Obesity-Induced Methylation of Osteopontin Contributes to Adipogenic Differentiation of Adipose-Derived Mesenchymal Stem Cells by Min Tang, Rui Chen, Hao Wang, Guowei Sun, Fan Yin, Beibei Liang, Yang Yang, Gaowa Sharen, Huafeng Wei, Xuyu Zhou, Gang Huang, Jian Zhao

“…Consistent with these in vitro results, by intravenous injection of OPN-expressing adenovirus to the mice, we found OPN can delay the development of obesity and improve insulin sensitivity. …”
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CTRP9 Mitigates the Progression of Arteriovenous Shunt-Induced Pulmonary Artery Hypertension in Rats by Hua Guan, Xiaofeng Yang, Tao Shi, Yongjian Zhang, Aoqi Xiang, Yongxin Li

“…PAH was established by an arteriovenous shunt placement performed in rats. Adenovirus(Ad)-CTRP9 and Ad-green fluorescent protein viral particles were injected into the rats through the tail vein. …”
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Mouse Reporter Strain for Noninvasive Bioluminescent Imaging of Cells that have Undergone Cre-Mediated Recombination by Michal Safran, William Y. Kim, Andrew L. Kung, James W. Horner, Ron A. DePinho, William G. Kaelin

“…Organ-specific luciferase expression was also seen after intraparenchymal administration of an adenovirus encoding Cre. The ROSA26 L-S-L-Luc /+ strain should be useful for characterizing Cre mouse strains and for following the fate of cells that have undergone Cre-mediated recombination in vivo.…”
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Fhl1, a new spatially specific protein, regulates vein graft neointimal hyperplasia by Chaoqun Wang, Jiantao Chen, Zicong Feng, Bohao Jian, Suiqing Huang, Kangni Feng, Haoliang Liu, Zhuoming Zhou, Ziyin Ye, Jing Lu, Mengya Liang, Zhongkai Wu

“…Immunohistochemical analysis identified neointima‐specific markers, while NIH progression was assessed in SD rats with four and a half LIM domains protein 1 (Fhl1) knockout and in human saphenous veins (HSV) with adenovirus‐mediated Fhl1 overexpression. Results Typical neointimal formation commenced by day 11 postgrafting and peaked at day 19. …”
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膀胱癌细胞CAR 的表达对E1B 缺失腺病毒抗瘤活性的影响 by 袁中玉, 管忠震, 张力, 徐瑞华

“…【目的】观察不同组织类型膀胱癌细胞株表达柯萨奇病毒腺病毒受体( coxsackie and adenovirus receptor, CAR) 与E1B 缺失腺病毒(H101) 体外感染力及体内抗瘤活性的关系。…”
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The Interaction between Bmal1 and Per2 in Mouse BMSC Osteogenic Differentiation by Haiya Zhuo, Yuhong Wang, Qing Zhao

“…We also suppressed Per2 gene expression using an adenovirus vector harboring RNAi sequences, and similarly, the osteogenic differentiation ability of BMSCs was enhanced. …”
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SPDEF ameliorates UUO-induced renal fibrosis by transcriptional activation of NR4A1 by Hongshuang Wang, Ziheng Wei, Chang Xu, Fang Fang, Zheng Wang, Yan Zhong, Xiangting Wang

“…In this study, we used adenovirus to create a mouse kidney model with a specific knockdown of NR4A1 gene. …”
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Hepatic Cholesterol-25-Hydroxylase Overexpression Improves Systemic Insulin Sensitivity in Mice by Britta Noebauer, Alexander Jais, Jelena Todoric, Klaus Gossens, Hedwig Sutterlüty-Fall, Elisa Einwallner

“…Using several different experimental approaches, we demonstrated the significance of Ch25h on the border of “healthy” and “diseased” states of obesity. Adenovirus-mediated Ch25h overexpression in mice improved glucose tolerance and insulin sensitivity and lowered HOMA-IR. …”
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DS2 designer pre-fusion F vaccine induces strong and protective antibody response against RSV infection by Yiling Yang, Ruoke Wang, Fenglin Guo, Tian Zhao, Yuqing Lei, Qianqian Yang, Yige Zeng, Ziqing Yang, Tatchapon Ajavavarakula, Ruijie Tan, Mingxi Li, Haodi Dong, Mengyue Niu, Keyan Bao, Hao Geng, Qining Lv, Qi Zhang, Xuanling Shi, Peng Liu, Jiwan Ge, Xinquan Wang, Linqi Zhang

“…In this study, we generated three recombinant vaccines using the chimpanzee adenovirus vector AdC68 to express DS-Cav1, SC-TM, and DS2. …”
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Acute hemorrhagic conjunctivitis outbreaks associated with Coxsackievirus A-24 in India, 2023 by Nutan A. Chavan, Pooja Shinde, Sanjaykumar Tikute, Rajlakshmi Vishwanathan, Avinash R. Deoshatwar, Yogesh K. Gurav, Rishabh Waghchaure, Nishat H. Ahmed, Vannavada S. Rani, Vikram Khan, Aditya Kelkar, Harsh H. Jain, Amita Jain, Mallika Lavania, Babasaheb V. Tandale

“…The swabs were examined for qRT-PCR analyses, to detect adenovirus and enterovirus. Following this, conserved regions within the enteroviral 5′-UTR and VP2/3 C gene were further investigated for serotype identification. …”
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FOXA3, a Negative Regulator of Nur77 Expression and Activity in Testicular Steroidogenesis by Hansle Kim, Sudeep Kumar, Keesook Lee

“…In mouse primary Leydig cells, adenovirus-mediated overexpression of FOXA3 had similar effects and resulted in decreased production of testosterone. …”
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Uncoupling Protein 2 Increases Susceptibility to Lipopolysaccharide-Induced Acute Lung Injury in Mice by Qin Wang, Jianchun Wang, Mingdong Hu, Yu Yang, Liang Guo, Jing Xu, Chuanjiang Lei, Yan Jiao, JianCheng Xu

“…We up- or downregulated UCP2 expression using UCP2 recombinant adenovirus or the UCP2 inhibitor, genipin, in lungs of mice, and investigated the mechanisms of UCP2 in ALI. …”
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Gene Therapy Approaches by Ahmed Jumaa Ahmed, Hogir Saadi

“…For gene therapeutic approaches which are focused on lifelong expression of the therapeutic gene, retrovirus, adenovirus, adeno-associated viruses are acceptable. …”
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MYSM1 attenuates osteoarthritis by recruiting PP2A to deubiquitinate and dephosphorylate RIPK2 by Kang Wei, Chuankun Zhou, Zixing Shu, Xingru Shang, Yi Zou, Wei Zhou, Huanhuan Xu, Yulin Liang, Tian Ma, Xuying Sun, Jun Xiao

“…Our findings revealed reduced MYSM1 levels in the cartilage of OA patients and mouse models. Genetic or adenovirus-induced MYSM1 knockout exacerbated OA progression in mice, whereas MYSM1 overexpression mitigated it. …”
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Modern vaccines and coronavirus infections by Yu. A. Belikova, Yu. V. Samsonov, E. V. Abakushina

“…In Russia, a vector vaccine based on adenovirus DNA, which has the SARS-CoV-2 virus gene embedded in it, is undergoing clinical trials.…”
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Hand hygiene for prevention and control of viral infections: the role of Amuchina Gel Xgerm [Accepted for publication] by Claudio Cermelli, Elisabetta Blasi, Alessandra Capezzone de Joannon, Maria Ilaria Roselli, Daniele Frollano, Michela Procaccini

“…Results: Sixty second exposures to the product determined a ≥4 log10 reduction of virus titer in all cases. For adenovirus type 5, human coxsakievirus, herpesvirus 1 and influenza virus A H1N1, a ≥4 log10 reduction of virus titer was obtained already after 30 s. …”
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Inhibition of MEK1 Signaling Pathway in the Liver Ameliorates Insulin Resistance by Atsunori Ueyama, Nobuhiro Ban, Masanori Fukazawa, Tohru Hirayama, Minako Takeda, Tatsuo Yata, Hiroyasu Muramatsu, Masaki Hoshino, Marii Yamamoto, Masao Matsuo, Yuka Kawashima, Tatsuhiko Iwase, Takehisa Kitazawa, Youichi Kushima, Yuichiro Yamada, Yoshiki Kawabe

“…A hyperinsulinemic-euglycemic clamp test showed increased glucose infusion rate (GIR) in db/db mice treated with these compounds, and about 60% of the increase was attributed to the inhibition of endogenous glucose production, suggesting that the liver is responsible for the improvement of IR. By means of adenovirus-mediated Mek1 shRNA expression, we confirmed that blood glucose levels are reduced by suppression of MEK1 expression in the liver of db/db mice. …”
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A Systematic Comparison Identifies an ATP-Based Viability Assay as Most Suitable Read-Out for Drug Screening in Glioma Stem-Like Cells by A. Kleijn, J. J. Kloezeman, R. K. Balvers, M. van der Kaaij, C. M. F. Dirven, S. Leenstra, M. L. M. Lamfers

“…General applicability was assessed using distinct treatment modalities, being temozolomide, radiation, rapamycin, and the oncolytic adenovirus Delta24-RGD. The apoptosis and cytotoxicity assays did not unequivocally detect responses and were excluded from further testing. …”
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Plastic Bronchitis in Children: A Review of 55 Cases over a 10-Year Period by Xiaowen Chen, Shangzhi Wu, Zhanhang Huang, Yuneng Lin, Jiaxing Xu, Qingyun Xu, Dehui Chen

“…Respiratory pathogens were detected in 41 cases, and M. pneumoniae was the most common one (41.8%), followed by adenovirus (20.0%) and influenza B virus (10.9%). The casts were removed by alveolar lavage, combined with ambroxol immersion (63.6%) and forceps (30.9%). …”
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Comparison of and as Reporter Genes for Noninvasive Imaging of Bone Mesenchymal Stem Cells Transplanted into Infarcted Rat Myocardium by Shuo Hu, Wei Cao, Xiaoli Lan, Yong He, Juntao Lang, Congjiao Li, Jia Hu, Rei An, Zairong Gao, Yongxue Zhang

“…The purpose of this study was to investigate and compare the feasibility of rat sodium iodide symporter ( rNIS ) and human sodium iodide symporter ( hNIS ) as reporter genes for noninvasive monitoring of rat bone marrow mesenchymal stem cells (rBMSCs) transplanted into infarcted rat myocardium. rBMSCs were isolated from rat bone marrow. Adenovirus (Ad) was reconstructed to contain rNIS-enhanced green fluorescent protein (eGFP) or hNIS-eGFP. …”
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