Full-length and N-terminally truncated recombinant interleukin-38 variants are similarly inefficient in antagonizing interleukin-36 and interleukin-1 receptors by Alejandro Diaz-Barreiro, Dominique Talabot-Ayer, Arnaud Huard, Gea Cereghetti, Jenna Tonacini, Mike Maillasson, Antonio Francés-Monerris, Erwan Mortier, Gaby Palmer

“…In cell-based assays, neither full-length amino acid 2-152 IL-38 nor two N-terminally truncated forms of the protein showed efficient antagonist activity on IL-36R- and IL-1R1-mediated responses. …”
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Resilience of Fishery Economy in Fujian Coastal Areas from the Perspective of Institutional Evolution by Leng Yun, Wei Suqiong, You Xiaojun, Ren Zhihuang

“…This study highlights the importance of regional institutional change in the formation of fishery resilience, provides a new perspective on how institutional change affects economic activity, and uses quantitative methods to investigate the relationship between institutional change and industrial resilience. …”
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Metagenomic Sequencing Combined with Metabolomics to Explore Gut Microbiota and Metabolic Changes in Mice with Acute Myocardial Infarction and the Potential Mechanism of Allicin by Gao Y, Qin G, Liang S, Yin J, Wang B, Jiang H, Liu M, Luo F, Li X

“…Mechanistically, NP and in vivo experiments indicated that allicin might suppress pyroptosis and reduce inflammatory response via blocked activation of the NF-κB-mediated NLRP3/Caspase-1/GSDMD pathway. …”
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Effects of kelp phlorotannins on the growth, immunity, intestinal health and disease resistance against Vibrio splendidus of sea cucumber Apostichopus japonicus by Zhikai Zhang, Yan Chi, Yongheng Du, Feng Li, Ning Ma, Song Qin

“…On the other hand, the total antioxidant capacity and the activities of superoxide dismutase, catalase, glutathione peroxidase in coelomocytes lysis were significantly raised by phlorotannins while the malondialdehyde level was significantly reduced (P < 0.05). …”
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Compound identification of Shuangxinfang and its potential mechanisms in the treatment of myocardial infarction with depression: insights from LC-MS/MS and bioinformatic prediction by Yize Sun, Yize Sun, Haibin Zhao, Zheyi Wang

“…Neocryptotanshinone showed the strongest binding to MAPK3, suggesting it as a pivotal active ingredient. These findings offer new insights and targets for future research on PCF.…”
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Analysis of the structure and function of the tomato <i>Solanum lycopersicum</i> L. MADS-box gene <i>SlMADS5</i> by A. V. Nezhdanova, M. A. Slugina, E. A. Dyachenko, A. M. Kamionskaya, E. Z. Kochieva, A. V. Shchennikova

“…Two-hybrid analysis showed the ability of SlMADS5 to activate transcription of the target gene and interact with TAGL1. …”
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Collaboration-Based BIM Model Development Management System for General Contractors in Infrastructure Projects by Yu-Cheng Lin, Nan-Hai Lo, Hsin-Tzu Hu, Ya-Ting Hsu

“…The purpose of this study is to develop a CBMDM system to improve the efficiency of sharing and tracking information for CBMDM activities. The research scope of this study is to propose an approach and system for CBMDM work in large-scale construction and infrastructure projects. …”
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Adipose-derived mesenchymal stem cells combined with platelet-rich plasma are superior options for the treatment of osteoarthritis by Weijie He, Jie Zhao, Jiafei Liu, Fangxing Wang, Zhenyu Xu

“…Daily observations recorded activity levels and behavior, while weight changes were monitored weekly. …”
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Comparison of bioabsorbable screw versus metallic screw fixation for tibial tubercle fractures in adolescents: a retrospective cohort study by Tian Chen, Yuwei Wen, Danjiang Zhu, Wei Feng, Baojian Song, Qiang Wang

“…No significant differences were observed between the groups in fracture healing time, time to return to pre-injury activities, or knee joint function as assessed by the Lysholm and Tegner scores at the final follow-up. …”
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Mapping Biodiversity Coast‐to‐Coast‐to‐Coast Across Canada's Three Oceans Using eDNA Metabarcoding by Loïc Jacquemot, Brian P. V. Hunt, Shaorong Li, Angela D. Schulze, Christoph M. Deeg, Ben J. G. Sutherland, Amy Tabata, Connie Lovejoy, Kristina M. Miller

“…ABSTRACT Marine biodiversity worldwide is rapidly declining, and nowhere is this more evident than in coastal ecosystems where the impacts of climate change and anthropogenic activities concentrate. The ongoing biodiversity crisis affects all components of the marine food web, but data required to monitor biodiversity shifts at continental scales are scarce and taxonomically and spatially heterogeneous. …”
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Inhibitory Mechanism of Robiotic Bacteria on The Growth of Vibrio harveyi in Tiger Shrimp (Penaeus monodon) Larvae by . Widanarni, E. Ayuzar, . Sukenda

“… Three probiotics named SKT-b, 1Ub, and Ua had inhibitory activity against the growth of Vibrio harveyi. These strains were mutated by rifampicin resistant. …”
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Phα1β interaction with the Kv11.1 potassium channel in HEK293 cells transfected with the human ERG channel by João B. Calixto, Adara Aurea dos Santos, Juliano Ferreira, Alessandra Hubner Souza, Célio José de Castro Junior, Marcus Vinicius Gomez

“…Results: Phα1β was tested at concentrations of 56, 225, 450, and 900 pMol, resulting in a discreet inhibition of hERG potassium channel activity at higher concentrations, approximately 13.47%, with an IC50 value exceeding 900 pMol. …”
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Evaluation of Real-World Evidence to Assess Effectiveness Outcomes of Janus Kinase Inhibitors for Rheumatoid Arthritis: A Systematic Review of US Studies by Gandy C, Bazzazzadehgan S, Bruera S, Huang Y

“…In addition, the most common measure of clinical response throughout the studies was Clinical Disease Activity Index (CDAI), with 10 articles reporting mean CDAI changes between − 4.7 and 5.1. …”
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Hydrochemical assessment of borehole water in Effurun, Delta state Niger Delta, Nigeria: implications for public health and safety by Odunayo Tope Ojo, Chiaka Joy Ike, Adegoke Ige Aladeboyeje, Olayiwola Grace Olaseeni, Olumuyiwa Femi Adewumi

“…The central area exhibited moderate ion concentrations, while the southeastern region had the highest calcium levels, possibly due to geological formations rich in calcium or human activities. The study highlights diverse hydrochemical characteristics of Effurun's borehole water, with some areas showing contamination beyond acceptable limits. …”
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Long-term Cd remediation mechanisms and potential risks in soil with biochar application under dry-wet cycling at different soil moisture levels by Shuang Huang, Zhuowen Meng, Jingwei Wu, Lei Xin, Qin Zhao

“…This study highlighted that biochar was fairly effective in the long-term remediation of Cd in contaminated soils, but there was some risk of Cd activation in the later stages due to the ageing of biochar. …”
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Urine proteomics defines an immune checkpoint-associated nephritis signature by Cassian Yee, Jamie S Lin, James P Long, Shailbala Singh, Yanlan Dong

“…Thus, there is an urgent need for non-invasive biomarkers that can rapidly and accurately distinguish ICI-AIN from other causes of AKI.The urine and plasma proteome contain actively secreted proteins that provide real-time insights into dynamic physiological processes. …”
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Knowledge, attitude, and reasons for non-uptake of human papilloma virus vaccination among nursing students by Soni Chauhan, Surya Kant Tiwari, Vishal Dubey, Pragya Tripathi, Priyanka Pandey, Anuj Singh, Narendra Pal Singh Choudhary

“…Most participants expressed willingness to receive the vaccine (62.0%), citing reasons such as not being sexually active (35.8%) and needing more information (18.2%) for non-uptake of the vaccine. …”
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Influence of gestational weight gain on baby’s birth weight in Addis Ababa, Central Ethiopia: a follow-up study by Andrew Hayen, Yadeta Dessie, Maralyn Foureur, Fekede Asefa, Allison Cummins

“…Pregnancy-related weight management should be actively promoted through intensive counseling during routine antenatal care contacts.…”
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Statistical Downscaling Method for Vegetation Optical Depth Based on NDVI by Wang Xinyu, Fang Shibo, Han Jiahao

“…One involves integrating active microwave remote sensing, while the other involves integrating optical remote sensing.Currently, there is limited research focused on downscaling VOD, particularly using optical vegetation indices, which is very uncommon.Thus, statistical methods can be employed in conjunction with NDVI to spatially downscale VOD, exploring the feasibility of using optical remote sensing data for VOD downscaling. …”
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Diversity and Distribution of <i>Phytophthora</i> Species Along an Elevation Gradient in Natural and Semi-Natural Forest Ecosystems in Portugal by Carlo Bregant, Eduardo Batista, Sandra Hilário, Benedetto Teodoro Linaldeddu, Artur Alves

“…The genus <i>Phytophthora</i> includes a large number of species that are invading forest ecosystems worldwide, chiefly as a consequence of global trade and human activities. This paper reports the results of a survey of <i>Phytophthora</i> diversity in natural and semi-natural forest ecosystems in Portugal along an elevation gradient. …”
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