The Complete Inpatient Record Using Comprehensive Electronic Data (CIRCE) project: A team‐based approach to clinically validated, research‐ready electronic health record data by Andrea L. C. Schneider, Jennifer C. Ginestra, Meeta Prasad Kerlin, Michael G. S. Shashaty, Todd A. Miano, Daniel S. Herman, Oscar J. L. Mitchell, Rachel Bennett, Alexander T. Moffett, John Chandler, Atul Kalanuria, Zahra Faraji, Nicholas S. Bishop, Benjamin Schmid, Angela T. Chen, Kathryn H. Bowles, Thomas Joseph, Rachel Kohn, Rachel R. Kelz, George L. Anesi, Monisha Kumar, Ari B. Friedman, Emily Vail, Nuala J. Meyer, Blanca E. Himes, Gary E. Weissman

“…Conclusions The CIRCE Project represents a novel cooperative research model to capture clinically validated EHR data from a large diverse academic health system in the greater Philadelphia region and is designed to facilitate collaboration and data sharing to support learning health system activities. Ultimately, these data will be de‐identified and converted to a publicly available resource.…”
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IFNβ drives ferroptosis through elevating TRIM22 and promotes the cytotoxicity of RSL3 by Huiyue Dong, Huiyue Dong, Ling Zhu, Ling Zhu, Jingjing Sun, Jingjing Sun, Qiuyan Chen, Qiuyan Chen, Pengyang Liu, Pengyang Liu, Wei Zhang, Huajing Zeng, Rong Lin, Rong Lin, Zongyang Yu, Zongyang Yu, Jun Lu, Jun Lu, Jun Lu, Jun Lu

“…The cGAS-STING signaling pathway-activated mice were used to evaluate the effects of IFNβ on ferroptosis in vivo. …”
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Analysis on the current situation of nursing undergraduates' innovation ability based on nursing basic experiment course after epidemic situation (疫情后基于《护理学基础实验》课程的护理本科生创新能力的现状分析)... by ZHANG Ying (张莹), LI Chunxiang (李春香), YAO Yihao (姚一浩), LI Zhaofan (李兆帆), WEN Shubo (温书博), CHEN Wenbo (陈文博)

“…The results of multiple regression analysis showed that the position, scientific research experience, willingness to participate in scientific research, active communication and attitude to nursing major were the main factors affecting the innovation ability of nursing major students affected by epidemic (P＜0. 05). …”
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Ibrutinib disrupts blood-tumor barrier integrity and prolongs survival in rodent glioma model by Sanghee Lim, Minhye Kwak, Jeonghan Kang, Melissa Cesaire, Kayen Tang, Robert W. Robey, William J. E. Frye, Baktiar Karim, Donna Butcher, Martin J. Lizak, Mahalia Dalmage, Brandon Foster, Nicholas Nuechterlein, Charles Eberhart, Patrick J. Cimino, Michael M. Gottesman, Sadhana Jackson

“…Expression of tight junction gene and protein expression was decreased maximally 4 h after administration, along with inhibition of efflux transporter, ABCB1, activity. We demonstrated an additive effect of ibrutinib with doxil on rat glioma cells, as seen by a significant reduction in cell viability (p < 0.001) and increased CNS doxil concentration in the brain (56 ng/mL doxil alone vs. 74.6 ng/mL combination, p < 0.05). …”
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Risk factors for ocular biological parameters in Chinese preschool children: a cohort study from the Beijing whole childhood eye study by Xi Qin, Yunyun Sun, Yunyun Sun, Shana Wang, Xiaolan Xie, Lei Gao, Huijian Li, Huijian Li, Ruihua Wei, Jing Fu, Jing Fu, Bidan Zhu

“…One-way analysis of variance, univariate analysis, and multiple linear regression models (with age, sex, height, weight, parental myopia, continuous near-work time, electronic products use, and outdoor activity time as variables) were used to compare the effects of different variables on the AL, CR, and AL/CR ratio.ResultsOverall, 1,353 participants (708 boys; mean age, 4.37 ± 0.82 years) were included in this study. …”
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Variations in Sources, Composition, and Exposure Risks of PM2.5 in both Pre-Heating and Heating Seasons by Dingyuan Yang, Zhiyong Li, Ziyuan Yue, Jixiang Liu, Zhen Zhai, Zelin Li, Minglei Gao, Ailian Hu, Wenjia Zhu, Ning Ding, Zhenxin Li, Songtao Guo, Xiangxue Wang, Lei Wang, Jihong Wei

“…PM2.5 concentrations (in µg m−3) increased from 69.1 in the PHS to 129 in the HS, reflecting the impacts of heating activities. Water-soluble ions dominated in terms of PM2.5, accounting for 32.0% in the PHS and 42.3% in the HS, respectively. …”
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How Uremic Toxins Alter Atorvastatin Disposition: Molecular Mechanisms of Inhibition of the Enzyme CYP3A4 by Ashna Asim, Fen Wang, Dong Pu, Sisi Wang, Dian Wang, Wenwen Li, Feng Yu, Li Ji

“…Conclusion: ATV metabolism could be significantly altered in the presence of uremic toxins, suggesting a downregulated effect on the ATV uptake, possibly through Oatp1b1, and also on the activity of CYP3A4 through the PXR/NF-κB signaling pathway.…”
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Single-nucleotide polymorphisms in genes associated with the vitamin D pathway related to clinical and therapeutic outcomes of American tegumentary leishmaniasis by Iara Barreto Neves Oliveira, Ramon Vieira Nunes, Vanessa Rafaela Milhomem Cruz Leite, Camila Freire Araújo, Murilo Barros Silveira, Sebastião Alves Pinto, Lorena Andrade Lamounier, Clayton Luiz Borges, Edésio Martins, Iane de Oliveira Pires Porto, Rodrigo Saar Gomes, Fátima Ribeiro-Dias

“…BackgroundThe vitamin D pathway contributes to the microbicidal activity of macrophages against Leishmania infection. …”
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Molecular Data Confirm the Occurrence of the Allochthonous <i>Gambusia holbrooki</i> (Pisces: Poeciliidae) in Sicily and the Maltese Archipelago by Luca Vecchioni, Mirko Liuzzo, Arnold Sciberras, Jeffrey Sciberras, Justin Formosa, Alan Deidun, Gabriele Giacalone, Vincenzo Arizza, Marco Arculeo, Federico Marrone, Francesco Paolo Faraone

“…A major threat to biodiversity is represented by Invasive Alien Species (IAS), particularly on freshwater ecosystems, which are already heavily altered by human activities. Two of the most pernicious IAS are the eastern and western mosquitofish, i.e., <i>Gambusia holbrooki</i> and <i>G</i>. …”
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A clinical study of the immunogenicity and protective potency of a live recombinant GamLPV vaccine for intranasal use for the prevention of whooping cough in adult volunteers by Alevtina A. Lidzhieva, Alisa Yu. Medkova, Sergey V. Kulikov, Ludmila N. Sinyashina, Rezida A. Sioundioukova, Andrey P. Markov, Aleksey B. Verveda, Natalia E. Abaeva, Irina N. Chernyshova, Marina V. Gavrilova, Kristina K. Bushkova, Ilya N. Dyakov, Gennady I. Karataev

“…A new live recombinant pertussis vaccine for intranasal use (GamLPV) has completed preclinical studies in experiments on nonhuman primates and 2 phases of clinical trials involving adult healthy volunteers, in which the safety, immunogenicity and protective activity of the GamLPV were proven. Method and scheme of vaccine administration have been worked out. …”
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Targeting of the G9a, DNMT1 and UHRF1 epigenetic complex as an effective strategy against pancreatic ductal adenocarcinoma by Daniel Oyon, Amaya Lopez-Pascual, Borja Castello-Uribe, Iker Uriarte, Giulia Orsi, Sofia Llorente, Jasmin Elurbide, Elena Adan-Villaescusa, Emiliana Valbuena-Goiricelaya, Ainara Irigaray-Miramon, Maria Ujue Latasa, Luz A. Martinez-Perez, Luca Reggiani Bonetti, Felipe Prosper, Mariano Ponz-Sarvise, Silvestre Vicent, Antonio Pineda-Lucena, David Ruiz-Clavijo, Bruno Sangro, Urko Aguirre Larracoechea, Tian V. Tian, Andrea Casadei-Gardini, Irene Amat, Maria Arechederra, Carmen Berasain, Jesus M. Urman, Matias A. Avila, Maite G. Fernandez-Barrena

“…CM272 exhibited potent antiproliferative activity in PDAC cell lines, inducing apoptosis and altering key metabolic and cell cycle-related genes. …”
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Association between left ventricular reverse remodelling and the B-type natriuretic peptide–cGMP cascade after anterior acute myocardial infarction by Satoshi Yasuda, Kunihiro Nishimura, Kensuke Takagi, Hiroyuki Takahama, Naoto Minamino, Masashi Fujino, Satoshi Honda, Yasuhide Asaumi, Yu Kataoka, Fumiyuki Otsuka, Soshiro Ogata, Teruo Noguchi, Takahiro Nakashima, Kenichiro Sawada, Yoshiaki Morita, Kazuhiro Nakao, Hiroyuki Miura, Takamasa Iwai, Marina Arai, Eri Kiyoshige, Kota Murai, Hideo Matama, Shuichi Yoneda

“…Multivariable analyses identified logarithmic proBNP and emBNP concentrations from 12 hours to 5 days post-AMI and logarithmic cGMP concentration from immediately post-PPCI to 3 days post-AMI as independent predictors of LVRR (p&lt;0.05).Conclusions Early-phase BNP-cGMP cascade activation might play a crucial role in LVRR in anterior AMI.…”
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Villa d’époque romaine et habitat médiéval à Mont-Saint-Jean (Sarthe) : bilan des recherches 2008-2020 by Florian Sarreste, Paul-André Besombes, Phaedra Bouvet, Chloé Genies, Étienne Jaffrot, Florian Jedrusiak, Thomas Jubeau, Anthony Ledauphin, Annaïg Le Martret, Christophe Loiseau, Hugo Meunier, Aurore Noël, Sandrine Paradis-Grenouillet, Boris Robin

“…Two successive workshops attest to forging activity on the site between the year 70 and the second half of the 2nd century. …”
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Modeling the experience of Iranian telecommunication company customers from commercial sales in line with their sustainability by Mohammad Karvand, Mahdi Mahmodzadeh, Hossein Hakimpour, Monireh Salehnia

“…The results showed that the categories and components that make up the customer experience in line with their sustainability consist of 9 categories and 26 elements including: operational prerequisites of customer experience management (strategic prerequisites, human prerequisites, and technical prerequisites), measurement and analysis of customer experience (collecting and recording customer experiences, analyzing customer experiences, interpreting customer experiences, and monitoring customer experience performance), service delivery experience (network quality, service delivery quality, and emotional effect), value co-creation (customer participation in value creation, service personalization, and customer relationship management), profitability (customer share, customer loyalty, and customer satisfaction), marketing mix (price, place, product, and promotion), brand image (brand reputation and social responsibility), supportive activities (complaint management and after-sales service), and barriers to brand switching (the nature of the company and switching costs). …”
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A Pattern for Iron Ore Mines Financing by Mehdi Ali Hosseini, Mohammad Hashem Botshekan, Amir Hossein Mozayani, Moslem Peymanifurushani

“…In revising the laws, attention should be paid to strengthening the monitoring of mineral activities and licenses in the Mining Law and its executive regulations. …”
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Presenting the model of customer participation with brands in social media with emphasis on cultural differences by Hamed Saghafian, Samad Aali, morteza mahmoodzadeh

“…The statistical population in the qualitative part includes 10 experts from the scientific community and academic specialists and experts of the top 500 companies in Iran based on the ranking of the Industrial Management Organization, who were selected purposefully; and in the quantitative part, it includes the managers of the top 500 companies in Iran based on the ranking of the industrial management organization, and the statistical sample will be selected from among the companies that have active accounts in social networks and considered as the statistical population; and based on Cochran's formula, 217 people were selected as a sample by random sampling method. …”
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Geoconservation in Latin America and the Caribbean by Maria Da Gloria Motta Garcia, Marcos Antonio Leite Do Nascimento

“…Moving forward to 2010, the landscape of geotourism activities unfolded with the I National Geotourism Congress held in Mérida, Venezuela, and the I Latin American and Caribbean Conference of Geoparks in Juazeiro do Norte, Brazil. …”
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Spatial Analysis of Factors Affecting the Formation of Smart Rural Tourism (Case Study: Tourism-Oriented Villages in Eastern Kermanshah Province) by Aliakbar Anabestani, Sajjad Barani Aliakbari

“…Some villages, such as Gara Ban, had gained global recognition and were home to a sect called Ahl-e Haqq Atash Beige or Mashayekhi, who had been actively working to build, maintain, and develop the location using the resources and assistance of their followers. …”
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Presenting the model of recruitment and selection of human resources of the public sector with the approach of the entrepreneurial government by Atieh sarayani, Vahid pourshahabi, Nourmohammad yaghobi, Amin reza kamaliyan

“…Specifically, such activities should create a pool of desirable candidates; increase their interest and attraction to the organization as an employer, and increase the likelihood that they will accept a job offer (Teimouri et al, 2018). …”
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Designing a model of institutionalization of organizational culture based on synergy in the tourism holding of Parsian Hotels Group by Behnam Rahemi, Majid Jahangirfard, Farshad Hajalian

“…Organizations must govern a culture in which employees find the necessary motivation and ability to carry out and continue the activity, and by feeling a sense of belonging to their organization, they can provide reasons for the organization's stability and effectiveness. …”
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