Epithelial cell diversity and immune remodeling in bladder cancer progression: insights from single-cell transcriptomics by Jianpeng Li, Yunzhong Jiang, Minghai Ma, Lu Wang, Minxuan Jing, Zezhong Yang, Mengzhao Zhang, Ke Chen, Jinhai Fan

“…Tumor cells in MIBC displayed enhanced glycolytic activity and downregulation of chemokines and MHC-II molecules, reducing immune cell recruitment and facilitating immune evasion. …”
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Clinical Significance of Peripheral Blood T Lymphocyte Subsets in Helicobacter pylori-Infected Patients by Yuka Satoh, Hatsue Ogawara, Osamu Kawamura, Motoyasu Kusano, Hirokazu Murakami

“…Tregs did not decrease, but the activation of humoral immunity and Th2 polarization were observed in the peripheral blood of H. pylori-infected patients. …”
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The issue of motivation for foreign languages learning in international research works: Scoping review by I. K. Tsalikova, S. V. Pakhotina

“…Today, foreign language competence of a person is a necessary means of active social and professional life. Despite this, quite a lot of young people do not always have the desire to learn foreign languages. …”
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Genome-wide microsatellite characterization and their marker development and transferability in Broussonetia Species by Xiaowen Jia, Hanyu Li, Ying Han, Lu Wang, Chanjuan Lai, Xi Liu, Pan Li, Zupei Lei, Yonghua Zhang

“…Genic-mapped SSRs may regulate biological processes by influencing gene activity and protein function. To verify SSRs polymorphism, we selected 30 ones from 10,752 potentially polymorphic SSRs loci for PCR amplification among these three species, all of which were successfully amplified and exhibited polymorphism across these three species. …”
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Lanthanide(III) and Yttrium(III) Complexes of Benzimidazole-2-Acetic Acid: Synthesis, Characterisation and Effect of La(III) Complex on Germination of Wheat

“…The complex was found to exhibit enhanced activity, compared to HBIA or metal salt alone at lower treatment periods.…”
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The MIR181A2HG/miR‐5680/VCAN‐CD44 Axis Regulates Gastric Cancer Lymph Node Metastasis by Promoting M2 Macrophage Polarization by Weijie Zang, Yongpu Yang, Junjie Chen, Qinsheng Mao, Wanjiang Xue, Yilin Hu

“…On the other hand, VCAN binds to CD44 receptors on the surface of GC cells through autocrine secretion, activating the Hippo pathway and upregulating SP1, thereby promoting the transcription of MIR181A2HG and establishing a feedback loop driving lymphatic metastasis. …”
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Exploring the therapeutic potential of 18β-Glycyrrhetinic acid in pulmonary arterial hypertension by integrating network pharmacology and experimental validation by Wenli Yang, Long Ma, Meidong Si, Fang Zhao, Ru Zhou

“…Methods: The analysis of the potential pharmacological activities of 18β-GA was conducted using the network pharmacology method. …”
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House Dust Mite and Cat Dander Extract Induce Asthma-Like Histopathology with an Increase of Mucosal Mast Cells in a Guinea Pig Model by Patricia Ramos-Ramírez, Jielu Liu, Sofia Mogren, Joshua Gregory, Malin Noreby, Anne Petrén, Ying Lei, Henric Olsson, Marianne van Hage, Jukka Kervinen, Lars Hellman, Cecilia Andersson, Gunnar Nilsson, Mikael Adner

“…Mast cell responses are important in asthma as they, upon activation, release mediators inducing bronchoconstriction, inflammatory cell recruitment, and often remodelling of the airways. …”
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Development and validation of an explainable machine learning prediction model of hemorrhagic transformation after intravenous thrombolysis in stroke by Yanan Lin, Yan Li, Yayin Luo, Jie Han

“…ObjectiveTo develop and validate an explainable machine learning (ML) model predicting the risk of hemorrhagic transformation (HT) after intravenous thrombolysis.MethodsWe retrospectively enrolled patients who received intravenous tissue plasminogen activator (IV-tPA) thrombolysis within 4.5 h after symptom onset to form the original modeling cohort. …”
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Association of Plasma Levels of Nitric Oxide Oxidative Metabolites with Acute Stroke in Patients Presenting to the Emergency Department of a Low-Middle Income Country by Shahan Waheed, Ayaz Ghouse Kalsekar, Ayeesha Kamran Kamal, Nathan S. Bryan, Asad I. Mian

“…Acute stroke incites an inflammatory reaction in the brain’s microvasculature, activating formation of nitric oxide oxidative metabolites, nitrate and nitrite (NOx, collectively), measurable in plasma. …”
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Community Caregivers’ Perspectives on Health IT Use for Children With Medical Complexity: Qualitative Interview Study by Farah Elkourdi, Onur Asan

“…Often, there is a need for medical technology and total care for activities of daily living, much of which is provided at home by family and caregivers. …”
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Political Crisis in France: «Gilets Jaunes» and the End of the «First Period» of the Emmanuel Macron’s Governance by E. O. Obichkina

“…The government’s response – revocation of the law that triggered the movement and the launch of «big national debates» – led to a relative decline in the activity of «gilets jaunes», but the main reason for the downturn is preparation for the upcoming European elections, which could be used as an opportunity to voice their discontent with the president and to return the civil protest in the electoral channel. …”
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Enhancing Periodontal Ligament Regeneration via PDLSC Delivery Using Electrospun PCL/Collagen/Cellulose Acetate Scaffolds and Collagen Hydrogel Incorporated with Curcumin-Loaded ZI... by Lan X, Wang Y, Yin M

“…CURZIF-8 hydrogels enhanced anti-inflammatory and antioxidative activities. In vivo study showed that the combined scaffold-hydrogel system significantly promoted PDL regeneration. …”
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The Effect of Ca and Mg Concentrations and Quantity and Their Correlation with Caries Intensity in School-Age Children by Milaim Sejdini, Kastriot Meqa, Nora Berisha, Ekrem Çitaku, Nora Aliu, Sokol Krasniqi, Sami Salihu

“…Magnesium, except the similar role as calcium, takes an active part in cellular reparation process. Materials and Methods. …”
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Achievements and prospects of applying high-throughput sequencing techniques to potato genetics and breeding by I. V. Bykova, N. A. Shmakov, D. A. Afonnikov, A. V. Kochetov, E. K. Khlestkina

“…The Potato Genome Sequencing Consortium activities included not only constructing genome libraries, sequencing, assembling and annotation of the genome, but also genome sequence-based investigations uncovering features of potato genome evolution, SNP identification, analysis of genes and gene networks regulating resistance to phytopathogens and technological characteristics. …”
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Effective treatment of severe acute pancreatitis and COVID-19 pneumonia with tocilizumab by Piotr Zielecki, Magdalena Kaniewska, Mariusz Furmanek, Tomasz Bulski, Grażyna Rydzewska

“…This mechanism blocks receptor complex signal transduction to inflammatory mediators responsible for B and T cell activation and inhibits cytokine storm [12]. IL-6 pathway blocking can be a new method for the treatment of severe COVID-19 patients [13], and tocilizumab is expected to become an effective drug against COVID-19, but currently scientific data are limited. …”
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Mixed pastures and biological efficiency in buffalo production systems: determinants for a sustainable livestock by Juan Pablo Uzcátegui-Varela, Martha Gloribet Ceballos Ramírez

“…The analysis of biological systems is characterized by the use of basic calculations during the production process that define the complex dynamics of natural capital, which is directly managed by human activities with a simplification and selection of biodiversity to support ecosystem function while generating products of agri-food interest. …”
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Impact of training dairy farm personnel on milking routine compliance, udder health, and milk quality by Zelmar Rodriguez, Mario Lopez-Benavides, Marianna B. Gentilini, Pamela L. Ruegg

“…The training session was delivered using an active learning approach prioritizing group discussions, and focused on the pathogenesis, identification, and risk factors for mastitis, as well as the rationale and importance of each step in the milking routine. …”
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Proteomic Identification and Functional Analysis of Babesia microti Reveals Heparin-Binding Proteins by Yu Chun Cai, Bin Xu, Yan Hong Chu, Ying Fang Yu, Jia Hui Sun, Zi Ran Mo, Han Yin Yang, Shu Ning Yan, Mu Xin Chen, Jia Xu Chen

“…Notably, BmPPIase and chaperonin recombinant proteins exhibited activity in specific heparin binding. Molecular interaction studies further confirmed the strong interaction between BmPPIase and heparin. …”
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Predictive value of systemic immune inflammation index combined with coagulation index in traumatic coagulopathy in patients with severe trauma by Chen Wang, Yongyong Huang, Shiyun Liao, Jiming Song

“…SII in TIC group was significantly higher than that in non-TIC group. neutrophil count (NEU), platelet count (PLT), lymphocyte count (LYM), activated partial thromboplastin time (APTT), prothrombin time (PT), fibrinogen (FIB) level, and D-Dimer (D-D) level in TIC group were higher than those in non-TIC group, while LYM, FIB was lower than that in non-TIC group. …”
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