Intratumor heterogeneity in KRAS signaling shapes treatment resistance by Oleksi Petrenko, Varvara Kirillov, Stephen D'Amico, Nancy C. Reich

“…Here, we investigate the role of intratumor heterogeneity in pancreatic ductal adenocarcinoma, focusing on oncogenic KRAS addiction and treatment resistance. Integrated analysis of single-cell and bulk RNA sequencing data reveals that most tumors display a mixture of cells with vastly different degrees of KRAS dependency. …”
Get full text

To the Problem of Developing the Concept of Organising Social and Psychological-Pedagogical Work with Adolescents on the Internet by N.V. Bogdanovich, V.V. Delibalt

“…Such socially significant problems as cyberbullying, online sexual grooming, Internet addiction and other manifestations pose complex tasks for professionals to build work with clients not only offline but also online. …”
Get full text

Exploring the multidimensional nature of the psychopathy construct in social media context: Insights from Instagram by Mojtaba Elhami Athar

“…To address this gap in the literature, the current study examined the relationships between multiple dimensions of the psychopathy construct, as measured by the Youth Psychopathic Traits Inventory – Short Version (YPI-S), and indices of cybercrime, cyber abuse, sadfishing, Instagram addiction, and Instagram activity metrics (daily time spent, frequency of sharing stories/posts, and selfie-sharing), as well as indices of successful online careers in the context of Instagram. …”
Get full text

Methamphetamine Use: A Narrative Review of Adverse Effects and Related Toxicities by Amber N. Edinoff, Sarah E. Kaufman, Keionne M. Green, Daniel A. Provenzano, Jesse Lawson, Elyse M. Cornett, Kevin S. Murnane, Adam M. Kaye, Alan D. Kaye

“…Methamphetamine has been labeled "America's most dangerous drug" and has received significant public health attention. Stimulant addiction and tolerance are heavily documented in the literature; increasingly larger doses maintain euphoria in short time periods to withstand stimulant tolerance. …”
Get full text

Ambiguous Territory by Kathy Velikov, Cathryn Dwyre, Chris Perry, David Salomon

“…Such a scenario describes certain addictions. An illustration of such an addiction on a planetary scale is exemplified by the neologism agrilogistics. …”
Get full text

Metaverse: Technological evolution and social impact by Marković-Blagojević Marija, Radić Nikola, Cvjetković Milena

“…Through the evolution of virtual worlds and technological advancements, the Metaverse is becoming increasingly prevalent, offering richer socialization experiences and economic opportunities while simultaneously raising concerns about privacy, security, and media addiction. National policies and the attitudes of international organizations also play a crucial role in shaping the future of the Metaverse, with different countries having different strategies and priorities. …”
Get full text

Delirium and High Creatine Kinase and Myoglobin Levels Related to Synthetic Cannabinoid Withdrawal by Ahmet Bulent Yazici, Esra Yazici, Atila Erol

“…Effects of SCs on the central nervous system are similar to other cannabinoids, but 2–100 times more potent than marijuana. Thus, addiction and withdrawal symptoms are more severe than natural cannabinoids. …”
Get full text

Impact of a soft tip nicotine-free harmless cigarette as part of a smoking cessation program with psychological support and varenicline: an integrated workplace smoking cessation i... by Marilena Maglia, Pasquale Caponnetto, Riccardo Polosa, Cristina Russo, Giuseppe Santisi

“…There is an association between cigarette addiction and work-related stressors, with high prevalence rates for smokers, at least double those of other adults. …”
Get full text

The Political Economy of the Gifts on Tiktok by Cristina-Oana Cristea

“…It is a multifaceted object of study, allowing research on various topics such as security and surveillance, algorithms and addiction, and communication and online interactions. …”
Get full text

The transformation of the image of God during the development of eating disorders and eventual therapy: a sociological study by Dariusz Tułowiecki

“…Her eating disorders took the form of anorexia, addiction to dieting, and bulimia. While attending the group, the respondent goes through the 12 steps of OA, which assume acknowledging one’s powerlessness against eating disorders, discovering a Higher Power which can make one recover, committing one’s life to God – the Higher Power, and building a bond with God through prayer, regardless of the way God is perceived. …”
Get full text

Substance Abuse: A Public Health Concern by Ulfat Amin, Adil Mudasir Malla, Ishrat Amin, Roohi Jan

“…It refers to the harmful or hazardous use of psychoactive substances, including drugs and alcohol, that can lead to various health problems, such as addiction, mental health disorders, and physical illness. …”
Get full text

Estimation for Two Sensitive Variables Using Randomization Response Model Under Stratified Random Sampling by Gi-Sung Lee, Ki-Hak Hong, Sung-Hwan Kim, Chang-Kyoon Son

“…When direct survey are about sensitive characteristics such as addiction to drugs, alcoholism, proneness to tax invasion and sexual violence, nonresponse bias and response bias become serious problems because people oftentimes do not wish to give true information. …”
Get full text

The effect of rehabilitation on remission following detoxification treatment in alcohol and substance use disorders: A pilot study by Mustafa Danisman, Gamze Zengin Ispir, Kubra Sezer Katar, Zehra Ucar Hasanli, Ziya Bilgin

“…Rehabilitation services are of critical importance in combating addiction and need to be expanded in our country. [Med-Science 2024; 13(4.000): 840-6]…”
Get full text

Efektivitas pelatihan pengelolaan diri berbasis agama untuk mengurangi kecanduan internet pada siswa madrasah aliyah by Hidayat Ma'ruf, Muafatin Muafatin

“…Tingkat kecanduan internet diungkap melalui kuesioner yang diadaptasi dari IADQ (Internet Addiction Diagnostic Questionare) dan dianalisis dengan menggunakan Paired T Test melalui SPSS. …”
Get full text

Role of Hypothalamus in Acupuncture’s Effects by Ryan Bae, Hyung Kyu Kim, Baoji Lu, Jing Ma, Juping Xing, Hee Young Kim

“…Acupuncture, a traditional oriental medicine, can affect brain regions, such as the hypothalamus, anterior cingulate, posterior cingulate, and hippocampus, and produces specific therapeutic effects, such as pain relief, suppression of hypertension, and alleviation of drug addiction. Among the brain regions, the hypothalamus, a small yet critical region in the brain, plays a pivotal role in maintaining homeostasis by regulating a wide array of physiological processes, including stress responses, energy balance, and pain modulation. …”
Get full text

Sleeping Beauties in Anatomy Literature by Shiva Malgard, Mohsen Fazeli-Varzaneh, Gholamreza Hassanzadeh, Shadi Asadzandi

Get full text

La Costituzione siciliana del 1812 by Angelo Grimaldi

“…The Constitution provider for separation of powers but the English Constitutionl mo - del couldn’t be put into practice because it was based on royal assent, (the King can do no wrong) and this interna corporis whic would be led to the impeachment as being a political responsibility not a juridical responsibility. There was the addiction of feudalism but all feudal possession were transformed in Habeas corpus. …”
Get full text

Pain management for the neurosurgical patient in spinal procedures: overview of historic and new modalities by Ashley M. Carter, Samantha Yost, Jessica Tobin, Simran Phuyal, Brandon Lucke-Wold

“…The potent pain-relieving properties of opioids come at a steep price. Their addictive nature and side effects raise critical concerns in managing pain after surgical spine procedures. …”
Get full text

Community mental health funding, stakeholder engagement and outcomes: a realist synthesis by Walter P Wodchis, Vicky Stergiopoulos, Katie N Dainty, Maritt Kirst, Andrea Duncan

Get full text

Low-tech serious games in higher education: bridging the digital divide and enhancing student thinking and performance by Chong-Wen Chen

“…However, such digital-focused approaches risk widening the digital divide and may lead to digital addiction. Additionally, games rooted in behaviorism may not meaningfully improve student performance. …”
Get full text