Characterising melanoma diagnostic pathways for patients in routine practice using administrative health data in Ontario, Canada: a population-based study by Frances C Wright, Timothy P Hanna, Patti A Groome, Nicole J Look Hong, Meaghan E Mavor, Yuka Asai, Hugh Langley

“…Indicator variables characterised the patient’s keratinocyte carcinoma and dermatologist history, presentation pattern, procedure types, number of visits and procedures, and the activity on the diagnosis date. χ2 tests and Pearson residuals were used. …”
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Hydrogen production by water electrolysis: Advances, challenges and future prospects by Zheng ZHANG, Lingjun SONG

“…In catalyst development, new materials and structural improvements are under exploration for improving catalyst activity, stability, and cost-effectiveness. By optimizing system design and component synergy, electrolysis technology for hydrogen production is developing toward improved catalyst performance, reduced energy consumption, and efficient equipment. …”
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Elucidating the Role of HIF-1α/YAP Signaling Pathway in Regulating Inflammation in Human Periodontal Stem Cells: An in vitro Study by Zhao HW, Liu ST, Wang XJ, Zhang XM, Ma X

“…YAP knockdown via siRNA transfection reversed these effects, increasing IL-1β and TNF-α levels (P < 0.01) while significantly reducing HIF-1α expression (P < 0.05).Conclusion: This study demonstrated that DMOG reduces inflammatory cytokine expression in hPDLSCs by stabilizing HIF-1α and activating the YAP signaling pathway. These findings provide a mechanistic basis for targeting the HIF-1α/YAP axis to control periodontal inflammation and support the potential of PHD inhibitors as therapeutic agents for periodontitis.Keywords: periodontitis, HIF-1α, YAP, DMOG, inflammation…”
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The Effect of Cumin on the Formation of <i>β</i>-Carboline Heterocyclic Amines in Smoked Meat and Simulated Systems by Xiuxiu Liu, Wenyu Chen, Minghao Sun, Xufang Lv, Xing Shen, Zhongping Chai, Maomao Zeng

“…Additionally, the Hetian cumin extract demonstrated superior antioxidant capacity, with an FRAP antioxidant activity reaching 21.04 μM TE/g dw, the highest among all samples. …”
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Differential controls on CO2 and CH4 emissions from the free-flowing Neretva River, Bosnia and Herzegovina by Martin Dalvai Ragnoli, Thea Schwingshackl, Serafine Kattus, Julius Lissy, Elisabeth Weninger, Gabriel Singer

“…This remote river network has so far remained barely influenced by human activities and the hydromorphological status is to date not altered. …”
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Methodological and practical aspects of using satellite imagery to assess the military impact on soils by Vitalii Lebed, Maksym Solokha, Vadym Solovei, Anatolii Kucher, Ludmila Vorotyntseva

“…This study aimed to assess the condition of soils and the extent of their damage due to military activity within the Chkalovske territorial community of the Chuhuiv District in the Kharkiv Region. …”
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Phylogenomic analysis reveals exceptions to the co-evolution of ZAR1 and ZRK immune gene families in plants by Li Yang, Shengyi Liu, M. Eric Schranz, Klaas Bouwmeester

“…Abstract Background HOPZ-ACTIVATED RESISTANCE 1 (ZAR1) is a nucleotide-binding leucine-rich repeat (NLR) protein functioning as a recognition hub to initiate effector-triggered immunity against bacterial pathogens. …”
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Deciphering the Role of CD36 in Gestational Diabetes Mellitus: Linking Fatty Acid Metabolism and Inflammation in Disease Pathogenesis by Huang L, Zhang T, Zhu Y, Lai X, Tao H, Xing Y, Li Z

“…This review provides an overview of the current knowledge regarding the expression and function of CD36 in various tissues throughout pregnancy and explores how CD36 dysregulation can activate inflammatory pathways, worsen insulin resistance, and disrupt lipid metabolism, thereby complicating the necessary metabolic adjustments during pregnancy. …”
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Knowledge, attitude and practice of community pharmacy personnel in tuberculosis patient detection: a multicentre cross-sectional study in a high-burden tuberculosis setting by Rovina Ruslami, Rizky Abdulah, Rob E Aarnoutse, Ivan Surya Pradipta, Khairunnisa Khairunnisa, Muh Akbar Bahar, Mersa Nurain Kausar, Efi Fitriana

“…A comprehensive assessment is needed to develop effective strategies to engage the community pharmacy in TBPD activities.…”
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Adipose tissue-derived microRNA-450a-5p induces type 2 diabetes mellitus by downregulating DUSP10 by Jiaojiao Zhu, Yanting Hou, Wei Yu, Jingzhou Wang, Xiaolong Chu, Xueting Zhang, Huai Pang, Dingling Ma, Yihan Tang, Menghuan Li, Chenggang Yuan, Jianxin Xie, Cuizhe Wang, Jun Zhang

“…Additionally, microRNA-450a-5p was found to regulate DUSP10 expression and insulin signaling activity, influencing glucose tolerance and insulin sensitivity across various models, including normal diet, HFD-induced obese, adipose tissue-specific microRNA-450a-5p-knockout, and db/db mice. …”
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Transcranial photobiomodulation for reducing symptoms of autism spectrum disorder and modulating brain electrophysiology in children aged 2–7: an open label study by Yuli Fradkin, Joaquin A. Anguera, Alexander J. Simon, Luis De Taboada, Eugenia Steingold

“…We collected electroencephalogram (EEG) data after each treatment session from all children who tolerated wearing the EEG cap to monitor changes in brain activity.ResultsThe intervention resulted in a significant 7-point reduction in average CARS-2 scores (t = 10.23, p &lt; .0001), along with decreased delta power and increased gamma and beta power in EEG readings. …”
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Effects of High‐Fructose Corn Syrup Addition to Broiler Diets on Performance, Carcass Yield, Visceral Weights, Gut pH and Some Blood Parameters by Gökhan Şen, Mehmet Demirci, Şevket Evci, Ali Şenol, Mehmet Akif Karsli

“…Blood samples were taken at the end of the experiment and used to spectrophotometrically determine triglyceride, total cholesterol, high‐density lipoprotein (HDL‐CHO), low‐density lipoprotein (LDL‐CHO), glucose (GLU), creatinine (CRE), uric acid and insulin concentrations, as well as aspartate aminotransferase and alanine aminotransferase activities and oxidative stress markers. Proinflammatory cytokine levels were measured using ELISA test kits. …”
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Predictors of Neurological and Functional Recovery in Patients with Moderate to Severe Ischemic Stroke: The EPICA Study by Manuel Murie-Fernández, Mercedes Molleda Marzo

“…A large proportion of patients recovered from severe dependency on activities of daily living (ADL) at D0 to a mild or moderate disability requiring some help at M3: mean NIHSS=10.8 to 5.7; median modified Rankin Scale mRS=4 to 3; Barthel index BI=40 to 70; all p values<0.001. …”
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Un port rural antique de fond d’estuaire à Blainville-sur-Orne (Calvados) by Cécile Allinne

“…The example in the Landes also proves that these types of constructions were well adapted to a river environment with low activity and subject to the tides, as was the case in the upper part of the ancient estuary of the Orne river. …”
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Synthesis and characteristics of Fe/Ni/Cr oxide nanoparticles/PLA hybrid composite coatings on Mg–Zn–Ca alloy by Prakash Kumar, Aditya Kudva S, AnilKumar T, Ramesh S, M.R. Ramesh, Ashwini Prabhu, Gajanan Anne

“…Coleus amboinicus is known for its various medicinal properties, including immunoregulatory effects, antimicrobial activity, anti-inflammatory properties, and potential use in treating sepsis and other ailments. …”
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Cranioplasty infection in porous hydroxyapatite: Potential antibacterial properties by Ismail Zaed, Corrado Iaccarino, Francesca Faedo, Laura Grillini, Elisabetta Galassi, Alessandro Dotti, Angelo Nataloni, Francesca Carolina Mannella, Andrea Cardia

“…Method: The test method has been designed to evaluate the potential antimicrobial activity of specimens under dynamic contact conditions to overcome difficulties in ensuring contact of inoculum to the specimen surface. …”
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Studying sex differences in responses to fibroblast growth factor 21 administration in obese mice consuming a sweet-fat diet by N. М. Bazhan, T. V. Jakovleva, A. Yu. Kazantseva, N. E. Kostina, P. E. Orlov, N. Yu. Balybina, K. О. Baranov, E. N. Makarova

“…FGF21 administration reduced body weight, did not alter total energy consumption, and activated orexigenic pathways of hypothalamus in mice of both sexes. …”
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Identification and Verification of Novel Biomarkers Involving Rheumatoid Arthritis with Multimachine Learning Algorithms: An In Silicon and In Vivo Study by Fucun Liu, Juelan Ye, Shouli Wang, Yang Li, Yuhang Yang, Jianru Xiao, Aimin Jiang, Xuhua Lu, Yunli Zhu

“…Chemokine- and Th cell-related signatures were significantly activated in RA tissues. Four promising and novel biomarkers, including CRTAM, PTTG1IP, ITGB2, and MMP13, were identified and verified, which could be treated as novel treatment and diagnostic targets for RA. …”
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Presenting the Model of Eco-Leadership in Elementary Schools with an Interpretive Phenomenological Approach by Adel Zahed babolan, Seyyedmohammad Seyyedkalan

“…Many principals and teachers argue that talking about ecological educational and training activities and observing the environmental conditions of schools is still the missing link in the educational system, which is impossible without valid reflections and criticisms of the school environment. …”
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Consumer Products Nerve Injuries Among Patients Products Presenting to United States Emergency Departments Between 2012 and 2021: A Nationwide Cohort by Ganga A, Mukhdomi T, Kim EJ, Ly E, Patel Y, Dankievitch KN, Kendall MC

“…Injuries often occur either due to activity (ie sports related injury) or due to consumer products such as stairs or bedframes. …”
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