Dynamic Complement Protein Changes in Aqueous Humor and Plasma of Patients With Retinal Vein Occlusion During Ranibizumab Treatment by Guo T, Zhao Y, Liang S, Wang J, Liu H, Zhou Y, Xu H, Chen Z

“…At baseline, CRVO had higher levels of C4 (p = 0.003), C4b (p < 0.001), C3b/iC3b (p < 0.001), C5 (p = 0.020), C5a (p = 0.007), CFD (p = 0.002), CFH (p < 0.001), and CFI (p < 0.001) in AH compared to BRVO.Conclusion: Ranibizumab treatment reduced the intraocular but not circulating activation of classical and alternative complement pathways in RVO patients. …”
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Phosphatidylinositol promoted the proliferation and invasion of pituitary adenoma cells by regulating POU1F1 expression by Tongjiang Xu, Xiaodong Zhai, RuiWei Wang, Xiaoben Wu, ZhiZhen Zhou, MiaoMiao Shang, Chongcheng Wang, Tengfei Qi, Wei Yang

“…Inhibiting AKT phosphorylation reduced the expression of POU1F1, C2orf15 and LDHA in PI-stimulated cells while activating AKT increased their expression in PITPNM1-silencing cells, which was similar to the function of ERK. …”
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The Safety and Efficacy of the Repeated PRRT with [90Y]Y/[177Lu]Lu-DOTATATE in Patients with NET by Anna Zemczak, Paweł Gut, Dariusz Pawlak, Maciej Kołodziej, Leszek Królicki, Beata Kos-Kudła, Marek Ruchała, Grzegorz Kamiński, Jolanta Kunikowska

“…The median cumulative administered activity was 22.2 GBq (the range: 17.8–30.7 GBq). Myelodysplastic syndrome occurred in one patient (3.8%), and grade 4 renal toxicity was also detected in one patient (3.8%). …”
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Refining management strategies for Lennox–Gastaut syndrome: Updated algorithms and practical approaches by Stéphane Auvin, Alexis Arzimanoglou, Mercè Falip, Pasquale Striano, J. Helen Cross

“…It is characterized by a variety of different types of seizures (abnormal electrical activity in the brain), which are difficult to treat and often cause people with the condition to fall and injure themselves. …”
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Assessing the impact of sewage and wastewater on antimicrobial resistance in nearshore Antarctic biofilms and sediments by Melody S Clark, Benjamin H Gregson, Carla Greco, Harisree Paramel Nair, Marlon Clark, Claire Evans, Kevin A. Hughes, Kudzai Hwengwere, Marcus Leung, Lloyd S Peck, Caray A. Walker, William Chow

“…Thus, more work is required to understand the true extent of the Antarctic microbiota biodiversity, their associated resistomes and the impact that human activities have on the Antarctic environment.…”
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Puerarin Ameliorates the Ferroptosis in Diabetic Liver Injure Through the JAK2/STAT3 Pathway Inhibition Based on Network Pharmacology and Experimental Validation by Fan X, Liu S, Yu J, Hua J, Feng Y, Wang Z, Shen Y, Lan W, Wang J

“…Xiaoxu Fan,1 Shuangqiao Liu,1 Jing Yu,2 Jian Hua,1 Yingtong Feng,1 Zhen Wang,1 Yiwei Shen,1 Wei Lan,2 Jingxia Wang1 1School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, People’s Republic of China; 2School of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi, People’s Republic of ChinaCorrespondence: Jingxia Wang, School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, People’s Republic of China, Email 601435@bucm.edu.cn Wei Lan, School of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi, People’s Republic of China, Email lanwei516@sina.comBackground: Diabetic liver injury (DLI) is a common complication of diabetes mellitus (DM), which seriously endangers the health of diabetic patients. Puerarin, the main active component of Pueraria lobata, has shown positive effects in lowering blood glucose and lipids, resisting oxidative stress, and protecting the liver. …”
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IL-33/ST2 axis in diverse diseases: regulatory mechanisms and therapeutic potential by Feiya Sheng, Mi Li, Jia-Mei Yu, Si-Yu Yang, Liang Zou, Guan-Jun Yang, Le-Le Zhang, Le-Le Zhang

“…While most cytokines are actively synthesized within cells, IL-33 is produced passively in response to tissue damage or cell necrosis, indicating its role as a signaling molecule following cellular infection, stress, or trauma. …”
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Comprehensive analysis of the 5-HTTLPR allelic polymorphism effect on behavioral and neurophysiological indicators of executive control in people from different ethnic groups in Si... by A. N. Savostyanov, D. V. Bazovkina, S. A. Lashin, S. S. Tamozhnikov, A. E. Saprygin, T. N. Astakhova, U. N. Kavai-ool, N. V. Borisova, A. G. Karpova

“…The amplitude of the premotor peak of the evoked brain potential was used as a neurophysiological marker of the person’s readiness to the execution of target-directed activity. It was revealed that the frequency of the S-allele polymorphism 5-HTTLPR was significantly higher for both mongoloid groups compared to the Caucasoids. …”
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Sistem Identifikasi Pembicara Berbahasa Indonesia Menggunakan X-Vector Embedding by Alim Misbullah, Muhammad Saifullah Sani, Husaini, Laina Farsiah, Zahnur, Kikye Martiwi Sukiakhy

“…Untuk membangun model, fitur-fitur diekstrak dengan menggunakan MFCC, dihitung voice activity detection (VAD), dilakukan augmentasi dan normalisasi fitur menggunakan cepstral mean and variance normalization (CMVN) serta dilakukan filtering. …”
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Multicomponent rehabilitation to improve independence and functioning in elderly patients with common age-associated diseases: a scoping review by Omar Baritello, Hanna Stein, Heinz Völler, Annett Salzwedel, Theo Taxis, Machteld Luizink-Dogan

“…Care dependency, physical function, health-related quality of life (HRQL) and activities of daily living (ADL) after ≥6 months follow-up were the outcomes of interest.Data extraction and synthesis Four reviewers independently screened titles, abstracts and full texts for inclusion and extracted data. …”
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Effects of ursolic acid on growth performance, serum biochemistry, antioxidant capacity, and intestinal health of broilers by X.W. Zhang, X. Li, Y. Yin, M. Wang, Y.F. Wang, J.Y. Chen, Y.R. Zhao

“…The UA supplementation improved total antioxidant capacity, total superoxide dismutase, and glutathione peroxidase activity in serum (P < 0.05), and increased these levels in the jejunum (P < 0.05). …”
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Effects of a social participation-focused virtual reality intervention for community-dwelling stroke survivors with physical disabilities: a randomised controlled trial protocol by Janita Pak Chun Chau, Suzanne Hoi Shan Lo, Vivian Wing Yan Lee, Kai Chow Choi, Alexander Yuk Lun Lau, David R Thompson, Eddie Chi Fai Kwok

“…Introduction Studies show that stroke survivors encounter physical and psychological limitations that restrict their participation in social and community activities. Systematic reviews have yielded inconclusive evidence regarding the effectiveness of different interventions intended to support stroke survivors’ social participation. …”
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A Study of Trichomonas vaginalis Infection and Correlates in Women with Vaginal Discharge Referred at Fann Teaching Hospital in Senegal by Roger C. Tine, Khadime Sylla, Rougyatou Ka, Lamine Dia, Doudou Sow, Souleye Lelo, Khardiata Diallo, Babacar Faye, Thérèse Dieng, Cheikh T. Ndour, Ahmet Y. Sow

“…Trichomonas vaginalis remains prevalent among sexually active women. Strategies aiming at improving disease awareness in these high-risk groups are needed to improve trichomoniasis prevention but extensive epidemiological data are still needed for a better understanding of the disease transmission dynamic.…”
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Evaluation of the antibacterial and antibiofilm effect of mycosynthesized silver and selenium nanoparticles and their synergistic effect with antibiotics on nosocomial bacteria by Nahed Fathallah Fahmy, Marwa Mahmoud Abdel-Kareem, Heba A. Ahmed, Mena Zarif Helmy, Ekram Abdel-Rahman Mahmoud

“…Mycosynthesized silver nanoparticles (AgNPs) and selenium nanoparticles (SeNPs) using Aspergillus carneus MAK 259 has been investigated and demonstrate antibacterial, antibiofilm and synergistic activities against (MRSA) and (MDR P. aeruginosa). Results In the current research, silver nanoparticles (AgNPs) and selenium nanoparticles (SeNPs) were produced extracellularly using A. carneus MAK 259 culture supernatants. …”
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A tale for two roles: Root-secreted methyl ferulate inhibits P. nicotianae and enriches the rhizosphere Bacillus against black shank disease in tobacco by Siqi Ma, Qianru Chen, Yanfen Zheng, Tingting Ren, Rui He, Lirui Cheng, Ping Zou, Changliang Jing, Chengsheng Zhang, Yiqiang Li

“…Our findings also revealed that methyl ferulate strongly inhibited P. nicotianae (EC50 = 67.51 µg/mL), effectively controlling tobacco black shank disease by impairing NADH dehydrogenase function (the activity decreased by 50%). Furthermore, methyl ferulate recruited disease-suppressive rhizosphere microbes, such as Bacillus (the relative abundance of these microbes increases from 4.69% to 13.79%), thereby increasing disease resistance. …”
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Simvastatin Posttreatment Controls Inflammation and Improves Bacterial Clearance in Experimental Sepsis by Flora Magno de Jesus Oliveira, Cassiano Felippe Gonçalves-de-Albuquerque, Isabel Matos Medeiros de Moraes, Patrícia Alves Reis, Vinicius Novaes Rocha, Patrícia Torres Bozza, Adriana Ribeiro Silva, Hugo Caire de Castro Faria Neto

“…We measured plasma biochemical markers of organ dysfunction, cell migration, cell activation, bacterial elimination, production of nitric oxide 24 h after CLP, survival rate for 7 days, and cognitive impairment 15 days after CLP. …”
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OSSERVARE E INSEGNARE L’ESPRESSIONE DELL’APPROSSIMAZIONE NELL’ITALIANO PARLATO ACCADEMICO: L’USO DI LISTE ED ECCETERA by Elisa Fiorenza

“…Finally, the study presents an applicative part dedicated to the proposal of teaching activities on LAD+“etcetera” aimed at developing metalinguistic awareness in spoken Italian in an academic context. …”
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Modified Delphi expert elicitation of the clinical and economic burden of obstructive hypertrophic cardiomyopathy in England and Northern Ireland by Faizel Osman, Michael Hurst, Belinda Sandler, Taryn Krause, Carla Zema, Teresa Lemmer, Kathleen Noon, Deepak Alexander

“…Objective To estimate the resource use of patients with obstructive hypertrophic cardiomyopathy (HCM), stratified by New York Heart Association (NYHA) class, in the English and Northern Irish healthcare systems via expert elicitation.Design Modified Delphi framework methodology.Setting UK HCM secondary care centres (n=24).Participants Cardiologists who actively treated patients with HCM were eligible, of whom 10 from English and Northern Irish centres participated. …”
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Colorectal Cancer Racial Equity Post Volume, Content, and Exposure: Observational Study Using Twitter Data by Chau Tong, Drew Margolin, Jeff Niederdeppe, Rumi Chunara, Jiawei Liu, Lea Jih-Vieira, Andy J King

“…These accounts were defined as those actively sharing information related to racial equity in CRC outcomes. …”
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Reduction on Proinflammatory Cytokines after Application of Transcutaneous Electrical Nerve Stimulation (TENS) in Patients with a Breast Cancer: A Nonrandomized, Open, and Single-A... by Tábata Cristina do Carmo Almeida, Simone Meneghette Zatta, Laércio da Silva Paiva, Luís Eduardo Werneck de Carvalho, Jean Schoueri, Luiz Carlos de Abreu, Fernando Luiz Affonso Fonseca, Fernando Adami

“…Studies also suggest that the worst prognosis of breast cancer, one of the types with the highest incidence in the world, may be related to increased inflammatory activity. Considering that inflammation is increased in breast cancer and that TENS can reduce proinflammatory cytokines even without blocking the pain pathway, our hypothesis is that the anti-inflammatory effect of TENS can bring benefits to these patients. …”
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