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48041
Common features of environmentally and socially engaged community programs addressing the intersecting challenges of planetary and human health: mixed methods analysis of survey an...
Published 2025-01-01“…Inclusion criteria comprised adult practitioners offering environmentally and socially engaged community programs of creative and cultural activities leading to health and environmental outcomes. …”
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48042
High-dose ascorbic acid synergizes with anti-PD1 therapy in non-small cell lung cancer in vitro and in vivo models
Published 2025-01-01“…The combination of anti-PD1 and high-dose AA showed dramatic antitumor effects in a syngeneic mouse model of lung cancer by significantly reducing tumor growth and increasing CD8+ T cell-dependent cytotoxicity and macrophage activity. Comprehensive protein analysis confirmed that high-dose AA in anti-PD1-treated tumor tissues enhanced the antitumor effects by regulating various immune-related mechanisms, including the B cell and T cell receptor signaling pathways, Fc gamma R-mediated phagocytosis, and natural killer (NK) cell-mediated cytotoxicity.DiscussionOur results suggest that high-dose AA may be a promising adjuvant to potentiate the efficacy of anti-PD1 immunotherapy.…”
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48043
DNA barcoding of terrestrial invasive plant species in Southwest Michigan
Published 2024-06-01“…Abstract Because of the detrimental effects of terrestrial invasive plant species (TIPS) on native species, ecosystems, public health, and the economy, many countries have been actively looking for strategies to prevent the introduction and minimize the spread of TIPS. …”
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48044
The book graphics of Vilnius printing houses in XVI-XVII centuries
Published 2024-08-01“… The printing activities flourished in Vilnius from the end of the sixteenth century. …”
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48045
Water use dynamics of almond and pistachio crops in the Mediterranean region amid climate change
Published 2025-02-01“…The simulated crop responses to warming-only and eCO2 revealed compounding effects on chill accumulation, phenology, biomass accumulation, and eventually on crop water use. The active growth period from bud break to dormancy was prolonged by 10–25 days for both crops under simulated Representative Concentration Pathways (RCP4.5 and RCP8.5) scenarios compared to the baseline. …”
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48046
Research Progress on Neural Processing of Hand and Forearm Tactile Sensation: A Review Based on fMRI Research
Published 2025-01-01“…These studies use general linear models (GLM) to identify brain regions activated during touch processing, or employ functional connectivity(FC) analysis to examine interactions between brain regions, thereby exploring the neural mechanisms underlying the central nervous system’s processing of various aspects of tactile sensation, including discriminative touch and affective touch. …”
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48047
Book phenomenon in library philosophy and library research
Published 2024-08-01“…Another aspect is the book as a tool, a communicative tool, self-created as the result of human mental activities (like tools such as a spade or axe, but with different goals) for a specific goal—social communication (including religion, philosophy, fiction, thinking, etc.) and historical memory. …”
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48048
Malignant Paraganglioma With Calvarial Metastases Presenting With Recurrent Catecholamine-Induced Cardiomyopathy
Published 2025-01-01“…Conclusion: Our case highlights the importance of active surveillance in PGL and pheochromocytoma to allow early intervention for metastatic disease and reviews the controversial management of rare calvarial or cerebral metastases, including peptide receptor radionuclide therapy.…”
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48049
Changing of taste organ in Persian sturgeon (Acipenser persicus, Borodin, 1897) during early development
Published 2024-04-01“…The results of the maximum development process (5th DPH-8th DPH) of taste buds show the compatibility of the development of taste buds of the Persian sturgeon with the start of active feeding of this species (in the 8th DPH).Conclusion: In this research, the development process of the taste organ of Persian sturgeon from the time of hatching through the 23rd day was examined. …”
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48050
Differential Regulation of DC Function, Adaptive Immunity, and MyD88 Dependence by Two Squalene Emulsion-Based Vaccine Adjuvants
Published 2024-05-01“…Considering MF59 was reported to activate MyD88 to mediate its adjuvant effects, this study also investigated whether the above-explored adjuvant effects of AddaVax and AddaS03 depended on MyD88. …”
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48051
Barreras percibidas y nivel de actividad física en universitarios colombianos durante la pandemia por covid-19
Published 2023-07-01“…Los instrumentos para recoger la información fueron el Cuestionario Internacional de Actividad Física (IPAQ) y el Barriers to Being Active Quiz (BBAQ). Los resultados mostraron que el 55.64% de los participantes reportó bajos niveles de actividad física, con porcentajes mayores en el grupo de fisioterapia; el 85.79% presentaron, al menos, una barrera para realizar actividad física, con diferencias estadísticamente significativas entre el grupo de fisioterapia comparado con el grupo de deporte para las barreras falta de tiempo, voluntad e influencia social. …”
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48052
IUENNA – openIng the soUthErn jauNtal as a micro-regioN for future Archaeology: A «para-description»
Published 2023-12-01“…The project marks a novel initiative in Austrian Classical studies by providing a robust model for the active and sustainable long-term archiving of digital archaeological data. …”
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48053
Characterization of a New Immunosuppressive and Antimicrobial Peptide, DRS-DA2, Isolated from the Mexican Frog, Pachymedusa dacnicolor
Published 2024-01-01“…Interestingly, DRS-DA2N and DRS-DA2NEQ exhibit a dual activity by inducing the death of leukocytes as well as that of Gram-negative and Gram-positive bacteria, including multiresistant strains, without affecting other cells such as epithelial cells or erythrocytes. …”
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48054
Effectiveness of a train-the-trainer workshop series on teaching methods among nurse educators: an exemplar from Vietnam
Published 2025-01-01“…Substantial gains were observed in three specific areas: the classic progress of activities in team-based learning, Kolb’s experiential learning cycle in simulation debriefing techniques, and the core value of the peer mentoring model had significantly improved. …”
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48055
Fracture, Dissolution, and Cementation Events in Ordovician Carbonate Reservoirs, Tarim Basin, NW China
Published 2020-01-01“…Results show that dissolution occurred at depth and was caused by (1) acidic fluids derived from Middle-Late Silurian and/or Devonian-Permian hydrocarbon generation and maturation, (2) high-temperature fluids, of which some were associated with Late Permian igneous activity, and (3) Mg-rich fluids that accompanied Jurassic-Cretaceous deformation and the formation of partially open fractures and stylobreccias (fault breccias). …”
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48056
The intervention of curcumin on rodent models of hepatic fibrosis: A systematic review and meta-analysis.
Published 2024-01-01“…<h4>Conclusion</h4>The analysis results indicate that curcumin can reduce liver cell apoptosis by maintaining the stability of liver cell membrane, inhibit the activation and proliferation of hepatic stellate cells by reducing inflammatory response, and alleviate tissue peroxidation damage by clearing oxygen free radicals.…”
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48057
Antibody and serum bactericidal response to Burkholderia pseudomallei in acute localized and septicemic melioidosis cases with diabetes mellitus
Published 2025-01-01“…Blood samples were collected from the respective cases in active phase of the disease within 1 or 2 days of being culture positive. …”
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48058
Epidemiological and clinical characteristics of hospitalized pediatric patients with Mycoplasma pneumoniae pneumonia before and after the COVID-19 pandemic in China: a retrospectiv...
Published 2025-01-01“…Abstract Background In China many respiratory pathogens stayed low activities amid the COVID-19 pandemic due to strict measures and controls. …”
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48059
CCR2 signaling regulates anti-chlamydia T cell immune responses in the airway.
Published 2025-02-01“…CCR2, a member of the G protein-coupled receptor (GPCR) superfamily, is widely expressed on monocytes, macrophages, activated T cells, and other cell types, and plays a critical role in coordinating the immune response to various infections. …”
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48060
MiR-181a-5p Delivered by Adipose-Derived Mesenchymal Stem Cell Exosomes Alleviates Klebsiella pneumonia Infection-Induced Lung Injury by Targeting STAT3 Signaling
Published 2022-01-01“…ADSC-derived exosomal miR-181a-5p repressed pulmonary outgrowth and dissemination of K. pneu infection in mice, repressed cellular infiltration in lung tissue, and attenuated the inflammasome activity and the levels of IL-1β and IL-18 in the lung. …”
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