DNA Methylation May be Involved in the Analgesic Effect of Hyperbaric Oxygen via Regulating FUNDC1 by Kun Liu, Hao Wu, Rui Gao, Guang Han

“…Western blotting was also used to assess expression of FUNDC1, BCL2, and adenovirus E1B19 kDa-interacting protein 3-like (NIX) and BCL2 and adenovirus E1B19 kDa-interacting protein3 (BNIP3). …”
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Widespread Arterial Thrombosis after ChAdOx1 nCov-19 Vaccination by Giorgio Berlot, Ariella Tomasini, Cristina La Fata, Stefania Pintacuda, Sara Rigutti, Anna Falanga

“…Vaccine-induced thrombotic thrombocytopenia is an uncommon complication of COVID-19 vaccines using adenovirus mRNA carriers and has been associated with thrombosis of the cerebral venous sinuses and portal system. …”
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Upregulation of Tumor Necrosis Factor-α-Induced Protein 8-Like 2 mRNA Is Negatively Correlated with Serum Concentrations of Tumor Necrosis Factor-α and Interleukin 6 in Type 2 Diab... by Yongliang Liu, Xinmei Wang, Yan Zhao, Peiqing Zhao, Lianqing Wang, Qiaoli Zhai, Xiaowei Zhang, Wenxiu Tian, Xinxin Xiang, Tao Li

“…Differentiated THP-1 cells were exposed to siTIPE2 and TIPE2 adenovirus. Results. TIPE2 was significantly increased in PBMCs from T2DM patients compared with those from healthy controls and was negatively correlated with serum TNF-α, IL-6, and hsCRP concentrations but positively correlated with HbA1c and LDL-C in T2DM patients. …”
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Oncolytic Immunotherapy: Where Are We Clinically? by Akseli Hemminki

“…While safety and efficacy of many types of oncolytic viruses, including adenovirus, herpes, reo, and vaccinia seem promising, few mechanisms of action studies have been performed with human substrates. …”
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hCTLA4-Gene-Modified Human Bone Marrow-Derived Mesenchymal Stem Cells (hBMMSCs) Maintain POSTN Secretion to Enhance the Migration Capability of Allogeneic hBMMSCs through the Integ... by Lei Song, Fei Zhang, Rui Zhou, Jun Xiao, Lei He, Fei Dai

“…In the present study, we investigated whether CTLA4-modified hBMMSCs are involved in the migration of allogeneic hBMMSCs (allo-hBMMSCs) by maintaining POSTN secretion. hBMMSCs were isolated from different groups, named hBMMSCs and allo-hBMMSCs. hBMMSCs that were infected with the negative control (NC), empty adenovirus- or recombinant adenovirus-expressing CTLA4, POSTN, or CTLA4 plus the shRNA of POSTN were named NC hBMMSCs, CTLA4-modified hBMMSCs, POSTN-modified hBMMSCs, or CTLA4+shPOSTN-modified hBMMSCs, respectively. …”
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Waning neutralizing antibodies through 180 days after homologous and heterologous boosters of inactivated COVID-19 vaccine by Zhifei Chen, Fangqin Xie, Hairong Zhang, Dong Li, Suhan Zhang, Mengping Zhang, Junrong Li, Jianfeng Xie, Lina Zhang, Xiuhui Yang, Dongjuan Zhang

“…This cohort study involved 320 healthy individuals, who were randomly assigned to four groups, to receive boosters with inactivated vaccine (COVac and BIBP), the adenovirus type-5-vectored vaccine (Convidecia), and the recombinant protein-based vaccine (Zifivax), respectively, all the vaccines studied had the Wuhan variant as their parental variant. …”
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Entangled evidence: epistemic injustice, and systemic neglect in the assessment of menstrual disorders following COVID-19 vaccines by Maurizia Mezza

“…In the context of the COVID-19 pandemic, pharmacovigilance activities detected and assessed symptoms, such as rare blood clotting disorders, myocarditis, and erythema multiforme, potentially linked to some adenovirus-based and mRNA-based vaccines. While some presumed side effects were swiftly assessed, others, such as menstrual disorders following mRNA vaccination, were subjected to prolonged debates. …”
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The Effect of Vascular Endothelial Growth Factor on Bone Marrow Mesenchymal Stem Cell Engraftment in Rat Fibrotic Liver upon Transplantation by Ke Yuan, Chunyou Lai, Lingling Wei, Tianhang Feng, Qinyan Yang, Tianying Zhang, Tao Lan, Yutong Yao, Guangming Xiang, Xiaolun Huang

“…Evan’s blue dye assay suggests that after injecting with VEGF adenovirus solution, the rat’s hepatic sinusoidal permeability would be increased. …”
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miR-212 Promotes Cardiomyocyte Hypertrophy through Regulating Transcription Factor 7 Like 2 by Jinxia Yuan, Guoliang Yuan

“…The overexpression of miR-212 adenovirus was constructed, and the expression of miR-212 was overexpressed, and its effect on cardiac hypertrophy (CH) was detected by immunofluorescence and qRT-PCR. …”
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Obesity-Induced Methylation of Osteopontin Contributes to Adipogenic Differentiation of Adipose-Derived Mesenchymal Stem Cells by Min Tang, Rui Chen, Hao Wang, Guowei Sun, Fan Yin, Beibei Liang, Yang Yang, Gaowa Sharen, Huafeng Wei, Xuyu Zhou, Gang Huang, Jian Zhao

“…Consistent with these in vitro results, by intravenous injection of OPN-expressing adenovirus to the mice, we found OPN can delay the development of obesity and improve insulin sensitivity. …”
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CTRP9 Mitigates the Progression of Arteriovenous Shunt-Induced Pulmonary Artery Hypertension in Rats by Hua Guan, Xiaofeng Yang, Tao Shi, Yongjian Zhang, Aoqi Xiang, Yongxin Li

“…PAH was established by an arteriovenous shunt placement performed in rats. Adenovirus(Ad)-CTRP9 and Ad-green fluorescent protein viral particles were injected into the rats through the tail vein. …”
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Mouse Reporter Strain for Noninvasive Bioluminescent Imaging of Cells that have Undergone Cre-Mediated Recombination by Michal Safran, William Y. Kim, Andrew L. Kung, James W. Horner, Ron A. DePinho, William G. Kaelin

“…Organ-specific luciferase expression was also seen after intraparenchymal administration of an adenovirus encoding Cre. The ROSA26 L-S-L-Luc /+ strain should be useful for characterizing Cre mouse strains and for following the fate of cells that have undergone Cre-mediated recombination in vivo.…”
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Fhl1, a new spatially specific protein, regulates vein graft neointimal hyperplasia by Chaoqun Wang, Jiantao Chen, Zicong Feng, Bohao Jian, Suiqing Huang, Kangni Feng, Haoliang Liu, Zhuoming Zhou, Ziyin Ye, Jing Lu, Mengya Liang, Zhongkai Wu

“…Immunohistochemical analysis identified neointima‐specific markers, while NIH progression was assessed in SD rats with four and a half LIM domains protein 1 (Fhl1) knockout and in human saphenous veins (HSV) with adenovirus‐mediated Fhl1 overexpression. Results Typical neointimal formation commenced by day 11 postgrafting and peaked at day 19. …”
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The Interaction between Bmal1 and Per2 in Mouse BMSC Osteogenic Differentiation by Haiya Zhuo, Yuhong Wang, Qing Zhao

“…We also suppressed Per2 gene expression using an adenovirus vector harboring RNAi sequences, and similarly, the osteogenic differentiation ability of BMSCs was enhanced. …”
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SPDEF ameliorates UUO-induced renal fibrosis by transcriptional activation of NR4A1 by Hongshuang Wang, Ziheng Wei, Chang Xu, Fang Fang, Zheng Wang, Yan Zhong, Xiangting Wang

“…In this study, we used adenovirus to create a mouse kidney model with a specific knockdown of NR4A1 gene. …”
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Gene Therapy Approaches by Ahmed Jumaa Ahmed, Hogir Saadi

“…For gene therapeutic approaches which are focused on lifelong expression of the therapeutic gene, retrovirus, adenovirus, adeno-associated viruses are acceptable. …”
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FOXA3, a Negative Regulator of Nur77 Expression and Activity in Testicular Steroidogenesis by Hansle Kim, Sudeep Kumar, Keesook Lee

“…In mouse primary Leydig cells, adenovirus-mediated overexpression of FOXA3 had similar effects and resulted in decreased production of testosterone. …”
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Hepatic Cholesterol-25-Hydroxylase Overexpression Improves Systemic Insulin Sensitivity in Mice by Britta Noebauer, Alexander Jais, Jelena Todoric, Klaus Gossens, Hedwig Sutterlüty-Fall, Elisa Einwallner

“…Using several different experimental approaches, we demonstrated the significance of Ch25h on the border of “healthy” and “diseased” states of obesity. Adenovirus-mediated Ch25h overexpression in mice improved glucose tolerance and insulin sensitivity and lowered HOMA-IR. …”
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Acute hemorrhagic conjunctivitis outbreaks associated with Coxsackievirus A-24 in India, 2023 by Nutan A. Chavan, Pooja Shinde, Sanjaykumar Tikute, Rajlakshmi Vishwanathan, Avinash R. Deoshatwar, Yogesh K. Gurav, Rishabh Waghchaure, Nishat H. Ahmed, Vannavada S. Rani, Vikram Khan, Aditya Kelkar, Harsh H. Jain, Amita Jain, Mallika Lavania, Babasaheb V. Tandale

“…The swabs were examined for qRT-PCR analyses, to detect adenovirus and enterovirus. Following this, conserved regions within the enteroviral 5′-UTR and VP2/3 C gene were further investigated for serotype identification. …”
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Uncoupling Protein 2 Increases Susceptibility to Lipopolysaccharide-Induced Acute Lung Injury in Mice by Qin Wang, Jianchun Wang, Mingdong Hu, Yu Yang, Liang Guo, Jing Xu, Chuanjiang Lei, Yan Jiao, JianCheng Xu

“…We up- or downregulated UCP2 expression using UCP2 recombinant adenovirus or the UCP2 inhibitor, genipin, in lungs of mice, and investigated the mechanisms of UCP2 in ALI. …”
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