Nr5a2 promotes cancer stem cell properties and tumorigenesis in nonsmall cell lung cancer by regulating Nanog by Ting Ye, Jingyuan Li, Zhiwei Sun, Yongli Liu, Liangsheng Kong, Shixia Zhou, Junlin Tang, Jianyu Wang, H. Rosie Xing

“…More importantly, we revealed that Nr5a2’s regulatory role in promoting LLC‐SD self‐renewal is mediated by transcriptional activation of its direct target Nanog. Taken together, in this study, we have provided convincing evidence in vitro and in vivo demonstrating that Nr5a2 can induce lung CSC properties and promote tumorigenesis and progression through transcriptional up‐regulation of Nanog.…”
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Autoinflammatory diseases. Part 1: concept, classification, immunobiology, diagnosis by O.V. Shvaratska, M.V. Kalichevska, O.V. Klymenko, O.M. Taran, O.V. Klimova, Y.V. Vilenskyi, T.M. Plekhanova, T.K. Mavropulo

“…Systemic autoinflammatory diseases (SAIDs) are a group of inherited monogenic diseases characterized by dysregulated innate immunity leading to excessive activation of inflammatory pathways. Recently, some molecular mechanisms typical for autoinflammation have also been recognized in the pathogenesis of several autoimmune and immunodeficiency states. …”
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Alternative silencing states of transposable elements in Arabidopsis associated with H3K27me3 by Valentin Hure, Florence Piron-Prunier, Tamara Yehouessi, Clémentine Vitte, Aleksandra E. Kornienko, Gabrielle Adam, Magnus Nordborg, Angélique Déléris

“…These H3K27me3-marked TEs not only comprise degenerate relics but also seemingly intact copies that display the epigenetic features of responsive PcG target genes as well as an active H3K27me3 regulation. We also show that H3K27me3 can be deposited on newly inserted transgenic TE sequences in a TE-specific manner indicating that silencing is determined in cis. …”
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3D bioprinting lobule-like hepatorganoids with induced vascularization for orthotopic implantation by Jianing Yan, Zhichao Ye, Yiwei Lu, Yuyang Yuan, Xiaofeng Wang, Tingting Yan, Jun Yin, Yifan Wang

“…In this research, we developed a 3D bioprinting method using gelatin methacryloyl (GelMA) hydrogel to fabricate lobule-like hepatorganoids, which faithfully mimic the structure of hepatic lobules with lower level of hypoxia (lobule vs 60°, 90°, control; 0.4880 vs 1.009, 0.6778, 0.8704; p < 0.01), high secretion of albumin (lobule vs 60°, 90°, control; 13.47 vs 12.39, 12.65, 10.08 mg/L; p < 0.01) and urea (lobule vs 60°, 90°, control; 5.304 vs 5.233, 4.781, 4.358 mg/L; p < 0.01) in vitro; and promotion of angiogenesis and maintenance of activity following orthotopic implantation. Loaded with a prolonged released system of vascular endothelial growth factor (VEGF) and infused with human umbilical vein endothelial cells (HUVECs), we developed a fabricating method of vascularized lobule-like hepatorganoids (VLH) which possessed promoted vascularization. …”
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Depressive symptoms in older adults are associated with changes in stress-related markers, functional connectivity and brain volume by Edelweiss Touron, Robin de Flores, Laurent Coulbault, Cassandre Palix, Anne Chocat, Elizabeth Kuhn, Brigitte Landeau, Florence Mézenge, Daniel Roquet, Léa Chauveau, Sacha Haudry, Denis Vivien, Vincent de La Sayette, Natalie L. Marchant, Gaël Chételat, Géraldine Poisnel, for the Medit-Ageing Research Group

“…Conclusions Our findings show that subclinical depressive symptoms are associated with increased sympatho-adrenomedullary axis activity, together with lower GM volume in a hippocampal subfield (i.e., CA1) particularly sensitive to AD. …”
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Repeated low-intensity noise exposure exacerbates age-related hearing loss via RAGE signaling pathway by Jianbin Sun, Na Sai, Tong Zhang, Chaoying Tang, Shuhang Fan, Qin Wang, Da Liu, Xianhai Zeng, Juanjuan Li, Weiwei Guo, Shiming Yang, Weiju Han

“…Proteomics analysis revealed an upregulation in the receptor for the advanced glycation end-products (RAGE) signaling pathway, which was associated with an activated inflammatory response, vascular injury, and mitochondrial and synaptic dysfunction. …”
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Effect of adipose tissue deposition on insulin resistance in middle‐aged and elderly women: Based on QCT and MRI mDIXON‐Quant by Ying Liu, Lei Gao, Mengfei Wu, Boyang Yang, Dongxue Ren, Zekun Zhang, Wei Zhang, Yan Wang

“…Early identification and active treatment of adipose tissue deposition, especially hepatic fat deposition, may reserve and delay the progression of IR and even metabolic syndrome.…”
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The association of lifestyle with cardiovascular and all-cause mortality based on machine learning: a prospective study from the NHANES by Xinghong Guo, Mingze Ma, Lipei Zhao, Jian Wu, Yan Lin, Fengyi Fei, Clifford Silver Tarimo, Saiyi Wang, Jingyi Zhang, Xinya Cheng, Beizhu Ye

“…As age increases, the effects of dietary scores and sedentary time on mortality risk become more pronounced, while the influence of physical activity tends to diminish. Conclusion We develop a ML model based on lifestyle behaviors to predict all-cause and cardiovascular mortality. …”
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The Isolation of Lead-Tolerant PGPR from Red Clover Soil and Its Role in Promoting the Growth of Alfalfa by Wanting Nie, Yuchen Wu, Jingwen Jiang, Zicheng Wang, Meiqi Mu, Siwen Zhao, Minghao Yang, Xi Long, Xiujie Yin, Xiaohua Teng

“…They could all significantly raise the chlorophyll content and antioxidant enzyme activity in alfalfa (<i>p</i> < 0.05) and the content of malondialdehyde (MDA) in alfalfa. …”
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Inequalities in physical comorbidity: a longitudinal comparative cohort study of people with severe mental illness in the UK by Tim Doran, Darren M Ashcroft, Evangelos Kontopantelis, David Reeves, Siobhan Reilly, Claire Planner, Ivan Olier, Linda Gask

“…The provision of appropriate timely health prevention, promotion and monitoring activities to reduce these health inequalities are needed, especially in deprived areas.…”
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Aspirin modulates generation of procoagulant phospholipids in cardiovascular disease, by regulating LPCAT3 by Majd B. Protty, Victoria J. Tyrrell, Ali A. Hajeyah, Bethan Morgan, Daniela Costa, Yong Li, Anirban Choudhury, Rito Mitra, David Bosanquet, Alex Reed, Iuliia K. Denisenko, Katsuyuki Nagata, Hideo Shindou, Benjamin F. Cravatt, Alastair W. Poole, Takao Shimizu, Zaheer Yousef, Peter W. Collins, Valerie B. O’Donnell

“…LPCAT3 inhibition selectively prevented 12-LOX-derived diacyl-eoxPL generation. LPCAT3 activity was not directly altered by aspirin. P2Y12 inhibition or aspirin had little impact on eoxPL in leukocytes. …”
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Direct-acting oral anticoagulant removal by intraoperative hemoadsorption in CABG and/or single valve surgery: interim analysis of the International Safe and Timely Antithrombotic... by Michael Schmoeckel, Matthias Thielmann, Keti Vitanova, Thomas Eberle, Nandor Marczin, Kambiz Hassan, Andreas Liebold, Sandra Lindstedt, Georg Mächler, Marijana Matejic-Spasic, Daniel Wendt, Efthymios N. Deliargyris, Robert F. Storey

“…Methods The hemoadsorption device was incorporated into the cardiopulmonary bypass (CPB) circuit and active for the duration of the pump run. Patients on DOACs undergoing CABG and/or single valve surgery before completing the recommended washout were included. …”
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Associations between contextual and compositional characteristics of early childcare facilities with health, health behaviours and well-being among young children aged 0 to 6 years... by Jennifer Hilger-Kolb, Sven Schneider, Raphael Herr, Nina Osenbruegge, Stephanie Hoffmann, Max Herke, Claudia Pischke, Leonie Sundmacher, Katharina Diehl

“…In recent years, an increasing amount of studies has focused on contextual and compositional characteristics of early childcare facilities and their association with health (eg, self-rated health), health behaviour (eg, physical activity) and well-being (eg, emotional well-being) in this age group. …”
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Efficacy, efficiency and safety of a cardiac telerehabilitation programme using wearable sensors in patients with coronary heart disease: the TELEWEAR-CR study protocol by Andrew Xanthopoulos, Eleni Kapreli, Garyfallia Pepera, Konstantinos I Gourgoulianis, Varsamo Antoniou, Gregory Giamouzis, Constantinos Davos, Ladislav Batalik, Vasileios Stavrou, John Skoularigis

“…Secondary outcomes will be the physical activity, the safety of the exercise intervention (number of adverse events that may occur during the exercise), the quality of life, the training adherence, the anxiety and depression levels, the nicotine dependence and cost-effectiveness. …”
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Prevalence and prognostic value of ventricular conduction delay in heart failure with preserved ejection fraction by Anouk Achten, Jerremy Weerts, Johan van Koll, Mohammed Ghossein, Sanne G.J. Mourmans, Arantxa Barandiarán Aizpurua, Antonius M.W. van Stipdonk, Kevin Vernooy, Frits W. Prinzen, Hans-Peter Brunner-La Rocca, Christian Knackstedt, Vanessa P.M. van Empel

“…Only 4 % had a QRS area ≥69µVs, indicating delayed lateral wall activation. After a median of 3 years follow-up, 30 % of the patients had an adverse outcome. …”
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BPZ inhibits early mouse embryonic development by disrupting maternal-to-zygotic transition and mitochondrial function by Zhiming Ding, Huilei Chen, Huiru Cheng, Caiyun Wu, Hongzhen Ruan, Bingjing Zhu, Ping Zhou, Zuying Xu, Huifen Xiang

“…Mechanistically, BPZ exposure inhibits the activation of the zygotic genome and impedes maternal mRNA degradation, thereby interfering with maternal-to-zygotic transition (MZT). …”
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The ArcB kinase sensor participates in the phagocyte-mediated stress response in Salmonella Typhimurium by Coral Pardo-Esté, Coral Pardo-Esté, Francisca Urbina, Nicolas Aviles, Nicolas Pacheco, Alan Briones, Carolina Cabezas, Vicente Rojas, Valentina Pavez, Yoelvis Sulbaran-Bracho, Yoelvis Sulbaran-Bracho, Alejandro A. Hidalgo, Juan Castro-Severyn, Juan Castro-Severyn, Claudia P. Saavedra

“…The ArcA transcription factor activates genes related to metabolism, membrane permeability, and virulence, and its presence is required for pathogenicity in Salmonella Typhimurium, which can be phosphorylated independently of its cognate sensor, ArcB. …”
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Antioxidant Potential, Subacute Toxicity, and Beneficiary Effects of Methanolic Extract of Pomelo (Citrus grandis L. Osbeck) in Long Evan Rats by Md. Yousuf Ali, Nur-E Noushin Rumpa, Sudip Paul, Md. Sakib Hossen, E. M. Tanvir, Tareq Hossan, Moumoni Saha, Nadia Alam, Nurul Karim, Md. Ibrahim Khalil, Siew Hua Gan

“…Pomelo extract contained high concentrations of polyphenols, flavonoids, and ascorbic acid while exhibiting high 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity and ferric reducing antioxidant power values. …”
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Kaempferol protects against high-salt-induced hypertension and vascular endothelial injury by inhibiting ferroptosis through the ATF4/ACSL4 pathway by Qiuer Liang, Minghao Chen, Guangtian Chen, Pengli Xu, Lai Kwan Lam, Pengcheng Xie, Ting Xie, Wanqing Tu, Tianhao Liu, Xiaopeng Peng, Haoyao Yuan, Liguo Chen, Ya Xiao

“…Using an 8 % high-salt diet model, we evaluated the effects of Kae (200 mg/kg/day) in wild-type (WT) and activating transcription factor 4 (ATF4+/−) knockout mice. …”
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SEGS-1 episomes generated during cassava mosaic disease enhance disease severity by Evangelista Chiunga, Evangelista Chiunga, Evangelista Chiunga, Catherine D. Aimone, Cyprian Rajabu, Mary M. Dallas, Joseph Ndunguru, José T. Ascencio-Ibáñez, Elijah M. Ateka, Linda Hanley-Bowdoin

“…The functional regions of SEGS-1 were mapped using TME3 to sequences flanking the episome junction, but the junction itself was not required for activity. All cassava cultivars have SEGS-1 sequences in their genomes that have the potential to negatively impact the development of stable CMD resistance by cassava breeding programs.…”
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