Protocol for the DisCoVeRy trial: multicentre, adaptive, randomised trial of the safety and efficacy of treatments for COVID-19 in hospitalised adults by Florence Ader, Jean-François Timsit, Yazdan Yazdanpanah, François-Xavier Lescure, Laetitia Moinot, Christelle Delmas, Hélène Espérou, Laurent Abel, Benjamin Leveau, Vinca Icard, Toni Alfaiate, Linda Wittkop, Charles Burdet, France Mentré, Marion Schneider, Nathan Peiffer-Smadja, Julien Poissy, Lila Bouadma, Bruno Lina, Florence Morfin-Sherpa, Maude Bouscambert, Alexandre Gaymard, Gilles Peytavin, Jeremie Guedj, Claire Andrejak, Cedric Laouenan, Drifa Belhadi, Axelle Dupont, Basma Basli, Anissa Chair, Samira Laribi, Julie Level, Marie-Capucine Tellier, Aline Dechanet, Dominique Costagliola, Sandrine Couffin-Cadiergues, Juliette Saillard, Claire Fougerou, Carole Cagnot, Soizic Le Mestre, Delphine Lebrasseur-Longuet, Ventzislava Petrov-Sanchez, Alpha Diallo, NoéMie Mercier, Sarah Tubiana, Benjamin Hamze, Ambre Gelley, Marion Noret, Eric D’Ortenzio, Oriane Puechal, Caroline Semaille

“…The objective of the trial is to evaluate the clinical efficacy and safety of different investigational re-purposed therapeutics relative to Standard of Care (SoC) in patients hospitalised with COVID-19.Methods and analysis DisCoVeRy is a phase III, open-label, adaptive, controlled, multicentre clinical trial in which hospitalised patients with COVID-19 in need of oxygen therapy are randomised between five arms: (1) a control group managed with SoC and four therapeutic arms with re-purposed antiviral agents: (2) remdesivir + SoC, (3) lopinavir/ritonavir + SoC, (4) lopinavir/ritonavir associated with interferon (IFN)-β−1a + SoC and (5) hydroxychloroquine + SoC. …”
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Adaptive treatment margins to reduce organs at risk dose in patients with no or minimal anatomical changes in radiotherapy of non-small cell lung cancer by Djoya Hattu, Daisy Emans, Janine Bouten, Richard Canters, Judith van Loon, Dirk De Ruysscher

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Adapting and deploying a digital program for training non-specialist providers on a brief psychological intervention for depression in rural Gujarat, India. by Aakrushi Brahmbhatt, Darshana Rathod, Udita Joshi, Azaz Khan, G Sai Teja, Shrey Desai, Ajay Chauhan, Shobha Shah, Deepti Bhatt, Sethuraman Venkatraman, Deepak Tugnawat, Satchit Balsari, Vikram Patel, Anant Bhan, John A Naslund

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Target Detection Using Fused Unidentical Photonics-Based LFM Sub-Band Radar Signals With an Adaptive Feed Forward Network Equalizer by Bikash Nakarmi, S. M. Rezwanul Islam, Hum Nath Parajuli, Ikechi Augustine Ukaegbu, Aigerim Ashimbayeva, Carlo Molardi, T. D. Subash, Xiangchuan Wang, Shilong Pan

“…This paper proposes and experimentally demonstrates sub-bands fusion of photonically generated linear frequency modulated (Ph-LFM) radar signals with unidentical bandwidth and chirp rates using an adaptive, delay-less feed-forward network equalizer (FFNE). …”
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Comprehensive review of mapping climate change impacts on tea cultivation: bibliometric and content analysis of trends, influences, adaptation strategies, and future directions by Altyeb Ali Abaker Omer, Altyeb Ali Abaker Omer, Chun-Hua Zhang, Chun-Hua Zhang, Jie Liu, Jie Liu, Zhi-guo Shan, Zhi-guo Shan

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Rapid Adaptation to Prevent Drug Use (RAPD): protocol of a pilot randomized trial to enhance the impact of an evidence-based intervention for youth by Andria B. Eisman, Christine Koffkey, Robert T. Partridge, Suzanne Brown, Bo Kim

“…Aim 2: design and pilot test RAPD (Rapid Adaptation to Prevent Drug use) based on aim 1 findings. …”
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Adapting self-measured blood pressure monitoring to reduce health disparities (ASPIRE): a pilot hybrid effectiveness‑implementation study protocol by Rasha Khatib, Nicole Glowacki, Iridian Guzman, Maureen Shields, Joseph Chase, Melanie Gordon

“…Objectives This study aims to evaluate the feasibility of study methods implementing the ASPIRE (adapting self-measured blood pressure to reduce health disparities) toolkit in a primary care setting. …”
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Adapting to change: exploring the distribution dynamics of the alien and potentially invasive aphid species Cinara curvipes (Hemiptera: Aphididae) in the context of global warming by K. Wieczorek, A. Bugaj-Nawrocka, B. Borowiak-Sobkowiak, A. Endrestøl, H. P. Ravn, W. Solarz, R. Durak

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Cross-cultural adaptation of the writer-reader relationship in non-translated and translated English health information websites on HIV and TB diagnostic testing by Amy Dara Hochberg

Subjects: “…cross-cultural adaptation…”
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Discovery of amino acid substitutions in penicillin-binding proteins associated with adaptation to D-Ala-D-Lac in vancomycin-resistant Enterococcus faecalis by Nese Caglayan, Banu Sancak, Zeynep Kanlidere, Tanil Kocagoz, Tanil Kocagoz

“…For the first time, we identified specific adaptations in certain VRE PBPs that may facilitate the D-Ala-D-Lac utilization. …”
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Adapting and Implementing a Blended Collaborative Care Intervention for Older Adults with Multimorbidity: Quantitative and Qualitative Results from the ESCAPE Pilot Study by Josefine Schulze, Dagmar Lühmann, Jonas Nagel, Cornelia Regner, Christine Zelenak, Kristina Bersch, Christoph Herrmann-Lingen, Matthew M. Burg, Birgit Herbeck-Belnap

“…Blended Collaborative Care (BCC) is a promising strategy to address care complexity by partnering care managers (CMs) with primary care providers (PCPs) and specialists. This study aimed to adapt and pilot a BCC intervention for patients aged 65+ with heart failure and physical–mental multimorbidity. …”
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Incorporating health literacy principles into the adaptation of a methods motivational interviewing approach for enrolling black adults in a pilot randomized trial by Olayinka O. Shiyanbola, Meng-Jung Wen, Martha A. Maurer

“…Participants reported positive orientation experiences due to a better understanding of the study information, expectations, and rationale behind randomization. Implementing an adapted MMI approach focused on health literacy principles may improve trial enrollment and retention rates among Black adults.…”
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Balancing central control and sensory feedback produces adaptable and robust locomotor patterns in a spiking, neuromechanical model of the salamander spinal cord. by Alessandro Pazzaglia, Andrej Bicanski, Andrea Ferrario, Jonathan Arreguit, Dimitri Ryczko, Auke Ijspeert

“…The locomotor circuits, modeled as a spiking neural network of adaptive leaky integrate-and-fire neurons, are coupled to a three-dimensional mechanical model of a salamander with realistic physical parameters and simulated muscles. …”
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Innovative Strategy to Improve Precision and to Save Power of a Real-Time Control Process Using an Online Adaptive Fuzzy Logic Controller by R. Lasri, I. Rojas, H. Pomares, O. Valenzuela

“…Through a training board that allows us to control the temperature, all the used algorithms should present their best performances in this control process; therefore, our self-organized and online adaptive fuzzy logic controller (FLC) will be required to present great improvements in the control task and a real high control performance. …”
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A Self-Adaptive Frequency Decomposition Approach for Denoising to Enhance Data-Driven Learning of Cyclic Time Series in Medical Signal Estimation by Shang-Wei Chao, Feng-Li Lian

Subjects: “…Adaptive frequency band decomposition…”
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Cultural & region-specific adaptation of KAP (Knowledge, attitude, and practice) tool to capture healthy lifestyle within primary care settings. by Ahmed Sameer Alnuaimi, Muslim Abbas Syed, Abduljaleel Abdullatif Zainel, Hafiz Ahmed Mohamed, Mohamed Iheb Bougmiza, Mohamed Ahmed Syed

“…<h4>Methods</h4>The KAP survey was tailored to capture the construct of healthy lifestyles (within the context of Qatar primary care settings) by reviewing existing surveys, adaptation to local context, expert consultation and feedback, pilot testing, feedback analysis, cognitive interviews and translation and validation.…”
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Adaptive Sliding Mode Fixed-Time Tracking Control Based on Fixed-Time Sliding Mode Disturbance Observer with Dead-Zone Input by Hongbin Wang, Bo Su, Yueling Wang, Jing Gao

“…Aiming at the problem of fixed-time trajectory tracking control for high-order dynamic systems with external time-varying disturbance and input dead-zone, an adaptive fixed-time sliding mode control algorithm is proposed by employing a fixed-time sliding mode disturbance observer (FTSMDO) and high-order fixed-time sliding mode algorithm. …”
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A comparison of adaptive algorithms for solving plane problems in the linear elasticity theory using the zero- and first-order Raviart – Thomas elements by Petukhov Dmitrii, Frolov Maksim

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Enhanced IoT-Based Face Mask Detection Framework Using Optimized Deep Learning Models: A Hybrid Approach With Adaptive Algorithms by Parul Dubey, Pushkar Dubey, Celestine Iwendi, Cresantus N. Biamba, Deepak Dasaratha Rao

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Adaptation of an in vitro one-compartment pharmacodynamic chemostat for testing efficacy of ceftazidime against Burkholderia pseudomallei outside a BSL3 facility by Hana Farizah Zamri, Mohammad Ridhuan Mohd Ali, Ahmad Izzan Irfan Sha'ari, Nurul Husna Mohd Mazalan, Norazah Ahmad, Nur Asyura Nor Amdan, Nusaibah Abdul Rahim, Zakuan Zainy Deris

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