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50041
Safety profiles of IDH inhibitors: a pharmacovigilance analysis of the FDA Adverse Event Reporting System (FAERS) database
Published 2025-02-01“…AEs were standardized and classified according to the preferred term (PT) and system organ classification (SOC) in the Medical Dictionary for Regulatory Activities (MedDRA) version 26.0. Disproportionality analyses including the reporting odds ratio and the Bayesian confidence propagation neural network were performed in data mining to assess IDH inhibitor-relatedAEs. …”
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50042
AGD1/USP10/METTL13 complexes enhance cancer stem cells proliferation and diminish the therapeutic effect of docetaxel via CD44 m6A modification in castration resistant prostate can...
Published 2025-01-01“…Additionally, this process activates the pSTAT3/PI3K-AKT signaling pathway. Organoid models and liposomal-chitosan nanocomplex drug delivery systems showed that reducing AGD1 expression enhanced the therapeutic effect of docetaxel in CRPC. …”
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50043
Energy management education for persons living with long COVID-related fatigue (EMERGE): protocol of a two-parallel arms target trial emulation study in a multicentre outpatient in...
Published 2025-02-01“…Four self-reported questionnaires (fatigue impact, self-efficacy in performing energy management strategies, competency in performing daily activities, health-related quality of life) will be administered at baseline (T0; week 0), after lesson 7 (T1; week 6), post-intervention (T2; week 14) and follow-up (T3, week 24). …”
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50044
Therapeutic Effect of Human Umbilical Cord Mesenchymal Stem Cells at Various Passages on Acute Liver Failure in Rats
Published 2018-01-01“…P5 hUC-MSCs also successfully downregulated the hepatic activity index (HAI) scores. Compared to P10 hUC-MSCs in vivo, P5 hUC-MSCs significantly enhanced the regeneration and inhibited the apoptosis of hepatocytes. …”
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50045
Presenting a Leadership Empowerment Model through Sense-making by Using the Cognitive and Behavioral Scripts
Published 2024-06-01“…In this extensive study, a total of 111 randomly selected groups operating at various organizational levels within companies active in the pharmaceutical industry were meticulously examined to gather a broad spectrum of insights. …”
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50046
Korelasi Kadar Hemoglobin dengan Kadar Nitric Oxide pada Preeklamsia dan Kehamilan Normal
Published 2015-09-01“…<br />Kata kunci: hemoglobin, nitric oxide, preeklamsia, kehamilan normal</p><p> </p><p>Abstract <br />Endothelial cell activation or dysfunction becomes a major factor pathogenesis of preeclampsia. …”
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50047
Evaluating Whether Nonimmersion Virtual Reality Simulation Training Improves Nursing Competency in Isolation Wards: Randomized Controlled Trial
Published 2025-01-01“…Although NIVR simulation training does not significantly surpass traditional methods in imparting theoretical knowledge, it does reduce task completion time for specific activities. Its capacity for safe, repetitive practice and realistic scenario simulation makes NIVR a valuable tool in medical education. …”
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50048
Pengembangan Game Edukasi Bilomatika untuk Meningkatkan Hasil Belajar Siswa pada Mata Pelajaran Matematika Kelas 1 SD
Published 2019-12-01“…This study aims to develop an educational game called "Bilomatika", an educational game that contains material of Numbers for first grade of elementary students, so that it can be used as a medium in learning activities. The method used in this study is Research and Development (R & D) with a model of Waterfall. …”
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50049
Agronomic characteristics, mineral nutrient content, antioxidant capacity, biochemical composition, and fatty acid profile of Iranian pistachio (Pistacia vera L.) cultivars
Published 2025-01-01“…Total phenolic content varied from 99.9 (‘Rezaei’) to 184.30 mg/g (‘Fandoghi’), and antioxidant activity ranged from 39.14 (‘Shahpasand’) to 82.89% (‘Sefied’). …”
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50050
PLL-g-HPA Hydrogel Loaded Human Umbilical Cord Mesenchymal Stem Cells Promote Burn Wound Healing in Rat Model by Regulating Inflammation Response
Published 2025-01-01“…The cytotoxicity to human foreskin fibroblasts (HFF) were assessed by CCK-8 assay and live/dead quantification and antibacterial activity against Escherichia coli and Staphylococcus aureus was also detected by colony forming unit. …”
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50051
Explainable machine learning for modeling of net ecosystem exchange in boreal forests
Published 2025-01-01“…Using explainable artificial intelligence methods, we show that the most important input variables during the peak season are photosynthetically active radiation, diffuse radiation, and vapor pressure deficit (or air temperature), whereas, on the whole-year scale, vapor pressure deficit (or air temperature) is replaced by soil temperature. …”
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50052
Effect of stocking density on growth performance of African catfish Clarias gariepinus and water spinach Ipomoea aquatica in aquaponics systems with the addition of AB mix nutrient
Published 2023-03-01“…One of the obstacles in aquaponic activities is that vegetable growth is not optimal due to a lack of dissolved nutrients, so further research is needed to make better plant growth. …”
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50053
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50054
Performance evaluation model of the narrators of Rahian Noor camps.
Published 2025-02-01“…In addition, based on this response, four categories of questionnaires were prepared for different groups (pilgrims, caravan managers, memorial servants, and memorial officials) and finally, a model was presented to evaluate the narrators' performance step by step.Originality/Value: This research is conducted for the first time in the field of Rahian Noor camps, and considering the structural differences with other organizations, including the honorary nature of the narrators and their voluntary activities, it has an innovative and practical structure. …”
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50055
Impact of Methotrexate and 7‐Hydroxymethotrexate Exposure on Renal Toxicity in Pediatric Non‐Hodgkin Lymphoma
Published 2025-01-01“…ABSTRACT Background 7‐Hydroxymethotrexate (7‐OHMTX) is the main metabolite in plasma following high‐dose MTX (HD‐MTX), which may result in activity and toxicity of the MTX. Moreover, 7‐OHMTX could produce crystalline‐like deposits within the renal tubules under acidic conditions or induce renal inflammation, oxidative stress, and cell apoptosis through various signaling pathways, ultimately leading to kidney damage. …”
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50056
The effects of contralateral limb cross-education training on post-surgical rehabilitation outcomes in patients with anterior cruciate ligament reconstruction: a randomized control...
Published 2025-01-01“…The Lysholm score, range of motion (ROM), and surface electromyographic activity of the rectus femoris muscle were significantly higher in the experimental group compared to the control group (P < 0.01). …”
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50057
Reflexões após 3 anos: relatando o desabrochar de reumatologistas através de atividades profissionais confiabilizadoras.
Published 2025-02-01“…RESUMO Introdução: As 14 atividades profissionais confiabilizadoras (entrustable professional activities -EPA) aprovadas pelo American College of Rheumatology (ACR) foram desenvolvidas para serem “o conjunto abrangente de tarefas ou responsabilidades que qualquer reumatologista deve ser capaz de executar”. …”
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50058
Bentonite-Amended Geo-Polymerised Fly Ash-GGBS Mixture for Waste Containment Applications
Published 2025-01-01“…Geopolymerisation is done through the incorporation of alkali and is known to enhance pozzolanic activity by converting part of silica to reactive silica, producing more pozzolanic compounds and part modification of pozzolanic reaction compounds. …”
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50059
Protein Level and Infantile Diarrhea in a Postweaning Piglet Model
Published 2020-01-01“…In addition, the Adenosine 5′-monophosphate (AMP)-activated protein kinase (AMPK) signaling pathway (P<0.01) was inhibited in the HP group. …”
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50060
Estates in Slavonia after World War II: Confiscation of the property of Slavonian nobility after World War II
Published 2024-01-01“…The main accusation against the owners of these economic entities was the alleged collaboration with the enemy, although they had only been conducting their regular economic activities during World War II. Using examples of individual Slavonian noble families, we will illustrate how this process took place in everyday court practice. …”
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