Effect of RAS mutations and related immune characteristics on the prognosis of patients with MSI-H/dMMR colorectal cancer by Yupeng Jiang, Yuyao Liu, Hong Huang, Tiantian Zhao, Zengyi Zhao, Yawen Gao

“…Abstract Purpose Microsatellite high instability/deficient mismatch repair (MSI-H/dMMR) colorectal cancer (CRC) has an active tumor microenvironment, rendering it more sensitive to immune checkpoint inhibitors. …”
Get full text

Study on the drying characteristics of green pellets of ultrafine iron ore concentrate by Wen B.-L., Zhang X.-P., Liu D.-L., Li J.-X., Sun X.-D., Yang J.-L.

“…The moisture diffusion coefficient and convective mass transfer coefficient increased with rising temperature and air velocity, following the order of Deff > Dcal > D*eff as determined by the Weibull distribution function, Dincer model, and Fick’s second law. Additionally, the activation energy value of ultrafine iron ore concentrate for drying derived from the Arrhenius formula was 4515.60 J/(mol·K). …”
Get full text

Effect of Artemisia annua on anticoccidial action, intestinal microbiota and metabolites of Hu lambs by Shuaiqi Liu, Shiheng Li, Shuqi Cheng, Manyu Liu, Jing Li, Senyang Li, Xiaoying Li, Longxian Zhang, Fuchun Jian

“…In this study, the effect of different doses and extraction methods of Artemisia annua (A. annua) on anticoccidial activity and growth performance was assessed by oocysts output (OPG), fecal index, average daily gain (ADG) and the new production value of experimental lambs. …”
Get full text

卒中：回眸2024 Highlights in Stroke in 2024 by 熊云云1，2，3，4，李光硕1，马宇洁1，李祉馨1，沈柯佳1，马瑛1，孙大鹏1，孙溢阳1，王拥军1，2，3，5，6，7（XIONG Yunyun1,2,3,4, LI Guangshuo1, MA Yujie1, LI Zhixin1, SHEN Kejia1, MA Ying1, SUN Dapeng1, SUN Yiyang1, WANG Yongjun1,2,3,5,6,7 ）

“…Stroke researchers worldwide have actively contributed their expertise, and further refined the diagnosis, treatment, and management strategies for cerebrovascular diseases. …”
Get full text

Dopamine receptors and key elements of the neurotrophins (BDNF, CDNF) expression patterns during critical periods of ontogenesis in the brain structures of mice with autism-like be... by P. D. Pravikova, M. A. Arssan, E. A. Zalivina, E. M. Kondaurova, E. A. Kulikova, I. I. Belokopytova, V. S. Naumenko

“…In BTBR embryos, on the 14th day of prenatal development, an increase in the expression of the Ngfr gene encoding the p75NTR receptor, which may lead to the activation of apoptosis, was found in the hippocampus and frontal cortex. …”
Get full text

Spatiotemporal Evolution and Driving Mechanisms of kNDVI in Different Sections of the Yangtze River Basin Using Multiple Statistical Methods and the PLSPM Model by Zhenjiang Wu, Fengmei Yao, Adeel Ahmad, Fan Deng, Jun Fang

“…Based on these findings, it is recommended that the upstream focus on enhancing vegetation adaptation management to climate change, the midstream need to coordinate the relationship between topography and human activities, and the downstream should concentrate on controlling the negative impacts of urban expansion on vegetation.…”
Get full text

Mechanisms and thresholds of land use affecting surface water quality in Hangzhou City’s residential areas by Qianhu Chen, Jinye Huang

“…Green spaces per unit area must perform environmental purification in high-rise residential areas due to their higher population density, which puts more demands on their design and ecological service activities. Thus, multi-story and high-rise residential areas should raise their minimum green area ratio by 3.2% and 2%, respectively, while small high-rise residential areas should remain unaltered. …”
Get full text

Five lessons from a mid-level health manager intervention to increase uptake of tuberculosis prevention therapy in Uganda: ‘it is a completely different thing to implement what you... by Jason Johnson-Peretz, Canice Christian, Cecilia Akatukwasa, Fred Atwine, Elijah Kakande, Moses R. Kamya, Diane V. Havlir, Carol S. Camlin, Gabriel Chamie

“…IPT is known to reduce active tuberculosis (TB), a leading cause of death among PLHIV, by 40–60%. …”
Get full text

Umbilical Cord Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Deliver miR-21 to Promote Corneal Epithelial Wound Healing through PTEN/PI3K/Akt Pathway by Xiaolong Liu, Xuran Li, Guangyuan Wu, Pengfei Qi, Yanyan Zhang, Zhiyu Liu, Xinyue Li, Yu Yu, Xiangmei Ye, Yang Li, Dongguang Yang, Yueqiu Teng, Ce Shi, Xin Jin, Sen Qi, Yuting Liu, Shudan Wang, Ying Liu, Fenglin Cao, Qingran Kong, Zhenkun Wang, Hong Zhang

“…Results also show that the benefits are associated with decreased PTEN level and activated the PI3K/Akt signaling pathway in HCECs. …”
Get full text

The humble charm of modern stereotypes about fo­reigners and yasak in Russia during the 16th–17th centuries by Samigulov G.Kh.

“…Research objectives: The main purpose of the study is to consider some fairly actively used stereotypes and their validity. Research materials: The reason for writing the proposed publication article was the work of A.Yu. …”
Get full text

Sex-Specific Analysis of the Relationship Between Ventricular Premature Contractions Frequency Distribution and Heart Rate: A Cross-Sectional Study in Chinese Adults by Li Z, Fang Y, Wu J, Ma W

“…Heart rate variability (HRV) indices were assessed to evaluate autonomic nervous system activity.Results: Among the 478 patients, 267 were males and 211 were females with a mean age of 65.7± 13.0 years. …”
Get full text

A Survey of Machine Learning in Edge Computing: Techniques, Frameworks, Applications, Issues, and Research Directions by Oumayma Jouini, Kaouthar Sethom, Abdallah Namoun, Nasser Aljohani, Meshari Huwaytim Alanazi, Mohammad N. Alanazi

“…Hot topics included big data, cloud, edge, multimedia, security, privacy, QoS, and activity recognition, while critical domains included industry, healthcare, agriculture, transportation, smart homes and cities, and assisted living. …”
Get full text

BMSC-Derived Exosomes Ameliorate Osteoarthritis by Inhibiting Pyroptosis of Cartilage via Delivering miR-326 Targeting HDAC3 and STAT1//NF-κB p65 to Chondrocytes by Honggang Xu, Bin Xu

“…Incubation with BMSC-Exos could significantly improve the survival rate, migration ability, and chondrocyte-specific genes (COL2A1, SOX9, Agg, and Prg4) and miR-326 expression of OA chondrocytes and significantly inhibit pyroptosis of chondrocytes by downregulation of the levels of inflammatory cytokines, Caspase-1 activity, and pyroptosis-related proteins such as GSDMD, NLRP3, ASC, IL-1β, and IL-18 (P<0.01). …”
Get full text

Barriers to social participation for people with disabilities in NTD-endemic areas of Benin and Côte d'Ivoire: Assessing scope and associated factors. by Yévèdo Borel Tossou, Paule Héléna Biaka, Fifamin Noël Christelle Gbaguidi, Vignon Bedie, Sonagnon Inès Elvire Agbo, Fernand Aimé Guedou, Kouakou Jerôme Kouadio, Sèdjro Gimatal Esaï Anagonou, Franck Zinsou Mignanwande, Parfait Djossou, Brunelle Vanessa Yemadje, Flora Sylvie Houndjrebo, Jeanne d'Arc Natacha Lessanh Arrawo, Yvette Faihoun, Harvey Johnson, Ghislain Emmanuel Sopoh, Jean Gabin Houezo, Mamadou Kaloga, Agui Sylvestre Dizoe, Mark Nichter, Anna Gine-March, Roch Christian Johnson

“…Factors (OR [95%IC], p-value) associated with RSPs were age (30 to 44 years (1.66 [1.06-2.59], p = 0.026), 45 to 59 years (2.26 [1.43-3.58], p = 0.001), and 60 to 74 years (2.35 [1.29-4.27], p = 0.005); Secondary/University level of education ((0.42 [0.28-0.65], p = 0.000); occupation (shopkeeper/housekeeper (0.40 [0.17-0.91]), p = 0.029), farmer (0.21 [0.11-0.40], p = 0.000), and other professions (0.44 [0.20-0.96], p = 0.038)); and income-generating activities (IGAs) (1.53 [1.06-2.22], p = 0.023). Our results demonstrate that the magnitude of RSPs among PWDs is high. …”
Get full text

Impaired Glucose Metabolisms of Patients with Obstructive Sleep Apnea and Type 2 Diabetes by Ye Zhang, Yanpeng Xing, Haibo Yuan, Xiaokun Gang, Weiying Guo, Zhuo Li, Guixia Wang

“…The impairment of hypothalamic-pituitary-adrenal axis activity may be one of the underlying mechanisms of the glycometabolic dysfunctions in OSA with T2DM patients.…”
Get full text

Fotografía del rodaje de la película Plácido, de Luis García Berlanga (Plana de l'Om, Manresa, 1961) by Col·lecció Francesc Escala Bartrolí

“…Worthy of note, however, is the state of the conservation of the building in the center of the image, notably rundown in 1961, and the changes that have taken place since then in the stores and profesional activities. Thus, Doctor Oromí Pujol's clinic, specializing in syphilis and dermatology, is today an outlet. …”
Get full text

Inhibition of TFF3 synergizes with c-MET inhibitors to decrease the CSC-like phenotype and metastatic burden in ER+HER2+ mammary carcinoma by Chuyu He, Xuejuan Wang, Yi-Shiou Chiou, Basappa Basappa, Tao Zhu, Vijay Pandey, Peter E. Lobie

“…Mechanistically, TFF3 was observed to activate c-MET signaling through a positive-feedback loop to enhance the CSC-like phenotype of ER+HER2+ MC. …”
Get full text

Demographic and Clinical Determinants of Tuberculosis and TB Recurrence: A Double-Edged Retrospective Study from Pakistan by Mariam Ahmed Mujtaba, Matthew Richardson, Hira Shahzad, Muhammad Ishaq Javed, Ghazala Kaukab Raja, Pakeeza Arzoo Shaiq, Pranabashis Haldar, Sadia Saeed

“…It is necessary to curb recurrence so that attempts to deal with active disease can be made more effective. This study aimed to characterize sociodemographic and clinical factors associated with recurrent TB in a high-burden setting. …”
Get full text

Support for, and perceived effectiveness of, the UK soft drinks industry levy among UK adults: cross-sectional analysis of the International Food Policy Study by David Hammond, Jean Adams, Martin White, David Pell, Tarra Penney, Lana Vanderlee

Get full text

The embeddedness of responsible research innovation in Sabadell’s territorial policies: the case of smart specialization in industrial systems by Anastasios Andronikidis, Amalia Kouskoura, Eleni Kalliontzi, Ioannis Bakouros

“…This included assessing how each system element influences others, leading to the development of a system grid that highlights the most active and ambivalent elements crucial for advancing the city’s policy objectives. …”
Get full text