The First Ground‐Level Enhancement of Solar Cycle 25 as Seen by the High‐Energy Particle Detector (HEPD‐01) on Board the CSES‐01 Satellite by Matteo Martucci, Monica Laurenza, Simone Benella, Francesco Berrilli, Dario DelMoro, Luca Giovannelli, Alexandra Parmentier, Mirko Piersanti, Gabor Albrecht, Simona Bartocci, Roberto Battiston, William J. Burger, Donatella Campana, Luca Carfora, Giuseppe Consolini, Livio Conti, Andrea Contin, Cinzia De Donato, Cristian De Santis, Francesco Maria Follega, Roberto Iuppa, Alessandro Lega, Nadir Marcelli, Giuseppe Masciantonio, Matteo Mergé, Marco Mese, Alberto Oliva, Giuseppe Osteria, Francesco Palma, Beatrice Panico, Francesco Perfetto, Piergiorgio Picozza, Michele Pozzato, Ester Ricci, Marco Ricci, Sergio Bruno Ricciarini, Zouleikha Sahnoun, Valentina Scotti, Alessandro Sotgiu, Roberta Sparvoli, Vincenzo Vitale, Simona Zoffoli, Paolo Zuccon

“…The event was associated with the major, long‐duration X1‐class flare and the concomitant coronal mass ejection (CME) that erupted from the Active Region 12887. This is the first direct measurement from space of solar particles emitted during the current solar cycle, recorded by a single instrument in the energy range from ∼50 MeV/n up to ∼250 MeV/n. …”
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Piloting an external quality assurance program (QAP) for COVID-19 antigen rapid diagnostic tests (Ag-RDTs): findings and lessons learned from Cambodia by Vonthanak Saphonn, John Kaldor, Deborah Williamson, Sothavireak Bory, Philip Cunningham, Jessica Markby, Kennarey Seang, Jacqueline Prestedge, Chan Leakhena Phoeung, Marilyn Ninan, Kanika Heng, Andrew Valley

“…However, to ensure sustainability and practicability of this activity, in-country EQA panel preparation may need to be considered.…”
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Inflammatory rheumatic diseases with onset after SARS-CoV-2 infection or COVID-19 vaccination: a report of 267 cases from the COVID-19 and ASD group by Laura Massaro, Annamaria Iagnocco, Florenzo Iannone, Corrado Campochiaro, Maria De Santis, Ilaria Cavazzana, Piero Ruscitti, Roberto Giacomelli, Rosario Foti, Lorenzo Dagna, Giovanna Cuomo, Giacomo De Luca, Francesco Caso, Ilenia Di Cola, Clodoveo Ferri, Vincenzo Raimondo, Francesco Ursini, Veronica Brusi, Giuseppe Varcasia, Roberta Pellegrini, Domenico Olivo, Giuseppe Murdaca, Carlo Selmi, Olga Addimanda, Erika Pigatto, Francesca Francioso, Rossella De Angelis, Jacopo Ciaffi, Luana Mancarella, Marcella Visentini, Francesca Motta, Virginia Caira, Alberto Lo Gullo, Caterina Naclerio, Elena Marchetti, Sebastiano Lorusso, Jessica Luppino, Roberta Foti, Massimo Reta

“…Despite the short follow-up period, IJD and PMR patients’ response to first-line therapy was favourable, with both groups achieving a drop in baseline disease activity scores of ~30% and ~70% respectively.Conclusion Our article reports the largest cohort published to date of new-onset IRD following SARS-CoV-2 infection or COVID-19 vaccines. …”
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MRI-based analysis of the microstructure of the thalamus and hypothalamus and functional connectivity between cortical networks in episodic cluster headache by Chiara Abagnale, Antonio Di Renzo, Giada Giuliani, Gabriele Sebastianelli, Francesco Casillo, Lucia Ziccardi, Vincenzo Parisi, Cherubino Di Lorenzo, Mariano Serrao, Francesca Caramia, Vittorio Di Piero, Gianluca Coppola

“…Conclusion Our findings presented the possibility of a correlation between the FC of the SN and the inability to switch between internalizing and externalizing brain activity during demanding cognitive tasks, such as recurring headaches. …”
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Methyl 3-Bromo-4,5-dihydroxybenzoate Attenuates Inflammatory Bowel Disease by Regulating TLR/NF-κB Pathways by Jing Huang, Lei Li, Liyan Xu, Lixin Feng, Yuxin Wang, Attila Gabor SIK, Meng Jin, Rongchun Wang, Kechun Liu, Xiaobin Li

“…Here, we aimed to illustrate the anti-inflammatory activity and the underlying mechanism of methyl 3-bromo-4,5-dihydroxybenzoate (MBD), a compound derived from marine organisms, especially in IBD, using a zebrafish model. …”
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Monitoring changes of forest height in California by Samuel Favrichon, Jake Lee, Yan Yang, Yan Yang, Ricardo Dalagnol, Ricardo Dalagnol, Fabien Wagner, Le Bienfaiteur Sagang, Le Bienfaiteur Sagang, Sassan Saatchi, Sassan Saatchi, Sassan Saatchi

“…Forests of California are undergoing large-scale disturbances from wildfire and tree mortality, caused by frequent droughts, insect infestations, and human activities. Mapping and monitoring the structure of these forests at high spatial resolution provides the necessary data to better manage forest health, mitigate wildfire risks, and improve carbon sequestration. …”
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Identification of a transcription factor AoMsn2 of the Hog1 signaling pathway contributes to fungal growth, development and pathogenicity in Arthrobotrys oligospora by Qianqian Liu, Kexin Jiang, Shipeng Duan, Na Zhao, Yanmei Shen, Lirong Zhu, Ke-Qin Zhang, Jinkui Yang

“…A previous study showed that high-osmolarity glycerol (Hog1) signaling regulates the osmoregulation and nematocidal activity of A. oligospora. However, the function of downstream transcription factors of the Hog1 signaling in the nematode-trapping (NT) fungi remains unclear. …”
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Ginger protects against vein graft remodeling by precisely modulating ferroptotic stress in vascular smooth muscle cell dedifferentiation by Xiaoyu Yu, Weiwei Wu, Jingjun Hao, Yuxin Zhou, Deyang Yu, Wei Ding, Xuejuan Zhang, Gaoli Liu, Jianxun Wang

“…Furthermore, both ingredients co-target peroxisome proliferator-activated receptor gamma (PPARγ), decreasing PPARγ-mediated nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 1 (Nox1) expression. …”
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A new phase of China-ASEAN health cooperation: the China-ASEAN Beijing Declaration on Cooperation in Innovation of Health Products and Technologies by Jie Qiao, Siyan Zhan, Minghui Ren, Haijun Wang, Yangmu Huang, Zhenyu Zhang, Yanan Luo, Hui Yin, Zhongwei Jia, Wei Huang, Hong Zhou, Jue Liu, Xiaoyun Liu, Qiudan Sun, Xiaojia Li, Jing Bai, Fangjing Liu, Yihong Liu, Yinzi Jin, Ming Xu, on behalf of China-ASEAN Science and Technology Cooperation Center for Public Health

“…The Declaration will play an active role in regional public health governance and development cooperation, in order to promote the R&D and accessibility of health products in the region and to help achieve faster and more equitable access to health products for a broader population.…”
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Glucose‐induced LINC01419 reprograms the glycolytic pathway by recruiting YBX1 to enhance PDK1 mRNA stability in hepatocellular carcinoma by Yanfang Liu, Junjiao Song, Qili Shi, Bing Chen, Wenying Qiu, Yizhe Liu, Shenglin Huang, Xianghuo He

“…Furthermore, YY1 contributed to the transcriptional activation of LINC01419 in HCC under high‐glucose conditions. …”
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Uncovering molecular mechanisms of soybean response to 12C6+ heavy ion irradiation through integrated transcriptomic and metabolomic profiling by Honglei Ren, Bixian Zhang, Chunlei Zhang, Xiulin Liu, Xueyang Wang, Fengyi Zhang, Kezhen Zhao, Rongqiang Yuan, Ahmed M. Abdelghany, Sobhi F. Lamlom

“…Specifically, we observed significant up-regulation of 24 DEGs, notable down-regulation of 8 DEMs, and significant activation of 15 metabolic pathways, all of which contributed to the observed phenotypic changes. …”
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Implementation of model-informed precision dosing for tamoxifen therapy in patients with breast cancer: A prospective intervention study by Ruben Y.M. van Nijnatten, Sanne M. Buijs, Bram C. Agema, Raphaël M.J. Fischer, Inge Ghobadi Moghaddam-Helmantel, Caroline M.E. Contant, Felix E. de Jongh, Auke M.T. Huijben, Manon Kop, Annemieke van der Padt-Pruijsten, Hanneke J.M. Zuetenhorst, Ron H.N. van Schaik, Birgit C.P. Koch, A. Jager, Stijn L.W. Koolen, Ron H.J. Mathijssen

“…It is converted by CYP2D6 into endoxifen, its most active metabolite. Patients with endoxifen plasma concentrations <16 nM face a higher risk of recurrence. …”
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The Role of Intravitreal Anti-VEGF Agents in Rabbit Eye Model of Open-Globe Injury by Xiao Zhao, Han Han, Yinting Song, Mei Du, Mengyu Liao, Xue Dong, Xiaohong Wang, Ferenc Kuhn, Annette Hoskin, Heping Xu, Hua Yan

“…Vitreous levels of vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), transforming growth factor-beta (TGF-β), and plasminogen activator inhibitor-1 (PAI-1) were significantly increased in rabbit eyes after OGI. …”
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Effectiveness and Safety of Hair Growth Formulation Containing L.f (Teak) Leaf Extract: A Randomized, Double-Blind, Placebo-Controlled Study on Males with Androgenic Alopecia by Nutchaninad Tanuphol B.ATM, Neti Waranuch PhD, Vanuchawan Wisuitiprot PhD, Wudtichai Wisuitiprot PhD, Kamonlak Insumrong PhD, Prapapan Temkitthawon PhD, Nungruthai Suphrom PhD, Katechan Jampachaisri PhD, Corine Girard PhD, Kornkanok Ingkaninan PhD

“…Teak ( Tectona grandis L.f) leaf extract exhibited a potent S5AR inhibitory activity. To prove the effectiveness and safety of teak leaf extract as a hair growth promotor, a double-blind, randomized placebo-controlled trial was conducted. …”
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Lactate accumulation promotes immunosuppression and fibrotic transformation of bone marrow microenvironment in myelofibrosis by Mariarita Spampinato, Cesarina Giallongo, Sebastiano Giallongo, Enrico La Spina, Andrea Duminuco, Lucia Longhitano, Rosario Caltabiano, Lucia Salvatorelli, Giuseppe Broggi, Elisabetta P. Pricoco, Vittorio Del Fabro, Ilaria Dulcamare, Antonio Massimo DI Mauro, Alessandra Romano, Francesco Di Raimondo, Giovanni Li Volti, Giuseppe A. Palumbo, Daniele Tibullo

“…Results Our results show an activation of a cancer-associated phenotype (CAF) related to mineralized matrix formation and early fibrosis development. …”
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Preparation of Sea-buckthorn Oil Microcapsule Composite Film and the Preservation Effect of Hand-grabbed Mutton by Bingbing ZHANG, Guishan LIU, Delang XIE, Haiyang MA, Yang LI, Fang MA, Xiaojun LI, Qingqing CAO, Xiaoxue LI, Qian ZHANG

“…The mechanical properties, surface morphology and antioxidant and antibacterial activities of the composite film were measured, and the film was fitted on the surface of hand-grabbed mutton. …”
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Physio-Biochemical Indexes as Indicators of Cadmium Tolerance in <i>Brassica napus</i> L. Cultivars by Yu Qiu, Shuhe Wei, Jie Zhan, Brett H. Robinson, Lidia Skuza, Jianming Xue, Huiping Dai, Li Zhan, Ziyang Tang

“…There were significant positive correlations between TI and chlorophyll a (Chla), chlorophyll b (Chlb), carotenoids (Car), net photosynthetic rate (Pn), transpiration rate (Tr), and activities of antioxidant enzymes and non-enzymatic antioxidants such as superoxide dismutase (SOD), ascorbate peroxidase (APX), glutathione (GSH), and ascorbic acid (ASA), while negatively correlating with intercellular CO₂ concentration (Ci) and malondialdehyde (MDA) content. …”
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Climate change and the sustainable use of medicinal plants: a call for “new” research strategies by Olha Mykhailenko, Olha Mykhailenko, Banaz Jalil, Lyndy J. McGaw, Javier Echeverría, Marce Takubessi, Marce Takubessi, Michael Heinrich, Michael Heinrich

“…Climate change and human activities severely impact the viability of plants and ecosystems, threatening the environment, biodiversity, and the sustainable development of plant-based products. …”
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Comparative Proteomic Analysis of Visceral Adipose Tissue in Morbidly Obese and Normal Weight Chinese Women by Chen Shang, Wei Sun, Chunlin Wang, Xiangqing Wang, Huijuan Zhu, Linjie Wang, Hongbo Yang, Xue Wang, Fengying Gong, Hui Pan

“…These altered VAT proteins were involved in the attenuation of the liver X receptor/retinoid X receptor (LXR/RXR) signaling pathway and the activation of the acute-phase response process. Three proteins (ACSL1, HADH, and UCHL1) were validated by western blotting using the same set of VAT samples from 6 morbidly obese and 7 normal weight patients, and the results indicated that the magnitude and direction of the protein changes were in accordance with the proteomic analysis. …”
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Targeting KRAS G12C and G12S mutations in lung cancer: In silico drug repurposing and antiproliferative assessment on A549 cells by Mansour S. Alturki, Nada Tawfeeq, Amal Alissa, Zahra Ahbail, Mohamed S. Gomaa, Abdulaziz H. Al Khzem, Thankhoe A. Rants'o, Mohammad J. Akbar, Waleed S. Alharbi, Bayan Y. Alshehri, Amjad N. Alotaibi, Fahad A. Almughem, Abdullah A. Alshehri

“…The antiproliferative efficacy of these drugs was evaluated by MTS tests, and their IC50 values were determined in which natamycin, although non-selective, and cortisone showed the highest activity with IC50 of 53.42 and 53.51 μg/mL, respectively, followed by cefadroxil (84.63 μg/mL). …”
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