Molecular Docking Appraisal of Phytochemicals as Potential Inhibitors of PI3K/Akt Pathway for Breast Cancer Treatment by Magdalene Eno Effiong, Mercy Bella-Omunagbe, Israel Sunmola Afolabi, Shalom Nwodo Chinedu

“…Aim: This study evaluated the anticancer properties of P ostreatus through a structure-based virtual screening of 22 biologically active compounds present in the mushroom. Method: Model optimization was carried out on PI3K, PTEN, mTOR, Akt, PDK1, FoxO1, GSK-3, MDM2, H-Ras, and BAD proteins in the PI3K/Akt/mTOR pathway and molecular docking of compounds/control inhibitors in the binding pocket were simulated AutoDock Vina in PyRx. …”
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Explaining the Antecedents and Consequences of the Glass Cliff in Service Organizations by Sara Kavoosi, Ali Safari, Ali Shaemi Barzoki

“…Drawing from the qualitative aspect of the study, it is recommended that decision-makers and senior managers in service organizations diligently consider the origins of the glass cliff phenomenon and actively engage in managing the factors that contribute to the unique challenges faced by women in high-risk managerial positions Conclusion This investigation stands as one of the initial studies that, by leveraging a hybrid research methodology, provides a comprehensive framework to thoroughly understand the causal conditions, strategic responses, and consequences of the glass cliff phenomenon.…”
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Effectiveness of digital health applications on the quality of life in patients with overweight or obesity: a systematic review by Melanie Mäder, Tonio Schönfelder, Ria Heinrich, Carsta Militzer-Horstmann, Patrick Timpel

“…The evaluated interventions consisted of websites or apps, all of which included nutrition and physical activity features, and functioned independently with minimal or no involvement of a healthcare professional. …”
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The Effective Compound Combination of Bufei Yishen Formula III Improves the Mitochondrial Dysfunction via Inhibiting JNK/Sab Pathway in COPD Mice by Song M, Han M, Zhang H, Yang Y, Tian Y, Li J, Zhao J

“…Furthermore, ECC-BYF III ameliorated mitochondrial dysfunction by restoring the mitochondrial membrane potential, increasing mitochondrial complex I activity, and decreasing tumor necrosis factor-α (TNF-α) level and protein expressions of SH3BP5 (Sab), Phospho-JNK (P-JNK), and cleaved CASP3.Conclusion: The results suggest that the potential therapeutic benefit of ECC-BYF III against mitochondrial dysfunction in COPD is due to the inhibition of the JNK/Sab pathway, which will help to further understand the potential mechanisms of ECC-BYF III in the treatment of COPD. …”
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Utilization of personal protective equipment and the hygiene sanitation practices of farmers in the application of pesticides by G. Fizulmi, H. Agustina

“…This study gathered 91 respondents in Jonggol Village, which has the largest agricultural land in Bogor Regency and with farmers who actively use pesticides. Accordingly, this location has a population at risk of pesticide exposure. …”
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Lactoferrin Induces Osteoblast Growth through IGF-1R by Jian-Ming Hou, En-Yu Chen, Fan Lin, Qing-Ming Lin, Ying Xue, Xu-Hua Lan, Man Wu

“…Lactoferrin promoted osteoblast proliferation while inhibiting apoptosis through IGF-1R. Lactoferrin activated PI3K and RAS phosphorylation via an IGF-1R independent pathway.…”
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Prevalence of gastrointestinal symptoms after recovery from COVID-19: A questionnaire-based study in the Aseer region by Mohammed Attieh Alzahrani, Khalid Siraj Altalhiyyah, Mohammed Mousa Albariqi, Meshal Ali Alkhayri, Saad Ali Alshahrani, Sultan Saad Alnasser, Nawaf Mohammed Alshehri, Saad Haif Alqahtani, Saud Haif Alqahtani

“…Conclusions: In conclusion, the current study showed that nearly two-thirds of active COVID-19 patients experienced gastrointestinal tract symptoms. …”
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Evaluating the Sustainability of Wheat–Maize System with a Long-Term Fertilization Experiment by Yun Shao, Jiahui An, Xueping Wang, Shouchen Ma, Ye Meng, Yang Gao, Shoutian Ma

“…The results indicated that following prolonged fertilization, the soil nutrient content, enzyme activity, and crop yield of each organic fertilizer treatment were significantly greater than those of the chemical fertilizer treatment alone, resulting in a more stable yield. …”
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Synthetic inhibition of SREBP2 and the mevalonate pathway blocks rhabdomyosarcoma tumor growth in vitro and in vivo and promotes chemosensitization by Silvia Codenotti, Michela Asperti, Maura Poli, Luisa Lorenzi, Alberto Pietrantoni, Matteo Cassandri, Francesco Marampon, Alessandro Fanzani

“…Finally, we found that forced Akt1 activation in RD cells was sufficient to drive SREBP2, HMGCR and SQLE protein expression, promoting increased susceptibility to MVP inhibitors. …”
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Literature study of Zn supplementation in feed for optimizing Nile tilapia Oreochromis niloticus growth by Muhammad Agus Suprayudi, Hendri Inarto, Julie Ekasari

“…The results of this literature review indicate that zinc supplementation in feed can have a positive impact on overall fish growth by increasing digestive enzyme activity, particularly protease enzymes. The level of zinc supplementation in fish is influenced by several factors including, fish size, feed consumption quantity, and duration of maintenance. …”
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Severe pregnancy-associated atypical hemolytic uremia syndrome in the context of the COVID-19 pandemic: a novel survival case report by Yan Yang, Xiao-jin Li, Hua-Yan Yuan, Jing-Jing Xiong, Peng-Fei Li, Zhen Wang

“…Abstract Background Pregnancy-associated atypical hemolytic uremic syndrome (aHUS) is a form of thrombotic microangiopathy (TMA) caused by uncontrolled activation of the complement system during pregnancy or the postpartum period. …”
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Effect of intramuscular treatment with different iron dextran dosages and non-inferiority study to gleptoferron by Isabel Hennig-Pauka, Martin Ganter, Dirk Bornhorn, Wesley Lyons, Enric Marco, Glen Almond, Bettina Schneider, Lothar Kreienbrock, Ken Steen Pedersen

“…Currently, combined iron products containing an active substance against coccidia are also used on farms. …”
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"Preparation and curing kinetics of “bottlebrush-like structure” green bio-based ultra-low-temperature polyfarnesene nanocomposites" by WU Ming-li, LI Yong-xu, CAO Lan?鄢

“…Based on the Sestak-Berggren model of thermal analysis kinetics, the curing kinetic parameters were solved, including the reaction orders, pre-exponential factor and activation energy, and the curing kinetic equation of the composite, dα/dt=3.667×107exp(-7.514×104/RT)α1.211(1－α)1.164, where α was curing degree, t was curing time, R was molar gas constant and T was curing temperature, was established." …”
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Sistem Pendeteksi Sleep-Disordered Breathing Berdasarkan High dan Low Frequency Menggunakan Metode Naïve Bayes by Achmad Ghifari, Edita Rosana Widasari

“…Abstract  Sleep is an activity in which the brain gives the body total rest. …”
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The carbon footprint of pasture-based buffalo milk production in Colombia by Andrés F. Pérez, Felipe Vélez S., Juan F. Naranjo R.

“…Herd gross energy (GE) intake was calculated using IPCC Tier 2 equations, considering daily gross energy intake per animal category, diet digestibility, and daily net energy requirements for pregnancy, lactation, growth, activity and maintenance. Dry matter intake (DMI) was determined by dividing gross energy intake values by 18.45 MJ of metabolizable energy per kg dry matter, representing the feed’s energy density. …”
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Assessment of the Effects of Newly Fabricated CaO, CuO, ZnO Nanoparticles on Callus Formation Maintenance of <i>Alfalfa</i> (<i>Medicago sativa</i> L.) Under In Vitro Salt Stress by Mustafa Akçay, Merve Simsek Geyik, Busra Yazicilar, Fatma Boke, Hayrunnisa Nadaroglu, Okkes Atıcı, İsmail Bezirganoğlu

“…The callus induction stage, without salt treatments, showed the best results with 0.8 ppm CaO NPs for both H₂O₂ levels and peroxidase (POX) activity compared to the other NPs. The highest protein rate was obtained from the callus induction stage and callus formation stage after 50 mM treatment NaCl with 0.8 ppm CuO. …”
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Clinical Practice Guideline for the Treatment of Traumatic Shock Patients from the Korean Society of Traumatology by Pil Young Jung, Byungchul Yu, Chan-Yong Park, Sung Wook Chang, O Hyun Kim, Maru Kim, Junsik Kwon, Gil Jae Lee, Korean Society of Traumatology (KST) Clinical Research Group

“…Early administration of tranexamic acid is recommended in trauma patients who are actively bleeding or at high risk of hemorrhage (1B). …”
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Evaluation of circadian rhythm and prognostic variability pre-and post-CEA or CAS treatment in patients with carotid artery stenosis by Yi Quan, Zhongzhu Wang, Tao Zhang, Yanyong Sui, Xin Zhang, Xueliang Ji, Ao-fei Liu, Weijian Jiang

“…Additionally, increased physical activity after treatment was linked to improved neurological recovery.ConclusionThis study highlights the critical role of circadian rhythm regulation and cardiovascular health in stroke recovery following CEA or CAS. …”
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Development of a core outcome set for school-based intervention studies on preventing childhood overweight and obesity: study protocol by Mai Chinapaw, Teatske M Altenburg, Tessa J Roseboom, Jo Salmon, Deirdre Harrington, Lotte W de Vries, Iris Grooten, Janneke Van 't Hooft, Arend van Deutekom

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The use of heparin-containing lubricant in clinical practice by T.B. Romanova, M.H. Rabadanova, E.G. Rybakova, Z.U. Teviyeva, M.S. Gorshkova

“…The following clinical cases of patients with DES are considered: 1. a student, an active user of electronic gadgets; 2. An accountant who spends a lot of time at the computer and has been wearing soft contact lenses for 17 years. 3. …”
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