Single-Nucleus RNA Sequencing Reveals Cellular Transcriptome Features at Different Growth Stages in Porcine Skeletal Muscle by Ziyu Chen, Xiaoqian Wu, Dongbin Zheng, Yuling Wang, Jie Chai, Tinghuan Zhang, Pingxian Wu, Minghong Wei, Ting Zhou, Keren Long, Mingzhou Li, Long Jin, Li Chen

“…Additionally, these cells exhibited more active communication with other cell types compared to 170-day-old pigs. …”
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Diversity and Complexity of CTXΦ and Pre-CTXΦ Families in <em>Vibrio cholerae</em> from Seventh Pandemic by Xiaorui Li, Yu Han, Wenxuan Zhao, Yue Xiao, Siyu Huang, Zhenpeng Li, Fenxia Fan, Weili Liang, Biao Kan

“…We identified two CTXΦ members and six pre-CTXΦ members with distinct <i>rstR</i> alleles, revealing complex chromosomal DNA integration patterns and arrangements of different prophages in these strains. Promoter activity assays showed that the transcriptional repressor RstR protected against CTXΦ superinfection by preventing the replication and integration of CTXΦ/pre-CTXΦ phages containing the same <i>rstR</i> allele, supporting the co-integration of the diverse CTXΦ/pre-CTXΦ members observed. …”
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Confronting needlestick and sharp injuries in healthcare: a decade of struggle and progress in a university teaching hospital by Shuk-Ching Wong, Lithia Lai-Ha Yuen, Germaine Kit-Ming Lam, Monica Oi-Tung Kwok, Crystal Yuen-Ki Siu, Bella Hong-Yan Li, Jonathan Hon-Kwan Chen, Simon Yung-Chun So, Kelvin Hei-Yeung Chiu, Vincent Chi-Chung Cheng

“…Notably, 54% (149/278) involved safety-equipped devices, yet 94% (140/149) of these were not activated properly. Following targeted training, NSI rates among interns significantly decreased from 0.82 to 0.46 per 10,000 patient days (R2 = 0.977, p = 0.001) and from 6.84 to 3.40 per 100 FTE (R2 = 0.874, p = 0.020) from 2019 to 2023. …”
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<i>Bridelia ferruginea</i> Tea Consumption Improves Antioxidant Status in Individuals Living with Type 2 Diabetes by Collins Afriyie Appiah, Jennifer Ngounda, Mavis Boakye-Yiadom, Felix Charles Mills-Robertson, Mariette Nel, Rabia Johnson, Corinna Walsh

“…., a tropical African plant, is known for its antioxidant activity. Methods: This comparative cross-sectional study assessed the oxidative status and associated parameters in 70 individuals living with type 2 diabetes (ILWT2D) who were receiving standard diabetes treatment and consistently drank Bridelia tea (Bridelia group) compared to 92 ILWT2D receiving standard diabetes treatment only (comparator group). …”
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Control of Ectoparasitic Monogenean Infestation on GIFT Tilapia (Oreochromis sp.) using Salt Addition by Yani Hadiroseyani, L.S. Harti, Sri Nuryati

“… Ectoparasitic monogenean infestation is one of fish diseases which may cause mass mortality, therefore controlling the parasites is one of the important factors to ensure the success of aquaculture activities. Salt addition is one of disease curative and controlling techniques which is cheap, easy and environmental friendly as well as effective to control ectoparasites in freshwater environment. …”
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Associations of healthy lifestyle and family income to poverty ratio with all-cause mortality among people with prediabetes and diabetes: a prospective cohort study by Zhu Li, Lin Zhou, Yongshi Wu, Tao Ding, Yuxin Gan, Xiang Fan

“…The weighted healthy lifestyle score was constructed based on smoking, alcohol consumption, physical activity, diet (HEI-2015), and body mass index. Generalized linear regression models were used to analyze the association between healthy lifestyle, PIR, and all-cause mortality. …”
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Common pathogenic aspects of diabetic retinopathy and nephropathy. Kidney transplantation and the course of diabetic retinopathy by I.V. Vorobyeva, L.K. Moshetova, A.V. Pinchuk, Е.V. Bulava, E.P. Delver, A.A. Belogurov

“…Key biological pathogenic mechanisms of microvascular complications involve over-production of reactive oxygen species and activation of intracellular signaling pathways and their modulators. …”
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Advantages of different dietary supplements for elite combat sports athletes: a systematic review and Bayesian network meta-analysis by Hua Luo, Tengku Fadilah Tengku Kamalden, Xiaolin Zhu, Changqing Xiang, Nurul Amelina Nasharuddin

“…Abstract With an increasing number of studies delving into the impact of dietary supplements on combat sports performance, researchers are actively seeking a more efficient dietary supplement for use in these sports. …”
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Club Cell Protein 16 Attenuates CD16brightCD62dim Immunosuppressive Neutrophils in Damaged Tissue upon Posttraumatic Sepsis-Induced Lung Injury by Nils Becker, Philipp Störmann, Andrea Janicova, Kernt Köhler, Klemens Horst, Ildiko Rita Dunay, Claudia Neunaber, Ingo Marzi, Jan Tilmann Vollrath, Borna Relja

“…Apoptosis was assessed by activated (cleaved) caspase-3. Results from untreated ctrl and IgG-treated mice were statistically comparable between all corresponding sham, TxT, and TxT+CLP groups. …”
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Cerebrospinal fluid β2-microglobulin promotes the tau pathology through microglia–astrocyte communication in Alzheimer's disease by Zehu Sheng, Lanyang Wang, Ming Chen, Fuxin Zhong, Shijing Wu, Shuyu Liang, Jiaqi Song, Lihua Chen, Yingxi Chen, Shiyu Chen, Weihua Yu, Yang Lü

“…However, more investigation is required to ascertain the relationship between β2M and glial activities in AD pathogenesis. Methods In this study, 211 participants from the Alzheimer’s disease Neuroimaging Initiative (ADNI) with CSF and Plasma β2M, CSF glial fibrillary acidic protein (GFAP), soluble triggering receptor expressed on myeloid cells 2 (sTREM2), Aβ42, phosphorylated-tau (P-tau) and total tau (T-tau) were divided into four groups, stage 0, 1, 2, and suspected non-AD pathology (SNAP) based on the National Institute on Aging- Alzheimer’s Association (NIA-AA) criteria. …”
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Research status and future prospect of carbon capture technology using steel slag in the context of carbon neutrality by Lei AN, Xiaoyuan ZHANG, Yu LIU

“…Owing to its abundant endogenous active components, such as Ca2+ and Mg2+, steel slag has the potential to be used as a functional material for carbon capture. …”
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Niacin alters ruminal microbial composition and metabolites in sheep fed a high-concentrate diet by Zhiqiang Cheng, Jiancheng Liu, Yingying Yu, Wentao Liu, Xiaobin Li, Fengming Li, Changjiang Zang, Kailun Yang

“…The concentrations of NH3-N (p &lt; 0.01), propionate (p &lt; 0.01), and butyrate (p &lt; 0.05) in the NA group were significantly higher than those in the CON group. (3) Compared to the CON group, the ruminal pyruvate content in the NA group was significantly increased at 0 h before feeding (p &lt; 0.05), and lactic acid (p &lt; 0.05) was significantly decreased at 1 and 3 h after feeding, lactate dehydrogenase activities was significantly decreased (p &lt; 0.01) at 3 and 5 h after feeding. (4) The number of specific operational taxonomic units (OTUs) in the CON and NA groups were 26 and 37, respectively, for a total of 1,178 OTUs; principal coordinate analysis (R2 = 0.172, p-value = 0.007) and non-metric multidimensional scaling (stress = 0.1646) results showed that the two groups of samples were significantly separated. (5) The species distribution bar graph shows that at the phylum level, the relative abundances of Bacteroidetes, Firmicutes, and Proteobacteria were 43.70, 36.25, and 12.77%, respectively. (6) Orthogonal projection to latent structure-discriminant analysis results showed that the two groups of samples were clearly separated in the positive and negative ionization modes, with R2Y and Q2Y values of 0.705, 0.857, 0.695, and 0.28, respectively. …”
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Increased risk for alcohol- and other substance-exposed pregnancies among women who smoke tobacco: A secondary analysis of a primary care-based intervention by Thomas F. Northrup, Angela L. Stotts, Stephen M. Fischer, Kirk L. von Sternberg, Mary M. Velasquez

“…Material and Methods Eligible women (N=261) were recruited from 12 primary care clinics in a public healthcare system, not pregnant, aged 18–44 years, drinking >3 drinks/ day or >7 drinks/week, sexually active, and not using effective contraception. We compared women who did and did not smoke tobacco on alcohol and drug severity, and psychological distress (e.g. anxiety) at baseline. …”
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Targeted intra-tumoral hyperthermia using uniquely biocompatible gold nanorods induces strong immunogenic cell death in two immunogenically ‘cold’ tumor models by Barry E. Kennedy, Erin B. Noftall, Cheryl Dean, Alexander Roth, Kate N. Clark, Darren Rowles, Kulbir Singh, Len Pagliaro, Carman A. Giacomantonio, Carman A. Giacomantonio, Carman A. Giacomantonio

“….™ were intratumorally injected and activated using NIR light to induce mild hyperthermia (42–48°C) for 5 minutes. …”
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Indicators of Esophageal pH-Impedance Monitoring and High-Resolution Manometry in Patients with Various Forms of Gastroesophageal Reflux Disease by I. V. Maev, E. V. Barkalova, M. A. Ovsepyan, D. N. Andreev, Yu. A. Kucheryavyi

“…In patients with ERB and BE, normal motor activity was noted in 25 % and 29 % of the cases, respectively. …”
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CCAAT/Enhancer-Binding Protein β Mediates Oxygen-Induced Retinal Neovascularization via Retinal Vascular Damage and Vascular Endothelial Growth Factor by Tingting Li, Xuan Cai, Xiangning Wang, Xueyan Zhang, Hui Zhang, Biwei Xu, Shiwei Li, Jianyan Hu, Qiang Wu

“…A potential mechanism may be that the activity of C/EBP β increases with its overexpression, which in turn aggravates the amount of the retinal vascular damage and promotes transcription of VEGF. …”
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A head-to-head comparison of the adult EQ-5D-5L and youth EQ-5D-Y-5L in adolescents with idiopathic scoliosis by Joshua M. Bonsel, Charles M. M. Peeters, Max Reijman, Tim Dings, Joost P. H. J. Rutges, Diederik H. R. Kempen, Jan A. N. Verhaar, Gouke J. Bonsel

“…Ceiling was mostly comparable between EQ-5D’s, ranging from 78 to 81% for mobility and self-care, 52–54% for usual activities, and 31–36% for pain/discomfort. The EQ-5D-5L showed more ceiling (57%) compared to the EQ-5D-Y-5L (41%) on anxiety/depression (p = 0.006). …”
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Evolution of human genes encoding cell surface receptors involved in the regulation of appetite: an analysis based on the phylostratigraphic age and divergence indexes by E. V. Ignatieva, S. A. Lashin, Z. S. Mustafin, N. A. Kolchanov

“…Cell surface receptors are transmembrane proteins that interact with molecules (ligands) located outside the cell. This interaction activates signal transduction pathways in the cell. …”
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Growth performance and gut health of Murrah buffalo calves fed with developed novel synbi- otic formulation by Antony J. Thanippilly, Sachin Kumar, Vinay V. Varada, Nitin Tyagi, Ashish K. Samanta

“…Results indicated that inulin showed the highest (p<0.05) prebiotic index and prebiotic activity score by FOS, MOS, and dextrins; hence, inulin was chosen for synbiotic formulation with L. salivarius BF17. …”
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Cocktail of Ropivacaine, Morphine, and Diprospan Reduces Pain and Prolongs Analgesic Effects after Total Knee Arthroplasty: A Prospective Randomized Controlled Trial by Zhenyu Luo, Weinan Zeng, Xi Chen, Qiang Xiao, Anjing Chen, Jiali Chen, Haoyang Wang, Zongke Zhou

“…Group B had lower resting VAS pain scores (1.54 ± 0.60, 95% CI = 1.37 to 1.70 vs. 2.00 ± 0.63, 95% CI = 2.05 to 2.34) and active VAS pain scores (2.64 ± 0.62, 95% CI = 2.46 to 2.81 vs. 3.16 ± 0.75, 95% CI = 2.95 to 3.36) within 48 h postoperatively than Group A (P<0.001), while none of the pain differences exceeded the minimal clinically important difference (MCID). …”
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