Markedly Increased High-Mobility Group Box 1 Protein in a Patient with Small-for-Size Syndrome by Darren G. Craig, Patricia Lee, E. Anne Pryde, Ernest Hidalgo, Peter C. Hayes, Stephen J. Wigmore, Stuart J. Forbes, Kenneth J. Simpson

“…Serum levels of HMGB1, sRAGE, IL-18, and other inflammatory mediators were measured by ELISA in a case of SFSS, and the results were compared with 8 patients with paracetamol-induced acute liver failure (ALF) and 6 healthy controls (HC). Results. …”
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Beneficial Effects of Human Mesenchymal Stromal Cells on Porcine Hepatocyte Viability and Albumin Secretion by Elisa Montanari, Joel Pimenta, Luca Szabó, François Noverraz, Solène Passemard, Raphael P. H. Meier, Jeremy Meyer, Jonathan Sidibe, Aurelien Thomas, Henk-Jan Schuurman, Sandrine Gerber-Lemaire, Carmen Gonelle-Gispert, Leo H. Buhler

“…Porcine hepatocytes transplanted during acute liver failure might support metabolic functions until the diseased liver recovers its function. …”
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Drug-induced autoimmune-like hepatitis: A disproportionality analysis based on the FAERS database. by Wangyu Ye, Yuan Ding, Meng Li, Zhihua Tian, Shaoli Wang, Zhen Liu

“…<h4>Background</h4>Drug-induced autoimmune-like hepatitis (DI-ALH) is a potentially life-threatening condition that can lead to acute liver failure and necessitate liver transplantation. …”
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Cryopreserved human alternatively activated macrophages promote resolution of acetaminophen-induced liver injury in mouse by Maria Elena Candela, Melisande Addison, Rhona Aird, Tak-Yung Man, Jennifer A. Cartwright, Candice Ashmore-Harris, Alastair M. Kilpatrick, Philip J. Starkey Lewis, Anna Drape, Mark Barnett, Donna Mitchell, Colin McLean, Neil McGowan, Marc Turner, James W. Dear, Stuart J. Forbes

“…Abstract Acute liver failure is a rapidly progressing, life-threatening condition most commonly caused by an overdose of acetaminophen (paracetamol). …”
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The management and clinical outcome of paracetamol poisoning in South African adults: A single-centre retrospective review by C Kotze, J Swanepoel, E C Kruger, E Decloedt

“…Paracetamol-induced hepatotoxicity is a common cause of acute liver failure in many high-income countries, but little is known about the factors associated with severity of liver injury and poor clinical outcomes among those treated in sub-Saharan African settings. …”
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Physiology and Pathophysiology of Marathon Running: A narrative Review by Lorin Braschler, Pantelis T. Nikolaidis, Mabliny Thuany, Daniela Chlíbková, Thomas Rosemann, Katja Weiss, Matthias Wilhelm, Beat Knechtle

“…Moreover, marathon running poses the risk of serious adverse events such as sudden cardiac death or acute liver failure. Concerning lung function, a decrease after a marathon race was observed. …”
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Protective Effect of Baccharis trimera Extract on Acute Hepatic Injury in a Model of Inflammation Induced by Acetaminophen by Bruno da Cruz Pádua, Joamyr Victor Rossoni Júnior, Cíntia Lopes de Brito Magalhães, Míriam Martins Chaves, Marcelo Eustáquio Silva, Maria Lucia Pedrosa, Gustavo Henrique Bianco de Souza, Geraldo Célio Brandão, Ivanildes Vasconcelos Rodrigues, Wanderson Geraldo Lima, Daniela Caldeira Costa

“…When administered in high doses, APAP is a clinical problem in the US and Europe, often resulting in severe liver injury and potentially acute liver failure. Studies have demonstrated that antioxidants and anti-inflammatory agents effectively protect against the acute hepatotoxicity induced by APAP overdose. …”
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Wits Transplant Unit Annual Report 2022: Adult and paediatric liver transplantation by E U Wessels, K Kinandu, M Beretta, S Berkenfeld, B Bobat, L Brannigan, R Britz, D Demopoulos, L Doedens, P Gaylard, H Maher, A Mahomed, V Mudau, D Parbhoo, S Rambarran, M Reynders, F van der Schyff, B Ströbele, J Fabian, J Loveland

“…In the paediatric population, the most common aetiologies for both pretransplant candidates and transplant recipients remained cholestatic disease and acute liver failure. There was a decrease in paediatric pretransplant mortality from 27% in 2017 to 6% in 2021. …”
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Analysis of fatty acid-derived lipids in critically ill patients after cardiac surgery yields novel pathophysiologically relevant mediators with possible relevance for systemic inf... by Holger Neb, Verena Roth, Jessica Roos, Jessica Roos, Tom Bauer, Anja Urbschat, Ulrike Heinicke, Carlo Angioni, Dieter Steinhilber, Dieter Steinhilber, Matthias Piesche, Matthias Piesche, Nerea Ferreirós, Robert Gurke, Robert Gurke, Gerd Geisslinger, Gerd Geisslinger, Edith Utech, Kai Zacharowski, Patrick Meybohm, Patrick Meybohm, Patrick Paulus, Elke Schmitt, Elke Schmitt, Thorsten Jürgen Maier, Thorsten Jürgen Maier

“…Many of these patients develop forms of acute kidney injury, heart or acute liver failure during intensive care. Lipid signaling is critically involved in triggering systemic inflammation processes, pain and vascular tone. …”
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The paediatric liver transplant experience in Johannesburg, South Africa: A broad overview and update by K Kinandu, A Beeton, M Beretta, S Berkenfeld, L Brannigan, R Britz, D Demopoulos, L Doedens, M Duncan, P Gaylard, C Hajinicolaou, W Lowman, H Maher, T De Maayer, V Mudau, S Rambarran, M Reynders, F van der Schyff, B Ströbele, S Tager, E Wessels, J Fabian, J Loveland

“…The most common indication for liver transplant was biliary atresia, followed by acute liver failure. Unadjusted recipient survival was 80% (95% CI: 75-85%) at one year, and 68% (95% CI: 59-75%) at five years. …”
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