Identification of cepharanthine as an effective inhibitor of African swine fever virus replication by Chuanxiang Qi, Jiyoung Lee, Yongqiang Zhang, Huan Chen, Jiaxuan Lv, Zhenzhong Wang, Jinming Li, Xiaodong Wu, Yong-Sam Jung, Zhiliang Wang, Yingjuan Qian

“…Our findings imply that CEP exhibits potential antiviral activity against ASFV infection in PAMs, positioning it as a promising therapeutic strategy for ASF.…”
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Clerodendrum volubile Ethanol Leaf Extract: A Potential Antidote to Doxorubicin-Induced Cardiotoxicity in Rats by Olufunke Esan Olorundare, Adejuwon Adewale Adeneye, Akinyele Olubiyi Akinsola, Daniel Ayodele Sanni, Mamoru Koketsu, Hasan Mukhtar

“…Also, CVE profoundly attenuated alterations in the cardiac tissue oxidative stress markers’ activities while improving DOX-associated cardiac histological lesions that were possibly mediated via free radical scavenging and/or antioxidant mechanisms. …”
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Chitosan-Based Semen Extenders: An Approach to Antibiotic-Free Artificial Insemination in Rabbit by Francisco Marco-Jiménez, Celia Ferriz-Nuñez, Maria Pilar Viudes-de-Castro, José Salvador Vicente, Laura Lorenzo-Rebenaque

“…<b>Conclusions</b>: Chitosan’s protective effect on sperm function, combined with its antimicrobial activity, makes it a promising alternative antimicrobial agent for the liquid storage of rabbit seminal AI doses.…”
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Yeokwisan: Standardised Herbal Formula Enhancing Gastric Mucosal Protection Against Gastric Ulcers in Mice, a Preclinical Study by Yun Mi Lee, Kyuhyung Jo, So Yeon Kim, Chang-Seob Seo, Eunjung Son, Aejin Kim, Dong-Seon Kim

“…Its inhibitory effect on gastric mucosal damage and anti-inflammatory activity in animal models of alcohol- and restraint stress-induced gastritis were also examined. …”
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Oridonin: A natural terpenoid having the potential to modulate apoptosis and survival signaling in cancer by Abhishek Chauhan, Hemant Joshi, Divya Kandari, Diwakar Aggarwal, Ritu Chauhan, Hardeep Singh Tuli, Arpit Mehrotra, Abhilasha Sood, Ujjawal Sharma, Darin Mansor Mathkor, Shafiul Haque, Naveen Chandra Joshi, Laurent Dufossé

“…Conclusion: Oridonin demonstrates robust anticancer activity by modulating signaling pathways and inducing apoptosis. …”
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Cardiac Resynchronization Therapy Reduces Metaboreflex Contribution to the Ventilatory Response in Heart Failure Population by Jérémie Jaussaud, Laurie Aimable, Pierre Bordachar, Pierre Dos Santos, Laurent Barandon, Philippe Ritter, Raymond Roudaut, Hervé Douard

“…We investigated the metaboreflex activation after cardiac resynchronization therapy (CRT). …”
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Association between P2X7 Receptor Polymorphisms and Bone Status in Mice by Susanne Syberg, Peter Schwarz, Solveig Petersen, Thomas H. Steinberg, Jens-Erik Beck Jensen, Jenni Teilmann, Niklas Rye Jørgensen

“…In strains with the 451L allele, pore-formation activity in osteoclasts in vitro was lower after application of ATP. …”
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Deep proteomics and network pharmacology reveal sex- and age-shared neuropathic pain signatures in mouse dorsal root ganglia by Sabrina Grundtner, Julia R. Sondermann, Feng Xian, Daniel Malzl, Daniel Segelcke, Esther M. Pogatzki-Zahn, Jörg Menche, David Gómez-Varela, Manuela Schmidt

“…Protein network and multidimensional analysis uncovered distinct hubs of sex- and age-shared biological pathways impacted by neuropathic pain, such as neuronal activity and synaptic function, DNA-damage, and neuroimmune interactions. …”
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Biocontrol Potential of Rhizospheric Bacillus Strains Against <i>Sclerotinia minor</i> Jagger Causing Lettuce Drop by Lihui Xu, Qinghua Shang, Mogens Nicolaisen, Rong Zeng, Shigang Gao, Ping Gao, Zhiwei Song, Fuming Dai, Jingze Zhang

“…Bioactivity experiments showed that Bac20 had higher inhibitory activity against <i>S. minor</i> Jagger than Bac45. …”
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Patient and public involvement in the design and protocol development for a platform randomised trial to evaluate diagnostic tests to optimise antimicrobial therapy (PROTECT) [vers... by Sammy Ainsworth, Cherry-Ann Waldron, Sarah Jones, Julie Carman, Martina Svobodova, Graham Prestwich, Margaret Ogden, Melanie Gager, Liza Keating

“…Background Our patient and public involvement activities were part of a project aiming to develop a master protocol and National Institute for Health and Care research application for the PROTECT trial aiming to assess the effectiveness, implementation, and efficiency of antimicrobial stewardship interventions, to safely reduce unnecessary antibiotic usage by excluding severe bacterial infection in acutely unwell patients. …”
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The adolescent Internet Adaptability Scale: Development and psychometric properties by Weijun Wang, Jianmei Ye, Rouchun Dong, Shihao Ma, Dawei Huang, Xin Zhao

“…It shows positive correlations with Internet use—parental active help, well-being, and meaning in life, and negative correlations with Internet addiction and depression, with stronger associations observed with positive indicators. …”
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Eco-friendly synthesis of chitosan NPs from Fioria vitifolia (L.) L: Potential to antibacterial, antioxidant, cytotoxicity properties of HepG2 cells and their evaluation of safety... by Mohamed Imath, Chinnasamy Ragavendran, Chinnaperumal Kamaraj, Ramalingam Karthik Raja, Gholamreza abdi

“…Also, Antioxidant assay reveals 74 % of DPPH scavenging activities at 100 μg/mL concentration. Using the MTT Assay, the dose-dependent response of FV-CNPs against HepG2 cells was determined, and an IC50 value of 59.41 µg/mL was obtained. …”
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Soluble Epoxide Hydrolase Inhibitor and 14,15-Epoxyeicosatrienoic Acid-Facilitated Long-Term Potentiation through cAMP and CaMKII in the Hippocampus by Han-Fang Wu, Yi-Ju Chen, Su-Zhen Wu, Chi-Wei Lee, I-Tuan Chen, Yi-Chao Lee, Chi-Chen Huang, Chung-Hsi Hsing, Chih-Wei Tang, Hui-Ching Lin

“…TPPU- or 14,15-EET-facilitated FSK-mediated LTP can be potentiated by an A1 adenosine receptor antagonist and a phosphodiesterase inhibitor, but is prevented by a cAMP-dependent protein kinase (PKA) inhibitor. sEHI and 14,15-EET upregulated the activation of extracellular signal-regulated kinases (ERKs) and Ca2+/calmodulin- (CaM-) dependent protein kinase II (CaMKII). …”
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Olfactory Impairment and Recovery in Zebrafish (<i>Danio rerio</i>) Following Cadmium Exposure by Chiara Maria Motta, Rosa Carotenuto, Chiara Fogliano, Luigi Rosati, Pabitra Denre, Raffaele Panzuto, Rossana Romano, Gianluca Miccoli, Palma Simoniello, Bice Avallone

“…Anthropic activities have significantly elevated cadmium levels, making it a significant stressor in aquatic ecosystems. …”
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Characterization of microbial communities in flavors and fragrances during storage by Yingjie Feng, Tingting Zhang, Jinchu Yang, Wenzhao Liu, Yongfeng Yang, Jihong Huang, Shen Huang, Zongcan Yang, Qianjin Liu, Wenchao Zheng, Qing Zhou, Qing Zhou

“…Functional analysis based on the Kyoto Encyclopedia of Genes and Genomes (KEGG) database indicated a shift in metabolic pathways within the microbial community, with heightened metabolic activity correlating with spoilage. These findings provide valuable insights for improving storage methods and quality control of flavors and fragrances.…”
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Phase 1 study of safety, tolerability, and efficacy of intradermal DNA vaccine ASP2390 in adults allergic to house dust mites by Thomas Kayser, MD, BS, Ronald Smulders, MD, PhD, Tomohiro Kusawake, PhD, Erik Wambre, PhD, Gurunadh R. Chichili, PhD, Mary B. Blauwet, DrPH, Anna Spence, MS, Melanie Patton, BS, Rima Tabash, PhD, Hannah A. DeBerg, PhD, Sugandhika Khosa, MS, Philipp Badorrek, MD, Jens M. Hohlfeld, MD, Brian C. Ferslew, PharmD, PhD

“…There were no substantial changes in allergen-specific immunoglobulin levels, basophil activation, or T helper cell subpopulations, and no difference in allergic clinical responses compared to placebo. …”
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Water utilization strategy of tomato grown on east-west orientation in solar greenhouses revealed based on hydroxide isotopes by Furong Han, Lili Zhangzhong, Wengang Zheng, Jingjing Li, Kaili Shi, Yibo Wei

“…Four ridges (R1, R2, R3, and R4) were arranged from south to north, to investigate the varying water utilization strategies of tomatoes across these ridges. Photosynthetically active radiation (PAR) is effective for plant photosynthesis. …”
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Solid-State Modification Strategies for Alpha-Mangostin Solubility Enhancement: A Review on Recent Progress by Nurin Syamimi Ahmad Izuren Shah, Muhammad Taher Bakhtiar, Syarifah Abd Rahim, Fatmawati Adam, Wan Hazman Danial, Mohd Rushdi Abu Bakar

“… Introduction: Enhancing the therapeutic efficacy of active pharmaceutical ingredients requires addressing the persistent challenge of improving their solubility. …”
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Assessing the effects of diabetes mellitus on the monocyte-to-lymphocyte ratio and the QuantiFERON-TB gold plus assays for tuberculosis treatment monitoring: a prospective cohort s... by Paulo Ranaivomanana, Arimanitra Razafimahefa, Mame Ndiaye, Crisca Razafimahatratra, Haja Ramamonjisoa, Perlinot Herindrainy, Mamy Raherison, Antso Hasina Raherinandrasana, Julio Rakotonirina, Jonathan Hoffmann, Rila Ratovoson, Niaina Rakotosamimanana

“…Diabetes mellitus (DM) is an important risk factor for the development of active tuberculosis (TB). QuantiFERON-TB Gold Plus (QFT-P), white blood cell count (WBC) assays and monocyte-to-lymphocyte ratio (MLR) reflect the inflammatory reactions associated with TB and offer the potential to monitor TB treatment to allow a better management of the disease. …”
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Atacama Large Aperture Submillimeter Telescope (AtLAST) science: Probing the transient and time-variable sky [version 2; peer review: 1 approved, 2 approved with reservations] by Pamela Klaassen, Mark Booth, Thomas Stanke, Evanthia Hatziminaoglou, Claudia Cicone, Martin Cordiner, Tony Mroczkowski, Doug Johnstone, Luca Di Mascolo, Minju Lee, Eelco van Kampen, Thomas Maccarone, Daizhong Liu, Matthew Smith, Amélie Saintonge, Sven Wedemeyer, Alexander Thelen, John Orlowski-Scherer, Tomasz Kamiński, Joe Bright, Atul Mohan, Michael Koss, Sigurd Næss, Francisco Miguel Montenegro-Montes, Paola Severgnini, Claudio Ricci, Jochen Greiner, Cristian Vignali

“…The study of transient and variable events, including novae, active galactic nuclei, and black hole binaries, has historically been a fruitful path for elucidating the evolutionary mechanisms of our universe. …”
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