Integrative deep immune profiling of the elderly reveals systems-level signatures of aging, sex, smoking, and clinical traitsResearch in context by Lennart Riemann, Rodrigo Gutierrez, Ivan Odak, Joana Barros-Martins, Lennart M. Roesner, Ximena Leon Lara, Christine Falk, Thomas F. Schulz, Gesine Hansen, Thomas Werfel, Reinhold Förster, Berislav Bošnjak, Felix Jenniches, Norman Klopp, Till Robin Lesker, Martin Stangel

“…Findings: We studied 97 innate and adaptive immune cell populations, revealing intricate age- and sex-related changes in the elderly immune system. …”
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Pacific sailfish (Istiophorus platypterus) in the Eastern Pacific Ocean, association with ocean currents and seasonal effects of upwelling using real-time Argos locations by Chelsea E. Clyde-Brockway, Chelsea E. Clyde-Brockway, Samir Harshad Patel, Gabriela Blanco, Samuel J. Friederichk, Stephen Morreale, Frank V. Paladino, Frank V. Paladino

“…Further research is needed to understand the mechanisms underlying these behavioral adaptations and the ecological factors that contribute to sailfish resilience. …”
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Characterization and Probiotic Potential of <i>Levilactobacillus brevis</i> DPL5: A Novel Strain Isolated from Human Breast Milk with Antimicrobial Properties Against Biofilm-Formi... by Ivan Iliev, Galina Yahubyan, Elena Apostolova-Kuzova, Mariyana Gozmanova, Daniela Mollova, Iliya Iliev, Lena Ilieva, Mariana Marhova, Velizar Gochev, Vesselin Baev

“…Furthermore, genome-wide sequencing and analysis of <i>L. brevis</i> DPL5 with cutting-edge Nanopore technology has uncovered over 50 genes linked to probiotic activity, supporting its ability to adapt and thrive in the harsh gut environment. The genome also contains multiple biosynthetic gene clusters such as lanthipeptide class IV, Type III polyketide synthase (T3PKS), and ribosomally synthesized, and post-translationally modified peptides (RiPP-like compounds), all of which are associated with antibacterial properties. …”
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Temporal dynamics of summer phytoplankton communities and their response to environmental changes in the northern Yellow Sea (2011-2020) by Yibo Wang, Yibo Wang, Zhiliang Liu, Zhiliang Liu, Yanping Qi, Yang Chen, Yang Chen, Haibo Zhang, Xihan Liu, Xihan Liu, Du Su, Du Su

“…The Yellow Sea Cold Water Mass prominently influenced summer phytoplankton community structure, exhibiting lower phytoplankton abundance, Dia/Dino index, and species richness in the cold water mass region, where adaptable species such as Tripos muelleri and Paralia sulcata predominated. …”
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A deep learning algorithm to generate synthetic computed tomography images for brain treatments from 0.35 T magnetic resonance imaging by Luca Vellini, Flaviovincenzo Quaranta, Sebastiano Menna, Elisa Pilloni, Francesco Catucci, Jacopo Lenkowicz, Claudio Votta, Michele Aquilano, Andrea D’Aviero, Martina Iezzi, Francesco Preziosi, Alessia Re, Althea Boschetti, Danila Piccari, Antonio Piras, Carmela Di Dio, Alessandro Bombini, Gian Carlo Mattiucci, Davide Cusumano

“…Conclusion: The proposed DL algorithm generates in less than 2 min accurate sCT images in the brain for online adaptive radiotherapy, potentially eliminating the need for CT simulation in MR-only workflows for brain treatments.…”
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Egg freshness during storage: the effect of laying hen age and shelf life prediction using a novel hybrid modeling method by Yifeng Lu, Jing Li, Zihao He, Linyun Chen, Huixin Tian, Chen Xu, Xinglian Xu, Minyi Han

“…A novel hybrid model combining BP-ANN, cuckoo search and adaptive boosting (CS-BP-AdaBoost) was proposed for predicting the remaining egg shelf life, with the input being Haugh unit, yolk index, air cell depth, albumen pH, hen age, and breed. …”
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Soil warming increases the active antibiotic resistome in the gut of invasive giant African snails by Yiyue Zhang, Hong-Zhe Li, Martin Breed, Zhonghui Tang, Li Cui, Yong-Guan Zhu, Xin Sun

“…This suggests a link between active ARBs and secondary metabolism, enhancing the environmental adaptability and competitive advantage of these organisms in warmer environments. …”
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Identifying the healthy places to live in Australia with a new environmental quality health index by Shuang Zhou, Zhihu Xu, Wenzhong Huang, Yao Wu, Rongbin Xu, Zhengyu Yang, Pei Yu, Wenhua Yu, Tingting Ye, Bo Wen, Shanshan Li, Yuming Guo

“…Our methodology can be adapted globally to standardize risk evaluation.…”
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Randomized controlled trial of cognitive behavioral therapy versus health education for sleep disturbance and fatigue following stroke and traumatic brain injury by Lucy Ymer, Adam McKay, Dana Wong, Kate Frencham, Natalie Grima, Monique Roper, Sylvia Nguyen, Jade Murray, Gershon Spitz, Jennie Ponsford

“…Objective: Evaluate efficacy of cognitive behavioural therapy for sleep and fatigue adapted for brain injury relative to health education control in alleviating sleep disturbance and fatigue after acquired brain injury. …”
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An autonomous navigation method for orchard mobile robots based on octree 3D point cloud optimization by Hailong Li, Hailong Li, Hailong Li, Kai Huang, Kai Huang, Yuanhao Sun, Yuanhao Sun, Xiaohui Lei, Xiaohui Lei, Quanchun Yuan, Quanchun Yuan, Jinqi Zhang, Xiaolan Lv, Xiaolan Lv

“…According to the sparsity and density of the point cloud, the 3D orchard map is adaptively divided and the key information of the orchard is retained. 2) In terms of path planning, by using octree nodes as the unit nodes for RRT* random tree expansion, an improved RRT* algorithm based on octree is proposed. …”
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Exploring segmented assimilation theory in health education utilization and its influencing factors among internal migrants in China: insights from the 2017 China migrants dynamic... by Ting Xu, Ting Xu, Zeyu Wang, Tingting Wang, Jiahua Shi, Aiyong Zhu, Enhong Dong, Enhong Dong

“…Specifically, first-generation migrants require accessible and culturally adapted health education programs to overcome systemic barriers, while second-generation underclass migrants need sustained support to leverage their engagement in health initiatives.…”
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Novel anthropometric indices are superior adiposity indexes to portend visual impairment in middle-aged and older Chinese population by Qing Chen, Yanan Hou, Yifan Zhou, Jianfeng Luo, KaiweiSa Abuduxukuer, Chuchu Wang, Jialong Dong, Yiting Wang, Wenming Shi, Fei Shi, Qing Peng

“…Objective To investigate differential associations of traditional and novel adiposity indices with visual impairment (VI) in the middle-aged and older Chinese population.Methods and analysis Based on the China Health and Retirement Longitudinal Study, 7750 Chinese older adults aged over 45 were included at baseline 2011, and 4133 participants who accomplished all three interviews from 2011 to 2015 were adapted for longitudinal analyses. We enrolled six adiposity indices, including the body mass index (BMI), waist-to-height ratio (WHtR), weight-adjusted-waist index (WWI), a body shape index (ABSI), body roundness index (BRI) and conicity index (ConI). …”
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Caregiver worry about COVID-19 as a predictor of social mitigation behaviours and SARS-CoV-2 infection in a 12-city U.S. surveillance study of households with children by Steven M. Brunwasser, Tebeb Gebretsadik, Anisha Satish, Jennifer C. Cole, William D. Dupont, Christine Joseph, Casper G. Bendixsen, Agustin Calatroni, Samuel J. Arbes, Jr, Patricia C. Fulkerson, Joshua Sanders, Leonard B. Bacharier, Carlos A. Camargo, Jr, Christine Cole Johnson, Glenn T. Furuta, Rebecca S. Gruchalla, Ruchi S. Gupta, Gurjit K. Khurana Hershey, Daniel J. Jackson, Meyer Kattan, Andrew Liu, George T. O'Connor, Katherine Rivera-Spoljaric, Wanda Phipatanakul, Marc E. Rothenberg, Max A. Seibold, Christine M. Seroogy, Stephen J. Teach, Edward M. Zoratti, Alkis Togias, Tina V. Hartert

“…Findings should inform studies weighing the adaptive value of worrying about infectious disease outbreaks against established detrimental health effects.…”
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Iterative optimization annotation pipeline and ALSS-YOLO-Seg for efficient banana plantation segmentation in UAV imagery by Ang He, Ang He, Ximei Wu, Ximei Wu, Xing Xu, Xing Xu, Jing Chen, Jing Chen, Xiaobin Guo, Xiaobin Guo, Sheng Xu, Sheng Xu

“…The model’s backbone includes an Adaptive Lightweight Channel Splitting and Shuffling (ALSS) module to improve information exchange between channels and optimize feature extraction, aiding accurate crop identification. …”
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Advancing treatment choices: CDK4/6 inhibitor switching in HR+/HER2- metastatic breast cancer by Paola Zagami, Angela Esposito, Beatrice Taurelli Salimbeni, Pier Paolo Maria Berton Giachetti, Roberta Scafetta, Matteo Lambertini, Massimo Di Maio, Giuseppe Curigliano, Carmen Criscitiello, Saverio Cinieri

“…Conclusion: Our survey highlights the importance of allowing CDK4/6i switching, thus likely prompting oncologists to adapt their treatment choices, leading to better AEs management for improving patients’ outcome.…”
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The preference of migratory waterbirds to winter at a key location on the East Asian-Australasian flyway and its implications for habitat conservation by Shuangliang Dai, Yanyan Zhou, Jingsi Gao, Guowei Cheng, Linlin Wang, Haiyan Bai, Xiaoyu Lei, Hualin Xu, Xian-zhong Mao

“…However, compared to other waterbirds, the black-faced spoonbill demonstrated stronger adaptability to harsh winters. In warmer and normal winters (FP < 36 %), protected areas were effective in resisting high anthropogenic pressure. …”
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Improved cattle farm classification: leveraging machine learning and linked national datasets by Guy-Alain Schnidrig, Guy-Alain Schnidrig, Rahel Struchen, Sara Schärrer, Dagmar Heim, Daniela Hadorn, Gertraud Schüpbach-Regula, Giulia Paternoster

“…Our flexible methodology could be adapted to other countries and datasets, enabling veterinary authorities to conduct more efficient and targeted disease surveillance in the future.…”
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Daily Usage of Proton Pump Inhibitors May Reduce the Severity of Critical Upper Gastrointestinal Bleeding in Elderly Patients by Hidetaka Matsuda, Takuto Nosaka, Yu Akazawa, Yasushi Saito, Yoshihiko Ozaki, Kazuto Takahashi, Tatsushi Naito, Kazuya Ofuji, Masahiro Ohtani, Katsushi Hiramatsu, Yasunari Nakamoto

“…Particularly in elderly patients with nonvariceal UGIB, habitual PPI use can alleviate the clinical symptoms of UGIB by suppressing the volume of bleeding, regardless of the adapted dose of PPIs.…”
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Using machine learning to predict patients with polycystic ovary disease in Chinese women by Chen-Yu Wang, Dee Pei, Chun-Kai Wang, Jyun-Cheng Ke, Siou-Ting Lee, Ta-Wei Chu, Yao-Jen Liang

“…Random Forest (RF), stochastic gradient boosting (SGB), multivariate adaptive regression splines (MARS), extreme gradient boosting (XGBoost), and gradient boosting with categorical features support (CatBoost) are five Mach-L algorithms that were used. …”
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Relationship Between Perilesional Skin Condition and Survival in Terminally Ill Patients with Pressure Ulcers by María Isabel Pastor-Orduña, Federico Palomar-Llatas, David Palomar-Albert, María Teresa Murillo-Llorente, Ignacio Ventura, Francisco Tomás-Aguirre, Marcelino Pérez-Bermejo

“…On the other hand, the negative correlation between total lymphocyte count and survival suggests that lymphocytopenia may be a marker of adaptive immunosuppression. Perilesional tissue epithelialization, overall functionality and serum albumin levels are key factors in predicting survival, highlighting the need for a comprehensive palliative care approach to optimize quality of life and prolong survival in terminally ill patients with PUs.…”
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