Bearberry in the treatment of acute uncomplicated cystitis (BRUMI): protocol of a multicentre, randomised double-blind clinical trial by Péter Hegyi, Noémi Gede, Szilárd Váncsa, Barbara Tóth, András Jávorházy, Péter Nyirády, Boglárka Csupor-Löffler, Péter Birinyi, George Zhanel, Kurt Naber, Reinhard Länger, Nóra Vörhendi, Dezső Csupor

“…Background Bearberry (Arctostaphylos uva-ursi) leaf is available as a treatment of uncomplicated cystitis in several European countries. The antimicrobial activity of its extracts and some of its individual constituents has been observed in vitro; however, the efficacy of bearberry compared with standard antimicrobial therapy has not been assessed yet.Objective The objective of the study is to assess the safety and non-inferiority of bearberry as an alternative therapy in the treatment of acute uncomplicated cystitis in comparison with standard antibiotic therapy (fosfomycin).Methods and analysis This is a randomised controlled double-blinded multicentre trial. …”
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Growth Performance, Serum Biochemical Profile, Oxidative Status, and Fertility Traits in Male Japanese Quail Fed on Ginger (Zingiber officinale, Roscoe) Essential Oil by Tchoffo Herve, Kana Jean Raphaël, Ngoula Ferdinand, Folack Tiwa Laurine Vitrice, Adoum Gaye, Moussa Mahamat Outman, Ngouozeu Moyo Willy Marvel

“…The serum content in total protein and globulin and the antioxidant enzymes activities increased in treated birds compared to the control. …”
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Synergistic photothermal conversion and visible-light photodegradation of antibiotic in S-type TiO2 derived Ti3C2-MXene loaded on NaYF4: Tm3+, Er3+, Yb3+ @BiOI by Seyyedeh Fatemeh Hosseini, Mir Saeed Seyed Dorraji, Shiva Mohajer, Seyedeh Narges Saeedi, Masoumeh Kianfar, Alexandr V. Koshelev, Nataliya A. Arkharova, Denis N. Karimov

“…Excellent catalytic activity is explained by the S-scheme mechanism, which produces holes at the valence band and superoxide radicals at the conductive band in the BiOI and Ti3C2, respectively. …”
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Effects of public roads on wildlife-vehicle collisions in two protected areas, Hluhluwe-iMfolozi Park and iSimangaliso Wetland Park, in KwaZulu-Natal, South Africa by Cameron T. Cormac, Cormac Price, Wendy Collinson, Dave J. Druce, Jarryd P. Streicher, Colleen T. Downs

“…Wildlife faces growing threats from anthropogenic activities, especially infrastructure. Protected areas (PAs) are not exempt, particularly those that experience high traffic volumes on public road passages both within and on their peripheries. …”
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Biodegradation of Phenol at High Initial Concentration by <i>Rhodococcus opacus</i> 3D Strain: Biochemical and Genetic Aspects by Tatiana O. Anokhina, Tatiana Z. Esikova, Valentina N. Polivtseva, Nataliya E. Suzina, Inna P. Solyanikova

“…In this work, it is shown that the immobilized cells can be stored for a long time (up to 2 years) without significant loss of their degradation activity. An assessment of the induction of genes potentially involved in this process was taken. …”
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Effect of Eight-Week Transcranial Direct-Current Stimulation Combined with Lat Pull-Down Resistance Training on Improving Pull-Up Performance for Male College Students by Qian Li, Jiaqi Yan, Hanya Dai, Minjie Qiao, Mingxin Gong, Wenxin Niu, Ye Yang, Lejun Wang

“…Additionally, muscle activation of BR, PD, and PM decreased significantly in both groups, while the RT + tDCS group also demonstrated a significant reduction in TB coactivation after training. …”
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Multi-omics elucidates the kidney damage caused by aquatic Cu via the gut-kidney axis in ducks by Mingcai Duan, Jinyu Liu, Zhaoxia Cai, Li Chen, Yong Tian, Wenwu Xu, Tao Zeng, Tiantian Gu, Lizhi Lu

“…GO and KEGG enrichment analyses were most involved in Interleukin-1 Receptor Activity, Taurine and hypotaurine metabolism, Nitrogen metabolism, and Proximal tubule bicarbonate reclamation. …”
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Little Red Dots: Rapidly Growing Black Holes Reddened by Extended Dusty Flows by Zhengrong Li, Kohei Inayoshi, Kejian Chen, Kohei Ichikawa, Luis C. Ho

“…The James Webb Space Telescope (JWST) observations have revolutionized extragalactic research, particularly with the discovery of little red dots (LRDs), which have been discovered as a population of dust-reddened broad-line active galactic nuclei (AGNs). Their unique V-shaped spectral feature, characterized by a red optical continuum and a UV excess in the rest frame, challenges us to discern the relative contributions of the galaxy and AGN. …”
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Efficacy of yeast beta-glucan 1,3/1,6 supplementation on respiratory infection, fatigue, immune markers and gut health among moderate stress adults in Klang Valley of Malaysia: pro... by Suzana Shahar, Kalavathy Ramasamy, Norhayati Ibrahim, Nur Nadia Mohamad Habibullah, Munirah Ismail, Mohd Zul Amin Kamaruddin, Shirley Gee Hoon Tang, Mohd Faisal Abdul Hamid

“…Introduction Yeast beta-glucan (YBG) are recognised for enhancing the immune system by activating macrophages, a key defence mechanism. Given the global prevalence and impact of upper respiratory tract infections (URTIs) on productivity and healthcare costs, YBG has shown promise as a potential therapeutic and preventive strategy for recurrent respiratory tract infections. …”
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Impact of vitamin E and selenium supplementation on growth, reproductive performance, and oxidative stress in dexamethasone-stressed Japanese quail cocks by Ifeanyi Emmanuel Uzochukwu, Luke Chukwudi Ali, Bright Chigozie Amaefule, Chisom C. Okeke, Charles Onochie Osita, Ndubuisi Samuel Machebe, Vesela Yancheva, Dóra Somogyi, Krisztián Nyeste

“…No marked differences were seen in the plasma glutathione peroxidase activities across groups. Sperm motility was impaired in the DEX-only group but improved (P < 0.05) with antioxidant supplementation. …”
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The absolute number of circulating Treg cells is reduced in difficult-to-treat RA patients and is ameliorated by low-dose IL-2 by Huanhuan Yan, Huanhuan Yan, Huanhuan Yan, Xiaoyu Zi, Xiaoyu Zi, Xiaoyu Zi, Huer Yan, Xiaoying Zhang, Xiaoying Zhang, Xiaoying Zhang, Jie Bai, Jie Bai, Jie Bai, Chong Gao, Xiaofeng Li, Xiaofeng Li, Xiaofeng Li, Caihong Wang, Caihong Wang, Caihong Wang

“…The number of Treg cells in RA patients was negatively correlated with the disease activity index. Treg cells in the new, treated, and D2T RA groups could be increased by low-dose IL-2 therapy without any side effects.ConclusionsThe number of lymphocytes and subsets in D2T RA patients was reduced, especially Treg cells, resulting in a shift in the balance of effector T cells/Treg cells toward effector T cells, which is ameliorated by low-dose IL-2 without obvious side effects.…”
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Seasonal malaria vaccination: protocol of a phase 3 trial of seasonal vaccination with the RTS,S/AS01E vaccine, seasonal malaria chemoprevention and the combination of vaccination... by Ismaila Thera, Irene Kuepfer, Daniel Chandramohan, Alassane Dicko, Issaka Zongo, Issaka Sagara, Matthew Cairns, Modibo Diarra, Amadou Tapily, Djibrilla Issiaka, Koualy Sanogo, Almahamoudou Mahamar, Frederic Sompougdou, Serge Yerbanga, Paul Milligan, Halidou Tinto, Opokua Ofori-Anyinam, Jean-Bosco Ouedraogo, B Greenwood

“…Incidence of clinical malaria is determined by case detection at health facilities. Weekly active surveillance for malaria is undertaken in a randomly selected subset of children. …”
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Health and Environmental Impact of Hospital Wastes: Systematic Review by Hela Ghali, Asma Ben Cheikh, Sana Bhiri, Lamia Bouzgarrou, Mohamed Ben Rejeb, Imed Gargouri, Houyem Said Latiri

“…Introduction: Healthcare activities are generally associated with the production of healthcare waste, a large part of which is assimilated to household waste (packaging, kitchen waste, green waste, etc.) and another category of waste which may have a risk to health and the environment given its nature and typology. …”
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Beyond Dermatological Findings: Multisystem Involvement in Prolidase Deficiency by Ezgi Yalcin Gungoren, Zeynep Meric, Asena Pinar Sefer, Asuman Deveci Ozkan, Salim Can, Royala Babayeva, Nurhan Kasap, Ercan Nain, Esra Ozek Yucel, Ayca Kiykim, Sevgi Bilgic-Eltan, Ayse Deniz Yucelten, Elif Karakoc-Aydiner, Ahmet Ozen, Safa Baris

“…Metabolic evaluations revealed low prolidase enzyme activity in P1 and P2. Conclusion: Beyond the well-known classical dermatological findings, the presence of recurrent opportunistic infections, gastrointestinal involvement, malignancy, and flow cytometry findings suggestive of combined immunodeficiency indicate that the diagnosis of prolidase deficiency may be underestimated. …”
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Comparative-effectiveness research of COVID-19 treatment: a rapid scoping review by Sharon E Straus, Jesmin Antony, Andrea C Tricco, Rachel Warren, Erin Macdonald, Ba Pham, Milan Patel, Fatemeh Yazdi, Amruta Radhakrishnan, Marco Ghassemi, Patricia Rios, Chantal Williams, Naveeta Ramkissoon, Matthew P Muller, Nazia Darvesh, Gordon V Cormack, Maura R Grossman, Melissa Kampman, Reid Robson

“…The results suggest future studies should focus on children, elderly ≥65 years of age, patients with mild symptoms, outpatient treatment, multimechanism therapies, harms and active comparators. The results also suggest that future living evidence synthesis and network meta-analysis would provide additional information for decision-makers on managing COVID-19.…”
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Effect of Massage on the TLR4 Signalling Pathway in Rats with Neuropathic Pain by Qian Wang, Jing Lin, Peng Yang, Yingye Liang, Dongming Lu, Kailong Wang, Wei Gan, Jianping Fu, Zhenbao Gan, Mingchen Ma, Pingting Wu, Fengshi He, Jun Pang, Hongliang Tang

“…SNL rats showed higher levels of TLR4, IRAK1, TRAF6, IL-6, and TNF-α, and massage effectively lowered the expression levels of these molecules. Inhibiting activation of the TLR4 signalling pathway, which can reduce the release of inflammatory factors, may be one mechanism by which massage treats neuropathic pain.…”
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Perception of phage therapy and research across selected professional and social groups in Poland by Maciej Żaczek, Marcin W. Zieliński, Andrzej Górski, Andrzej Górski, Andrzej Górski, Beata Weber-Dąbrowska, Ryszard Międzybrodzki, Ryszard Międzybrodzki, Ryszard Międzybrodzki

“…Consciousness of phage therapy varied between 8.9% (people taking care of household chores as their primary activity) to 37.7% (people with higher education) and 39.7% (inhabitants of large cities) while the readiness to use such treatments was very high (84.4%) despite the need to pay for it. …”
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Enhanced myofibroblast differentiation of eMSCs in intrauterine adhesions by Jun Song, Meiqi Li, Yuan Tao, Yumeng Li, Canrong Mai, Jingting Zhang, Lan Yao, Shaoquan Shi, Jianyong Xu

“…Results Our results indicate that the scar tissues in IUA are characterized with hyper-activation of pro-fibrotic fibroblast and myo-differentiation, along with reduced number of eMSCs. …”
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2′-Hydroxycinnamaldehyde induces ROS-mediated apoptosis in cancer cells by targeting PRX1 and PRX2 by Yae Jin Yoon, Yu-Jin Lee, Jiyeon Choi, Seung-Wook Chi, Sangku Lee, Kyung Chan Park, Byoung-Mog Kwon, Dong Cho Han

“…This indicates that ROS are critical effector for HCA activity. However, the molecular target of HCA for ROS induction has not been identified. …”
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Feasibility study of pilot scale vegetable waste composting project for Kundasang community’s waste management program by Noorafizah Murshid, Abu Zahrim Yaser, Junidah Lamaming, Mariani Rajin, Sariah Saalah, Mariana Taliban

“…. ·       Chicken manure is utilized as an activator. ·       Techno-economic effects and physiochemical aspects of composting were analyzed. ·       The system generates MYR 25000 annually with a 20-year capital cost normalization.…”
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