Gene networks for use in metabolomic data analysis of blood plasma from patients with postoperative delirium by V. A. Ivanisenko, N. V. Basov, A. A. Makarova, A. S. Venzel, A. D. Rogachev, P. S. Demenkov, T.  V. Ivanisenko, M. A. Kleshchev, E. V. Gaisler, G. B. Moroz, V. V. Plesko, Y. S. Sotnikova, Y. V. Patrushev, V. V. Lomivorotov, N. A. Kolchanov, A. G. Pokrovsky

“…Complementing this, an additional assembly of 35 regulators are considered to be regulators of activity, degradation, and translocation dynamics of enzymes integral to the aforementioned pathway. …”
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Effects of soil water on fungal community composition along elevational gradients on the northern slope of the Central Kunlun Mountains by Yongguang Zhang, Yongguang Zhang, Chaonan Li, Zhihao Zhang, Chenhong Li, Bo Zhang, Hongchen Jiang, Waqar Islam, Xiangzhen Li, Fanjiang Zeng

“…Soil fungi are essential to ecosystem processes, yet their elevational distribution patterns and the ecological mechanisms shaping their communities remain poorly understood and actively debated, particularly in arid regions. Here, we investigated the diversity patterns and underlying mechanisms shaping soil fungal communities along an elevational gradient (1,707–3,548 m) on the northern slope of the Central Kunlun Mountains in northwest China. …”
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Vertical distribution and variability of soil organic carbon and CaCO3 in deep Colluvisols modeled by hyperspectral imaging by Jessica Reyes-Rojas, Julien Guigue, Daniel Žížala, Vít Penížek, Tomáš Hrdlička, Petra Vokurková, Aleš Vaněk, Tereza Zádorová

“…The acceleration of soil erosion in undulating landscapes due to human activities has led to a larger area of land being affected by intensive soil redistribution. …”
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An interval bilateral regulation framework of water resources supply and demand in irrigation area under water sources uncertainty by Zhan Shu, Yan Kang, Ying Gao, Xuemai Shi, Wanxue Li, Shuo Zhang, Songbai Song, Lingjie Li

“…Climate change and human activities have diminished the stability of the water resources system, leading to multiple uncertainties in the prediction of incoming water, reservoir operation optimization on the water supply side, and adaptive adjustments of the water-use structure on the water demand side. …”
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Genotype-driven sensitivity of mice to tick-borne encephalitis virus correlates with differential host responses in peripheral macrophages and brain by Michaela Berankova, Jiri Holoubek, Vaclav Hönig, Zuzana Matusova, Martin Palus, Jiri Salat, Imtissal Krayem, Jarmila Vojtiskova, Pavel Svoboda, Veronika Pranclova, Lukas Valihrach, Peter Demant, Marie Lipoldova, Daniel Ruzek

“…Macrophages from both sensitive strains demonstrated elevated chemokine and proinflammatory cytokine production upon infection, whereas the resistant strain, STS, showed no cytokine/chemokine activation. Transcriptomic analysis of brain tissue demonstrated that the genetic background of the mouse strains dictated their transcriptional response to infection. …”
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Effectiveness of a nurse-led coaching in self-care intervention for elderly undergoing total laryngectomy: a randomised controlled trial by Yan Liu, Lai Wei, Xue Li, Jian Chen, Huifen Wang, Liyuan Zheng, Shu'e Liu, Danxia Peng, Sanxia Ye, Yuchen Lu, Zhidan Mei, Chun Xu

“…No adverse events (AEs) were observed in either group.Conclusion Nurse-led SC intervention for elderly patients with TL is an effective strategy that can bring multidimensional benefits, including higher self-efficacy, stronger SC ability to actively solve health problems, better QoL and nutritional status, as well as shorter hospital stays.Trial registration number ChiCTR2100043731.…”
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Maternal exposure to deltamethrin during pregnancy and lactation impairs hippocampal learning and memory function of male offspring by ferroptosis by Shasha Huang, Wanqi Li, Dengke Wang, Huiwen Feng, Bo Wang, Xinyu Dong, Wei Zhao, Dan Liu, Yuan Wang

“…Furthermore, the ferroptosis caused by DM exposure could active PL-C/IP3R signaling pathway and increase the intracellular Ca2+ and CaN level, leading to an imbalance of calcium homeostasis in the hippocampus. …”
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Genome-wide linkage mapping of Fusarium crown rot in common wheat (Triticum aestivum L.) by Faji Li, Can Guo, Qi Zhao, Weie Wen, Shengnan Zhai, Xinyou Cao, Cheng Liu, Dungong Cheng, Jun Guo, Yan Zi, Aifeng Liu, Jianmin Song, Jianjun Liu, Jindong Liu, Haosheng Li

“…Additionally, this study identified seven candidate genes that encode disease resistance proteins, the BTB/POZ domains, peroxidase activity, and leucine-rich repeat receptor-like protein kinase. …”
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Comprehensive health risk assessment of urban ambient air pollution (PM2.5, NO2 and O3) in Ghana by Boansi Adu Ababio, Gerheart Winfred Ashong, Thomas Peprah Agyekum, Blessed Adjei Yeboah, Marian Asantewah Nkansah, Jonathan Nartey Hogarh, Michael Kweku Commeh, Edward Ebow Kwaansa-Ansah, Kwabena Dabie, Felix Adulley, Eldad Boansi, Lorenda Sarbeng, Birago Adu Ababio, Maame Serwaa Boapea, Nana Kwabena Oduro Darko, Meshach Kojo Appiah

“…Urbanization and industrialization have drastically increased ambient air pollution in urban areas globally from vehicle emissions, solid fuel combustion and industrial activities leading to some of the worst air quality conditions. …”
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Immunoprotective effect of chitosan nanoparticles with different particle sizes against H9N2 avian influenza infection by Shangen Xu, Zhi Zhao, Chenxi Sun, Yile Ji, Qingshuang Luan, Qihong Zhang, Zheng Jin, Kai Zhao

“…Moreover, a mechanistic analysis revealed that the optimal NHC NPs combination triggered the activation of antigen presenting cells via TLR4 and participated in immune responses through the production of NO and TNF-α. …”
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Virtual reality-based vestibular rehabilitation therapy in patients with acute unilateral vestibulopathy: a randomized controlled trial by Jae Woo Lee, Chul Young Yoon, Chul Young Yoon, Jae Ha Kim, Jae Ha Kim, Young Joon Seo, Young Joon Seo, Young Joon Seo, Tae Hoon Kong, Tae Hoon Kong, Tae Hoon Kong

“…Subjective dizziness symptoms were evaluated using the visual analog scale (VAS), dizziness handicap inventory (DHI), and Activities-specific Balance Confidence (ABC) scale. …”
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One-pot synthesis and characterization of a BSA-Cu2S/CuS quantum dots drug delivery system based on biuret’s reaction by Porfirio Estrada-Rojas, Juan Francisco Hernández-Paz, Claudia Alejandra Rodríguez-González, Mónica Elvira Mendoza-Duarte, Santos Adriana Martel-Estrada, Laura Elizabeth Valencia-Gómez, Héctor Camacho-Montes, Imelda Olivas-Armendáriz

“…Among these, Cu _2 S and CuS quantum dots have demonstrated notable photothermal effects and antibacterial activity, making them promising candidates for various biomedical applications, including cancer treatment. …”
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Determination of the optimal frequency and duration of micro-spray patterns for high-temperature environment tomatoes based on the Fuzzy Borda model by Run Xue, Chuan Zhang, Haofang Yan, Kinde Negessa Disasa, Imran Ali Lakhiar, Muhammad Akhlaq, Muhammad Usman Hameed, Jun Li, Jiangtao Ren, Shuaishuai Deng, Biyu Wang, Rongxuan Bao

“…The micro-spray restored part of the photosynthetic mechanism of tomato that was stopped due to high temperature and reduced the photoprotective mechanism, actively dissipating excess energy into heat. F2 had a better effect on improving plant height, LAI, and SPAD than F1. …”
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Risk factors affecting polygenic score performance across diverse cohorts by Daniel Hui, Scott Dudek, Krzysztof Kiryluk, Theresa L Walunas, Iftikhar J Kullo, Wei-Qi Wei, Hemant Tiwari, Josh F Peterson, Wendy K Chung, Brittney H Davis, Atlas Khan, Leah C Kottyan, Nita A Limdi, Qiping Feng, Megan J Puckelwartz, Chunhua Weng, Johanna L Smith, Elizabeth W Karlson, Regeneron Genetics Center, Penn Medicine BioBank, Gail P Jarvik, Marylyn D Ritchie

“…Covariates with the largest differences included age, sex, blood lipids, physical activity, and alcohol consumption, with R2 being nearly double between best- and worst-performing quintiles for certain covariates. …”
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Reattempt Percutaneous Coronary Intervention of Chronic Total Occlusions after Prior Failures: A Single-Center Analysis of Strategies and Outcomes by Mingqiang Fu, Shufu Chang, Lei Ge, Dong Huang, Kang Yao, Feng Zhang, Qing Qin, Jianying Ma, Juying Qian, Junbo Ge

“…In multivariable regression analysis, J-CTO score, collateral channel scale, application of coronary multispiral computed tomography angiography, dual injection, intravascular ultrasound, active greeting technique, parallel wiring, and CTO morphology were predictors of recanalization success. …”
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Direct high-precision radon quantification for interpreting high-frequency greenhouse gas measurements by D. Kikaj, E. Chung, A. D. Griffiths, S. D. Chambers, G. Forster, G. Forster, A. Wenger, P. Pickers, P. Pickers, C. Rennick, S. O'Doherty, J. Pitt, K. Stanley, D. Young, L. S. Fleming, L. S. Fleming, K. Adcock, E. Safi, T. Arnold, T. Arnold

“…<p>We present a protocol to improve confidence in reported radon activity concentrations, facilitating direct site-to-site comparisons and integration with co-located greenhouse gas (GHG) measurements within a network of three independently managed observatories in the UK. …”
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Role of the Specialized Proresolving Mediator Resolvin D1 in Systemic Lupus Erythematosus: Preliminary Results by Luca Navarini, Tiziana Bisogno, Domenico Paolo Emanuele Margiotta, Alessandra Piccoli, Silvia Angeletti, Alice Laudisio, Massimo Ciccozzi, Antonella Afeltra, Mauro Maccarrone

“…The aim of the present pilot study is to evaluate plasma levels of RvD1 in patients with SLE and healthy subjects, investigating its potential role as a biomarker of SLE and assessing its relationship with disease activity and laboratory parameters. Methods. Thirty patients with SLE and thirty age- and sex-matched healthy subjects (HSs) have been consecutively recruited at Campus Bio-Medico University Hospital. …”
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Targeting MYCN upregulates L1CAM tumor antigen in MYCN-dysregulated neuroblastoma to increase CAR T cell efficacy by Laura Grunewald, Lena Andersch, Konstantin Helmsauer, Silke Schwiebert, Anika Klaus, Anton G. Henssen, Teresa Straka, Marco Lodrini, Sebastian G. Wicha, Steffen Fuchs, Falk Hertwig, Frank Westermann, Alice Vitali, Carlotta Caramel, Gabriele Büchel, Martin Eilers, Kathy Astrahantseff, Angelika Eggert, Uta E. Höpken, Johannes H. Schulte, Thomas Blankenstein, Kathleen Anders, Annette Künkele

“…L1CAM-CAR T cell effector function was assessed (activation markers, cytokine release, tumor cytotoxicity) after coculture with the model or MYCN-amplified neuroblastoma cell lines. …”
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Time Zero for Net Zero: A Coal Mine Baseline for Decarbonising Heat by Alison A. Monaghan, Luke Bateson, Adrian J. Boyce, Neil M. Burnside, Rebecca Chambers, Julia R. de Rezende, Eilidh Dunnet, Paul A. Everett, Stuart M. V. Gilfillan, Muhammad S. Jibrin, Gareth Johnson, Richard Luckett, Donald John MacAllister, Alan M. MacDonald, John W. Moreau, Laura Newsome, Alessandro Novellino, Barbara Palumbo-Roe, Ryan Pereira, Douglas Smith, Mike J. Spence, Vanessa Starcher, Helen Taylor-Curran, Christopher H. Vane, Thomas Wagner, David B. Walls

“…Focused on a mined, urban environment, a range of approaches have been applied to both characterise the environmental change before geothermal activities to generate “time zero” datasets, and to develop novel monitoring tools for cost-effective and environmentally-sound geothermal operations. …”
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Short-term caloric restriction or resveratrol supplementation alters large-scale brain network connectivity in male and female rats by Judith R. A. van Rooij, Judith R. A. van Rooij, Monica van den Berg, Monica van den Berg, Tamara Vasilkovska, Johan Van Audekerke, Johan Van Audekerke, Lauren Kosten, Daniele Bertoglio, Daniele Bertoglio, Mohit H. Adhikari, Mohit H. Adhikari, Marleen Verhoye, Marleen Verhoye

“…Therefore, we aimed to compare and unravel the sex-specific impact of these dietary interventions on spontaneous brain activity.MethodsHere, we used resting-state fMRI to investigate functional connectivity (FC) changes in five prominent resting-state brain networks (RSNs) in healthy 4 month old male and female F344 rats supplemented to either 40% CR or daily Rsv supplementation (10 mg/kg, oral) for the duration of 1 month.ResultsOur results demonstrated a decreased body weight (BW) in CR rats, as well as an increase in body weight in male Rsv supplemented rats, compared to female Rsv supplemented rats, whereas this difference between sexes was not observed in the control or CR groups. …”
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