TYRO3 blockade enhances anti-PD-1 therapy response by modulating expression of CCN1 in tumor microenvironment by Miso Park, Da-Sol Kuen, Keon Wook Kang, Yeonseok Chung, Jaewoo Park, Munkyung Choi, Yeonji Kim, Eun Chae Roh, Yong June Choi, Yoon Gyoon Kim, Sung Yun Cho

“…CCN1 overexpression in MC38 tumors diminishes responsiveness to anti-PD-1 therapy.Conclusions The activated TYRO3-CCN1 axis in cancer could dampen anti-PD-1 therapy responses. …”
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Transforming the Health Research Workforce in Mozambique: Achievements of the Mozambique Institute for Health Education and Research (MIHER) over a 13-Year Journey by Emília Virgínia Noormahomed, Sérgio Noormahomed, Matchecane Cossa, Nicole Joyce, Regina Daniel Miambo, Irina Mendes Sousa, Noémia Nhacupe, Tufária Mussá, Jahit Sacarlal, Lídia Gouveia, Luís Jorge Ferrão, Carla Carrilho, Mamudo Ismail, Davey Smith, Natasha K. Martin, Ravi Goyal, Kim E. Barrett, Sónia Santana Afonso, Amélia Mandane, Alarquia Saíde, Pompílio Vintuar, Brígida Singo, Boaventura Aleixo, Luck Injage, Elizabeth A. Winzeler, Paulo Correia-de-Sá, Maria do Rosário Oliveira Martins, Paulo Ferrinho, Sam Patel, Ana Olga Mocumbi, Stephen W. Bickler, Constance A. Benson, Roberto Badaró, Robert T. Schooley

“…Methods: Using mixed methods, data were comprehensively collected to identify MIHER’s primary achievements from 2010 to 2023. The activities took place in four public universities, five training institutions for healthcare workers, and 40 public healthcare units in Mozambique. …”
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Clinical efficacy of Tuina therapy combined with traditional Chinese exercises in the treatment of symptomatic lumbar disc herniation: a multicentre randomised controlled trial pro... by Zhihong Fan, Shenghong Jia, Xin Zhou, Chao Li, Jiahao Shao, Xiaofeng Liu, Yitao Liao, Yenan Xu, Dandan He, Shixiang Wu, Xian Zhang

“…Tuina and traditional Chinese exercises (TCEs) are effective in relieving pain and restoring dysfunction, and both are often used in China as a combination of passive therapy and active exercise to ease symptoms in patients with LDH. …”
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Machine learning-based identification and validation of amino acid metabolism related genes as novel biomarkers in chronic kidney disease by Guoqing Zhang, Hongyan Luo, Xiaohua Lu, Yonghua Liu, Mei Wang, Bo Li, Haixia Lu, Yali Zheng

“…Immune cells such as Activated CD4+ T cells, Regulatory T cells, Immature B cells and MDSC,etc.infiltrated differentially in the high and low risk groups of CKD. …”
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Pembrolizumab, radiotherapy, and an immunomodulatory five-drug cocktail in pretreated patients with persistent, recurrent, or metastatic cervical or endometrial carcinoma: Results... by Emiel A. De Jaeghere, Sandra Tuyaerts, An M. T. Van Nuffel, Ann Belmans, Kris Bogaerts, Regina Baiden-Amissah, Lien Lippens, Peter Vuylsteke, Stéphanie Henry, Xuan Bich Trinh, Peter A. van Dam, Sandrine Aspeslagh, Alex De Caluwé, Eline Naert, Diether Lambrechts, An Hendrix, Olivier De Wever, Koen K. Van de Vijver, Frédéric Amant, Katrien Vandecasteele, Hannelore G. Denys

“…In conclusion, PRIMMO did not meet its primary objective in both cohorts; pembrolizumab, radiotherapy, and an IDC had modest but durable antitumor activity with acceptable but not negligible toxicity. …”
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Weight loss for overweight and obese patients with prostate cancer: a study protocol of a randomised trial comparing clinic-based versus Telehealth delivered EXercise and nutrition... by Robert U Newton, Daniel A Galvão, Dennis R Taaffe, Suzanne K Chambers, David Joseph, Amanda Devine, Colin I Tang, Nigel Spry, Emily Jeffery, Dickon Hayne, Pedro Lopez, P Lyons-Wall, Christine Kudiarasu

“…Secondary endpoints include lean mass and abdominal aortic calcification, anthropometric measures and blood pressure assessment, objective measures of physical function and physical activity levels, patient-reported outcomes and blood markers. …”
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Sources and Health Risks of PM2.5-bound PAHs in a Small City along with the “Clean Heating” Policy by Zhiyong Li, Ziyuan Yue, Jixiang Liu, Zhen Zhai, Jianwei Meng, Lei Wang, Jihong Wei, Dingyuan Yang, Ailian Hu, Wenjia Zhu, Ning Ding, Xiaoxia Lu, Chunhao Lin

“…From the PHS to the HS, the mean concentrations for both PM2.5 and ∑18PAHs increased from 69.1 to 125.0 µg m–3 and from 8.09 to 26.2 ng m–3 due to the heating activities. The far lower PAHs in this study than those of small cities before CH implementation indicated the CH effectiveness. …”
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Evaluation of the Effects of Degradable Mulching Film on the Growth, Yield and Economic Benefit of Garlic by Jiangping Song, Huixia Jia, Yang Wang, Xiaohui Zhang, Wenlong Yang, Tingting Zhang, Naijian Wang, Jianqiang Yang, Haiping Wang

“…In comparison to PEM 0.008 mm, the application of BDMs 0.006 mm and 0.008 mm significantly enhanced potassium availability in the soil. Furthermore, the activities of catalase, phosphatase, and invertase were notably increased under the BDM 0.008 mm, suggesting that this type of mulch could improve the physicochemical properties of the soil. …”
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Binding of LncDACH1 to dystrophin impairs the membrane trafficking of Nav1.5 protein and increases ventricular arrhythmia susceptibility by Genlong Xue, Jiming Yang, Yang Zhang, Ying Yang, Ruixin Zhang, Desheng Li, Tao Tian, Jialiang Li, Xiaofang Zhang, Changzhu Li, Xingda Li, Jiqin Yang, Kewei Shen, Yang Guo, Xuening Liu, Guohui Yang, Lina Xuan, Hongli Shan, Yanjie Lu, Yang Baofeng, Zhenwei Pan

“…The conservative fragment of lncDach1 inhibited membrane distribution of dystrophin and Nav1.5, and promoted the inducibility of ventricular arrhythmia. Strikingly, activation of Dystrophin transcription by dCas9-SAM system in lncDach1-TG mice rescued the impaired membrane distribution of dystrophin and Nav1.5, and prevented the occurrence of ventricular arrhythmia. …”
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Synergistic effects of allantoin and Achyranthes japonica-biochar profoundly alleviate lead toxicity during barley growth by Ghulam Murtaza, Najmaldin Ezaldin Hassan, Muhammad Usman, Gang Deng, Zeeshan Ahmed, Javed Iqbal, Mohamed S. Elshikh, Humaira Rizwana, Basharat Ali, Rashid Iqbal, Maximilian Lackner

“…Likewise, these amendments significantly (p < 0.05) improved the activity of antioxidant enzymes, including SOD, POD, and CAT by 49 %, 29 %, and 49 %, respectively. …”
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Based on bioinformatics, SESN2 negatively regulates ferroptosis induced by ischemia reperfusion via the System Xc−/GPX4 pathway by Jiejie Hu, Lijun Qin, Guoqiang Zhu, Jingjing Ren, Hongxia Wang, Jing Jin, Haixue Zheng, Dan Li, Zhaoming Ge

“…Enhancing the expression of SESN2 can alleviate ferroptosis through the activation of the System Xc−/GPX4 pathway. By integrating bioinformatics analysis with mechanistic exploration, this study revealed that ferroptosis plays a crucial role in IR-induced BMVECs injury, with SESN2 acting as a negative regulator via the System Xc−/GPX4 pathway.…”
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Effect of TNF-α-Induced Sclerostin on Osteocytes during Orthodontic Tooth Movement by Fumitoshi Ohori, Hideki Kitaura, Aseel Marahleh, Akiko Kishikawa, Saika Ogawa, Jiawei Qi, Wei-Ren Shen, Takahiro Noguchi, Yasuhiko Nara, Itaru Mizoguchi

“…Osteocytes express receptor activator of nuclear factor kappa-B ligand (RANKL) and regulate osteoclast formation. …”
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High spatial resolution gene expression profiling and characterization of neuroblasts migrating in the peri-injured cortex using photo-isolation chemistry by Takuya Miyamoto, Kazuya Kuboyama, Mizuki Honda, Mizuki Honda, Yasuyuki Ohkawa, Shinya Oki, Shinya Oki, Kazunobu Sawamoto, Kazunobu Sawamoto

“…These data suggest that the proliferative activity of neuroblasts migrating toward lesions is suppressed by TGF-β secreted from cells surrounding the lesion. …”
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Linking weather and climate information services (WCIS) to Climate-Smart Agriculture (CSA) practices by Tafadzwanashe Mabhaudhi, Tinashe Lindel Dirwai, Cuthbert Taguta, Aidan Senzanje, Wuletawu Abera, Ajit Govid, Elliott Ronald Dossou-Yovo, Ermias Aynekulu, Vimbayi Grace Petrova Chimonyo

“…Results: The results revealed that seasonal forecasts were the main WCIS available to farmers who utilised them to plan predominantly for irrigation and water harvesting activities. Daily forecasts were linked to practices such as irrigation. …”
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Candidiasis mucocutánea crónica, infecciones micobacterianas y rosácea en un adulto mexicano con aumento de la función en STAT1 by Valeria Valerio-Gómez, Uriel Pérez-Blanco, Guillermo Velázquez-Sámano, Andrea Aída Velasco-Medina, Antonio Albarrán, Itzel Yoselín Sánchez, Laura Berrón-Ruiz, Sara Espinosa-Padilla, Lizbeth Blancas-Galicia

“…El STAT1 (Signal Transducer and Activator of Transcription 1) es un factor de transcripción citoplasmático, cuya función es la regulación del crecimiento, la diferenciación, la proliferación, el metabolismo y la apoptosis celular. …”
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Combining In Vitro, In Vivo, and In Silico Approaches to Explore the Effect of <i>Ceratonia siliqua</i> and <i>Ocimum basilicum</i> Rich Phenolic Formula on Lipid Metabolism and Pl... by Mohammadine Moumou, Amani Tayebi, Abderrahmane Hadini, Omar M. Noman, Abdulsalam Alhalmi, Hamza Ahmoda, Souliman Amrani, Hicham Harnafi

“…Methods: The phenolic composition was determined using HPLC-DAD analysis. The antioxidant activity was studied using various in vitro methods. …”
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Multidimensional analysis and enhancement strategies for ecological environment quality at the county level under dual carbon goals: a case study of Shaanxi Province, China by Jianfeng Li, Jianfeng Li, Jianfeng Li, Yongxin Hu, Yongxin Hu, Jian Li, Liangyan Yang, Liangyan Yang, Jie Yan

“…However, most studies on ecological environment quality (EEQ) focus on urban areas, with limited attention to county-level analyses, particularly regarding the complex interactions between climate, topography, and human activities. This study aims to address this gap by investigating the spatiotemporal evolution and multidimensional driving factors of EEQ in 107 counties of Shaanxi Province, China. …”
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Ablation of IGFBP5 expression alleviates neurogenic erectile dysfunction by inducing neurovascular regeneration by Jiyeon Ock, Guo Nan Yin, Fang-Yuan Liu, Yan Huang, Fitri Rahma Fridayana, Minh Nhat Vo, Ji-Kan Ryu

“…Finally, western blot analysis demonstrated that IGFBP5 ablation attenuated the JNK/c-Jun signaling pathway, activated the PI3K/AKT signaling pathway, and increased vascular endothelial growth factor and neurotrophic factor expression. …”
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Clinical significance of HER2 in urothelial carcinoma and analysis of its correlation with glycolytic metabolic characteristics by Andong Guo, Andong Guo, Chenrui Wu, Jishuang Cao, Kejia Zhu, Kejia Zhu, Sentai Ding, Sentai Ding

“…A significant correlation was found between positive HER2 status, advanced tumor stages, and increased LDH levels, suggesting a link between HER2 expression and heightened glycolytic activity. No significant relationships were observed between HER2 status and TyG levels, HOMA-IR, or HOMA-B. …”
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The Importance of Antimicrobial Strategies Associated with Clinical Cure and Increased Microbiological Eradication in Patients with Complicated Urinary Tract Infections and High Ri... by José Medina Polo, Jose Luis Alfonso Sánchez, Jorge Arca-Suárez, Ángel Estella, Pablo González, Martí Blasco, Alicia Gil, Leonor del Mar Periañez Párraga, Francisco Javier Membrillo de Novales

“…Conclusions and clinical implications: Selection of active antimicrobial agents associated with increased microbiological eradication should be prioritised in patients with cUTIs and a high risk of relapse. …”
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