PPARα Is Required for PPARδ Action in Regulation of Body Weight and Hepatic Steatosis in Mice by Wojciech G. Garbacz, Jeffrey T. J. Huang, Larry G. Higgins, Walter Wahli, Colin N. A. Palmer

“…Our results show that both PPARδ and PPARα receptors are essential for GW501516-driven adipose tissue reduction and subsequently hepatic steatosis, with PPARα working downstream of PPARδ.…”
Get full text

Antihyperglycemic Activity of Eucalyptus tereticornis in Insulin-Resistant Cells and a Nutritional Model of Diabetic Mice by Alis Guillén, Sergio Granados, Kevin Eduardo Rivas, Omar Estrada, Luis Fernando Echeverri, Norman Balcázar

“…Likewise, this extract had anti-inflammatory effects in adipose tissue when compared to control diabetic mice. …”
Get full text

Performance of PRP Associated with Porous Chitosan as a Composite Scaffold for Regenerative Medicine by Andréa Arruda Martins Shimojo, Amanda Gomes Marcelino Perez, Sofia Elisa Moraga Galdames, Isabela Cambraia de Souza Brissac, Maria Helena Andrade Santana

“…This study aimed to evaluate the in vitro performance of activated platelet-rich plasma associated with porous sponges of chitosan as a composite scaffold for proliferation and osteogenic differentiation of human adipose tissue-derived mesenchymal stem cells. The sponges were prepared by controlled freezing (−20, −80, or −196°C) and lyophilization of chitosan solutions (1, 2, or 3% w/v). …”
Get full text

Beyond Fat Mass: Exploring the Role of Adipokines in Rheumatic Diseases by Morena Scotece, Javier Conde, Rodolfo Gómez, Veronica López, Francisca Lago, Juan Jesus Gómez-Reino, Oreste Gualillo

“…The cloning of leptin in 1994 by Zhang et al. introduced a novel concept about white adipose tissue (WAT) as a very dynamic organ that releases a plethora of immune and inflammatory mediators, such as adipokines and cytokines, which are involved in multiple diseases. …”
Get full text

The Role of HMGB1 in the Pathogenesis of Type 2 Diabetes by Yanan Wang, Jixin Zhong, Xiangzhi Zhang, Ziwei Liu, Yuan Yang, Quan Gong, Boxu Ren

“…Importantly, we will summarize and renovate the role of HMGB1 and HMGB1-mediated inflammatory pathways in adipose tissue inflammation, insulin resistance, and islet dysfunction. …”
Get full text

Occurring of In Vitro Functional Vasculogenic Pericytes from Human Circulating Early Endothelial Precursor Cell Culture by Silvia Cantoni, Francesca Bianchi, Margherita Galletti, Elena Olivi, Francesco Alviano, Nazzareno Galiè, Carlo Ventura

“…We provided evidence that hPPCs have an immunophenotype consistent with Mesenchymal Stem Cells (MSCs) from human adipose tissue (hASCs) and fetal membranes of term placenta (FM-hMSCs). …”
Get full text

Gene by Sex Interaction for Measures of Obesity in the Framingham Heart Study by Ashlee M. Benjamin, Sunil Suchindran, Kaela Pearce, Jennifer Rowell, Lillian F. Lien, John R. Guyton, Jeanette J. McCarthy

“…These variants were clustered downstream of LYPLAL1, which encodes a lipase/esterase expressed in adipose tissue, a locus previously identified as having sex-specific effects on central obesity. …”
Get full text

Rs9939609 Variant of the Fat Mass and Obesity-Associated Gene and Trunk Obesity in Adolescents by Harald Mangge, Wilfried Renner, Gunter Almer, Daniel Weghuber, Reinhard Möller, Renate Horejsi

“…To investigate the genetic background of early obesity, we analysed the single nucleotide polymorphism (SNP) rs9939609 of FTO in 371 styrian adolescents towards degree of obesity, subcutaneous adipose tissue (SAT)-distribution determined by lipometry, early metabolic and preatherosclerotic symptoms. …”
Get full text

Renal Sinus Lipomatosis in Transplanted Kidneys: An Unusual Clinical Case by Luca Apicella, Gianfranco Vallone, Sossio Vitale, Gianluca Garofalo, Luigi Russo, Riccardo Gallo, Stefano Federico, Massimo Sabbatini

“…Renal sinus lipomatosis (RSL) represents an abnormal proliferation of the adipose tissue surrounding the renal pelvis of uncertain origin, associated with aging, obesity, steroid excess, infections, and calculosis. …”
Get full text

Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma Developed in a Patient with Progressive Muscular Dystrophy: A Case Report and Review of the Literature by Ryo Miyagi, Toshihiko Nishisho, Shinjiro Takata, Yoshimitsu Shimatani, Shunichi Toki, Koichi Sairyo

“…We hypothesize that degenerative changes occurring in adipose tissue during muscle atrophy can cause lipomatous neoplasms and moreover that the mutation of MD-related genes may lead to the proliferation of tumor cells or to malignancy.…”
Get full text

The effects of the extract of oolong tea and its metabolites from Andraca theae in high fat diet induced obese Wistar rat by Tung Yen-Chen, Hsieh Tsung-Hai, Yang Meei-Ju, Hung Wei-Lun, Ho Chi-Tang, Pan Min-Hsiung

“…TE significantly decreased abdominal adipose tissue, especially epididymal fat via increasing preadipocyte factor 1 (Pref-1), SRY (sex determining region Y)-box 9 (SOX-9) and decreasing peroxisome proliferator-activated receptor γ (PPARγ), CCAAT/enhancer binding protein (C/EBP)β, C/EBPα and C/EBPγ protein expression. …”
Get full text

Adiponectin: A New Regulator of Female Reproductive System by Kamil Dobrzyn, Nina Smolinska, Marta Kiezun, Karol Szeszko, Edyta Rytelewska, Katarzyna Kisielewska, Marlena Gudelska, Tadeusz Kaminski

“…Adiponectin is the hormone that belongs to the group of adipokines, chemical agents mainly derived from the white adipose tissue. The hormone plays pleiotropic roles in the organism, but the most important function of adiponectin is the control of energy metabolism. …”
Get full text

Effect of H2O2 induced oxidative stress on volatile organic compounds in differentiated 3T3-L1 cells by Adebowale Samuel Oyerinde, Vaithinathan Selvaraju, Melissa Boersma, Jeganathan Ramesh Babu, Thangiah Geetha

“…This study demonstrates that elevated OS alters VOC profiles in differentiated 3T3-L1 adipocytes, providing insights into the effects of OS on adipose tissue and identifying potential OS biomarkers.…”
Get full text

Stromal Vascular Fraction and Amniotic Epithelial Cells: Preclinical and Clinical Relevance in Musculoskeletal Regenerative Medicine by Francesca Veronesi, Melania Maglio, Deyanira Contartese, Lucia Martini, Aurelio Muttini, Milena Fini

“…Throughout the years, different cell types have been employed for the treatment of musculoskeletal diseases, in particular, mesenchymal stem cells (MSCs) derived from bone marrow (BMSCs) and adipose tissue (ADSCs). Though the results of these literature studies have been encouraging, there are some limitations, especially on long-term results. …”
Get full text

Metabolic Syndrome, Obesity, and Gastrointestinal Cancer by Shintaro Fujihara, Hirohito Mori, Hideki Kobara, Noriko Nishiyama, Mitsuyoshi Kobayashi, Makoto Oryu, Tsutomu Masaki

“…Obesity, which is accompanied by metabolic dysregulation often manifested in the metabolic syndrome, is an established risk factor for many cancers. Adipose tissue, particularly visceral fat, is an important metabolic tissue as it secretes systemic factors that alter the immunologic, metabolic, and endocrine milieu and also promotes insulin resistance. …”
Get full text

Oxidative Stress Markers in Patients with Metabolic Syndrome by Axana Rodríguez Núñez, Jorge Calá Fernández, Haydee Cruz Vadell, Miguel Ángel Montoya Deler

“…Oxidative stress plays an important role in the pathogenesis of the metabolic syndrome because it affects the function of pancreatic beta cells and alters glucose transport in muscle and adipose tissue.<br /><strong>Objective:</strong> to characterize a population with a metabolic syndrome diagnosis, according to biochemical and anthropometric variables between 2015-2016.…”
Get full text

Culture and Use of Mesenchymal Stromal Cells in Phase I and II Clinical Trials by Bourin Philippe, Sensebé Luc, Planat-Bénard Valérie, Roncalli Jérôme, Bura-Rivière Alessandra, Casteilla Louis

“…The most widely used MSCs are cultured from bone marrow or adipose tissue. For clinical trial implementation, BM MSCs and ADSCs should be produced according to Good Manufacturing Practices. …”
Get full text

Integration of Rabbit Adipose Derived Mesenchymal Stem Cells to Hydroxyapatite Burr Hole Button Device for Bone Interface Regeneration by Viswanathan Gayathri, Varma Harikrishnan, Parayanthala Valappil Mohanan

“…Adipose Derived Mesenchymal Stem Cells, multipotent stem cells isolated from adipose tissue, present close resemblance to the natural in vivo milieu and microenvironment of bone tissue and hence widely used for in bone tissue engineering applications. …”
Get full text

Therapeutic Effect of Stem Cells on Male Infertility in a Rat Model: Histological, Molecular, Biochemical, and Functional Study by Sally S. Mohammed, Mona F. Mansour, Noha A. Salem

“…Transplantation of adipose tissue-derived stem cells (ADMSCs) can improve the testicular damage histologically and functionally in a rat model.…”
Get full text

OSAS-Related Inflammatory Mechanisms of Liver Injury in Nonalcoholic Fatty Liver Disease by Elena Paschetta, Paola Belci, Anna Alisi, Daniela Liccardo, Renato Cutrera, Giovanni Musso, Valerio Nobili

“…In this review, we focus on molecular mechanisms linking OSAS to NAFLD, including hypoxia inducible factor (HIF), nuclear factor kappa B (NF-κB), YKL-40, unfolded protein response, and hypoxic adipose tissue inflammation, which all could provide novel potential therapeutic approaches for the management of NAFLD patients with OSAS.…”
Get full text