Silent cerebral lesions after catheter ablation for atrial fibrillation using cryoballoon, hotballoon, laserballoon and radiofrequency catheters: a Bayesian network meta-analysis by Tiantian Zheng, Youjin Kong, Li Wu, Chenxia Wu, Chenxia Wu, Wei Mao, Wei Mao, Xinbin Zhou, Xinbin Zhou

“…The NMA results demonstrated similar procedure-related complication rates and mean activated clotting time between CBA (SUCRA = 53.7%, 66.3%), hotballoon ablation (HBA) (SUCRA = 81.5%, 43.6%), LBA (SUCRA = 3.39%, 42.8%) and RFA (SUCRA = 61.3%, 47.3%). …”
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Development of a standardized patient-reported clinical questionnaire for children with spinal pain by Freja Gomez Overgaard, Henrik Hein Lauridsen, Mads Damkjær, Anne Reffsøe Ebbesen, Lise Hestbæk, Mikkel Brunsgaard Konner, Søren Francis Dyhrberg O’Neill, Stine Haugaard Pape, Michael Skovdal Rathleff, Christian Lund Straszek, Casper Nim

“…The questionnaire includes sections for parents/legal guardians and six domains for children covering pain, sleep, activities, trauma, concerns, and treatment, following the International Classification of Functioning, Disability, and Health (ICF). …”
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Spatiotemporal characteristics of macroinvertebrate functional feeding groups and biological assessment of water quality in the Hulan River Basin by Peilun Li, Shuhan Xiong, Jiacheng Liu, Xiangsheng Meng, Anqi Wang, Chunfeng Wang, Yanshen Zhang, Jilong Wang

“…This study demonstrates that macroinvertebrate FFGs are highly sensitive to human activities and agricultural pollution in the midstream and downstream areas of the Hulan River Basin. …”
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Very low urinary marinobufagenin excretion reflects a high risk of disease progression in non-advanced CKD by Davide Bolignano, Davide Bolignano, Marta Greco, Marta Greco, Loredana Tripodi, Mario D’Agostino, Paola Cianfrone, Roberta Misiti, Roberta Misiti, Sara Pugliese, Mariateresa Zicarelli, Michela Musolino, Michela Musolino, Daniela Patrizia Foti, Daniela Patrizia Foti, Michele Andreucci, Michele Andreucci, Giuseppe Coppolino, Giuseppe Coppolino

“…In this prospective study, we investigated the prognostic significance of urinary Marinobufagenin (uMBG), a cardiotonic steroid with acknowledged pro-fibrotic activity, for stratifying the risk of CKD progression in individuals with non-advanced renal disease.MethodsAfter baseline uMBG measurements, 108 CKD patients (eGFR 40.54 ± 17 mL/min/1.73 m2) were prospectively followed up to 24 months. …”
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Insights from a codesigned dynamic modelling study of child and adolescent obesity in Australia by Alison Hayes, Rebecca Wyse, Anna Lene Seidler, Kylie E Hunter, Rebecca K Golley, Louise A Baur, Anthony D Okely, Kenny Lawson, Jo-An Occhipinti, Louise Freebairn, Simon Keith Chiu, Joseph Carrello, L Kurt Kreuger

“…The potential economic benefits of the scenarios were estimated from changes in population healthcare spending and quality of life compared with base model projections.Results A series of interventions were explored in the model, including changes in early childhood behaviours, changes to diet and physical activity in childcare and school settings, financial support for organised sports and sugar-sweetened beverage taxation. …”
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Prevalence of Autoimmune Thyroiditis and Other Autoimmune Diseases in Relation to Serum BAFF/APRIL Levels in Prolactinoma Patients by Özlem Kanburoğlu Meletli, Alev Altınova, Başak Bolayır, Resul Karakuş, Meriç Coşkun, Mehmet Muhittin Yalçın, Müjde Aktürk, İlhan Yetkin, Füsun Saadet Toruner

“…The aim of this study was to investigate the prevalence of thyroid and non-thyroid autoimmune diseases, serum B-cell activating factor (BAFF), and proliferation- inducing ligand (APRIL) levels as indicators of increased autoimmunity, quality of life, depression, and anxiety in patients with prolactinoma. …”
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Multi-dimensional outcomes following extracorporeal cardiopulmonary resuscitation by Tharusan Thevathasan, Vanessa Wahl, Joshua Boettel, Megan Kenny, Julia Paul, Sophie Selzer, Abdulla Al Harbi, Eva-Maria Dorsch, Heinrich Audebert, Matthias Rose, Christoph Paul Klapproth, Sonia Lech, Katharina Schmitt, Steffen Desch, Ulf Landmesser, Ralf Westenfeld, Fabian Voss, Carsten Skurk

“…Many patients reported dizziness or dyspnea (>52%) during daily activities, with a median New York Heart Association class of 2, EQ-5D-5L score of 53 and elevated NT-proBNP levels. …”
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Analysis of Soil Microbial Community Structure and Function in <i>Morchella esculenta</i> Habitats in Jilin Province by Qi Yan, Peng Wang, Zhushan Liu, Ya Yu, Xiao Tan, Xiao Huang, Jiawei Wen, Weidong Zhang

“…The functional annotation analysis of soil microorganisms, based on the KEGG database, revealed that within level A (highest tier), metabolic activities were the most prominent. In contrast, at level B (secondary tier), global and overview maps, carbohydrate metabolism, and amino acid metabolism were dominant. …”
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Anti-inflammatory effects of Andrographis paniculata (Fah Talai Jone) via TNFα-JNK pathway and bioactive compound identification by Praphat Manuelo Ruengthanoo, Areeya Changthong, Pranee Sriraj, Jatuporn Prathumtet, Nutchapon Laikaew, Ratchadawan Aukkanimart

“…Methods: Ethanol (APE) and aqueous (APA) extracts of A. paniculata were prepared and analyzed for total phenolic and flavonoid content, antioxidant activity, and bioactive compound identification using high-performance liquid chromatography (HPLC). …”
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Germline Single-Nucleotide Polymorphism <i>GFI1-36N</i> Causes Alterations in Mitochondrial Metabolism and Leads to Increased ROS-Mediated DNA Damage in a Murine Model of Human Acu... by Jan Vorwerk, Longlong Liu, Theresa Helene Stadler, Daria Frank, Helal Mohammed Mohammed Ahmed, Pradeep Kumar Patnana, Maxim Kebenko, Eva Dazert, Bertram Opalka, Nikolas von Bubnoff, Cyrus Khandanpour

“…Since we have demonstrated that GFI1 plays an active role in metabolism, in this study, we investigated whether increased levels of reactive oxygen species (ROS) could contribute to the accumulation of genetic damage in <i>GFI1-36N</i> leukemic cells. …”
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Humoral and cellular response to SARS-CoV-2 mRNA vaccine in paediatric heart transplant recipients by Amanda Bermejo-Gómez, Laura Tarancon-Diez, Beatriz Lazaro-Martin, Begoña Santiago-Garcia, Nuria Gil Villanueva, Roberto Alonso, Mª Ángeles Muñoz-Fernández, Manuela Camino López, Alicia Hernanz-Lobo, María Luisa Navarro Gómez

“…In addition, anti-S IgG levels directly correlated with a higher SARS-CoV-2 specific T-cell response (rho = 0.43; p = 0.027 and rho = 0.45; p = 0.02 for IFN-γ+ and TNF-α+ production of CD8+ T-cells, respectively). Activated T-cell phenotype in HTR was associated with a lower humoral response to SARS-CoV-2 vaccine. …”
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Akkermansia muciniphila identified as key strain to alleviate gut barrier injury through Wnt signaling pathway by Xin Ma, Meng Li, Yuanyuan Zhang, Tingting Xu, Xinchen Zhou, Mengqi Qian, Zhiren Yang, Xinyan Han

“…We further investigated the alleviatory effects of these two strains on ETEC infection in the AIMD mice model, which revealed that A. muciniphila and B. fragilis relieved ETEC-induced intestinal inflammation by maintaining the proportion of Treg/Th17 cells and epithelial damage by moderately activating the Wnt/β-catenin signaling pathway, while the effect of A. muciniphila was better than B. fragilis. …”
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Nrf2/cyclooxygenase 2 signaling in Cr(VI)-induced carcinogenesis by Lei Zhao, Yi-Fang Wang, Andrea Adamcakova-Dodd, Peter S. Thorne, Ranakul Islam, Ke Jian Liu, Fei Chen, Jia Luo, Ling-Zhi Liu

“…Metabolomics and RNA-seq assays revealed enhanced activity of the arachidonic acid (AA)/eicosanoid metabolism pathway in lung tissues from mice exposed to Cr(VI). …”
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Low-Dose Ketamine Infusion for Perioperative Pain Management in Patients Undergoing Laparoscopic Gastric Bypass: A Prospective Randomized Controlled Trial by Mitchell T. Seman, Shawn H. Malan, Matthew R. Buras, Richard J. Butterfield, Kristi L. Harold, James A. Madura, David M. Rosenfeld, Andrew W. Gorlin

“…The patient satisfaction questionnaires showed a significant difference with the ketamine group reporting lower maximum pain scores, a decrease in how pain limited activities of daily living once discharged, and increased hospital pain management satisfaction scores. …”
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Oral delivery of bovine tuberculosis vaccine to free-ranging white-tailed deer by Kurt VerCauteren, Abigail Feuka, Michael Lavelle, Michael Glow, Keely Kohen, Patrick Ryan, Tony Aderman, Anthony Duffiney, Mitchell Palmer, Paola M. Boggiatto, Carly Kanipe, Hayden Hamby, Emily Ruell, Melinda Cosgrove, Michael Vanderklok, Nathan Snow, Kim M. Pepin, Henry Campa

“…Consumption, still images, and video data were analyzed to assess uptake of vaccine DUs by deer.Results and discussionVaccine DUs were deployed in 2024 at 11 agricultural sites on private land which had previously demonstrated moderate to high deer activity and at all but two sites &gt;50% of distributed vaccine DU’s were consumed, with 100% consumed at two sites. …”
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Optogenetic control of horizontally acquired genes prevent stuck fermentations in yeast by David Figueroa, Diego Ruiz, Nicolò Tellini, Matteo De Chiara, Eduardo I. Kessi-Pérez, Claudio Martínez, Gianni Liti, Amparo Querol, José M. Guillamón, Francisco Salinas

“…We then implemented an optogenetic system in this wine yeast strain to precisely regulate the expression of each gene, generating a collection of 12 strains that allow for light-activated gene expression. To evaluate the role of these genes during fermentation, we assayed this collection using microculture and fermentation experiments in synthetic must with varying amounts of nitrogen concentration. …”
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Long-term effects of dupilumab on chronic rhinosinusitis with nasal polyps: A step towards clinical remission by Mona Al-Ahmad, MD, FRCPC, Asmaa Ali, MD, PhD, Wafaa Talat, MD, PhD, Haitham A. Dawood, MD, PhD, Osama Imam, MD, PhD

“…Background and objectives: Clinical remission, defined as the absence of disease activity and symptoms, is an emerging goal in the management of chronic rhinosinusitis with nasal polyps (CRSwNP). …”
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Clinical significance of plasma-free amino acids and tryptophan metabolites in patients with non-small cell lung cancer receiving PD-1 inhibitor: a pilot cohort study for developin... by Akihiko Kawahara, Tetsuro Sasada, Koichi Azuma, Hidenobu Ishii, Norikazu Matsuo, Takaaki Tokito, Tomoaki Hoshino, Yohei Miyagi, Huihui Xiang, Tomoyuki Tagami, Rika Kasajima, Yumiko Kato, Sachise Karakawa, Shinya Kikuchi, Akira Imaizumi, Kenta Murotani

“…From the transcriptome analysis in PBMCs, this multivariate model was significantly correlated with the gene signatures related to immune responses, such as CD8 T-cell activation/proliferation and proinflammatory immune responses, and 12 amino acid-related genes were differentially expressed between the high-risk and low-risk groups.Conclusions The multivariate model with PFAAs and metabolites in plasma might be useful for stratifying patients who will benefit from PD-1 inhibitors.…”
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Clinical outcomes over 2 years following arthroscopic ankle lateral ligament repair with os subfibulare by Shohei Sano, Noriyuki Kanzaki, Kiminari Kataoka, Koji Nukuto, Tetsuya Yamamoto, Yuta Nakanishi, Kyohei Nishida, Kanto Nagai, Yuichi Hoshino, Takehiko Matsushita, Ryosuke Kuroda

“…The mean scores for pain and related symptoms, foot function and activities of daily living, social functioning, shoe-related, and general health and well-being subscales of the SAFE-Q also showed significant improvements in both groups. …”
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Canadian Rhinology Working Group consensus statement: biologic therapies for chronic rhinosinusitis by Andrew Thamboo, S. Kilty, I. Witterick, Y. Chan, C. J. Chin, A. Janjua, A. Javer, J. Lee, E. Monterio, B. Rotenberg, J. Scott, K. Smith, D. D. Sommer, L. Sowerby, M. Tewfik, E. Wright, M. Desrosiers

“…Abstract Background Recent evidence suggests that biologic therapy with targeted activity within the Type 2 inflammatory pathway can improve the clinical signs and symptoms of chronic rhinosinusitis with nasal polyposis (CRSwNP). …”
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