-Tyrosine Confers Residualizing Properties to a -Amino Acid-Rich Residualizing Peptide for Radioiodination of Internalizing Antibodies by Fook T. Lee PhD, Ingrid J. G. Burvenich PhD, Nancy Guo MBBS, MSc, Pece Kocovski BSc (Honors), Henri Tochon-Danguy PhD, Uwe Ackermann PhD, Graeme J. O’Keefe PhD, Sylvia Gong PhD, Angela Rigopoulos BSc, MSc, Zhanqi Liu MBBS, PhD, Hui K. Gan MBBS, FRACP, PhD, Andrew M. Scott MBBS, FRACP, MD

“…Results: Biodistribution studies using xenografts at 72 hours post injection showed that 131 I-PEG 4 -tptddYddtpt-ch806 tumor uptake was similar to 111 In-CHX-A″-DTPA-ch806. 125 I-PEG 4 -tptddyddtpt-ch806 showed a lower tumor uptake value but higher than directly labeled 125 I-ch806. 124 I-PEG 4 -tptddYddtpt-ch806 was produced at 23% labeling efficiency, 98% radiochemical purity, 25.9 MBq/mg specific activity, and 64% cell binding in the presence of antigen excess. …”
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Intravesical BCG in patients with non-muscle invasive bladder cancer induces trained immunity and decreases respiratory infections by J Alfred Witjes, Alina Vrieling, Mihai G Netea, Leo A B Joosten, Katja K H Aben, Sita H Vermeulen, Joost L Boormans, Antoine G van der Heijden, Boris Novakovic, Jelmer H van Puffelen, Liesbeth van Emst, Denise Kooper, Tahlita C M Zuiverloon, Ursula T H Oldenhof, Tessel E Galesloot, Lambertus A L M Kiemeney, Egbert Oosterwijk

“…An epigenomics approach combining chromatin immuno precipitation-sequencing and RNA-sequencing with in vitro trained immunity experiments identified enhanced inflammasome activity in BCG-treated individuals. Finally, germline variation in genes that affect trained immunity was associated with recurrence and progression after BCG therapy in NMIBC.Conclusion We conclude that BCG immunotherapy induces trained immunity in NMIBC patients and this may account for the protective effects against respiratory infections. …”
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Peptide-based vaccine targeting IL17A attenuates experimental spondyloarthritis in HLA-B27 transgenic rats by Tetsuya Tomita, Hiromi Rakugi, Hiroki Hayashi, Ryuichi Morishita, Jiao Sun, Yuka Yanagida, Shota Yoshida, Satoshi Baba, Akiko Tenma, Masayoshi Toyoura, Sotaro Kawabata, Takako Ehara, Ryoko Asaki, Makoto Sakaguchi, Hideki Tomioka, Munehisa Shimamura, Hironori Nakagami

“…Enzyme-linked immunospot (ELISpot) assays for IL4- and interferon-γ-secreting splenocytes were conducted to evaluate IL17A-specific T cell activation. We also evaluated the effect of IL17A vaccine in SpA therapeutic model.Results The IL17A peptide-based vaccine with alum adjuvant successfully induced antibody production and suppressed the arthritis score and joint thickness. …”
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Surface functionalization of titanium implants with controlled-release glutathione conjugate for antioxidant and osteogenesis by Huichuan Xu, Kosuke Nozaki, Ziniu Yu, Nobuyuki Kawashima, Takeshi Ueno, Huaze Wu, Hao Wu, Noriyuki Wakabayashi

“…Moreover, VPA-GSH-treated Ti surfaces facilitated alkaline phosphatase activity and extracellular matrix (ECM) mineralization. …”
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PARP-1 Is Critical for Recruitment of Dendritic Cells to the Lung in a Mouse Model of Asthma but Dispensable for Their Differentiation and Function by Laura C. Echeverri Tirado, Mohamed A. Ghonim, Jeffrey Wang, Amir A. Al-Khami, Dorota Wyczechowska, Hanh H. Luu, Hogyoung Kim, Maria Dulfary Sanchez-Pino, José Yélamos, Lina M. Yassin, A. Hamid Boulares

“…PARP-1 expression and activity were also required for VCAM-1 in differentiated DCs. …”
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Application of case-based learning combined with problem-based learning in standardized training of cerebrospinal fluid drainage (CBL结合PBL教学模式在脑脊液外引流规范化培训中的应用)... by YIN Yating (殷亚婷), ZHEN Qin (郑琴), LIU Fang (刘芳), CHEN Lishan (陈丽珊), XUE Qiang (薛强)

“…It is able to inspire the nurses' initiative to learn, participate and interact actively. (目的 探讨以案例为基础的学习(CBL)结合以问题为基础的学习(PBL)教学模式在脑脊液引流规范化培训中的应用效果。…”
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The SUPERCOLD-CGM Survey. II. [C i](1–0) Emission and the Physical Conditions of Cold Gas in Enormous Lyα Nebulae at z ∼ 2 by Jianan Li, Bjorn H. C. Emonts, Zheng Cai, Jianrui Li, Ran Wang, Montserrat Villar-Martín, Fabrizio Arrigoni Battaia, Mingyu Li, Yunjing Wu, Ilsang Yoon, Matthew D. Lehnert, Kyle Massingill, Craig Sarazin, Jason X Prochaska, Mark Lacy, Brian Mason

“…Our sample also includes a radio-detected active galactic nuclei, Q1416+2649, which shows [C i ](1–0) and CO(4−3) luminosities an order of magnitude fainter for its far-infrared luminosity than other QSOs in our sample, possibly due to a lower molecular gas mass.…”
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Investigating The Performance Of Local And Indigenous Businesses In Times Of Economic Recession With Emphasis On Developing The Capabilities Of Cooperatives In Sistan And Baluchest... by Ali Asghar Tabavar, Abdoulnaser Derakhshan, Sahar Arefi

“…A more general definition of economic recession is a significant decrease in activity in the entire economy that lasts at least a few months. …”
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Designing a model for fostering organizational resilience based on organizational agility components by Heidar kadivar zinkanloo, gholamabbas shekari, saeed emamgholizadeh

“…Zyhier (2023) showed that the effect of cognitive retention on critical thinking is positive and significant.In line with the obtained results, the following suggestions are presented:1- It is suggested to provide an environment for students to plan their learning activities and have self-direction in learning, as well as to have a flexible learning environment so that students can have cognitive order and to reduce cognitive dissonance.2- Strengthening inference and analysis skills in order to strengthen the spirit of criticism and questioning among students.…”
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The relationship between cognitive dissonance, scientific reasoning and systemic thinking with the academic progress of Babol University physics students with the mediating role of... by Akram Kamel Zaherolmahni, Mohammad hassani, Hasan ghalavandi

“…In line with the obtained results, the following suggestions are presented: 1- It is suggested to provide an environment for students to plan their learning activities and have self-direction in learning, as well as to have a flexible learning environment so that students can have cognitive order and to reduce cognitive dissonance. 2- Strengthening inference and analysis skills in order to strengthen the spirit of criticism and questioning among students.…”
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Identifying the factors affecting the growth of the employees of the country's property and documents registration organization by Najmeh Ahmadi, Kolsoum Nami, Nader Ghourchian, Parivash Jafari

“…Saberi Nasrabad Sefali et al, (2022) showed that the components of employee growth (leadership actions, employee participation, accessibility, and training of employees and learning capacity) have a positive and significant relationship with employee productivity; therefore, the management of the university should make more efforts and activities to increase the productivity of the employees in order to improve the growth components of the employees. …”
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Presenting a merit-oriented service compensation system model for veterans in sports by Hoseain Aeinehchi, Mohammad reza Esmaeilzadeh Ghandehari, Hoseain peymanizad, Hasan Fahim Davin

“…A proper compensation management system helps business owners and managers to significantly boost employee performance by having a more active and motivated workforce (Mabaso, 2018). Service compensation has one of the most vital effects on the quality of work and the effectiveness of human capital. …”
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Explanation and validation of the coordination model of the marketing and sales department in the insurance industry in Iran by Alireza Jahed, Ehsan Abedi, Hamidreza Saeednia

“…Biemans et al, (2022) showed that there are different relationships between marketing and sales departments in different work areas, and coordinating the activities of these two departments can help the organization to achieve its goals. …”
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Presenting the entrepreneurship development model in the national oil refining industry with the approach of environmental damage prevention by Jalal Abdi, Reza Yousefi Saeedabadi, Maryam Taghvaee Yazdi

“…Economic growth and development of countries depends on entrepreneurs and entrepreneurial activities. Therefore, the development of entrepreneurship is necessary to achieve economic development and progress of countries (Zali & Razavi, 2016). …”
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Investigating causal relationships between entrepreneurial education and sustainable employment generation in Islamic Azad Universities in Tehran by Sana Abdulali, Mohammad Naghi Imani GelepordesariI, Asghar Sharifi

“…Third, there is a two-way Granger causality between entrepreneurial activity and employment rate, which indicates a dynamic interaction between entrepreneurship and employment. …”
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Editorial by Joanna Krasodomska, Nadia Albu, Anna Szychta

“…The authors argue that harmonizing reporting standards and fostering active stakeholder engagement are crucial for enhancing the quality and consistency of sustainability disclosures. …”
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Perceived effects of the hidden curriculum of return to entrepreneurship with the mediation of goal orientation by Ahmad KarimiDashtaki, Mohammadbagher Akbarpour Zangalani

“…Goal orientation refers to a set of behavioral intentions that explain a person's attitude to participate in learning activities. In other words, goal orientation expresses a coherent pattern of a person's beliefs, which causes a person to approach situations in different ways, engage in activities in that field, and finally provide an answer (Ames, 1992). …”
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Should the Food and Drug Administration Limit Placebo-Controlled Trials? by Max Goodman, Connor Pedersen

“…Placebo-only-controlled versus active-controlled trials of new drugs for nine common life-threatening diseases. …”
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Determinants of continuation on HIV pre-exposure propylaxis among female sex workers at a referral hospital in Uganda: a mixed methods study using COM-B model by Samuel Kawuma, Rodgers Katwesigye, Happy Walusaga, Praise Akatukunda, Joan Nangendo, Charles Kabugo, Moses R. Kamya, Fred C. Semitala

“…Results Of the 292 FSWs initiated on PrEP, median age was 26 years (interquartile range, 21–29), 101 (34.6) % were active on PrEP, 137 (46.9%) were lost to follow-up, 45 (15.4%) were no longer eligible to continue PrEP, eight (2.7%) were transferred out and one (0.3%) had died. …”
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Designing a Policy Making Model in Iran' Sport with the Approach of Sport for All Development by Behdad Sadeghi, Rahmatollah Gholipour, Mojtaba Amiri, Marjan Saffari

“…Therefore, it is recommended to implement a national physical activity monitoring plan based on a comprehensive and electronic system. …”
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