A lyophilised formulation of chimpanzee adenovirus vector for long-term stability outside the deep-freeze cold chain by Frédéric Mathot, Edwige Lefebvre, Bernard G. Francq, Delphine Guillaume, Erwan Bourlès

“…Abstract Background The adenovirus-vaccine platform has come to prominence with the COVID-19 vaccination campaigns. …”
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KPC pancreatic cancer cells are a novel immunocompetent murine model supporting human adenovirus replication and tumor oncolysis by Marc Otero-Mateo, Francesc Estrany Jr, Sabrina Arcas-Márquez, Laura Moya-Borrego, Giancarlo Castellano, Miquel Castany, Ramon Alemany, Cristina Fillat

Subjects: “…oncolytic adenovirus…”
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The oncolytic adenovirus TILT-123 with pembrolizumab in platinum resistant or refractory ovarian cancer: the phase 1a PROTA trial by Matthew Stephen Block, James Hugo Armstrong Clubb, Johanna Mäenpää, Santeri Pakola, Dafne Carolina Alves Quixabeira, Tatiana Kudling, Elise Jirovec, Lyna Haybout, Mirte van der Heijden, Sanae Zahraoui, Susanna Grönberg-Vähä-Koskela, Sini Raatikainen, Victor Arias, Saru Basnet, Nea Ojala, Teijo Pellinen, Annabrita Hemmes, Katja Välimäki, Annukka Pasanen, Tuomo Alanko, Daniel Adamo, Susan Ramadan, Jorma Sormunen, Juha Kononen, Julia Wanda Cohen, Michael Jon Chisamore, John Goldfinch, Suvi Sorsa, Riikka Havunen, Claudia Kistler, Aino Kalervo, Víctor Cervera-Carrascon, João Manuel dos Santos, Akseli Hemminki

“…Clinical responses were associated with higher serum anti-adenovirus neutralizing antibody titer at baseline and post-treatment. …”
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Human Neutrophil Defensin-1, -3, and -4 Are Elevated in Nasal Aspirates from Children with Naturally Occurring Adenovirus Infection by V. S. Priyadharshini, F. Ramírez-Jiménez, M. Molina-Macip, C. Renteria-Rosales, J. Santiago-Cruz, Paola Zarate-Segura, E. Lara-Padilla, Luis M. Teran

“…Background. Adenoviruses are highly contagious pathogens which cause respiratory disease particularly in children; they may induce severe disease in infants. …”
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OFFICIAL MEDICATIONS FOR ANTI-TUMOR GENE THERAPY by E. R. Nemtsova, O. A. Bezborodova, R. I. Yakubovskaya, A. D. Kaprin

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Effect of microencapsulated Fiber2-displaying probiotics loaded with inulin nanoparticles on immunity against fowl adenovirus serotype 4 in chickens by Biao Wang, Meiyuan Tian, Yashu Yang, Zhipeng Jia, Faisal R Anjum, Chunli Ma, Dexing Ma

“…The internalization of PINs into the probiotic E. faecalis, which delivering Fiber2 protein of fowl adenovirus serotype 4 (FAdV-4), was investigated. The expression of the Fiber2 protein in E. faecalis was detected using western blot analysis. …”
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Recombinant Adenovirus siRNA Knocking Down the Ndufs4 Gene Alleviates Myocardial Apoptosis Induced by Oxidative Stress Injury by Beibei Wang, Jinsheng Zhang, Aijun Xu

“…The results showed that the adenovirus infection rate was about 90%, and Ndufs4 mRNA and protein were decreased by 76.7% and 64.9%, respectively. …”
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Distinct phenotypes in the preeclamptic-like mouse model induced by adenovirus carrying sFlt1 and recombinant sFlt1 protein by Yingying Wei, Haojun Tian, Xuancheng Wei, Ai Zhang, Mengtian Wei, Ruixue Wang, Lu Zhang, Ping Qiao, Kai Wang

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Dendritic cell maturation is induced by p53-armed oncolytic adenovirus via tumor-derived exosomes enhancing systemic antitumor immunity by Tomoko Ohtani, Shinji Kuroda, Nobuhiko Kanaya, Yoshihiko Kakiuchi, Kento Kumon, Masashi Hashimoto, Chiaki Yagi, Ryoma Sugimoto, Satoru Kikuchi, Shunsuke Kagawa, Hiroshi Tazawa, Yasuo Urata, Toshiyoshi Fujiwara

Subjects: “…Oncolytic adenovirus…”
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Transient lymphocyte count decrease correlates with oncolytic adenovirus efficacy in humans: mechanistic and biomarker findings from TUNIMO phase I trial by Tuomo Alanko, Akseli Hemminki, Víctor Cervera-Carrascón, Riikka Havunen, Kristian Taipale, Dafne C A Quixabeira, Jorma Sormunen, Katriina Peltola, Suvi Sorsa, Santeri A Pakola, Elise Jirovec, Lyna Haybout, Claudia Kistler, Tatiana V Kudling, Victor Arias, James H A Clubb, Mirte van der Heijden, Teijo Pellinen, Joao M Santos

“…Peripheral lymphocyte count decrease is a promising biomarker for assessing oncolytic adenovirus therapy response.…”
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Immunogenicity of Pfizer mRNA COVID-19 Vaccination Followed by J&J Adenovirus COVID-19 Vaccination in Two Patients with Chronic Lymphocytic Leukemia by Zoe L. Lyski, Myung Sun Kim, David Xthona Lee, David Sampson, Hans-Peter Raué, Vikram Raghunathan, Debbie Ryan, Amanda E. Brunton, Mark K. Slifka, William B. Messer, Stephen E. Spurgeon

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Detection and molecular characterization of mastadenoviruses in calves with respiratory system infection by İlke Karayel Hacıoğlu, Selda Duran Yelken, Feray Alkan

Subjects: “…bovine adenovirus…”
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Adenoviral Pneumonia Outbreak in Immunocompetent Adults—A Missed Antimicrobial Stewardship Opportunity? by Branimir Gjurasin, Lorna Stemberger Maric, Tvrtko Jukic, Leona Radmanic Matotek, Snjezana Zidovec Lepej, Marko Kutlesa, Neven Papic

Subjects: “…adenovirus…”
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Impact of co-infections and immune responses on clinical severity of human adenovirus 3 and 7 infections in hospitalized children with lower respiratory tract infections: a comparative study by Xiaolin Ma, Yuting Wu, Ri De, Hailan Yao, Feng He, Yi Wang, Wei Wang, Chao Yan, Qinwei Song, Chunjie Guo, Li Wen, Linqing Zhao, Ling Cao, Chunmei Zhu

Subjects: “…human adenovirus serotypes 3…”
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Estimating the prevalence of six common respiratory viral infections in Zhangzhou, China using nasopharyngeal swabs in adults and throat swabs in Children by Yuanjun Zeng, Guowei Wang, Huicong Yang, Hongmei Li, Yueli Guo, Huili Liu, Xiaojun Xu, Chunbin Zhang

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Automatic monitoring of activity intensity in a chicken flock using a computer vision-based background image subtraction technique: An experimental infection study with fowl adenovirus by Hiroshi Iseki, Eri Furukawa, Tomoya Shimasaki, Shogo Higaki

“…Subsequently, an experimental infection study using fowl adenovirus was performed, with four cages per infected and non-infected group, and six chickens per cage. …”
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Exploiting the Achilles’ Heel of Viral RNA Processing to Develop Novel Antivirals by Ali Zahedi Amiri, Choudhary Ahmed, Subha Dahal, Filomena Grosso, Haomin Leng, Peter Stoilov, Maria Mangos, Johanne Toutant, Lulzim Shkreta, Liliana Attisano, Benoit Chabot, Martha Brown, Mario Huesca, Alan Cochrane

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Monitoring of Biodistribution and Persistence of Conditionally Replicative Adenovirus in a Murine Model of Ovarian Cancer Using Capsid-Incorporated mCherry and Expression of Human Somatostatin Receptor Subtype 2 Gene by Igor P. Dmitriev, Elena A. Kashentseva, Kenneth H. Kim, Qiana L. Matthews, Stephanie S. Krieger, Jesse J. Parry, Kim N. Nguyen, Walter J. Akers, Samuel Achilefu, Buck E. Rogers, Ronald D. Alvarez, David T. Curiel

“…A significant limiting factor to the human clinical application of conditionally replicative adenovirus (CRAd)-based virotherapy is the inability to noninvasively monitor these agents and their potential persistence. …”
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Etiological, Clinical, and Epidemiological Characteristics of Acute Viral Gastroenteritis in an Adult Population in a Tertiary Level Hospital in Spain by Sara Herranz-Ulldemolins, Anna Sellarès-Crous, Miriam J. Álvarez-Martínez, M. Eugenia Valls, Marta Aldea Novo, Anna Vilella Morató, Laura Rodriguez, Mireia Navarro, Roser Vendrell, Josep Barrachina, Miguel J. Martínez, M. Ángeles Marcos

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A phase 1b clinical trial to determine the safety, tolerability and immunogenicity of simian adenovirus and poxvirus vectored vaccines against Mycobacterium avium complex subspecies in patients with active Crohn’s diseaseResearch in context by Jeremy Sanderson, Jeremy Aboagye, Rebecca Makinson, Katerina Rapi, Samuel Provstgaard-Morys, Lisa Stockdale, Alison Lawrie, Isabelle Lanigan, Nishat Halim, Abdel Douiri, Emily Greenlay, Rayka Malek, Emma Gray, Lindsey West, Fatima El Oulidi, Paul Ian Cross, Michael Stallibrass, Sarah C. Gilbert, Adrian V.S. Hill, Katie J. Ewer

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