of periodontal disease increases with age; more than 70% of adults 65 years and older have periodontal disease. …”
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Factors Affecting Placement of a Child with Intellectual Disability by Isack Kandel, Joav Merrick

“…In a pilot study, we attempted to isolate the main factors involved in the parental decision either to keep the child at home or place the child by examining a sample comprised of 50 parents of children suffering severe intellectual disability studying in a special education school and 48 parents of adults with intellectual disability working in sheltered workshops. …”
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A Peripheral Ameloblastic Fibro-Odontoma in a 3-Year-Old Girl: Case Report, Immunohistochemical Analysis, and Literature Review by Yi-Chun Lin, Hsiu-Ming Hsu, Chiang-Shin Liu, Kuo Yuan

“…Ameloblastic fibro-odontoma (AFO) predominantly occurs in the jaw bones of children and young adults. Extraosseous AFO is extremely rare. We describe a peripheral ameloblastic fibro-odontoma in the maxillary gingiva of a 3-year-old girl. …”
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Increased Signal Complexity Improves the Breadth of Generalization in Auditory Perceptual Learning by David J. Brown, Michael J. Proulx

“…Adapting an established auditory interval discrimination paradigm to utilise complex signals, we trained human adults on a standard interval for either 2, 4, or 10 days. …”
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Predictive biomarkers of performance under stress: a two-phase study protocol to develop a wearable monitoring system by Cassandra Pattinson, Graham Kerr, Simon S Smith, Chamindie Punyadeera, Ian Stewart, Kerrie Mengersen, Karen A Sullivan, Jonathan M Flintoff, Sarah Ahamed, Shahnewaz Ali, Angus Bagley, Daniel Broszczak, Blair Crewther, Louis de Waal, Shannon L Edmed, Tharindu Fernando, Clinton Fookes, Francesca D Frentiu, Andrew P Hunt, Ottmar V Lipp, Ben McMaster, Luke Ney, Senn L Oon, Ajay Pandey, Parth Pandit, Jonathan M Peake, Muthukuttige Madusha Nuwanthi Perera, Virginie Perlo, Luke Schmidt, Kirsten Spann, Danielle Young, Tony J Parker

“…This article outlines a protocol for a study to identify biomarkers that predict performance under heat, musculoskeletal, psychosocial and sleep stress, for future integration into a wearable sensor system. In Phase I, healthy adults aged between 18 and 45 years (n=104) will be recruited for an intervention trial that involves exposure to one of the four stressors: heat, musculoskeletal, psychosocial or sleep deprivation. …”
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Formulated Beta-Cyfluthrin Shows Wide Divergence in Toxicity among Bird Species by Laura M. Addy-Orduna, María-Elena Zaccagnini, Sonia B. Canavelli, Pierre Mineau

“…Single doses were administered to adults by gavage. Approximate lethal doses 50 (LD50) and their confidence intervals were determined by approximate D-optimal design. …”
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Exploring the Experience of Nursing Home Residents Participation in a Hope-Focused Group by Sharon L. Moore, Susan E. Hall, Jennifer Jackson

“…A qualitative intervention was used to explore how older adults living in a long-term care environment (nursing home) understand hope and experience being participants in a group in which a hope intervention was carried out. …”
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Comparing the Quality of Life and Hearing Thresholds Following Stapedectomy Versus Laser Stapedotomy with NiTiBOND Piston by Péter Révész, Eszter Kopjár, Zsolt Szakács, Vilmos Warta, Alexandra Csongor, Imre Gerlinger, István Szanyi

“…METHODS: A retrospective cohort study was performed comparing stapedotomy with NiTiBOND prostheses (n=20) and stapedectomy with autogenous cortical bone columella (n=20), applying the Glasgow Benefit Inventory (GBI) and the Hearing Handicap Inventory for Adults outcome measures with hearing thresholds. Univariate comparative statistical methods were applied. …”
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Empowering the undergraduate journey: A decade of research on the impact of life coaching with university students by Levi Huffman, Erin M. Lefdahl-Davis, Alexandra Alayan, Daphne Washington

“…This mixed-methods study reveals significant evidence that providing professional life coaching to undergraduates can be a highly effective method to develop young adults, enhance retention, and increase well-being and life satisfaction.…”
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Distribution and population size estimation of the moor frog Rana arvalis Nilsson, 1842 in Ljubljansko barje Nature Park, central Slovenia by David Stanković, Maja Cipot

“…The overall population size was estimated through egg mass count and is calculated to be more than 19,000 adults. All findings were distributed in two separate clusters. …”
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Cryptogenic stroke in young patients and cannabis use: case presentation and literature review by A. Atkočiūnas, A. Jasionis, G. Lengvenis, R. Badaras, K. Ryliškienė

“… Approximately 10% of ischemic strokes occur in people under the age of 50 – this is called early on set or stroke in young adults. In this patient population, there is an especially high number of cryptogenic strokes, where etiology is not identified or several causes are identified, or their exact meaning is not entirely clear, e. g., patent foramen ovale. …”
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Religious and Spiritual Struggles Brief Inventory: Initial Validation and Psychometric Study by Juan González-Rivera, Yazmín Álvarez-Alatorre

“…Conclusions: These results suggest that the instrument can measure four types of R/E struggles in Puerto Rican adults. Furthermore, this new instrument will allow the advancement of new research on R/E struggles in Puerto Rico and Latin America.…”
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